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Items: 14


Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.

O'Dowd H, Shannon DE, Chandupatla KR, Dixit V, Engtrakul JJ, Ye Z, Jones SM, O'Brien CF, Nicolau DP, Tessier PR, Crandon JL, Song B, Macikenas D, Hanzelka BL, Le Tiran A, Bennani YL, Charifson PS, Grillot AL.

ACS Med Chem Lett. 2015 Jun 22;6(7):822-6. doi: 10.1021/acsmedchemlett.5b00196. eCollection 2015 Jul 9.


A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.

Locher CP, Jones SM, Hanzelka BL, Perola E, Shoen CM, Cynamon MH, Ngwane AH, Wiid IJ, van Helden PD, Betoudji F, Nuermberger EL, Thomson JA.

Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65. doi: 10.1128/AAC.04347-14. Epub 2014 Dec 22.


Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease.

Zhou Y, Bartels DJ, Hanzelka BL, Müh U, Wei Y, Chu HM, Tigges AM, Brennan DL, Rao BG, Swenson L, Kwong AD, Lin C.

Antimicrob Agents Chemother. 2008 Jan;52(1):110-20. Epub 2007 Oct 15.


Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.

Zhou Y, Müh U, Hanzelka BL, Bartels DJ, Wei Y, Rao BG, Brennan DL, Tigges AM, Swenson L, Kwong AD, Lin C.

J Biol Chem. 2007 Aug 3;282(31):22619-28. Epub 2007 Jun 6.


A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal.

Müh U, Hare BJ, Duerkop BA, Schuster M, Hanzelka BL, Heim R, Olson ER, Greenberg EP.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16948-52. Epub 2006 Oct 30.


Detection, purification, and structural elucidation of the acylhomoserine lactone inducer of Vibrio fischeri luminescence and other related molecules.

Schaefer AL, Hanzelka BL, Parsek MR, Greenberg EP.

Methods Enzymol. 2000;305:288-301. No abstract available.


Acylhomoserine lactone synthase activity of the Vibrio fischeri AinS protein.

Hanzelka BL, Parsek MR, Val DL, Dunlap PV, Cronan JE Jr, Greenberg EP.

J Bacteriol. 1999 Sep;181(18):5766-70.


Acyl homoserine-lactone quorum-sensing signal generation.

Parsek MR, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4360-5.


Mutational analysis of the Vibrio fischeri LuxI polypeptide: critical regions of an autoinducer synthase.

Hanzelka BL, Stevens AM, Parsek MR, Crone TJ, Greenberg EP.

J Bacteriol. 1997 Aug;179(15):4882-7.


Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein.

Schaefer AL, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP.

Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9505-9.


Quorum sensing in Vibrio fischeri: probing autoinducer-LuxR interactions with autoinducer analogs.

Schaefer AL, Hanzelka BL, Eberhard A, Greenberg EP.

J Bacteriol. 1996 May;178(10):2897-901.


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