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Items: 1 to 50 of 214

1.

Clustering of Tau fibrils impairs the synaptic composition of α3-Na+/K+-ATPase and AMPA receptors.

Shrivastava AN, Redeker V, Pieri L, Bousset L, Renner M, Madiona K, Mailhes-Hamon C, Coens A, Buée L, Hantraye P, Triller A, Melki R.

EMBO J. 2019 Jan 10. pii: e99871. doi: 10.15252/embj.201899871. [Epub ahead of print]

2.

Voxel-Based Statistical Analysis of 3D Immunostained Tissue Imaging.

Vandenberghe ME, Souedet N, Hérard AS, Ayral AM, Letronne F, Balbastre Y, Sadouni E, Hantraye P, Dhenain M, Frouin F, Lambert JC, Delzescaux T.

Front Neurosci. 2018 Nov 15;12:754. doi: 10.3389/fnins.2018.00754. eCollection 2018.

3.

Cerebrospinal fluid leakage after posterior fossa surgery may impair brain metabolite clearance.

Goulay R, Aron Badin R, Flament J, Emery E, Hantraye P, Vivien D, Gaberel T.

Neurochirurgie. 2018 Dec;64(6):422-424. doi: 10.1016/j.neuchi.2018.08.003. Epub 2018 Oct 24.

PMID:
30477647
4.

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer's disease.

Ceyzériat K, Ben Haim L, Denizot A, Pommier D, Matos M, Guillemaud O, Palomares MA, Abjean L, Petit F, Gipchtein P, Gaillard MC, Guillermier M, Bernier S, Gaudin M, Aurégan G, Joséphine C, Déchamps N, Veran J, Langlais V, Cambon K, Bemelmans AP, Baijer J, Bonvento G, Dhenain M, Deleuze JF, Oliet SHR, Brouillet E, Hantraye P, Carrillo-de Sauvage MA, Olaso R, Panatier A, Escartin C.

Acta Neuropathol Commun. 2018 Oct 16;6(1):104. doi: 10.1186/s40478-018-0606-1.

5.

Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease.

Palfi S, Gurruchaga JM, Lepetit H, Howard K, Ralph GS, Mason S, Gouello G, Domenech P, Buttery PC, Hantraye P, Tuckwell NJ, Barker RA, Mitrophanous KA.

Hum Gene Ther Clin Dev. 2018 Sep;29(3):148-155. doi: 10.1089/humc.2018.081.

6.

In Vivo Multidimensional Brain Imaging in Huntington's Disease Animal Models.

Flament J, Hantraye P, Valette J.

Methods Mol Biol. 2018;1780:285-301. doi: 10.1007/978-1-4939-7825-0_15.

PMID:
29856025
7.

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

Galvan L, Francelle L, Gaillard MC, de Longprez L, Carrillo-de Sauvage MA, Liot G, Cambon K, Stimmer L, Luccantoni S, Flament J, Valette J, de Chaldée M, Auregan G, Guillermier M, Joséphine C, Petit F, Jan C, Jarrige M, Dufour N, Bonvento G, Humbert S, Saudou F, Hantraye P, Merienne K, Bemelmans AP, Perrier AL, Déglon N, Brouillet E.

Brain. 2018 May 1;141(5):1434-1454. doi: 10.1093/brain/awy057.

8.

Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates.

Senova S, Poupon C, Dauguet J, Stewart HJ, Dugué GP, Jan C, Hosomi K, Ralph GS, Barnes L, Drouot X, Pouzat C, Mangin JF, Pain F, Doignon I, Aron-Badin R, Brouillet E, Boyden ES, Mitrophanous KA, Hantraye P, Palfi S.

Sci Rep. 2018 Feb 20;8(1):3362. doi: 10.1038/s41598-018-21486-8.

9.

Feedback control of microbubble cavitation for ultrasound-mediated blood-brain barrier disruption in non-human primates under magnetic resonance guidance.

Kamimura HA, Flament J, Valette J, Cafarelli A, Aron Badin R, Hantraye P, Larrat B.

J Cereb Blood Flow Metab. 2018 Jan 30:271678X17753514. doi: 10.1177/0271678X17753514. [Epub ahead of print]

PMID:
29381130
10.

Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat.

d'Orange M, Aurégan G, Cheramy D, Gaudin-Guérif M, Lieger S, Guillermier M, Stimmer L, Joséphine C, Hérard AS, Gaillard MC, Petit F, Kiessling MC, Schmitz C, Colin M, Buée L, Panayi F, Diguet E, Brouillet E, Hantraye P, Bemelmans AP, Cambon K.

Brain. 2018 Feb 1;141(2):535-549. doi: 10.1093/brain/awx342.

11.

A validation dataset for Macaque brain MRI segmentation.

Balbastre Y, Rivière D, Souedet N, Fischer C, Hérard AS, Williams S, Vandenberghe ME, Flament J, Aron-Badin R, Hantraye P, Mangin JF, Delzescaux T.

Data Brief. 2017 Nov 4;16:37-42. doi: 10.1016/j.dib.2017.11.008. eCollection 2018 Feb.

12.

Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque.

Comoy EE, Mikol J, Jaffré N, Lebon V, Levavasseur E, Streichenberger N, Sumian C, Perret-Liaudet A, Eloit M, Andreoletti O, Haïk S, Hantraye P, Deslys JP.

Nat Commun. 2017 Nov 2;8(1):1268. doi: 10.1038/s41467-017-01347-0.

13.

βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease.

Audrain M, Souchet B, Alves S, Fol R, Viode A, Haddjeri A, Tada S, Orefice NS, Joséphine C, Bemelmans AP, Delzescaux T, Déglon N, Hantraye P, Akwa Y, Becher F, Billard JM, Potier B, Dutar P, Cartier N, Braudeau J.

Cereb Cortex. 2018 Nov 1;28(11):3976-3993. doi: 10.1093/cercor/bhx260.

PMID:
29048465
14.

Primatologist: A modular segmentation pipeline for macaque brain morphometry.

Balbastre Y, Rivière D, Souedet N, Fischer C, Hérard AS, Williams S, Vandenberghe ME, Flament J, Aron-Badin R, Hantraye P, Mangin JF, Delzescaux T.

Neuroimage. 2017 Nov 15;162:306-321. doi: 10.1016/j.neuroimage.2017.09.007. Epub 2017 Sep 9.

PMID:
28899745
15.

A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina.

Chaffiol A, Caplette R, Jaillard C, Brazhnikova E, Desrosiers M, Dubus E, Duhamel L, Macé E, Marre O, Benoit P, Hantraye P, Bemelmans AP, Bamberg E, Duebel J, Sahel JA, Picaud S, Dalkara D.

Mol Ther. 2017 Nov 1;25(11):2546-2560. doi: 10.1016/j.ymthe.2017.07.011. Epub 2017 Jul 20.

16.

Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.

Cambon K, Zimmer V, Martineau S, Gaillard MC, Jarrige M, Bugi A, Miniarikova J, Rey M, Hassig R, Dufour N, Auregan G, Hantraye P, Perrier AL, Déglon N.

Mol Ther Methods Clin Dev. 2017 May 11;5:259-276. doi: 10.1016/j.omtm.2017.05.001. eCollection 2017 Jun 16.

17.

Advanced imaging of transplant survival, fate, differentiation, and integration.

Van Camp N, Diguet E, Hantraye P.

Prog Brain Res. 2017;230:283-303. doi: 10.1016/bs.pbr.2016.11.001. Epub 2017 Mar 23.

PMID:
28552233
18.

Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate.

Goulay R, Flament J, Gauberti M, Naveau M, Pasquet N, Gakuba C, Emery E, Hantraye P, Vivien D, Aron-Badin R, Gaberel T.

Stroke. 2017 Aug;48(8):2301-2305. doi: 10.1161/STROKEAHA.117.017014. Epub 2017 May 19.

PMID:
28526764
19.

Cortical areas involved in behavioral expression of external pallidum dysfunctions: A PET imaging study in non-human primates.

Galineau L, Kas A, Worbe Y, Chaigneau M, Herard AS, Guillermier M, Delzescaux T, Féger J, Hantraye P, Tremblay L.

Neuroimage. 2017 Feb 1;146:1025-1037. doi: 10.1016/j.neuroimage.2016.10.039. Epub 2016 Oct 29.

PMID:
27989846
20.

Posttransplant Lymphoproliferative Disorders in Neuronal Xenotransplanted Macaques.

Cavicchioli L, Ferraresso S, Westmoreland S, Kaliyaperumal S, Knight H, Crossan C, Scobie L, Danesi A, Vadori M, Trez D, Badin RA, Hantraye P, Cozzi E.

Vet Pathol. 2017 Mar;54(2):336-344. doi: 10.1177/0300985816669407. Epub 2016 Oct 1.

PMID:
27694423
21.

New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo.

Palombo M, Ligneul C, Najac C, Le Douce J, Flament J, Escartin C, Hantraye P, Brouillet E, Bonvento G, Valette J.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6671-6. doi: 10.1073/pnas.1504327113. Epub 2016 May 25.

22.

mRNA trans-splicing in gene therapy for genetic diseases.

Berger A, Maire S, Gaillard MC, Sahel JA, Hantraye P, Bemelmans AP.

Wiley Interdiscip Rev RNA. 2016 Jul;7(4):487-98. doi: 10.1002/wrna.1347. Epub 2016 Mar 28. Review.

23.

High-throughput 3D whole-brain quantitative histopathology in rodents.

Vandenberghe ME, Hérard AS, Souedet N, Sadouni E, Santin MD, Briet D, Carré D, Schulz J, Hantraye P, Chabrier PE, Rooney T, Debeir T, Blanchard V, Pradier L, Dhenain M, Delzescaux T.

Sci Rep. 2016 Feb 15;6:20958. doi: 10.1038/srep20958.

24.

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.

Audrain M, Fol R, Dutar P, Potier B, Billard JM, Flament J, Alves S, Burlot MA, Dufayet-Chaffaud G, Bemelmans AP, Valette J, Hantraye P, Déglon N, Cartier N, Braudeau J.

Mol Neurodegener. 2016 Jan 12;11:5. doi: 10.1186/s13024-016-0070-y.

25.

Cell Therapy for Parkinson's Disease: A Translational Approach to Assess the Role of Local and Systemic Immunosuppression.

Aron Badin R, Vadori M, Vanhove B, Nerriere-Daguin V, Naveilhan P, Neveu I, Jan C, Lévèque X, Venturi E, Mermillod P, Van Camp N, Dollé F, Guillermier M, Denaro L, Manara R, Citton V, Simioni P, Zampieri P, D'avella D, Rubello D, Fante F, Boldrin M, De Benedictis GM, Cavicchioli L, Sgarabotto D, Plebani M, Stefani AL, Brachet P, Blancho G, Soulillou JP, Hantraye P, Cozzi E.

Am J Transplant. 2016 Jul;16(7):2016-29. doi: 10.1111/ajt.13704. Epub 2016 Mar 3.

26.

Three-dimensional SPACE fluid-attenuated inversion recovery at 3 T to improve subthalamic nucleus lead placement for deep brain stimulation in Parkinson's disease: from preclinical to clinical studies.

Senova S, Hosomi K, Gurruchaga JM, Gouello G, Ouerchefani N, Beaugendre Y, Lepetit H, Lefaucheur JP, Badin RA, Dauguet J, Jan C, Hantraye P, Brugières P, Palfi S.

J Neurosurg. 2016 Aug;125(2):472-80. doi: 10.3171/2015.7.JNS15379. Epub 2016 Jan 8.

PMID:
26745490
27.

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.

Rocher AB, Gubellini P, Merienne N, Boussicault L, Petit F, Gipchtein P, Jan C, Hantraye P, Brouillet E, Bonvento G.

Neurobiol Dis. 2016 Feb;86:131-9. doi: 10.1016/j.nbd.2015.10.016. Epub 2015 Nov 25.

PMID:
26626081
28.

Current status of neuronal cell xenotransplantation.

Vadori M, Aron Badin R, Hantraye P, Cozzi E.

Int J Surg. 2015 Nov;23(Pt B):267-272. doi: 10.1016/j.ijsu.2015.09.052. Epub 2015 Sep 25. Review.

29.

Gene transfer engineering for astrocyte-specific silencing in the CNS.

Merienne N, Delzor A, Viret A, Dufour N, Rey M, Hantraye P, Déglon N.

Gene Ther. 2015 Oct;22(10):830-9. doi: 10.1038/gt.2015.54. Epub 2015 Jun 5.

30.

Translational research for Parkinson׳s disease: The value of pre-clinical primate models.

Aron Badin R, Vadori M, Cozzi E, Hantraye P.

Eur J Pharmacol. 2015 Jul 15;759:118-26. doi: 10.1016/j.ejphar.2015.03.038. Epub 2015 Apr 2. Review.

PMID:
25841877
31.

The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study.

Carrillo-de Sauvage MA, Flament J, Bramoulle Y, Ben Haim L, Guillermier M, Berniard A, Aurégan G, Houitte D, Brouillet E, Bonvento G, Hantraye P, Valette J, Escartin C.

J Cereb Blood Flow Metab. 2015 Jun;35(6):917-21. doi: 10.1038/jcbfm.2015.48. Epub 2015 Apr 1.

32.

The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

Ben Haim L, Ceyzériat K, Carrillo-de Sauvage MA, Aubry F, Auregan G, Guillermier M, Ruiz M, Petit F, Houitte D, Faivre E, Vandesquille M, Aron-Badin R, Dhenain M, Déglon N, Hantraye P, Brouillet E, Bonvento G, Escartin C.

J Neurosci. 2015 Feb 11;35(6):2817-29. doi: 10.1523/JNEUROSCI.3516-14.2015.

33.

Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.

Francelle L, Galvan L, Gaillard MC, Petit F, Bernay B, Guillermier M, Bonvento G, Dufour N, Elalouf JM, Hantraye P, Déglon N, de Chaldée M, Brouillet E.

Neurobiol Aging. 2015 Mar;36(3):1601.e7-16. doi: 10.1016/j.neurobiolaging.2014.11.014. Epub 2014 Dec 18.

34.

Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease.

Grealish S, Diguet E, Kirkeby A, Mattsson B, Heuer A, Bramoulle Y, Van Camp N, Perrier AL, Hantraye P, Björklund A, Parmar M.

Cell Stem Cell. 2014 Nov 6;15(5):653-65. doi: 10.1016/j.stem.2014.09.017. Epub 2014 Nov 6.

35.

[18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain.

Lavisse S, Inoue K, Jan C, Peyronneau MA, Petit F, Goutal S, Dauguet J, Guillermier M, Dollé F, Rbah-Vidal L, Van Camp N, Aron-Badin R, Remy P, Hantraye P.

Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):478-94. doi: 10.1007/s00259-014-2962-9. Epub 2014 Dec 9.

PMID:
25488184
36.

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.

Francelle L, Galvan L, Gaillard MC, Guillermier M, Houitte D, Bonvento G, Petit F, Jan C, Dufour N, Hantraye P, Elalouf JM, De Chaldée M, Déglon N, Brouillet E.

Hum Mol Genet. 2015 Mar 15;24(6):1563-73. doi: 10.1093/hmg/ddu571. Epub 2014 Nov 14.

37.

Ectosomes: a new mechanism for non-exosomal secretion of tau protein.

Dujardin S, Bégard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Aurégan G, Hantraye P, Brouillet E, Buée L, Colin M.

PLoS One. 2014 Jun 27;9(6):e100760. doi: 10.1371/journal.pone.0100760. eCollection 2014.

38.

Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions.

Boussicault L, Hérard AS, Calingasan N, Petit F, Malgorn C, Merienne N, Jan C, Gaillard MC, Lerchundi R, Barros LF, Escartin C, Delzescaux T, Mariani J, Hantraye P, Beal MF, Brouillet E, Véga C, Bonvento G.

J Cereb Blood Flow Metab. 2014 Sep;34(9):1500-10. doi: 10.1038/jcbfm.2014.110. Epub 2014 Jun 18.

39.

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells.

Drouet V, Ruiz M, Zala D, Feyeux M, Auregan G, Cambon K, Troquier L, Carpentier J, Aubert S, Merienne N, Bourgois-Rocha F, Hassig R, Rey M, Dufour N, Saudou F, Perrier AL, Hantraye P, Déglon N.

PLoS One. 2014 Jun 13;9(6):e99341. doi: 10.1371/journal.pone.0099341. eCollection 2014.

40.

Differential dopamine receptor occupancy underlies L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.

Sahin G, Thompson LH, Lavisse S, Ozgur M, Rbah-Vidal L, Dollé F, Hantraye P, Kirik D.

PLoS One. 2014 Mar 10;9(3):e90759. doi: 10.1371/journal.pone.0090759. eCollection 2014.

41.

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.

Dujardin S, Lécolle K, Caillierez R, Bégard S, Zommer N, Lachaud C, Carrier S, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Colin M, Buée L.

Acta Neuropathol Commun. 2014 Jan 30;2:14. doi: 10.1186/2051-5960-2-14.

42.

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.

Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, Watts C, Miskin J, Kelleher M, Deeley S, Iwamuro H, Lefaucheur JP, Thiriez C, Fenelon G, Lucas C, Brugières P, Gabriel I, Abhay K, Drouot X, Tani N, Kas A, Ghaleh B, Le Corvoisier P, Dolphin P, Breen DP, Mason S, Guzman NV, Mazarakis ND, Radcliffe PA, Harrop R, Kingsman SM, Rascol O, Naylor S, Barker RA, Hantraye P, Remy P, Cesaro P, Mitrophanous KA.

Lancet. 2014 Mar 29;383(9923):1138-46. doi: 10.1016/S0140-6736(13)61939-X. Epub 2014 Jan 10.

PMID:
24412048
43.

Intracellular metabolites in the primate brain are primarily localized in long fibers rather than in cell bodies, as shown by diffusion-weighted magnetic resonance spectroscopy.

Najac C, Marchadour C, Guillermier M, Houitte D, Slavov V, Brouillet E, Hantraye P, Lebon V, Valette J.

Neuroimage. 2014 Apr 15;90:374-80. doi: 10.1016/j.neuroimage.2013.12.045. Epub 2013 Dec 29.

PMID:
24382523
44.

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.

Damiano M, Diguet E, Malgorn C, D'Aurelio M, Galvan L, Petit F, Benhaim L, Guillermier M, Houitte D, Dufour N, Hantraye P, Canals JM, Alberch J, Delzescaux T, Déglon N, Beal MF, Brouillet E.

Hum Mol Genet. 2013 Oct 1;22(19):3869-82. doi: 10.1093/hmg/ddt242. Epub 2013 May 29.

45.

BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities.

Quesseveur G, David DJ, Gaillard MC, Pla P, Wu MV, Nguyen HT, Nicolas V, Auregan G, David I, Dranovsky A, Hantraye P, Hen R, Gardier AM, Déglon N, Guiard BP.

Transl Psychiatry. 2013 Apr 30;3:e253. doi: 10.1038/tp.2013.30.

46.

Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.

Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Buée L, Colin M.

Mol Ther. 2013 Jul;21(7):1358-68. doi: 10.1038/mt.2013.66. Epub 2013 Apr 23.

47.

IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates.

Aron Badin R, Spinnewyn B, Gaillard MC, Jan C, Malgorn C, Van Camp N, Dollé F, Guillermier M, Boulet S, Bertrand A, Savasta M, Auguet M, Brouillet E, Chabrier PE, Hantraye P.

PLoS One. 2013;8(1):e52680. doi: 10.1371/journal.pone.0052680. Epub 2013 Jan 3.

48.

In vivo imaging of integration and function of striatal grafts in rodent and nonhuman primate animal models.

Hantraye P, Badin RA.

Prog Brain Res. 2012;200:329-43. doi: 10.1016/B978-0-444-59575-1.00015-6. Review.

PMID:
23195426
49.

In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin.

Kraska A, Santin MD, Dorieux O, Joseph-Mathurin N, Bourrin E, Petit F, Jan C, Chaigneau M, Hantraye P, Lestage P, Dhenain M.

PLoS One. 2012;7(9):e46196. doi: 10.1371/journal.pone.0046196. Epub 2012 Sep 25.

50.

Designing primate models to assess the prodromal phase of Huntington's disease.

Aron Badin R, Hantraye P.

Rev Neurol (Paris). 2012 Nov;168(11):802-5. doi: 10.1016/j.neurol.2012.07.002. Epub 2012 Sep 13. Review.

PMID:
22981299

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