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Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract.

Furter M, Sellin ME, Hansson GC, Hardt WD.

Cell Rep. 2019 May 28;27(9):2665-2678.e3. doi: 10.1016/j.celrep.2019.04.106.


Mucus and mucins in diseases of the intestinal and respiratory tracts.

Hansson GC.

J Intern Med. 2019 May;285(5):479-490. doi: 10.1111/joim.12910. Epub 2019 Apr 22.


Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis.

van der Post S, Jabbar KS, Birchenough G, Arike L, Akhtar N, Sjovall H, Johansson MEV, Hansson GC.

Gut. 2019 Mar 26. pii: gutjnl-2018-317571. doi: 10.1136/gutjnl-2018-317571. [Epub ahead of print]


The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals.

Svensson F, Lang T, Johansson MEV, Hansson GC.

Sci Rep. 2018 Nov 30;8(1):17503. doi: 10.1038/s41598-018-35499-w.


Assembly, Release, and Transport of Airway Mucins in Pigs and Humans.

Ermund A, Trillo-Muyo S, Hansson GC.

Ann Am Thorac Soc. 2018 Nov;15(Supplement_3):S159-S163. doi: 10.1513/AnnalsATS.201804-238AW.


Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier.

Birchenough G, Schroeder BO, Bäckhed F, Hansson GC.

Gut Microbes. 2019;10(2):246-250. doi: 10.1080/19490976.2018.1513765. Epub 2018 Sep 25.


Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs.

Fernández-Blanco JA, Fakih D, Arike L, Rodríguez-Piñeiro AM, Martínez-Abad B, Skansebo E, Jackson S, Root J, Singh D, McCrae C, Evans CM, Åstrand A, Ermund A, Hansson GC.

JCI Insight. 2018 Sep 6;3(17). pii: 120994. doi: 10.1172/jci.insight.120994. eCollection 2018 Sep 6.


Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity.

Nyström EEL, Birchenough GMH, van der Post S, Arike L, Gruber AD, Hansson GC, Johansson MEV.

EBioMedicine. 2018 Jul;33:134-143. doi: 10.1016/j.ebiom.2018.05.031. Epub 2018 Jun 7.


The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation.

Ermund A, Meiss LN, Dolan B, Bähr A, Klymiuk N, Hansson GC.

Eur Respir J. 2018 Aug 30;52(2). pii: 1800457. doi: 10.1183/13993003.00457-2018. Print 2018 Aug.


Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.

Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bähr A, Klymiuk N, Wine JJ, Koeck PJB, Thornton DJ, Hebert H, Hansson GC.

J Biol Chem. 2018 Apr 13;293(15):5746-5754. doi: 10.1074/jbc.RA117.001014. Epub 2018 Feb 13.


Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration.

Schroeder BO, Birchenough GMH, Ståhlman M, Arike L, Johansson MEV, Hansson GC, Bäckhed F.

Cell Host Microbe. 2018 Jan 10;23(1):27-40.e7. doi: 10.1016/j.chom.2017.11.004. Epub 2017 Dec 21.


Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.

Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087.


Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic Study.

Jabbar KS, Arike L, Verbeke CS, Sadik R, Hansson GC.

J Clin Oncol. 2018 Feb 1;36(4):367-375. doi: 10.1200/JCO.2017.73.7288. Epub 2017 Nov 22.


Progress in understanding mucus abnormalities in cystic fibrosis airways.

Wine JJ, Hansson GC, König P, Joo NS, Ermund A, Pieper M.

J Cyst Fibros. 2018 Mar;17(2S):S35-S39. doi: 10.1016/j.jcf.2017.09.003. Epub 2017 Sep 23. Review.


The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin.

Ermund A, Meiss LN, Rodriguez-Pineiro AM, Bähr A, Nilsson HE, Trillo-Muyo S, Ridley C, Thornton DJ, Wine JJ, Hebert H, Klymiuk N, Hansson GC.

Biochem Biophys Res Commun. 2017 Oct 21;492(3):331-337. doi: 10.1016/j.bbrc.2017.08.113. Epub 2017 Aug 30.


Bacteria Tell Us How to Protect Our Intestine.

Birchenough G, Hansson GC.

Cell Host Microbe. 2017 Jul 12;22(1):3-4. doi: 10.1016/j.chom.2017.06.011.


OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium.

Ermund A, Recktenwald CV, Skjåk-Braek G, Meiss LN, Onsøyen E, Rye PD, Dessen A, Myrset AH, Hansson GC.

Clin Exp Pharmacol Physiol. 2017 Jun;44(6):639-647. doi: 10.1111/1440-1681.12744.


Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection.

Birchenough GM, Dalgakiran F, Witcomb LA, Johansson ME, McCarthy AJ, Hansson GC, Taylor PW.

Sci Rep. 2017 Mar 6;7(1):83. doi: 10.1038/s41598-017-00123-w.


Functional mucous layer and healing of proximal colonic anastomoses in an experimental model.

Bosmans JW, Jongen AC, Birchenough GM, Nyström EE, Gijbels MJ, Derikx JP, Bouvy ND, Hansson GC.

Br J Surg. 2017 Apr;104(5):619-630. doi: 10.1002/bjs.10456. Epub 2017 Feb 13.


Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases.

Arike L, Holmén-Larsson J, Hansson GC.

Glycobiology. 2017 Apr 1;27(4):318-328. doi: 10.1093/glycob/cww134.


Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16.

Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13833-13838. Epub 2016 Nov 14.


Immunological aspects of intestinal mucus and mucins.

Johansson ME, Hansson GC.

Nat Rev Immunol. 2016 Oct;16(10):639-49. doi: 10.1038/nri.2016.88. Epub 2016 Aug 8. Review.


A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.

Birchenough GM, Nyström EE, Johansson ME, Hansson GC.

Science. 2016 Jun 24;352(6293):1535-42. doi: 10.1126/science.aaf7419.


Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP.

Lang T, Klasson S, Larsson E, Johansson ME, Hansson GC, Samuelsson T.

Mol Biol Evol. 2016 Aug;33(8):1921-36. doi: 10.1093/molbev/msw066. Epub 2016 Apr 4.


Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice.

Bergstrom K, Fu J, Johansson ME, Liu X, Gao N, Wu Q, Song J, McDaniel JM, McGee S, Chen W, Braun J, Hansson GC, Xia L.

Mucosal Immunol. 2017 Jan;10(1):91-103. doi: 10.1038/mi.2016.45. Epub 2016 May 4.


The Reduction-insensitive Bonds of the MUC2 Mucin Are Isopeptide Bonds.

Recktenwald CV, Hansson GC.

J Biol Chem. 2016 Jun 24;291(26):13580-90. doi: 10.1074/jbc.M116.726406. Epub 2016 Apr 25.


The Densely O-Glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria.

Arike L, Hansson GC.

J Mol Biol. 2016 Aug 14;428(16):3221-3229. doi: 10.1016/j.jmb.2016.02.010. Epub 2016 Feb 12. Review.


Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization.

Johansson ME, Jakobsson HE, Holmén-Larsson J, Schütte A, Ermund A, Rodríguez-Piñeiro AM, Arike L, Wising C, Svensson F, Bäckhed F, Hansson GC.

Cell Host Microbe. 2015 Nov 11;18(5):582-92. doi: 10.1016/j.chom.2015.10.007. Epub 2015 Oct 29.


Quantitative Imaging of Gut Microbiota Spatial Organization.

Earle KA, Billings G, Sigal M, Lichtman JS, Hansson GC, Elias JE, Amieva MR, Huang KC, Sonnenburg JL.

Cell Host Microbe. 2015 Oct 14;18(4):478-88. doi: 10.1016/j.chom.2015.09.002. Epub 2015 Oct 1.


Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus.

Ermund A, Meiss LN, Gustafsson JK, Hansson GC.

Eur J Pharmacol. 2015 Oct 5;764:109-17. doi: 10.1016/j.ejphar.2015.06.051. Epub 2015 Jun 30.


Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis.

Hannan TJ, Roberts PL, Riehl TE, van der Post S, Binkley JM, Schwartz DJ, Miyoshi H, Mack M, Schwendener RA, Hooton TM, Stappenbeck TS, Hansson GC, Stenson WF, Colonna M, Stapleton AE, Hultgren SJ.

EBioMedicine. 2014 Oct 24;1(1):46-57. doi: 10.1016/j.ebiom.2014.10.011. eCollection 2014 Nov.


CD103+ CD11b+ Dendritic Cells Induce Th17 T Cells in Muc2-Deficient Mice with Extensively Spread Colitis.

Wenzel UA, Jonstrand C, Hansson GC, Wick MJ.

PLoS One. 2015 Jun 29;10(6):e0130750. doi: 10.1371/journal.pone.0130750. eCollection 2015.


Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles.

Hickey CA, Kuhn KA, Donermeyer DL, Porter NT, Jin C, Cameron EA, Jung H, Kaiko GE, Wegorzewska M, Malvin NP, Glowacki RW, Hansson GC, Allen PM, Martens EC, Stappenbeck TS.

Cell Host Microbe. 2015 May 13;17(5):672-80. doi: 10.1016/j.chom.2015.04.002.


New developments in goblet cell mucus secretion and function.

Birchenough GM, Johansson ME, Gustafsson JK, Bergström JH, Hansson GC.

Mucosal Immunol. 2015 Jul;8(4):712-9. doi: 10.1038/mi.2015.32. Epub 2015 Apr 15. Review.


The composition of the gut microbiota shapes the colon mucus barrier.

Jakobsson HE, Rodríguez-Piñeiro AM, Schütte A, Ermund A, Boysen P, Bemark M, Sommer F, Bäckhed F, Hansson GC, Johansson ME.

EMBO Rep. 2015 Feb;16(2):164-77. doi: 10.15252/embr.201439263. Epub 2014 Dec 18.


Multiple enzyme approach for the characterization of glycan modifications on the C-terminus of the intestinal MUC2mucin.

van der Post S, Thomsson KA, Hansson GC.

J Proteome Res. 2014 Dec 5;13(12):6013-23. doi: 10.1021/pr500874f. Epub 2014 Nov 25.



Jabbar KS, Verbeke C, Hyltander AG, Sjövall H, Hansson GC, Sadik R.

J Natl Cancer Inst. 2014 Oct 29;106(11). pii: dju330. doi: 10.1093/jnci/dju330. Print 2014 Nov. No abstract available. Erratum in: J Natl Cancer Inst. 2014 Nov;106(11):dju337 doi:10.1093/jnci/dju337.


Hypertonic saline releases the attached small intestinal cystic fibrosis mucus.

Ermund A, Meiss LN, Scholte BJ, Hansson GC.

Clin Exp Pharmacol Physiol. 2015 Jan;42(1):69-75. doi: 10.1111/1440-1681.12322.


Carbachol-induced colonic mucus formation requires transport via NKCC1, K⁺ channels and CFTR.

Gustafsson JK, Lindén SK, Alwan AH, Scholte BJ, Hansson GC, Sjövall H.

Pflugers Arch. 2015 Jul;467(7):1403-1415. doi: 10.1007/s00424-014-1595-y. Epub 2014 Aug 21.


Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.

Schütte A, Ermund A, Becker-Pauly C, Johansson ME, Rodriguez-Pineiro AM, Bäckhed F, Müller S, Lottaz D, Bond JS, Hansson GC.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12396-401. doi: 10.1073/pnas.1407597111. Epub 2014 Aug 11.


AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus.

Bergström JH, Berg KA, Rodríguez-Piñeiro AM, Stecher B, Johansson ME, Hansson GC.

PLoS One. 2014 Aug 11;9(8):e104186. doi: 10.1371/journal.pone.0104186. eCollection 2014.


Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis.

Wenzel UA, Magnusson MK, Rydström A, Jonstrand C, Hengst J, Johansson ME, Velcich A, Öhman L, Strid H, Sjövall H, Hansson GC, Wick MJ.

PLoS One. 2014 Jun 19;9(6):e100217. doi: 10.1371/journal.pone.0100217. eCollection 2014.


The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system.

Pelaseyed T, Bergström JH, Gustafsson JK, Ermund A, Birchenough GM, Schütte A, van der Post S, Svensson F, Rodríguez-Piñeiro AM, Nyström EE, Wising C, Johansson ME, Hansson GC.

Immunol Rev. 2014 Jul;260(1):8-20. doi: 10.1111/imr.12182. Review.


Modified-chitosan/siRNA nanoparticles downregulate cellular CDX2 expression and cross the gastric mucus barrier.

Sadio A, Gustafsson JK, Pereira B, Gomes CP, Hansson GC, David L, Pêgo AP, Almeida R.

PLoS One. 2014 Jun 12;9(6):e99449. doi: 10.1371/journal.pone.0099449. eCollection 2014.


Membrane protein profiling of human colon reveals distinct regional differences.

van der Post S, Hansson GC.

Mol Cell Proteomics. 2014 Sep;13(9):2277-87. doi: 10.1074/mcp.M114.040204. Epub 2014 Jun 2.


Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly.

Nilsson HE, Ambort D, Bäckström M, Thomsson E, Koeck PJB, Hansson GC, Hebert H.

J Mol Biol. 2014 Jul 15;426(14):2567-2579. doi: 10.1016/j.jmb.2014.04.027. Epub 2014 May 8.


Is the intestinal goblet cell a major immune cell?

Johansson ME, Hansson GC.

Cell Host Microbe. 2014 Mar 12;15(3):251-2. doi: 10.1016/j.chom.2014.02.014.


Proteomic mucin profiling for the identification of cystic precursors of pancreatic cancer.

Jabbar KS, Verbeke C, Hyltander AG, Sjövall H, Hansson GC, Sadik R.

J Natl Cancer Inst. 2014 Feb;106(2):djt439. doi: 10.1093/jnci/djt439.


Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture.

Sommer F, Adam N, Johansson ME, Xia L, Hansson GC, Bäckhed F.

PLoS One. 2014 Jan 9;9(1):e85254. doi: 10.1371/journal.pone.0085254. eCollection 2014.


Dynamic changes in mucus thickness and ion secretion during Citrobacter rodentium infection and clearance.

Gustafsson JK, Navabi N, Rodriguez-Piñeiro AM, Alomran AH, Premaratne P, Fernandez HR, Banerjee D, Sjövall H, Hansson GC, Lindén SK.

PLoS One. 2013 Dec 30;8(12):e84430. doi: 10.1371/journal.pone.0084430. eCollection 2013.

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