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A cell-based assay for CD63-containing extracellular vesicles.

Cashikar AG, Hanson PI.

PLoS One. 2019 Jul 24;14(7):e0220007. doi: 10.1371/journal.pone.0220007. eCollection 2019.


Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response.

Mittal E, Skowyra ML, Uwase G, Tinaztepe E, Mehra A, Köster S, Hanson PI, Philips JA.

MBio. 2018 Nov 27;9(6). pii: e01765-18. doi: 10.1128/mBio.01765-18.


Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation.

Rimer JM, Lee J, Holley CL, Crowder RJ, Chen DL, Hanson PI, Ory DS, Schaffer JE.

J Biol Chem. 2018 Aug 24;293(34):13284-13296. doi: 10.1074/jbc.RA118.003410. Epub 2018 Jul 6.


Triggered recruitment of ESCRT machinery promotes endolysosomal repair.

Skowyra ML, Schlesinger PH, Naismith TV, Hanson PI.

Science. 2018 Apr 6;360(6384). pii: eaar5078. doi: 10.1126/science.aar5078.


Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis.

Jackson CE, Scruggs BS, Schaffer JE, Hanson PI.

Biophys J. 2017 Sep 19;113(6):1342-1352. doi: 10.1016/j.bpj.2017.05.032. Epub 2017 Jun 16.


Torsins Are Essential Regulators of Cellular Lipid Metabolism.

Grillet M, Dominguez Gonzalez B, Sicart A, Pöttler M, Cascalho A, Billion K, Hernandez Diaz S, Swerts J, Naismith TV, Gounko NV, Verstreken P, Hanson PI, Goodchild RE.

Dev Cell. 2016 Aug 8;38(3):235-47. doi: 10.1016/j.devcel.2016.06.017. Epub 2016 Jul 21.


Structure and membrane remodeling activity of ESCRT-III helical polymers.

McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A.

Science. 2015 Dec 18;350(6267):1548-51. doi: 10.1126/science.aad8305. Epub 2015 Dec 3.


Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis.

Clark DJ, Fondrie WE, Liao Z, Hanson PI, Fulton A, Mao L, Yang AJ.

Anal Chem. 2015 Oct 20;87(20):10462-9. doi: 10.1021/acs.analchem.5b02586. Epub 2015 Sep 29.


Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum.

Goodchild RE, Buchwalter AL, Naismith TV, Holbrook K, Billion K, Dauer WT, Liang CC, Dear ML, Hanson PI.

J Cell Sci. 2015 Aug 1;128(15):2854-65. doi: 10.1242/jcs.167452. Epub 2015 Jun 19.


Structure of cellular ESCRT-III spirals and their relationship to HIV budding.

Cashikar AG, Shim S, Roth R, Maldazys MR, Heuser JE, Hanson PI.

Elife. 2014 May 30;3. doi: 10.7554/eLife.02184.


CK2 involvement in ESCRT-III complex phosphorylation.

Salvi M, Raiborg C, Hanson PI, Campsteijn C, Stenmark H, Pinna LA.

Arch Biochem Biophys. 2014 Mar 1;545:83-91. doi: 10.1016/ Epub 2014 Jan 15.


An essential and NSF independent role for α-SNAP in store-operated calcium entry.

Miao Y, Miner C, Zhang L, Hanson PI, Dani A, Vig M.

Elife. 2013 Jul 16;2:e00802. doi: 10.7554/eLife.00802.


Multivesicular body morphogenesis.

Hanson PI, Cashikar A.

Annu Rev Cell Dev Biol. 2012;28:337-62. doi: 10.1146/annurev-cellbio-092910-154152. Epub 2012 Jul 20. Review.


Tools to discriminate between targets of CK2 vs PLK2/PLK3 acidophilic kinases.

Salvi M, Trashi E, Cozza G, Negro A, Hanson PI, Pinna LA.

Biotechniques. 2012 Jul 1;53(1). doi: 10.2144/000113866.


Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum.

Vander Heyden AB, Naismith TV, Snapp EL, Hanson PI.

EMBO J. 2011 Jul 22;30(16):3217-31. doi: 10.1038/emboj.2011.233.


Stable isotope labeling with amino acids in cell culture based mass spectrometry approach to detect transient protein interactions using substrate trapping.

Thomas SN, Wan Y, Liao Z, Hanson PI, Yang AJ.

Anal Chem. 2011 Jul 15;83(14):5511-8. doi: 10.1021/ac200950k. Epub 2011 Jun 15.


Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition.

Merrill SA, Hanson PI.

J Biol Chem. 2010 Nov 12;285(46):35428-38. doi: 10.1074/jbc.M110.126318. Epub 2010 Aug 30.


Membrane budding and scission by the ESCRT machinery: it's all in the neck.

Hurley JH, Hanson PI.

Nat Rev Mol Cell Biol. 2010 Aug;11(8):556-66. doi: 10.1038/nrm2937. Epub 2010 Jun 30. Review.


Cell-free reconstitution of multivesicular body formation and receptor sorting.

Sun W, Vida TA, Sirisaengtaksin N, Merrill SA, Hanson PI, Bean AJ.

Traffic. 2010 Jun;11(6):867-76. doi: 10.1111/j.1600-0854.2010.01053.x. Epub 2010 Feb 27.


Interaction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion.

Naismith TV, Dalal S, Hanson PI.

J Biol Chem. 2009 Oct 9;284(41):27866-74. doi: 10.1074/jbc.M109.020164. Epub 2009 Aug 3.


Cell biology of the ESCRT machinery.

Hanson PI, Shim S, Merrill SA.

Curr Opin Cell Biol. 2009 Aug;21(4):568-74. doi: 10.1016/ Epub 2009 Jun 26. Review.


LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation.

Vander Heyden AB, Naismith TV, Snapp EL, Hodzic D, Hanson PI.

Mol Biol Cell. 2009 Jun;20(11):2661-72. doi: 10.1091/mbc.E09-01-0094. Epub 2009 Apr 1.


TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia.

Weihl CC, Temiz P, Miller SE, Watts G, Smith C, Forman M, Hanson PI, Kimonis V, Pestronk A.

J Neurol Neurosurg Psychiatry. 2008 Oct;79(10):1186-9. doi: 10.1136/jnnp.2007.131334.


Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease.

Ju JS, Miller SE, Hanson PI, Weihl CC.

J Biol Chem. 2008 Oct 31;283(44):30289-99. doi: 10.1074/jbc.M805517200. Epub 2008 Aug 20.


Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly.

Shim S, Merrill SA, Hanson PI.

Mol Biol Cell. 2008 Jun;19(6):2661-72. doi: 10.1091/mbc.E07-12-1263. Epub 2008 Apr 2.


The pathophysiological basis of dystonias.

Breakefield XO, Blood AJ, Li Y, Hallett M, Hanson PI, Standaert DG.

Nat Rev Neurosci. 2008 Mar;9(3):222-34. doi: 10.1038/nrn2337. Review.


Plasma membrane deformation by circular arrays of ESCRT-III protein filaments.

Hanson PI, Roth R, Lin Y, Heuser JE.

J Cell Biol. 2008 Jan 28;180(2):389-402. doi: 10.1083/jcb.200707031. Epub 2008 Jan 21.


Ubiquitin depletion and dominant-negative VPS4 inhibit rhabdovirus budding without affecting alphavirus budding.

Taylor GM, Hanson PI, Kielian M.

J Virol. 2007 Dec;81(24):13631-9. Epub 2007 Oct 3.


CHMP4B, a novel gene for autosomal dominant cataracts linked to chromosome 20q.

Shiels A, Bennett TM, Knopf HL, Yamada K, Yoshiura K, Niikawa N, Shim S, Hanson PI.

Am J Hum Genet. 2007 Sep;81(3):596-606. Epub 2007 Jul 27.


Luminal chloride-dependent activation of endosome calcium channels: patch clamp study of enlarged endosomes.

Saito M, Hanson PI, Schlesinger P.

J Biol Chem. 2007 Sep 14;282(37):27327-33. Epub 2007 Jul 3.


Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.

Weihl CC, Miller SE, Hanson PI, Pestronk A.

Hum Mol Genet. 2007 Apr 15;16(8):919-28. Epub 2007 Feb 28.


Effects of genetic variations in the dystonia protein torsinA: identification of polymorphism at residue 216 as protein modifier.

Kock N, Naismith TV, Boston HE, Ozelius LJ, Corey DP, Breakefield XO, Hanson PI.

Hum Mol Genet. 2006 Apr 15;15(8):1355-64. Epub 2006 Mar 14.


SNARE complex zero layer residues are not critical for N-ethylmaleimide-sensitive factor-mediated disassembly.

Lauer JM, Dalal S, Marz KE, Nonet ML, Hanson PI.

J Biol Chem. 2006 May 26;281(21):14823-32. Epub 2006 Mar 7.


Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation.

Weihl CC, Dalal S, Pestronk A, Hanson PI.

Hum Mol Genet. 2006 Jan 15;15(2):189-99. Epub 2005 Dec 1.


AAA+ proteins: have engine, will work.

Hanson PI, Whiteheart SW.

Nat Rev Mol Cell Biol. 2005 Jul;6(7):519-29. Review.


p97 Is in a complex with cholera toxin and influences the transport of cholera toxin and related toxins to the cytoplasm.

Abujarour RJ, Dalal S, Hanson PI, Draper RK.

J Biol Chem. 2005 Apr 22;280(16):15865-71. Epub 2005 Feb 3.


Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1.

Lin Y, Kimpler LA, Naismith TV, Lauer JM, Hanson PI.

J Biol Chem. 2005 Apr 1;280(13):12799-809. Epub 2005 Jan 4. Erratum in: J Biol Chem. 2006 Dec 15;281(50):38966.


From the neuromuscular junction to cellular architecture and beyond--commentary on 30 years of imaging by John E. Heuser.

Hanson PI, Stahl PD.

Eur J Cell Biol. 2004 Jul;83(6):229-42. No abstract available.


TorsinB--perinuclear location and association with torsinA.

Hewett JW, Kamm C, Boston H, Beauchamp R, Naismith T, Ozelius L, Hanson PI, Breakefield XO, Ramesh V.

J Neurochem. 2004 Jun;89(5):1186-94.


TorsinA in the nuclear envelope.

Naismith TV, Heuser JE, Breakefield XO, Hanson PI.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7612-7. Epub 2004 May 10.


Perinuclear biogenesis of mutant torsin-A inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors.

Bragg DC, Camp SM, Kaufman CA, Wilbur JD, Boston H, Schuback DE, Hanson PI, Sena-Esteves M, Breakefield XO.

Neuroscience. 2004;125(3):651-61.


The early onset dystonia protein torsinA interacts with kinesin light chain 1.

Kamm C, Boston H, Hewett J, Wilbur J, Corey DP, Hanson PI, Ramesh V, Breakefield XO.

J Biol Chem. 2004 May 7;279(19):19882-92. Epub 2004 Feb 17.


The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate.

Chae TH, Kim S, Marz KE, Hanson PI, Walsh CA.

Nat Genet. 2004 Mar;36(3):264-70. Epub 2004 Feb 1. Erratum in: Nat Genet. 2004 Apr;36(4):427.


Distinct roles for the AAA ATPases NSF and p97 in the secretory pathway.

Dalal S, Rosser MF, Cyr DM, Hanson PI.

Mol Biol Cell. 2004 Feb;15(2):637-48. Epub 2003 Nov 14.


Defining the SNARE complex binding surface of alpha-SNAP: implications for SNARE complex disassembly.

Marz KE, Lauer JM, Hanson PI.

J Biol Chem. 2003 Jul 18;278(29):27000-8. Epub 2003 Apr 30.


TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress.

Hewett J, Ziefer P, Bergeron D, Naismith T, Boston H, Slater D, Wilbur J, Schuback D, Kamm C, Smith N, Camp S, Ozelius LJ, Ramesh V, Hanson PI, Breakefield XO.

J Neurosci Res. 2003 Apr 15;72(2):158-68.


Sealed with a twist: complexin and the synaptic SNARE complex.

Marz KE, Hanson PI.

Trends Neurosci. 2002 Aug;25(8):381-3. Review.


NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.

Hanley JG, Khatri L, Hanson PI, Ziff EB.

Neuron. 2002 Mar 28;34(1):53-67.


Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling.

Cong M, Perry SJ, Hu LA, Hanson PI, Claing A, Lefkowitz RJ.

J Biol Chem. 2001 Nov 30;276(48):45145-52. Epub 2001 Sep 27.

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