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New insights on Drosophila antimicrobial peptide function in host defense and beyond.

Hanson MA, Lemaitre B.

Curr Opin Immunol. 2019 Dec 11;62:22-30. doi: 10.1016/j.coi.2019.11.008. [Epub ahead of print] Review.


Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.

Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu ZJ, Müller CE, Stevens RC.

Sci Adv. 2019 Nov 27;5(11):eaax9115. doi: 10.1126/sciadv.aax9115. eCollection 2019 Nov.


Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness.

Hanson MA, Lemaitre B, Unckless RL.

Front Immunol. 2019 Nov 8;10:2620. doi: 10.3389/fimmu.2019.02620. eCollection 2019.


Maternal Obesity during Pregnancy Alters Daily Activity and Feeding Cycles, and Hypothalamic Clock Gene Expression in Adult Male Mouse Offspring.

Cleal JK, Bruce KD, Shearer JL, Thomas H, Plume J, Gregory L, Shepard JN, Spiers-Fitzgerald KL, Mani R, Lewis RM, Lillycrop KA, Hanson MA, Byrne CD, Cagampang FR.

Int J Mol Sci. 2019 Oct 30;20(21). pii: E5408. doi: 10.3390/ijms20215408.


Surgical approach to the substernal goiter.

Hanson MA, Shaha AR, Wu JX.

Best Pract Res Clin Endocrinol Metab. 2019 Aug;33(4):101312. doi: 10.1016/j.beem.2019.101312. Epub 2019 Aug 22. Review.


Niche Modification, Human Cultural Evolution and the Anthropocene.

Low FM, Gluckman PD, Hanson MA.

Trends Ecol Evol. 2019 Oct;34(10):883-885. doi: 10.1016/j.tree.2019.07.005. Epub 2019 Aug 15.


Correction: Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach.

Hanson MA, Dostálová A, Ceroni C, Poidevin M, Kondo S, Lemaître B.

Elife. 2019 May 28;8. pii: e48778. doi: 10.7554/eLife.48778.


DOHaD - the challenge of translating the science to policy.

Hanson MA, Poston L, Gluckman PD.

J Dev Orig Health Dis. 2019 Jun;10(3):263-267. doi: 10.1017/S2040174419000205. Epub 2019 May 14.


More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila.

Dudzic JP, Hanson MA, Iatsenko I, Kondo S, Lemaitre B.

Cell Rep. 2019 Apr 23;27(4):1050-1061.e3. doi: 10.1016/j.celrep.2019.03.101.


Evolutionary and developmental mismatches are consequences of adaptive developmental plasticity in humans and have implications for later disease risk.

Gluckman PD, Hanson MA, Low FM.

Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20180109. doi: 10.1098/rstb.2018.0109.


Developing differences: early-life effects and evolutionary medicine.

Kuijper B, Hanson MA, Vitikainen EIK, Marshall HH, Ozanne SE, Cant MA.

Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20190039. doi: 10.1098/rstb.2019.0039.


Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach.

Hanson MA, Dostálová A, Ceroni C, Poidevin M, Kondo S, Lemaitre B.

Elife. 2019 Feb 26;8. pii: e44341. doi: 10.7554/eLife.44341. Erratum in: Elife. 2019 May 28;8:.


An online resource for GPCR structure determination and analysis.

Munk C, Mutt E, Isberg V, Nikolajsen LF, Bibbe JM, Flock T, Hanson MA, Stevens RC, Deupi X, Gloriam DE.

Nat Methods. 2019 Feb;16(2):151-162. doi: 10.1038/s41592-018-0302-x. Epub 2019 Jan 21. Review.


Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood.

Lillycrop KA, Garratt ES, Titcombe P, Melton PE, Murray RJS, Barton SJ, Clarke-Harris R, Costello PM, Holbrook JD, Hopkins JC, Childs CE, Paras-Chavez C, Calder PC, Mori TA, Beilin L, Burdge GC, Gluckman PD, Inskip HM, Harvey NC, Hanson MA, Huang RC, Cooper C; EpiGen Consortium, Godfrey KM.

Int J Obes (Lond). 2019 May;43(5):974-988. doi: 10.1038/s41366-018-0254-3. Epub 2019 Jan 8.


Publisher Correction: Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.

Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC.

Nat Chem Biol. 2019 Feb;15(2):206. doi: 10.1038/s41589-018-0214-1.


Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.

Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC.

Nat Chem Biol. 2019 Jan;15(1):11-17. doi: 10.1038/s41589-018-0160-y. Epub 2018 Dec 3. Erratum in: Nat Chem Biol. 2019 Feb;15(2):206.


Avoidable early life environmental exposures.

Poore KR, Hanson MA, Faustman EM, Neira M.

Lancet Planet Health. 2017 Aug;1(5):e172-e173. doi: 10.1016/S2542-5196(17)30048-7. Epub 2017 Aug 4. No abstract available.


High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening.

Qin S, Meng M, Yang D, Bai W, Lu Y, Peng Y, Song G, Wu Y, Zhou Q, Zhao S, Huang X, McCorvy JD, Cai X, Dai A, Roth BL, Hanson MA, Liu ZJ, Wang MW, Stevens RC, Shui W.

Chem Sci. 2018 Feb 20;9(12):3192-3199. doi: 10.1039/c7sc04698g. eCollection 2018 Mar 28.


Origins of lifetime health around the time of conception: causes and consequences.

Fleming TP, Watkins AJ, Velazquez MA, Mathers JC, Prentice AM, Stephenson J, Barker M, Saffery R, Yajnik CS, Eckert JJ, Hanson MA, Forrester T, Gluckman PD, Godfrey KM.

Lancet. 2018 May 5;391(10132):1842-1852. doi: 10.1016/S0140-6736(18)30312-X. Epub 2018 Apr 16. Review.


5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ.

Cell. 2018 Feb 8;172(4):719-730.e14. doi: 10.1016/j.cell.2018.01.001. Epub 2018 Feb 1.


Structure of the glucagon receptor in complex with a glucagon analogue.

Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B.

Nature. 2018 Jan 3;553(7686):106-110. doi: 10.1038/nature25153.


Correction: Fat and Carbohydrate Intake over Three Generations Modify Growth, Metabolism and Cardiovascular Phenotype in Female Mice in an Age-Related Manner.

Hoile SP, Grenfell LR, Hanson MA, Lillycrop KA, Burdge GC.

PLoS One. 2017 Dec 7;12(12):e0189655. doi: 10.1371/journal.pone.0189655. eCollection 2017.


Transcriptome-wide analysis suggests that temporal changes in the relative contributions of hyperplasia, hypertrophy and apoptosis underlie liver growth in pregnant mice.

Price LR, Lillycrop KA, Irvine NA, Hanson MA, Burdge GC.

Biol Reprod. 2017 Nov 1;97(5):762-771. doi: 10.1093/biolre/iox136.


Uncovering state-dependent relationships in shallow lakes using Bayesian latent variable regression.

Vitense K, Hanson MA, Herwig BR, Zimmer KD, Fieberg J.

Ecol Appl. 2018 Mar;28(2):309-322. doi: 10.1002/eap.1645. Epub 2018 Jan 19.


Watershed vs. within-lake drivers of nitrogen: phosphorus dynamics in shallow lakes.

Ginger LJ, Zimmer KD, Herwig BR, Hanson MA, Hobbs WO, Small GE, Cotner JB.

Ecol Appl. 2017 Oct;27(7):2155-2169. doi: 10.1002/eap.1599. Epub 2017 Sep 7.


Crystal structures of agonist-bound human cannabinoid receptor CB1.

Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ.

Nature. 2017 Jul 27;547(7664):468-471. doi: 10.1038/nature23272. Epub 2017 Jul 5.


Structural Basis for Apelin Control of the Human Apelin Receptor.

Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F.

Structure. 2017 Jun 6;25(6):858-866.e4. doi: 10.1016/j.str.2017.04.008. Epub 2017 May 18.


Structure of the full-length glucagon class B G-protein-coupled receptor.

Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B.

Nature. 2017 Jun 8;546(7657):259-264. doi: 10.1038/nature22363. Epub 2017 May 17.


Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC.

Nature. 2017 Jun 8;546(7657):312-315. doi: 10.1038/nature22378. Epub 2017 May 17.


Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.

Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F.

Nat Commun. 2017 May 17;8:15383. doi: 10.1038/ncomms15383.


ANRIL Promoter DNA Methylation: A Perinatal Marker for Later Adiposity.

Lillycrop K, Murray R, Cheong C, Teh AL, Clarke-Harris R, Barton S, Costello P, Garratt E, Cook E, Titcombe P, Shunmuganathan B, Liew SJ, Chua YC, Lin X, Wu Y, Burdge GC, Cooper C, Inskip HM, Karnani N, Hopkins JC, Childs CE, Chavez CP, Calder PC, Yap F, Lee YS, Chong YS, Melton PE, Beilin L, Huang RC, Gluckman PD, Harvey N, Hanson MA, Holbrook JD; EpiGen Consortium, Godfrey KM.

EBioMedicine. 2017 May;19:60-72. doi: 10.1016/j.ebiom.2017.03.037. Epub 2017 Apr 26.


X chromosome drive in a widespread Palearctic woodland fly, Drosophila testacea.

Keais GL, Hanson MA, Gowen BE, Perlman SJ.

J Evol Biol. 2017 Jun;30(6):1185-1194. doi: 10.1111/jeb.13089. Epub 2017 May 13.


Early local delivery of vancomycin suppresses ectopic bone formation in a rat model of trauma-induced heterotopic ossification.

Seavey JG, Wheatley BM, Pavey GJ, Tomasino AM, Hanson MA, Sanders EM, Dey D, Moss KL, Potter BK, Forsberg JA, Qureshi AT, Davis TA.

J Orthop Res. 2017 Nov;35(11):2397-2406. doi: 10.1002/jor.23544. Epub 2017 Apr 11.


Correction: The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight.

Kiserud T, Piaggio G, Carroli G, Widmer M, Carvalho J, Neerup Jensen L, Giordano D, Cecatti JG, Aleem HA, Talegawkar SA, Benachi A, Diemert A, Kitoto AT, Thinkhamrop J, Lumbiganon P, Tabor A, Kriplani A, Gonzalez R, Hecher K, Hanson MA, Gülmezoglu AM, Platt LD.

PLoS Med. 2017 Mar 24;14(3):e1002284. doi: 10.1371/journal.pmed.1002284. eCollection 2017 Mar. Erratum in: PLoS Med. 2017 Apr 20;14 (4):e1002301.


Reduced fetal vitamin D status by maternal undernutrition during discrete gestational windows in sheep.

Cleal JK, Hargreaves MR, Poore KR, Tang JCY, Fraser WD, Hanson MA, Green LR.

J Dev Orig Health Dis. 2017 Jun;8(3):370-381. doi: 10.1017/S2040174417000149. Epub 2017 Mar 22.


The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight.

Kiserud T, Piaggio G, Carroli G, Widmer M, Carvalho J, Neerup Jensen L, Giordano D, Cecatti JG, Abdel Aleem H, Talegawkar SA, Benachi A, Diemert A, Tshefu Kitoto A, Thinkhamrop J, Lumbiganon P, Tabor A, Kriplani A, Gonzalez Perez R, Hecher K, Hanson MA, Gülmezoglu AM, Platt LD.

PLoS Med. 2017 Jan 24;14(1):e1002220. doi: 10.1371/journal.pmed.1002220. eCollection 2017 Jan. Erratum in: PLoS Med. 2017 Mar 24;14 (3):e1002284. PLoS Med. 2017 Apr 20;14 (4):e1002301.


The legacy of large regime shifts in shallow lakes.

Ramstack Hobbs JM, Hobbs WO, Edlund MB, Zimmer KD, Theissen KM, Hoidal N, Domine LM, Hanson MA, Herwig BR, Cotner JB.

Ecol Appl. 2016 Dec;26(8):2660-2674. doi: 10.1002/eap.1382. Epub 2016 Sep 12.


Immune genes and divergent antimicrobial peptides in flies of the subgenus Drosophila.

Hanson MA, Hamilton PT, Perlman SJ.

BMC Evol Biol. 2016 Oct 24;16(1):228.


Crystal Structure of the Human Cannabinoid Receptor CB1.

Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, Kufareva I, Wu B, Zhao Q, Hanson MA, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ.

Cell. 2016 Oct 20;167(3):750-762.e14. doi: 10.1016/j.cell.2016.10.004.


Developmental origins of epigenetic transgenerational inheritance.

Hanson MA, Skinner MK.

Environ Epigenet. 2016;2(1). pii: dvw002. Epub 2016 Mar 6.


Background to the Cape Town Manifesto: harnessing the power of the normal.

Hanson MA.

J Dev Orig Health Dis. 2016 Oct;7(5):498-500. Epub 2016 May 5. No abstract available.


A complex behavioural change intervention to reduce the risk of diabetes and prediabetes in the pre-conception period in Malaysia: study protocol for a randomised controlled trial.

Skau JK, Nordin AB, Cheah JC, Ali R, Zainal R, Aris T, Ali ZM, Matzen P, Biesma R, Aagaard-Hansen J, Hanson MA, Norris SA.

Trials. 2016 Apr 27;17(1):215. doi: 10.1186/s13063-016-1345-x.


Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).

Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW.

J Biol Chem. 2016 Jun 17;291(25):12991-3004. doi: 10.1074/jbc.M116.721977. Epub 2016 Apr 8.


Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH.

Bruce KD, Szczepankiewicz D, Sihota KK, Ravindraanandan M, Thomas H, Lillycrop KA, Burdge GC, Hanson MA, Byrne CD, Cagampang FR.

Biochim Biophys Acta. 2016 Jul;1861(7):584-93. doi: 10.1016/j.bbalip.2016.03.026. Epub 2016 Apr 23.


Double-blinded, placebo-controlled study of early tranexamic acid treatment in swine uncontrolled hemorrhage model.

Sondeen JL, Hanson MA, Prince MD, de Guzman R, Polykratis IA, Aden JK 3rd, Cap AP, Dubick MA.

J Trauma Acute Care Surg. 2016 Jan;80(1):81-8. doi: 10.1097/TA.0000000000000860.


Maternal Factors Are Associated with the Expression of Placental Genes Involved in Amino Acid Metabolism and Transport.

Day PE, Ntani G, Crozier SR, Mahon PA, Inskip HM, Cooper C, Harvey NC, Godfrey KM, Hanson MA, Lewis RM, Cleal JK.

PLoS One. 2015 Dec 14;10(12):e0143653. doi: 10.1371/journal.pone.0143653. eCollection 2015.


Developmental aspects of a life course approach to healthy ageing.

Hanson MA, Cooper C, Aihie Sayer A, Eendebak RJ, Clough GF, Beard JR.

J Physiol. 2016 Apr 15;594(8):2147-60. doi: 10.1113/JP270579. Epub 2016 Feb 4. Review.


The International Federation of Gynecology and Obstetrics (FIGO) recommendations on adolescent, preconception, and maternal nutrition: "Think Nutrition First".

Hanson MA, Bardsley A, De-Regil LM, Moore SE, Oken E, Poston L, Ma RC, McAuliffe FM, Maleta K, Purandare CN, Yajnik CS, Rushwan H, Morris JL.

Int J Gynaecol Obstet. 2015 Oct;131 Suppl 4:S213-53. doi: 10.1016/S0020-7292(15)30034-5. No abstract available.


Polyunsaturated fatty acid biosynthesis is involved in phenylephrine-mediated calcium release in vascular smooth muscle cells.

Irvine NA, Lillycrop KA, Fielding B, Torrens C, Hanson MA, Burdge GC.

Prostaglandins Leukot Essent Fatty Acids. 2015 Oct;101:31-9. doi: 10.1016/j.plefa.2015.08.001. Epub 2015 Aug 20.


Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast.

Lofthouse EM, Brooks S, Cleal JK, Hanson MA, Poore KR, O'Kelly IM, Lewis RM.

J Physiol. 2015 Oct 15;593(20):4549-59. doi: 10.1113/JP270743. Epub 2015 Sep 9.

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