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Characterisation of a human antibody that potentially links cytomegalovirus infection with systemic lupus erythematosus.

Neo JYJ, Wee SYK, Bonne I, Tay SH, Raida M, Jovanovic V, Fairhurst AM, Lu J, Hanson BJ, MacAry PA.

Sci Rep. 2019 Jul 10;9(1):9998. doi: 10.1038/s41598-019-46329-y.


Persistent confirmed low-grade dysplasia in Barrett's esophagus is a risk factor for progression to high-grade dysplasia and adenocarcinoma in a US Veterans cohort.

Song KY, Henn AJ, Gravely AA, Mesa H, Sultan S, Shaheen NJ, Shaukat A, Hanson BJ.

Dis Esophagus. 2019 Jul 5. pii: doz061. doi: 10.1093/dote/doz061. [Epub ahead of print]


Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.

Gu Y, Wong YH, Liew CW, Chan CEZ, Murali TM, Yap J, Too CT, Purushotorman K, Hamidinia M, El Sahili A, Goh ATH, Teo RZC, Wood KJ, Hanson BJ, Gascoigne NRJ, Lescar J, Vathsala A, MacAry PA.

Nat Commun. 2019 Feb 21;10(1):893. doi: 10.1038/s41467-019-08790-1.


Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine.

Skibinski DAG, Jones LA, Zhu YO, Xue LW, Au B, Lee B, Naim ANM, Lee A, Kaliaperumal N, Low JGH, Lee LS, Poidinger M, Saudan P, Bachmann M, Ooi EE, Hanson BJ, Novotny-Diermayr V, Matter A, Fairhurst AM, Hibberd ML, Connolly JE.

Sci Rep. 2018 Dec 20;8(1):18007. doi: 10.1038/s41598-018-36703-7.


American Gastroenterological Association Institute Guideline on the Medical Management of Opioid-Induced Constipation.

Crockett SD, Greer KB, Heidelbaugh JJ, Falck-Ytter Y, Hanson BJ, Sultan S; American Gastroenterological Association Institute Clinical Guidelines Committee.

Gastroenterology. 2019 Jan;156(1):218-226. doi: 10.1053/j.gastro.2018.07.016. Epub 2018 Oct 16. Review. No abstract available.


Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells.

Park HY, Tan PS, Kavishna R, Ker A, Lu J, Chan CEZ, Hanson BJ, MacAry PA, Caminschi I, Shortman K, Alonso S, Lahoud MH.

NPJ Vaccines. 2017 Nov 6;2:31. doi: 10.1038/s41541-017-0033-5. eCollection 2017.


Not Too Hot, Not Too Cold, but "Just Right".

Hanson BJ, Shaukat A.

Am J Gastroenterol. 2017 Nov;112(11):1686-1688. doi: 10.1038/ajg.2017.358.


TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants.

Lai J, Choo JAL, Tan WJ, Too CT, Oo MZ, Suter MA, Mustafa FB, Srinivasan N, Chan CEZ, Lim AGX, Zhong Y, Chan SH, Hanson BJ, Gascoigne NRJ, MacAry PA.

Sci Rep. 2017 Aug 30;7(1):9923. doi: 10.1038/s41598-017-10265-6.


Structural Mimicry of the Dengue Virus Envelope Glycoprotein Revealed by the Crystallographic Study of an Idiotype-Anti-idiotype Fab Complex.

Wong YH, Goh BC, Lim SY, Teo EW, Lim APC, Dedon PC, Hanson BJ, MacAry PA, Lescar J.

J Virol. 2017 Aug 10;91(17). pii: e00406-17. doi: 10.1128/JVI.00406-17. Print 2017 Sep 1.


Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma.

Chan JHS, Chua YL, Peh HY, Jovanovic V, Gascoigne NRJ, Wong WSF, Chew FT, Hanson BJ, Kemeny DM, MacAry PA.

J Allergy Clin Immunol. 2017 May;139(5):1705-1708.e6. doi: 10.1016/j.jaci.2016.10.028. Epub 2016 Dec 5. No abstract available.


Targeting Epstein-Barr virus-transformed B lymphoblastoid cells using antibodies with T-cell receptor-like specificities.

Lai J, Tan WJ, Too CT, Choo JA, Wong LH, Mustafa FB, Srinivasan N, Lim AP, Zhong Y, Gascoigne NR, Hanson BJ, Chan SH, Chen J, MacAry PA.

Blood. 2016 Sep 8;128(10):1396-407. doi: 10.1182/blood-2016-03-707836. Epub 2016 Jun 23.


Safety and Outcomes of Capsule Endoscopy in Patients with Left Ventricular Assist Device: a Single-Center Retrospective Case Series.

Hanson BJ, Koene RJ, Roy SS, Eckman PM, John R, Chaudhary NA, Vega-Peralta J.

J Cardiovasc Transl Res. 2016 Aug;9(4):402-4. doi: 10.1007/s12265-016-9701-5. Epub 2016 Jun 1.


The Molecular Engineering of an Anti-Idiotypic Antibody for Pharmacokinetic Analysis of a Fully Human Anti-Infective.

Lim SY, Chan CE, Lisowska MM, Hanson BJ, MacAry PA.

PLoS One. 2015 Dec 23;10(12):e0145381. doi: 10.1371/journal.pone.0145381. eCollection 2015.


The diagnostic targeting of a carbohydrate virulence factor from M.Tuberculosis.

Chan CE, Götze S, Seah GT, Seeberger PH, Tukvadze N, Wenk MR, Hanson BJ, MacAry PA.

Sci Rep. 2015 May 15;5:10281. doi: 10.1038/srep10281.


A facile method for simultaneously measuring neuronal cell viability and neurite outgrowth.

K Hancock M, Kopp L, Kaur N, Hanson BJ.

Curr Chem Genom Transl Med. 2015 Feb 27;9:6-16. doi: 10.2174/2213988501509010006. eCollection 2015.


Virus-specific T lymphocytes home to the skin during natural dengue infection.

Rivino L, Kumaran EA, Thein TL, Too CT, Gan VC, Hanson BJ, Wilder-Smith A, Bertoletti A, Gascoigne NR, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA.

Sci Transl Med. 2015 Mar 11;7(278):278ra35. doi: 10.1126/scitranslmed.aaa0526.


The role of phage display in therapeutic antibody discovery.

Chan CE, Lim AP, MacAry PA, Hanson BJ.

Int Immunol. 2014 Dec;26(12):649-57. doi: 10.1093/intimm/dxu082. Epub 2014 Aug 18. Review.


Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers.

Low JG, Lee LS, Ooi EE, Ethirajulu K, Yeo P, Matter A, Connolly JE, Skibinski DA, Saudan P, Bachmann M, Hanson BJ, Lu Q, Maurer-Stroh S, Lim S, Novotny-Diermayr V.

Vaccine. 2014 Sep 3;32(39):5041-8. doi: 10.1016/j.vaccine.2014.07.011. Epub 2014 Jul 18.


Chimerization and characterization of a monoclonal antibody with potent neutralizing activity across multiple influenza A H5N1 clades.

Mak TM, Hanson BJ, Tan YJ.

Antiviral Res. 2014 Jul;107:76-83. doi: 10.1016/j.antiviral.2014.04.011. Epub 2014 May 4.


Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue.

Chan KR, Ong EZ, Tan HC, Zhang SL, Zhang Q, Tang KF, Kaliaperumal N, Lim AP, Hibberd ML, Chan SH, Connolly JE, Krishnan MN, Lok SM, Hanson BJ, Lin CN, Ooi EE.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2722-7. doi: 10.1073/pnas.1317454111. Epub 2014 Jan 13.


Enhanced neutralizing antibody titers and Th1 polarization from a novel Escherichia coli derived pandemic influenza vaccine.

Skibinski DA, Hanson BJ, Lin Y, von Messling V, Jegerlehner A, Tee JB, Chye de H, Wong SK, Ng AA, Lee HY, Au B, Lee BT, Santoso L, Poidinger M, Fairhurst AM, Matter A, Bachmann MF, Saudan P, Connolly JE.

PLoS One. 2013 Oct 18;8(10):e76571. doi: 10.1371/journal.pone.0076571. eCollection 2013.


Novel phage display-derived mycolic acid-specific antibodies with potential for tuberculosis diagnosis.

Chan CE, Zhao BZ, Cazenave-Gassiot A, Pang SW, Bendt AK, Wenk MR, MacAry PA, Hanson BJ.

J Lipid Res. 2013 Oct;54(10):2924-32. doi: 10.1194/jlr.D036137. Epub 2013 Jun 24.


Dengue virus neutralization in cells expressing Fc gamma receptors.

Chawla T, Chan KR, Zhang SL, Tan HC, Lim AP, Hanson BJ, Ooi EE.

PLoS One. 2013 May 22;8(5):e65231. doi: 10.1371/journal.pone.0065231. Print 2013.


Label-free electronic detection of bio-toxins using aligned carbon nanotubes.

Palaniappan A, Goh WH, Fam DW, Rajaseger G, Chan CE, Hanson BJ, Moochhala SM, Mhaisalkar SG, Liedberg B.

Biosens Bioelectron. 2013 May 15;43:143-7. doi: 10.1016/j.bios.2012.12.019. Epub 2012 Dec 14.


Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection.

Rivino L, Kumaran EA, Jovanovic V, Nadua K, Teo EW, Pang SW, Teo GH, Gan VC, Lye DC, Leo YS, Hanson BJ, Smith KG, Bertoletti A, Kemeny DM, MacAry PA.

J Virol. 2013 Mar;87(5):2693-706. doi: 10.1128/JVI.02675-12. Epub 2012 Dec 19.


Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1.

Zou G, Kukkaro P, Lok SM, Ng JK, Tan GK, Hanson BJ, Alonso S, MacAry PA, Shi PY.

Antiviral Res. 2012 Sep;95(3):216-23. doi: 10.1016/j.antiviral.2012.06.010. Epub 2012 Jul 4.


The structural basis for serotype-specific neutralization of dengue virus by a human antibody.

Teoh EP, Kukkaro P, Teo EW, Lim AP, Tan TT, Yip A, Schul W, Aung M, Kostyuchenko VA, Leo YS, Chan SH, Smith KG, Chan AH, Zou G, Ooi EE, Kemeny DM, Tan GK, Ng JK, Ng ML, Alonso S, Fisher D, Shi PY, Hanson BJ, Lok SM, MacAry PA.

Sci Transl Med. 2012 Jun 20;4(139):139ra83. doi: 10.1126/scitranslmed.3003888.


Generation and characterization of a novel recombinant antibody against 15-ketocholestane isolated by phage-display.

Islam MO, Lim YT, Chan CE, Cazenave-Gassiot A, Croxford JL, Wenk MR, Macary PA, Hanson BJ.

Int J Mol Sci. 2012;13(4):4937-48. doi: 10.3390/ijms13044937. Epub 2012 Apr 19.


A human PrM antibody that recognizes a novel cryptic epitope on dengue E glycoprotein.

Chan AH, Tan HC, Chow AY, Lim AP, Lok SM, Moreland NJ, Vasudevan SG, MacAry PA, Ooi EE, Hanson BJ.

PLoS One. 2012;7(4):e33451. doi: 10.1371/journal.pone.0033451. Epub 2012 Apr 3.


Phage display approaches for the isolation of monoclonal antibodies against dengue virus envelope domain III from human and mouse derived libraries.

Moreland NJ, Susanto P, Lim E, Tay MY, Rajamanonmani R, Hanson BJ, Vasudevan SG.

Int J Mol Sci. 2012;13(3):2618-35. doi: 10.3390/ijms13032618. Epub 2012 Feb 27.


Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells.

Ho AW, Prabhu N, Betts RJ, Ge MQ, Dai X, Hutchinson PE, Lew FC, Wong KL, Hanson BJ, Macary PA, Kemeny DM.

J Immunol. 2011 Dec 1;187(11):6011-21. doi: 10.4049/jimmunol.1100987. Epub 2011 Oct 31.


Monoclonal antibodies against dengue NS2B and NS3 proteins for the study of protein interactions in the flaviviral replication complex.

Moreland NJ, Tay MY, Lim E, Rathore AP, Lim AP, Hanson BJ, Vasudevan SG.

J Virol Methods. 2012 Jan;179(1):97-103. doi: 10.1016/j.jviromet.2011.10.006. Epub 2011 Oct 20.


Comparison of the efficiency of antibody selection from semi-synthetic scFv and non-immune Fab phage display libraries against protein targets for rapid development of diagnostic immunoassays.

Chan CE, Chan AH, Lim AP, Hanson BJ.

J Immunol Methods. 2011 Oct 28;373(1-2):79-88. doi: 10.1016/j.jim.2011.08.005. Epub 2011 Aug 12.


Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection.

Chan KR, Zhang SL, Tan HC, Chan YK, Chow A, Lim AP, Vasudevan SG, Hanson BJ, Ooi EE.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12479-84. doi: 10.1073/pnas.1106568108. Epub 2011 Jul 11.


Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C).

Cai L, Loo LS, Atlashkin V, Hanson BJ, Hong W.

Mol Cell Biol. 2011 Apr;31(8):1734-47. doi: 10.1128/MCB.01044-10. Epub 2011 Feb 7.


Development of a GPR23 cell-based β-lactamase reporter assay.

Lee PH, Hanson BJ.

Methods Enzymol. 2010;485:349-68. doi: 10.1016/B978-0-12-381296-4.00020-8.


Unfolded protein response (UPR) gene expression during antibody-dependent enhanced infection of cultured monocytes correlates with dengue disease severity.

Paradkar PN, Ooi EE, Hanson BJ, Gubler DJ, Vasudevan SG.

Biosci Rep. 2011 Jun;31(3):221-30. doi: 10.1042/BSR20100078.


Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation.

Davis AA, Heilman CJ, Brady AE, Miller NR, Fuerstenau-Sharp M, Hanson BJ, Lindsley CW, Conn PJ, Lah JJ, Levey AI.

ACS Chem Neurosci. 2010 Aug 18;1(8):542-551.


Optimized expression of full-length IgG1 antibody in a common E. coli strain.

Chan CE, Lim AP, Chan AH, MacAry PA, Hanson BJ.

PLoS One. 2010 Apr 20;5(4):e10261. doi: 10.1371/journal.pone.0010261.


A simple method for Alexa Fluor dye labelling of dengue virus.

Zhang SL, Tan HC, Hanson BJ, Ooi EE.

J Virol Methods. 2010 Aug;167(2):172-7. doi: 10.1016/j.jviromet.2010.04.001. Epub 2010 Apr 23.


Prophylactic and therapeutic efficacy of a chimeric monoclonal antibody specific for H5 haemagglutinin against lethal H5N1 influenza.

Prabhu N, Prabakaran M, Hongliang Q, He F, Ho HT, Qiang J, Goutama M, Lim AP, Hanson BJ, Kwang J.

Antivir Ther. 2009;14(7):911-21. doi: 10.3851/IMP1413.


Utilization of the Tango beta-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation.

Wetter JA, Revankar C, Hanson BJ.

J Biomol Screen. 2009 Oct;14(9):1134-41. doi: 10.1177/1087057109343809. Epub 2009 Sep 2.


The use of antibodies in the treatment of infectious diseases.

Chan CE, Chan AH, Hanson BJ, Ooi EE.

Singapore Med J. 2009 Jul;50(7):663-72; quiz 673. Review.


Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.

Huang XP, Setola V, Yadav PN, Allen JA, Rogan SC, Hanson BJ, Revankar C, Robers M, Doucette C, Roth BL.

Mol Pharmacol. 2009 Oct;76(4):710-22. doi: 10.1124/mol.109.058057. Epub 2009 Jul 1.


A homogeneous fluorescent live-cell assay for measuring 7-transmembrane receptor activity and agonist functional selectivity through beta-arrestin recruitment.

Hanson BJ, Wetter J, Bercher MR, Kopp L, Fuerstenau-Sharp M, Vedvik KL, Zielinski T, Doucette C, Whitney PJ, Revankar C.

J Biomol Screen. 2009 Aug;14(7):798-810. doi: 10.1177/1087057109335260. Epub 2009 Jun 16.


Pharmacological characterization of receptor redistribution and beta-arrestin recruitment assays for the cannabinoid receptor 1.

van der Lee MM, Blomenröhr M, van der Doelen AA, Wat JW, Smits N, Hanson BJ, van Koppen CJ, Zaman GJ.

J Biomol Screen. 2009 Aug;14(7):811-23. doi: 10.1177/1087057109337937. Epub 2009 Jun 11.


Neutralizing human monoclonal antibody against H5N1 influenza HA selected from a Fab-phage display library.

Lim AP, Chan CE, Wong SK, Chan AH, Ooi EE, Hanson BJ.

Virol J. 2008 Oct 28;5:130. doi: 10.1186/1743-422X-5-130.


Fluorescent probes for cellular assays.

Hanson GT, Hanson BJ.

Comb Chem High Throughput Screen. 2008 Aug;11(7):505-13. Review.


Epitope characterization of the protective monoclonal antibody VN04-2 shows broadly neutralizing activity against highly pathogenic H5N1.

Lim AP, Wong SK, Chan AH, Chan CE, Ooi EE, Hanson BJ.

Virol J. 2008 Jul 11;5:80. doi: 10.1186/1743-422X-5-80.


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