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Items: 1 to 50 of 215

1.

Focus Issue Editorial: Synthetic Biology.

Hanson AD, Hibberd JM, Koffas MAG, Kopka J, Wurtzel ET.

Plant Physiol. 2019 Mar;179(3):772-774. doi: 10.1104/pp.19.00074. No abstract available.

PMID:
30808713
2.

The metabolite repair enzyme Nit1 is a dual-targeted amidase that disposes of damaged glutathione in Arabidopsis.

Niehaus TD, Patterson JA, Alexander DC, Folz JS, Pyc M, MacTavish BS, Bruner SD, Mullen RT, Fiehn O, Hanson AD.

Biochem J. 2019 Feb 19;476(4):683-697. doi: 10.1042/BCJ20180931.

PMID:
30692244
3.

Engineering Strategies to Boost Crop Productivity by Cutting Respiratory Carbon Loss.

Amthor JS, Bar-Even A, Hanson AD, Millar AH, Stitt M, Sweetlove LJ, Tyerman SD.

Plant Cell. 2019 Jan 22. pii: tpc.00743.2018. doi: 10.1105/tpc.18.00743. [Epub ahead of print]

4.

Essential metabolism for a minimal cell.

Breuer M, Earnest TM, Merryman C, Wise KS, Sun L, Lynott MR, Hutchison CA, Smith HO, Lapek JD, Gonzalez DJ, de Crécy-Lagard V, Haas D, Hanson AD, Labhsetwar P, Glass JI, Luthey-Schulten Z.

Elife. 2019 Jan 18;8. pii: e36842. doi: 10.7554/eLife.36842. [Epub ahead of print]

5.

Parts-Prospecting for a High-Efficiency Thiamin Thiazole Biosynthesis Pathway.

Sun J, Sigler CL, Beaudoin GAW, Joshi J, Patterson JA, Cho KH, Ralat MA, Gregory JF 3rd, Clark DG, Deng Z, Colquhoun TA, Hanson AD.

Plant Physiol. 2019 Mar;179(3):958-968. doi: 10.1104/pp.18.01085. Epub 2018 Oct 18.

6.

Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds.

Tian X, Werner ME, Roche KC, Hanson AD, Foote HP, Yu SK, Warner SB, Copp JA, Lara H, Wauthier EL, Caster JM, Herring LE, Zhang L, Tepper JE, Hsu DS, Zhang T, Reid LM, Wang AZ.

Nat Biomed Eng. 2018;2:443-452. Epub 2018 Apr 23.

7.

Newly-discovered enzymes that function in metabolite damage-control.

de Crécy-Lagard V, Haas D, Hanson AD.

Curr Opin Chem Biol. 2018 Dec;47:101-108. doi: 10.1016/j.cbpa.2018.09.014. Epub 2018 Sep 28. Review.

PMID:
30268903
8.

Plant metabolic engineering in the synthetic biology era: plant chassis selection.

Stewart CN Jr, Patron N, Hanson AD, Jez JM.

Plant Cell Rep. 2018 Oct;37(10):1357-1358. doi: 10.1007/s00299-018-2342-1. Epub 2018 Sep 8. No abstract available.

PMID:
30196331
9.

UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells.

Sane S, Hafner A, Srinivasan R, Masood D, Slunecka JL, Noldner CJ, Hanson AD, Kruisselbrink T, Wang X, Wang Y, Yin J, Rezvani K.

Mol Oncol. 2018 Oct;12(10):1753-1777. doi: 10.1002/1878-0261.12372. Epub 2018 Sep 3.

10.

Salvage of the 5-deoxyribose byproduct of radical SAM enzymes.

Beaudoin GAW, Li Q, Folz J, Fiehn O, Goodsell JL, Angerhofer A, Bruner SD, Hanson AD.

Nat Commun. 2018 Aug 6;9(1):3105. doi: 10.1038/s41467-018-05589-4.

11.

PlantSEED enables automated annotation and reconstruction of plant primary metabolism with improved compartmentalization and comparative consistency.

Seaver SMD, Lerma-Ortiz C, Conrad N, Mikaili A, Sreedasyam A, Hanson AD, Henry CS.

Plant J. 2018 Sep;95(6):1102-1113. doi: 10.1111/tpj.14003. Epub 2018 Aug 9.

PMID:
29924895
12.

Redesigning thiamin synthesis: Prospects and potential payoffs.

Hanson AD, Amthor JS, Sun J, Niehaus TD, Gregory JF 3rd, Bruner SD, Ding Y.

Plant Sci. 2018 Aug;273:92-99. doi: 10.1016/j.plantsci.2018.01.019. Epub 2018 Feb 5.

PMID:
29907313
13.

Synthetic biology meets plant metabolism.

Hanson AD, Jez JM.

Plant Sci. 2018 Aug;273:1-2. doi: 10.1016/j.plantsci.2018.04.004. Epub 2018 Apr 7. No abstract available.

PMID:
29907301
14.

Author Correction: Carboxythiazole is a key microbial nutrient currency and critical component of thiamin biosynthesis.

Paerl RW, Bertrand EM, Rowland E, Schatt P, Mehiri M, Niehaus TD, Hanson AD, Riemann L, Bouget FY.

Sci Rep. 2018 Jun 6;8(1):8876. doi: 10.1038/s41598-018-27042-8.

15.

Carboxythiazole is a key microbial nutrient currency and critical component of thiamin biosynthesis.

Paerl RW, Bertrand EM, Rowland E, Schatt P, Mehiri M, Niehaus TD, Hanson AD, Riemann L, Bouget FY.

Sci Rep. 2018 Apr 13;8(1):5940. doi: 10.1038/s41598-018-24321-2. Erratum in: Sci Rep. 2018 Jun 6;8(1):8876.

16.

Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function.

Niehaus TD, Elbadawi-Sidhu M, Huang L, Prunetti L, Gregory JF 3rd, de Crécy-Lagard V, Fiehn O, Hanson AD.

Biosci Rep. 2018 May 8;38(3). pii: BSR20180223. doi: 10.1042/BSR20180223. Print 2018 Jun 29.

17.

Identification of a metabolic disposal route for the oncometabolite S-(2-succino)cysteine in Bacillus subtilis.

Niehaus TD, Folz J, McCarty DR, Cooper AJL, Moraga Amador D, Fiehn O, Hanson AD.

J Biol Chem. 2018 May 25;293(21):8255-8263. doi: 10.1074/jbc.RA118.002925. Epub 2018 Apr 6.

PMID:
29626092
18.

Long-term regeneration and remodeling of the pig esophagus after circumferential resection using a retrievable synthetic scaffold carrying autologous cells.

La Francesca S, Aho JM, Barron MR, Blanco EW, Soliman S, Kalenjian L, Hanson AD, Todorova E, Marsh M, Burnette K, DerSimonian H, Odze RD, Wigle DA.

Sci Rep. 2018 Mar 7;8(1):4123. doi: 10.1038/s41598-018-22401-x.

19.

The PLUTO plastidial nucleobase transporter also transports the thiamin precursor hydroxymethylpyrimidine.

Beaudoin GAW, Johnson TS, Hanson AD.

Biosci Rep. 2018 Mar 29;38(2). pii: BSR20180048. doi: 10.1042/BSR20180048. Print 2018 Apr 27.

20.

Corrigendum: Divisions of labor in the thiamin biosynthetic pathway among organs of maize.

Guan JC, Hasnain G, Garrett TJ, Chase CD, Gregory J, Hanson AD, McCarty DR.

Front Plant Sci. 2018 Feb 20;9:148. doi: 10.3389/fpls.2018.00148. eCollection 2018.

21.

A plastidial pantoate transporter with a potential role in pantothenate synthesis.

Huang L, Pyc M, Alseekh S, McCarty DR, de Crécy-Lagard V, Gregory JF 3rd, Henry CS, Fernie AR, Mullen RT, Hanson AD.

Biochem J. 2018 Feb 28;475(4):813-825. doi: 10.1042/BCJ20170883.

PMID:
29382740
22.

An unusual diphosphatase from the PhnP family cleaves reactive FAD photoproducts.

Beaudoin GAW, Li Q, Bruner SD, Hanson AD.

Biochem J. 2018 Jan 11;475(1):261-272. doi: 10.1042/BCJ20170817.

PMID:
29229761
23.

Metabolite damage and repair in metabolic engineering design.

Sun J, Jeffryes JG, Henry CS, Bruner SD, Hanson AD.

Metab Eng. 2017 Nov;44:150-159. doi: 10.1016/j.ymben.2017.10.006. Epub 2017 Oct 10. Review.

PMID:
29030275
24.

A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.

Golubev A, Hanson AD, Gladyshev VN.

Antioxid Redox Signal. 2018 Oct 1;29(10):1003-1017. doi: 10.1089/ars.2017.7105. Epub 2017 Oct 17.

PMID:
28874059
25.

Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight.

Niehaus TD, Elbadawi-Sidhu M, de Crécy-Lagard V, Fiehn O, Hanson AD.

J Biol Chem. 2017 Sep 29;292(39):16360-16367. doi: 10.1074/jbc.M117.805028. Epub 2017 Aug 22.

26.

A strictly monofunctional bacterial hydroxymethylpyrimidine phosphate kinase precludes damaging errors in thiamin biosynthesis.

Thamm AM, Li G, Taja-Moreno M, Gerdes SY, de Crécy-Lagard V, Bruner SD, Hanson AD.

Biochem J. 2017 Jul 20. pii: BCJ20170437. doi: 10.1042/BCJ20170437. [Epub ahead of print]

PMID:
28729425
27.

Non-enzymatic molecular damage as a prototypic driver of aging.

Golubev A, Hanson AD, Gladyshev VN.

J Biol Chem. 2017 Apr 14;292(15):6029-6038. doi: 10.1074/jbc.R116.751164. Epub 2017 Mar 6. Review.

28.

Does Abiotic Stress Cause Functional B Vitamin Deficiency in Plants?

Hanson AD, Beaudoin GA, McCarty DR, Gregory JF 3rd.

Plant Physiol. 2016 Dec;172(4):2082-2097. Epub 2016 Nov 2. Review.

29.

A Guardian Angel Phosphatase for Mainline Carbon Metabolism.

Beaudoin GA, Hanson AD.

Trends Biochem Sci. 2016 Nov;41(11):893-894. doi: 10.1016/j.tibs.2016.08.005. Epub 2016 Aug 17.

PMID:
27544441
30.

Arabidopsis TH2 Encodes the Orphan Enzyme Thiamin Monophosphate Phosphatase.

Mimura M, Zallot R, Niehaus TD, Hasnain G, Gidda SK, Nguyen TN, Anderson EM, Mullen RT, Brown G, Yakunin AF, de Crécy-Lagard V, Gregory JF 3rd, McCarty DR, Hanson AD.

Plant Cell. 2016 Oct;28(10):2683-2696. Epub 2016 Sep 27.

31.

Systematic identification and analysis of frequent gene fusion events in metabolic pathways.

Henry CS, Lerma-Ortiz C, Gerdes SY, Mullen JD, Colasanti R, Zhukov A, Frelin O, Thiaville JJ, Zallot R, Niehaus TD, Hasnain G, Conrad N, Hanson AD, de Crécy-Lagard V.

BMC Genomics. 2016 Jun 24;17:473. doi: 10.1186/s12864-016-2782-3.

32.

A family of metal-dependent phosphatases implicated in metabolite damage-control.

Huang L, Khusnutdinova A, Nocek B, Brown G, Xu X, Cui H, Petit P, Flick R, Zallot R, Balmant K, Ziemak MJ, Shanklin J, de Crécy-Lagard V, Fiehn O, Gregory JF 3rd, Joachimiak A, Savchenko A, Yakunin AF, Hanson AD.

Nat Chem Biol. 2016 Aug;12(8):621-7. doi: 10.1038/nchembio.2108. Epub 2016 Jun 20.

PMID:
27322068
33.

'Nothing of chemistry disappears in biology': the Top 30 damage-prone endogenous metabolites.

Lerma-Ortiz C, Jeffryes JG, Cooper AJ, Niehaus TD, Thamm AM, Frelin O, Aunins T, Fiehn O, de Crécy-Lagard V, Henry CS, Hanson AD.

Biochem Soc Trans. 2016 Jun 15;44(3):961-71. doi: 10.1042/BST20160073. Review.

PMID:
27284066
34.

Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB).

Thiaville JJ, Frelin O, García-Salinas C, Harrison K, Hasnain G, Horenstein NA, Díaz de la Garza RI, Henry CS, Hanson AD, de Crécy-Lagard V.

Front Microbiol. 2016 Mar 31;7:431. doi: 10.3389/fmicb.2016.00431. eCollection 2016.

35.

Evidence That COG0325 Proteins are involved in PLP Homeostasis.

Prunetti L, El Yacoubi B, Schiavon CR, Kirkpatrick E, Huang L, Bailly M, ElBadawi-Sidhu M, Harrison K, Gregory JF, Fiehn O, Hanson AD, de Crécy-Lagard V.

Microbiology. 2016 Feb 12. doi: 10.1099/mic.0.000255. [Epub ahead of print]

PMID:
26872910
36.

Metabolite Damage and Metabolite Damage Control in Plants.

Hanson AD, Henry CS, Fiehn O, de Crécy-Lagard V.

Annu Rev Plant Biol. 2016 Apr 29;67:131-52. doi: 10.1146/annurev-arplant-043015-111648. Epub 2015 Nov 19. Review.

PMID:
26667673
37.

Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli.

Li K, Li G, Bradbury LM, Hanson AD, Bruner SD.

Biochem J. 2016 Feb 1;473(3):277-84. doi: 10.1042/BJ20150980. Epub 2015 Nov 12.

PMID:
26564203
38.

Bacterial and plant HAD enzymes catalyse a missing phosphatase step in thiamin diphosphate biosynthesis.

Hasnain G, Roje S, Sa N, Zallot R, Ziemak MJ, de Crécy-Lagard V, Gregory JF 3rd, Hanson AD.

Biochem J. 2016 Jan 15;473(2):157-66. doi: 10.1042/BJ20150805. Epub 2015 Nov 4.

PMID:
26537753
39.

Remobilization of Phytol from Chlorophyll Degradation Is Essential for Tocopherol Synthesis and Growth of Arabidopsis.

Vom Dorp K, Hölzl G, Plohmann C, Eisenhut M, Abraham M, Weber AP, Hanson AD, Dörmann P.

Plant Cell. 2015 Oct;27(10):2846-59. doi: 10.1105/tpc.15.00395. Epub 2015 Oct 9.

40.

MINEs: open access databases of computationally predicted enzyme promiscuity products for untargeted metabolomics.

Jeffryes JG, Colastani RL, Elbadawi-Sidhu M, Kind T, Niehaus TD, Broadbelt LJ, Hanson AD, Fiehn O, Tyo KE, Henry CS.

J Cheminform. 2015 Aug 28;7:44. doi: 10.1186/s13321-015-0087-1. eCollection 2015.

41.

Proteins of Unknown Biochemical Function: A Persistent Problem and a Roadmap to Help Overcome It.

Niehaus TD, Thamm AM, de Crécy-Lagard V, Hanson AD.

Plant Physiol. 2015 Nov;169(3):1436-42. doi: 10.1104/pp.15.00959. Epub 2015 Aug 12.

42.

Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS.

Kuznetsova E, Nocek B, Brown G, Makarova KS, Flick R, Wolf YI, Khusnutdinova A, Evdokimova E, Jin K, Tan K, Hanson AD, Hasnain G, Zallot R, de Crécy-Lagard V, Babu M, Savchenko A, Joachimiak A, Edwards AM, Koonin EV, Yakunin AF.

J Biol Chem. 2015 Jul 24;290(30):18678-98. doi: 10.1074/jbc.M115.657916. Epub 2015 Jun 12.

43.

Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family.

Niehaus TD, Gerdes S, Hodge-Hanson K, Zhukov A, Cooper AJ, ElBadawi-Sidhu M, Fiehn O, Downs DM, Hanson AD.

BMC Genomics. 2015 May 15;16:382. doi: 10.1186/s12864-015-1584-3.

44.

Improved evidence-based genome-scale metabolic models for maize leaf, embryo, and endosperm.

Seaver SM, Bradbury LM, Frelin O, Zarecki R, Ruppin E, Hanson AD, Henry CS.

Front Plant Sci. 2015 Mar 10;6:142. doi: 10.3389/fpls.2015.00142. eCollection 2015.

45.

A directed-overflow and damage-control N-glycosidase in riboflavin biosynthesis.

Frelin O, Huang L, Hasnain G, Jeffryes JG, Ziemak MJ, Rocca JR, Wang B, Rice J, Roje S, Yurgel SN, Gregory JF 3rd, Edison AS, Henry CS, de Crécy-Lagard V, Hanson AD.

Biochem J. 2015 Feb 15;466(1):137-45. doi: 10.1042/BJ20141237.

46.

Divisions of labor in the thiamin biosynthetic pathway among organs of maize.

Guan JC, Hasnain G, Garrett TJ, Chase CD, Gregory J, Hanson AD, McCarty DR.

Front Plant Sci. 2014 Aug 4;5:370. doi: 10.3389/fpls.2014.00370. eCollection 2014. Erratum in: Front Plant Sci. 2018 Feb 20;9:148.

47.

Arabidopsis and maize RidA proteins preempt reactive enamine/imine damage to branched-chain amino acid biosynthesis in plastids.

Niehaus TD, Nguyen TN, Gidda SK, ElBadawi-Sidhu M, Lambrecht JA, McCarty DR, Downs DM, Cooper AJ, Fiehn O, Mullen RT, Hanson AD.

Plant Cell. 2014 Jul;26(7):3010-22. doi: 10.1105/tpc.114.126854. Epub 2014 Jul 28.

48.

Plant-driven repurposing of the ancient S-adenosylmethionine repair enzyme homocysteine S-methyltransferase.

Bradbury LM, Ziemak MJ, El Badawi-Sidhu M, Fiehn O, Hanson AD.

Biochem J. 2014 Oct 15;463(2):279-86. doi: 10.1042/BJ20140753.

PMID:
25046177
49.

Salvage of the thiamin pyrimidine moiety by plant TenA proteins lacking an active-site cysteine.

Zallot R, Yazdani M, Goyer A, Ziemak MJ, Guan JC, McCarty DR, de Crécy-Lagard V, Gerdes S, Garrett TJ, Benach J, Hunt JF, Shintani DK, Hanson AD.

Biochem J. 2014 Oct 1;463(1):145-55. doi: 10.1042/BJ20140522.

PMID:
25014715
50.

High-throughput comparison, functional annotation, and metabolic modeling of plant genomes using the PlantSEED resource.

Seaver SM, Gerdes S, Frelin O, Lerma-Ortiz C, Bradbury LM, Zallot R, Hasnain G, Niehaus TD, El Yacoubi B, Pasternak S, Olson R, Pusch G, Overbeek R, Stevens R, de Crécy-Lagard V, Ware D, Hanson AD, Henry CS.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9645-50. doi: 10.1073/pnas.1401329111. Epub 2014 Jun 9.

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