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Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.

Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstråle M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW; IMI DIRECT Consortium.

Diabetologia. 2019 Jun 15. doi: 10.1007/s00125-019-4906-1. [Epub ahead of print]


Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study.

Bryrup T, Thomsen CW, Kern T, Allin KH, Brandslund I, Jørgensen NR, Vestergaard H, Hansen T, Hansen TH, Pedersen O, Nielsen T.

Diabetologia. 2019 Jun;62(6):1024-1035. doi: 10.1007/s00125-019-4848-7. Epub 2019 Mar 23.


Motivations for data sharing-views of research participants from four European countries: A DIRECT study.

Shah N, Coathup V, Teare H, Forgie I, Giordano GN, Hansen TH, Groeneveld L, Hudson M, Pearson E, Ruetten H, Kaye J.

Eur J Hum Genet. 2019 May;27(5):721-729. doi: 10.1038/s41431-019-0344-2. Epub 2019 Jan 30.


A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement.

Wang X, Piersma SJ, Nelson CA, Dai YN, Christensen T, Lazear E, Yang L, Sluijter M, van Hall T, Hansen TH, Yokoyama WM, Fremont DH.

Elife. 2018 Dec 21;7. pii: e38667. doi: 10.7554/eLife.38667.


Short-chain fatty acids and gut microbiota in multiple sclerosis.

Melbye P, Olsson A, Hansen TH, Søndergaard HB, Bang Oturai A.

Acta Neurol Scand. 2019 Mar;139(3):208-219. doi: 10.1111/ane.13045. Epub 2018 Dec 3.


The effect of drinking water pH on the human gut microbiota and glucose regulation: results of a randomized controlled cross-over intervention.

Hansen TH, Thomassen MT, Madsen ML, Kern T, Bak EG, Kashani A, Allin KH, Hansen T, Pedersen O.

Sci Rep. 2018 Nov 9;8(1):16626. doi: 10.1038/s41598-018-34761-5.


Recovery of gut microbiota of healthy adults following antibiotic exposure.

Palleja A, Mikkelsen KH, Forslund SK, Kashani A, Allin KH, Nielsen T, Hansen TH, Liang S, Feng Q, Zhang C, Pyl PT, Coelho LP, Yang H, Wang J, Typas A, Nielsen MF, Nielsen HB, Bork P, Wang J, Vilsbøll T, Hansen T, Knop FK, Arumugam M, Pedersen O.

Nat Microbiol. 2018 Nov;3(11):1255-1265. doi: 10.1038/s41564-018-0257-9. Epub 2018 Oct 22.


Sharing data for future research-engaging participants' views about data governance beyond the original project: a DIRECT Study.

Shah N, Coathup V, Teare H, Forgie I, Giordano GN, Hansen TH, Groeneveld L, Hudson M, Pearson E, Ruetten H, Kaye J.

Genet Med. 2019 May;21(5):1131-1138. doi: 10.1038/s41436-018-0299-7. Epub 2018 Sep 28.


Gut microbiota composition in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives.

Coello K, Hansen TH, Sørensen N, Munkholm K, Kessing LV, Pedersen O, Vinberg M.

Brain Behav Immun. 2019 Jan;75:112-118. doi: 10.1016/j.bbi.2018.09.026. Epub 2018 Sep 24.


The impact of silicon on cell wall composition and enzymatic saccharification of Brachypodium distachyon.

Głazowska S, Baldwin L, Mravec J, Bukh C, Hansen TH, Jensen MM, Fangel JU, Willats WGT, Glasius M, Felby C, Schjoerring JK.

Biotechnol Biofuels. 2018 Jun 20;11:171. doi: 10.1186/s13068-018-1166-0. eCollection 2018.


Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation.

Engelbrechtsen L, Gybel-Brask D, Mahendran Y, Crusell M, Hansen TH, Schnurr TM, Hogdall E, Skibsted L, Hansen T, Vestergaard H.

Sci Rep. 2018 May 30;8(1):8376. doi: 10.1038/s41598-018-26752-3.


Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum.

Crusell MKW, Hansen TH, Nielsen T, Allin KH, Rühlemann MC, Damm P, Vestergaard H, Rørbye C, Jørgensen NR, Christiansen OB, Heinsen FA, Franke A, Hansen T, Lauenborg J, Pedersen O.

Microbiome. 2018 May 15;6(1):89. doi: 10.1186/s40168-018-0472-x.


Impact of a vegan diet on the human salivary microbiota.

Hansen TH, Kern T, Bak EG, Kashani A, Allin KH, Nielsen T, Hansen T, Pedersen O.

Sci Rep. 2018 Apr 11;8(1):5847. doi: 10.1038/s41598-018-24207-3.


Improving veterans' access to gastroenterology clinical care.

Hansen TH.

JAAPA. 2018 Mar;31(3):47-49. doi: 10.1097/01.JAA.0000530296.15656.8a.


Effect of nitrogen and zinc fertilization on zinc and iron bioavailability and chemical speciation in maize silage.

Grujcic D, Hansen TH, Husted S, Drinic M, Singh BR.

J Trace Elem Med Biol. 2018 Sep;49:269-275. doi: 10.1016/j.jtemb.2018.02.012. Epub 2018 Feb 11.


Aberrant intestinal microbiota in individuals with prediabetes.

Allin KH, Tremaroli V, Caesar R, Jensen BAH, Damgaard MTF, Bahl MI, Licht TR, Hansen TH, Nielsen T, Dantoft TM, Linneberg A, Jørgensen T, Vestergaard H, Kristiansen K, Franks PW; IMI-DIRECT consortium, Hansen T, Bäckhed F, Pedersen O.

Diabetologia. 2018 Apr;61(4):810-820. doi: 10.1007/s00125-018-4550-1. Epub 2018 Jan 29.


Bone turnover, calcium homeostasis, and vitamin D status in Danish vegans.

Hansen TH, Madsen MTB, Jørgensen NR, Cohen AS, Hansen T, Vestergaard H, Pedersen O, Allin KH.

Eur J Clin Nutr. 2018 Jul;72(7):1046-1054. doi: 10.1038/s41430-017-0081-y. Epub 2018 Jan 23.


Genetic risk scores for body fat distribution attenuate weight loss in women during dietary intervention.

Svendstrup M, Allin KH, Sørensen TIA, Hansen TH, Grarup N, Hansen T, Vestergaard H.

Int J Obes (Lond). 2018 Mar;42(3):370-375. doi: 10.1038/ijo.2017.279. Epub 2017 Nov 16.


High Neonatal Blood Iron Content Is Associated with the Risk of Childhood Type 1 Diabetes Mellitus.

Kyvsgaard JN, Overgaard AJ, Thorsen SU, Hansen TH, Pipper CB, Mortensen HB, Pociot F, Svensson J.

Nutrients. 2017 Nov 6;9(11). pii: E1221. doi: 10.3390/nu9111221.


Chemical characterization by gas chromatography-mass spectrometry and inductively coupled plasma-optical emission spectroscopy of membrane permeates from an industrial dairy ingredient production used as process water.

Skou PB, Khakimov B, Hansen TH, Aunsbjerg SD, Knøchel S, Thaysen D, van den Berg F.

J Dairy Sci. 2018 Jan;101(1):135-146. doi: 10.3168/jds.2017-12950. Epub 2017 Oct 18.


Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins.

Engelbrechtsen L, Hansen TH, Mahendran Y, Pyl P, Andersson E, Jonsson A, Gjesing A, Linneberg A, Jørgensen T, Hansen T, Vestergaard H.

Sci Rep. 2017 Feb 21;7:43128. doi: 10.1038/srep43128.


Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial.

Garcia-Perez I, Posma JM, Gibson R, Chambers ES, Hansen TH, Vestergaard H, Hansen T, Beckmann M, Pedersen O, Elliott P, Stamler J, Nicholson JK, Draper J, Mathers JC, Holmes E, Frost G.

Lancet Diabetes Endocrinol. 2017 Mar;5(3):184-195. doi: 10.1016/S2213-8587(16)30419-3. Epub 2017 Jan 13.


Low perinatal zinc status is not associated with the risk of type 1 diabetes in children.

Kyvsgaard JN, Overgaard AJ, Jacobsen LD, Thorsen SU, Pipper CB, Hansen TH, Husted S, Mortensen HB, Pociot F, Svensson J.

Pediatr Diabetes. 2017 Nov;18(7):637-642. doi: 10.1111/pedi.12476. Epub 2016 Nov 22.


Sustained influence of metformin therapy on circulating glucagon-like peptide-1 levels in individuals with and without type 2 diabetes.

Preiss D, Dawed A, Welsh P, Heggie A, Jones AG, Dekker J, Koivula R, Hansen TH, Stewart C, Holman RR, Franks PW, Walker M, Pearson ER, Sattar N; DIRECT consortium group.

Diabetes Obes Metab. 2017 Mar;19(3):356-363. doi: 10.1111/dom.12826. Epub 2016 Dec 28.


Mother-plant-mediated pumping of zinc into the developing seed.

Olsen LI, Hansen TH, Larue C, Østerberg JT, Hoffmann RD, Liesche J, Krämer U, Surblé S, Cadarsi S, Samson VA, Grolimund D, Husted S, Palmgren M.

Nat Plants. 2016 Apr 11;2(5):16036. doi: 10.1038/nplants.2016.36.


Immunodominant West Nile Virus T Cell Epitopes Are Fewer in Number and Fashionably Late.

Kaabinejadian S, McMurtrey CP, Kim S, Jain R, Bardet W, Schafer FB, Davenport JL, Martin AD, Diamond MS, Weidanz JA, Hansen TH, Hildebrand WH.

J Immunol. 2016 May 15;196(10):4263-73. doi: 10.4049/jimmunol.1501821. Epub 2016 Apr 20.


Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials.

Kristensen NB, Bryrup T, Allin KH, Nielsen T, Hansen TH, Pedersen O.

Genome Med. 2016 May 10;8(1):52. doi: 10.1186/s13073-016-0300-5. Review.


Predicting outgrowth and inactivation of Clostridium perfringens in meat products during low temperature long time heat treatment.

Duan Z, Hansen TH, Hansen TB, Dalgaard P, Knøchel S.

Int J Food Microbiol. 2016 Aug 2;230:45-57. doi: 10.1016/j.ijfoodmicro.2016.03.019. Epub 2016 Apr 6.


TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells.

Ussher JE, van Wilgenburg B, Hannaway RF, Ruustal K, Phalora P, Kurioka A, Hansen TH, Willberg CB, Phillips RE, Klenerman P.

Eur J Immunol. 2016 Jul;46(7):1600-14. doi: 10.1002/eji.201545969. Epub 2016 May 30.


Erratum to: 'Intake of Macro- and Micronutrients in Danish Vegans'.

Kristensen NB, Madsen ML, Hansen TH, Allin KH, Hoppe C, Fagt S, Lausten MS, Gøbel RJ, Vestergaard H, Hansen T, Pedersen O.

Nutr J. 2016 Feb 9;15:16. doi: 10.1186/s12937-016-0136-2. No abstract available.


Multi-platform metabolomics analyses of a broad collection of fragrant and non-fragrant rice varieties reveals the high complexity of grain quality characteristics.

Mumm R, Hageman JA, Calingacion MN, de Vos RCH, Jonker HH, Erban A, Kopka J, Hansen TH, Laursen KH, Schjoerring JK, Ward JL, Beale MH, Jongee S, Rauf A, Habibi F, Indrasari SD, Sakhan S, Ramli A, Romero M, Reinke RF, Ohtsubo K, Boualaphanh C, Fitzgerald MA, Hall RD.

Metabolomics. 2016;12:38. doi: 10.1007/s11306-015-0925-1. Epub 2016 Jan 23.


Intake of macro- and micronutrients in Danish vegans.

Kristensen NB, Madsen ML, Hansen TH, Allin KH, Hoppe C, Fagt S, Lausten MS, Gøbel RJ, Vestergaard H, Hansen T, Pedersen O.

Nutr J. 2015 Oct 30;14:115. doi: 10.1186/s12937-015-0103-3. Erratum in: Nutr J. 2016;15:16.


Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

Sakala IG, Kjer-Nielsen L, Eickhoff CS, Wang X, Blazevic A, Liu L, Fairlie DP, Rossjohn J, McCluskey J, Fremont DH, Hansen TH, Hoft DF.

J Immunol. 2015 Jul 15;195(2):587-601. doi: 10.4049/jimmunol.1402545. Epub 2015 Jun 10.


Being two is better than one-catalytic reductions with dendrimer encapsulated copper- and copper-cobalt-subnanoparticles.

Ficker M, Petersen JF, Gschneidtner T, Rasmussen AL, Purdy T, Hansen JS, Hansen TH, Husted S, Moth Poulsen K, Olsson E, Christensen JB.

Chem Commun (Camb). 2015 Jun 21;51(49):9957-60. doi: 10.1039/c5cc00347d.


Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes.

Hansen TH, Vestergaard H, Jørgensen T, Jørgensen ME, Lauritzen T, Brandslund I, Christensen C, Pedersen O, Hansen T, Gjesing AP.

BMC Med Genet. 2015 Mar 20;16:17. doi: 10.1186/s12881-015-0160-7.


The gut microbiome in cardio-metabolic health.

Hansen TH, Gøbel RJ, Hansen T, Pedersen O.

Genome Med. 2015 Mar 31;7(1):33. doi: 10.1186/s13073-015-0157-z. eCollection 2015. Review.


Does intake of trace elements through urban gardening in Copenhagen pose a risk to human health?

Warming M, Hansen MG, Holm PE, Magid J, Hansen TH, Trapp S.

Environ Pollut. 2015 Jul;202:17-23. doi: 10.1016/j.envpol.2015.03.011. Epub 2015 Mar 18.


Expression, receptor binding, and biophysical characterization of guinea pig insulin desB30: a monomeric insulin variant.

Engholm E, Hansen TH, Johansson E, Strauss HM, Vinther TN, Jensen KJ, Hubálek F, Kjeldsen TB.

Chembiochem. 2015 Apr 13;16(6):954-8. doi: 10.1002/cbic.201402688. Epub 2015 Mar 5.


MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.

Kurioka A, Ussher JE, Cosgrove C, Clough C, Fergusson JR, Smith K, Kang YH, Walker LJ, Hansen TH, Willberg CB, Klenerman P.

Mucosal Immunol. 2015 Mar;8(2):429-40. doi: 10.1038/mi.2014.81. Epub 2014 Oct 1.


Association between tobacco smoking and response to tumour necrosis factor α inhibitor treatment in psoriatic arthritis: results from the DANBIO registry.

Højgaard P, Glintborg B, Hetland ML, Hansen TH, Lage-Hansen PR, Petersen MH, Holland-Fischer M, Nilsson C, Loft AG, Andersen BN, Adelsten T, Jensen J, Omerovic E, Christensen R, Tarp U, Østgård R, Dreyer L.

Ann Rheum Dis. 2015 Dec;74(12):2130-6. doi: 10.1136/annrheumdis-2014-205389. Epub 2014 Jul 25.


MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage.

Gold MC, McLaren JE, Reistetter JA, Smyk-Pearson S, Ladell K, Swarbrick GM, Yu YY, Hansen TH, Lund O, Nielsen M, Gerritsen B, Kesmir C, Miles JJ, Lewinsohn DA, Price DA, Lewinsohn DM.

J Exp Med. 2014 Jul 28;211(8):1601-10. doi: 10.1084/jem.20140507. Epub 2014 Jul 21.


A novel T-cell receptor mimic defines dendritic cells that present an immunodominant West Nile virus epitope in mice.

Kim S, Pinto AK, Myers NB, Hawkins O, Doll K, Kaabinejadian S, Netland J, Bevan MJ, Weidanz JA, Hildebrand WH, Diamond MS, Hansen TH.

Eur J Immunol. 2014 Jul;44(7):1936-46. doi: 10.1002/eji.201444450. Epub 2014 May 3.


Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.

Koivula RW, Heggie A, Barnett A, Cederberg H, Hansen TH, Koopman AD, Ridderstråle M, Rutters F, Vestergaard H, Gupta R, Herrgård S, Heymans MW, Perry MH, Rauh S, Siloaho M, Teare HJ, Thorand B, Bell J, Brunak S, Frost G, Jablonka B, Mari A, McDonald TJ, Dekker JM, Hansen T, Hattersley A, Laakso M, Pedersen O, Koivisto V, Ruetten H, Walker M, Pearson E, Franks PW; DIRECT Consortium.

Diabetologia. 2014 Jun;57(6):1132-42. doi: 10.1007/s00125-014-3216-x. Epub 2014 Apr 4.


Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells.

Reantragoon R, Corbett AJ, Sakala IG, Gherardin NA, Furness JB, Chen Z, Eckle SB, Uldrich AP, Birkinshaw RW, Patel O, Kostenko L, Meehan B, Kedzierska K, Liu L, Fairlie DP, Hansen TH, Godfrey DI, Rossjohn J, McCluskey J, Kjer-Nielsen L.

J Exp Med. 2013 Oct 21;210(11):2305-20. doi: 10.1084/jem.20130958. Epub 2013 Oct 7.


CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner.

Ussher JE, Bilton M, Attwod E, Shadwell J, Richardson R, de Lara C, Mettke E, Kurioka A, Hansen TH, Klenerman P, Willberg CB.

Eur J Immunol. 2014 Jan;44(1):195-203. doi: 10.1002/eji.201343509. Epub 2013 Oct 1.


Antibody-peptide-MHC fusion conjugates target non-cognate T cells to kill tumour cells.

King BC, Hamblin AD, Savage PM, Douglas LR, Hansen TH, French RR, Johnson PW, Glennie MJ.

Cancer Immunol Immunother. 2013 Jun;62(6):1093-105. doi: 10.1007/s00262-013-1408-8. Epub 2013 Apr 19.


Silicon alleviates iron deficiency in cucumber by promoting mobilization of iron in the root apoplast.

Pavlovic J, Samardzic J, Maksimović V, Timotijevic G, Stevic N, Laursen KH, Hansen TH, Husted S, Schjoerring JK, Liang Y, Nikolic M.

New Phytol. 2013 Jun;198(4):1096-107. doi: 10.1111/nph.12213. Epub 2013 Mar 18. Erratum in: New Phytol. 2013 Aug;199(3):866.


MAIT cell recognition of MR1 on bacterially infected and uninfected cells.

Young MH, U'Ren L, Huang S, Mallevaey T, Scott-Browne J, Crawford F, Lantz O, Hansen TH, Kappler J, Marrack P, Gapin L.

PLoS One. 2013;8(1):e53789. doi: 10.1371/journal.pone.0053789. Epub 2013 Jan 14.


Cowpox virus employs a two-pronged strategy to outflank MHCI antigen presentation.

McCoy WH 4th, Wang X, Yokoyama WM, Hansen TH, Fremont DH.

Mol Immunol. 2013 Sep;55(2):156-8. doi: 10.1016/j.molimm.2012.11.011. Epub 2013 Jan 10. Review.

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