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Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease.

Roostalu U, Salinas CBG, Thorbek DD, Skytte JL, Fabricius K, Barkholt P, John LM, Jurtz VI, Knudsen LB, Jelsing J, Vrang N, Hansen HH, Hecksher-Sørensen J.

Dis Model Mech. 2019 Nov 22;12(11). pii: dmm042200. doi: 10.1242/dmm.042200.


Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss.

Barkholt P, Rigbolt KTG, Falkenhahn M, Hübschle T, Schwahn U, Fernandez-Cachon ML, Schmidt T, Theis S, Hansen HH, Hay-Schmidt A, Pedersen PJ, Vrang N, Jelsing J.

Sci Rep. 2019 Nov 6;9(1):16161. doi: 10.1038/s41598-019-52257-8.


Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice.

Madsen MSA, Holm JB, Pallejà A, Wismann P, Fabricius K, Rigbolt K, Mikkelsen M, Sommer M, Jelsing J, Nielsen HB, Vrang N, Hansen HH.

Sci Rep. 2019 Oct 30;9(1):15582. doi: 10.1038/s41598-019-52103-x.


The Point Spread Function Formation in Plane Wave Imaging: A Theoretical Approximation in Fourier Migration.

Chen C, Hansen HHG, Hendriks GAGM, Menssen J, Lu JY, de Korte CL.

IEEE Trans Ultrason Ferroelectr Freq Control. 2019 Oct 2. doi: 10.1109/TUFFC.2019.2944191. [Epub ahead of print]


Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source.

Boland ML, Oró D, Tølbøl KS, Thrane ST, Nielsen JC, Cohen TS, Tabor DE, Fernandes F, Tovchigrechko A, Veidal SS, Warrener P, Sellman BR, Jelsing J, Feigh M, Vrang N, Trevaskis JL, Hansen HH.

World J Gastroenterol. 2019 Sep 7;25(33):4904-4920. doi: 10.3748/wjg.v25.i33.4904.


Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH.

Roth JD, Veidal SS, Fensholdt LKD, Rigbolt KTG, Papazyan R, Nielsen JC, Feigh M, Vrang N, Young M, Jelsing J, Adorini L, Hansen HH.

Sci Rep. 2019 Jun 21;9(1):9046. doi: 10.1038/s41598-019-45178-z.


In Vivo Blood Velocity Vector Imaging Using Adaptive Velocity Compounding in the Carotid Artery Bifurcation.

Saris AECM, Hansen HHG, Fekkes S, Menssen J, Nillesen MM, de Korte CL.

Ultrasound Med Biol. 2019 Jul;45(7):1691-1707. doi: 10.1016/j.ultrasmedbio.2019.03.008. Epub 2019 May 9.


3-D Strain Imaging of the Carotid Bifurcation: Methods and in-Human Feasibility.

Fekkes S, Hansen HHG, Menssen J, Saris AECM, de Korte CL.

Ultrasound Med Biol. 2019 Jul;45(7):1675-1690. doi: 10.1016/j.ultrasmedbio.2019.02.023. Epub 2019 Apr 18.


Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals.

Suppli MP, Rigbolt KTG, Veidal SS, Heebøll S, Eriksen PL, Demant M, Bagger JI, Nielsen JC, Oró D, Thrane SW, Lund A, Strandberg C, Kønig MJ, Vilsbøll T, Vrang N, Thomsen KL, Grønbæk H, Jelsing J, Hansen HH, Knop FK.

Am J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G462-G472. doi: 10.1152/ajpgi.00358.2018. Epub 2019 Jan 17.


Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis.

Tølbøl KS, Stierstorfer B, Rippmann JF, Veidal SS, Rigbolt KTG, Schönberger T, Gillum MP, Hansen HH, Vrang N, Jelsing J, Feigh M, Broermann A.

Dig Dis Sci. 2019 May;64(5):1238-1256. doi: 10.1007/s10620-018-5395-7. Epub 2018 Dec 3.


Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice.

Bech EM, Voldum-Clausen K, Pedersen SL, Fabricius K, Rudkjær LCB, Hansen HH, Jelsing J.

Biomed Pharmacother. 2019 Jan;109:167-173. doi: 10.1016/j.biopha.2018.10.040. Epub 2018 Nov 2.


The influence of timing the application of nitrogen fertilizer on early blight (Alternaria solani).

Abuley IK, Nielsen BJ, Hansen HH.

Pest Manag Sci. 2019 Apr;75(4):1150-1158. doi: 10.1002/ps.5236. Epub 2018 Nov 26.


3-D Single Breath-Hold Shear Strain Estimation for Improved Breast Lesion Detection and Classification in Automated Volumetric Ultrasound Scanners.

Hendriks GAGM, Chen C, Hansen HHG, de Korte CL.

IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Sep;65(9):1590-1599. doi: 10.1109/TUFFC.2018.2849687. Epub 2018 Jun 22.


Simultaneous Vascular Strain and Blood Vector Velocity Imaging Using High-Frequency Versus Conventional-Frequency Plane Wave Ultrasound: A Phantom Study.

Fekkes S, Saris AECM, Nillesen MM, Menssen J, Hansen HHG, de Korte CL.

IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Jul;65(7):1166-1181. doi: 10.1109/TUFFC.2018.2834724.


Response of primiparous and multiparous buffaloes to yeast culture supplementation during early and mid-lactation.

Hansen HH, El-Bordeny NE, Ebeid HM.

Anim Nutr. 2017 Dec;3(4):411-418. doi: 10.1016/j.aninu.2017.08.005. Epub 2017 Aug 18.


Comparative methane estimation from cattle based on total CO2 production using different techniques.

Haque MN, Hansen HH, Storm IMLD, Madsen J.

Anim Nutr. 2017 Jun;3(2):175-179. doi: 10.1016/j.aninu.2017.04.004. Epub 2017 Apr 12.


Improved Plane-Wave Ultrasound Beamforming by Incorporating Angular Weighting and Coherent Compounding in Fourier Domain.

Chen C, Hendriks GAGM, van Sloun RJG, Hansen HHG, de Korte CL.

IEEE Trans Ultrason Ferroelectr Freq Control. 2018 May;65(5):749-765. doi: 10.1109/TUFFC.2018.2811865.


INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis.

Roth JD, Feigh M, Veidal SS, Fensholdt LK, Rigbolt KT, Hansen HH, Chen LC, Petitjean M, Friley W, Vrang N, Jelsing J, Young M.

World J Gastroenterol. 2018 Jan 14;24(2):195-210. doi: 10.3748/wjg.v24.i2.195.


Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis.

Tølbøl KS, Kristiansen MN, Hansen HH, Veidal SS, Rigbolt KT, Gillum MP, Jelsing J, Vrang N, Feigh M.

World J Gastroenterol. 2018 Jan 14;24(2):179-194. doi: 10.3748/wjg.v24.i2.179.


Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.

Fernandez-Cachon ML, Pedersen SL, Rigbolt KT, Zhang C, Fabricius K, Hansen HH, Elster L, Fink LN, Schäfer M, Rhee NA, Langholz E, Wandall E, Friis SU, Vilmann P, Kristiansen VB, Schmidt C, Schreiter K, Breitschopf K, Hübschle T, Jorsal T, Vilsbøll T, Schmidt T, Theis S, Knop FK, Larsen PJ, Jelsing J.

Peptides. 2018 Mar;101:32-43. doi: 10.1016/j.peptides.2017.12.024. Epub 2017 Dec 28.


Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson's Disease.

Fabricius K, Barkholt P, Jelsing J, Hansen HH.

Front Neuroanat. 2017 Dec 8;11:109. doi: 10.3389/fnana.2017.00109. eCollection 2017.


Single primer isothermal amplification (SPIA) combined with next generation sequencing provides complete bovine coronavirus genome coverage and higher sequence depth compared to sequence-independent single primer amplification (SISPA).

Myrmel M, Oma V, Khatri M, Hansen HH, Stokstad M, Berg M, Blomström AL.

PLoS One. 2017 Nov 7;12(11):e0187780. doi: 10.1371/journal.pone.0187780. eCollection 2017.


Risk of Ectopic Pregnancy in Women With Inflammatory Bowel Disease: A 22-Year Nationwide Cohort Study.

de Silva PS, Hansen HH, Wehberg S, Friedman S, Nørgård BM.

Clin Gastroenterol Hepatol. 2018 Jan;16(1):83-89.e1. doi: 10.1016/j.cgh.2017.06.054. Epub 2017 Jul 8.


Mouse models of nonalcoholic steatohepatitis in preclinical drug development.

Hansen HH, Feigh M, Veidal SS, Rigbolt KT, Vrang N, Fosgerau K.

Drug Discov Today. 2017 Nov;22(11):1707-1718. doi: 10.1016/j.drudis.2017.06.007. Epub 2017 Jul 4. Review.


Evaluation of the feeding value of Dichrostachys cinerea pods for fattening pigs in Cuba.

Martín-Casas N, Reinoso-Pérez M, García-Díaz JR, Hansen HH, Nielsen MO.

Trop Anim Health Prod. 2017 Aug;49(6):1235-1242. doi: 10.1007/s11250-017-1321-9. Epub 2017 Jun 13.


Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls.

Maessen MFH, Eijsvogels TMH, Grotens A, Hopman MTE, Thijssen DHJ, Hansen HHG.

Cardiovasc Ultrasound. 2017 May 18;15(1):13. doi: 10.1186/s12947-017-0104-9.


Genome Sequence of a Bovine Rhinitis B Virus Identified in Cattle in Sweden.

Blomström AL, Oma V, Khatri M, Hansen HH, Stokstad M, Berg M, Myrmel M.

Genome Announc. 2017 May 11;5(19). pii: e00172-17. doi: 10.1128/genomeA.00172-17.


Three-dimensional ultrasound strain imaging of skeletal muscles.

Gijsbertse K, Sprengers AM, Nillesen MM, Hansen HH, Lopata RG, Verdonschot N, de Korte CL.

Phys Med Biol. 2017 Jan 21;62(2):596-611. doi: 10.1088/1361-6560/aa5077. Epub 2016 Dec 29.


Compound Ultrasound Strain Imaging for Noninvasive Detection of (Fibro)Atheromatous Plaques: Histopathological Validation in Human Carotid Arteries.

Hansen HH, de Borst GJ, Bots ML, Moll FL, Pasterkamp G, de Korte CL.

JACC Cardiovasc Imaging. 2016 Dec;9(12):1466-1467. doi: 10.1016/j.jcmg.2016.05.008. No abstract available.


A Comparison Between Compounding Techniques Using Large Beam-Steered Plane Wave Imaging for Blood Vector Velocity Imaging in a Carotid Artery Model.

Saris AE, Hansen HH, Fekkes S, Nillesen MM, Rutten MC, de Korte CL.

IEEE Trans Ultrason Ferroelectr Freq Control. 2016 Nov;63(11):1758-1771.


Validation of Noninvasive In Vivo Compound Ultrasound Strain Imaging Using Histologic Plaque Vulnerability Features.

Hansen HH, de Borst GJ, Bots ML, Moll FL, Pasterkamp G, de Korte CL.

Stroke. 2016 Nov;47(11):2770-2775. Epub 2016 Sep 29.


Glycaemic and insulinemic response to dietary carbohydrates in horses.

Brøkner C, Austbø D, Næsset JA, Blache D, Knudsen KE, Hansen HH, Tauson AH.

Acta Vet Scand. 2016 Oct 20;58(Suppl 1):69.


Fine mapping of a QTL on bovine chromosome 6 using imputed full sequence data suggests a key role for the group-specific component (GC) gene in clinical mastitis and milk production.

Olsen HG, Knutsen TM, Lewandowska-Sabat AM, Grove H, Nome T, Svendsen M, Arnyasi M, Sodeland M, Sundsaasen KK, Dahl SR, Heringstad B, Hansen HH, Olsaker I, Kent MP, Lien S.

Genet Sel Evol. 2016 Oct 19;48(1):79.


2-D Versus 3-D Cross-Correlation-Based Radial and Circumferential Strain Estimation Using Multiplane 2-D Ultrafast Ultrasound in a 3-D Atherosclerotic Carotid Artery Model.

Fekkes S, Swillens AE, Hansen HH, Saris AE, Nillesen MM, Iannaccone F, Segers P, de Korte CL.

IEEE Trans Ultrason Ferroelectr Freq Control. 2016 Oct;63(10):1543-1553. Epub 2016 Aug 25.


Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer's Disease.

Hansen HH, Fabricius K, Barkholt P, Kongsbak-Wismann P, Schlumberger C, Jelsing J, Terwel D, Termont A, Pyke C, Knudsen LB, Vrang N.

PLoS One. 2016 Jul 15;11(7):e0158205. doi: 10.1371/journal.pone.0158205. eCollection 2016.


Plane-Wave Compounding in Automated Breast Volume Scanning: A Phantom-Based Study.

Holländer B, Hendriks GA, Mann RM, Hansen HH, de Korte CL.

Ultrasound Med Biol. 2016 Oct;42(10):2493-503. doi: 10.1016/j.ultrasmedbio.2016.05.017. Epub 2016 Jul 9.


The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo.

Hansen HH, Weikop P, Mikkelsen MD, Rode F, Mikkelsen JD.

Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):46-51. doi: 10.1111/bcpt.12636. Epub 2016 Aug 23.


Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease.

Hansen HH, Fabricius K, Barkholt P, Mikkelsen JD, Jelsing J, Pyke C, Knudsen LB, Vrang N.

Brain Res. 2016 Sep 1;1646:354-365. doi: 10.1016/j.brainres.2016.05.038. Epub 2016 May 24.


Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass.

Barkholt P, Pedersen PJ, Hay-Schmidt A, Jelsing J, Hansen HH, Vrang N.

Mol Metab. 2016 Jan 25;5(4):296-304. doi: 10.1016/j.molmet.2016.01.006. eCollection 2016 Apr.


Automated 3D ultrasound elastography of the breast: a phantom validation study.

Hendriks GA, Holländer B, Menssen J, Milkowski A, Hansen HH, de Korte CL.

Phys Med Biol. 2016 Apr 7;61(7):2665-79. doi: 10.1088/0031-9155/61/7/2665. Epub 2016 Mar 15.


Changes in Binding of [(123)I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury.

Donat CK, Gaber K, Meixensberger J, Brust P, Pinborg LH, Hansen HH, Mikkelsen JD.

Neuromolecular Med. 2016 Jun;18(2):158-69. doi: 10.1007/s12017-016-8385-y. Epub 2016 Mar 11.


The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy.

Hansen HH, Barkholt P, Fabricius K, Jelsing J, Terwel D, Pyke C, Knudsen LB, Vrang N.

Brain Res. 2016 Mar 1;1634:158-170. doi: 10.1016/j.brainres.2015.12.052. Epub 2015 Dec 31.


A Framework for Local Mechanical Characterization of Atherosclerotic Plaques: Combination of Ultrasound Displacement Imaging and Inverse Finite Element Analysis.

Akyildiz AC, Hansen HH, Nieuwstadt HA, Speelman L, De Korte CL, van der Steen AF, Gijsen FJ.

Ann Biomed Eng. 2016 Apr;44(4):968-79. doi: 10.1007/s10439-015-1410-8. Epub 2015 Sep 23.


Carotid plaque elasticity estimation using ultrasound elastography, MRI, and inverse FEA - A numerical feasibility study.

Nieuwstadt HA, Fekkes S, Hansen HH, de Korte CL, van der Lugt A, Wentzel JJ, van der Steen AF, Gijsen FJ.

Med Eng Phys. 2015 Aug;37(8):801-7. doi: 10.1016/j.medengphy.2015.06.003. Epub 2015 Jun 27.


High plasma triglyceride levels strongly correlate with low kisspeptin in the arcuate nucleus of male rats.

Overgaard A, Axel AM, Lie ME, Hansen HH, Mikkelsen JD.

Endocr Regul. 2015 Apr;49(2):51-7.


The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease.

Hansen HH, Fabricius K, Barkholt P, Niehoff ML, Morley JE, Jelsing J, Pyke C, Knudsen LB, Farr SA, Vrang N.

J Alzheimers Dis. 2015;46(4):877-88. doi: 10.3233/JAD-143090.


Progression of carotid intima media thickness after radiotherapy: a long-term prospective cohort study.

Wilbers J, Dorresteijn LD, Haast R, Hoebers FJ, Kaanders JH, Boogerd W, van Werkhoven ED, Nowee ME, Hansen HH, de Korte CL, Kappelle AC, van Dijk EJ.

Radiother Oncol. 2014 Dec;113(3):359-63. doi: 10.1016/j.radonc.2014.10.012. Epub 2014 Nov 14.


The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat.

Hansen HH, Hansen G, Paulsen S, Vrang N, Mark M, Jelsing J, Klein T.

Eur J Pharmacol. 2014 Oct 15;741:254-63. doi: 10.1016/j.ejphar.2014.08.010. Epub 2014 Aug 24.


The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat.

Hansen HH, Jelsing J, Hansen CF, Hansen G, Vrang N, Mark M, Klein T, Mayoux E.

J Pharmacol Exp Ther. 2014 Sep;350(3):657-64. doi: 10.1124/jpet.114.213454. Epub 2014 Jul 3.


Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol.

Wilbers J, Kappelle AC, Kessels RP, Steens SC, Meijer FJ, Kaanders JH, Haast RA, Versteeg LE, Tuladhar AM, de Korte CL, Hansen HH, Hoebers FJ, Boogerd W, van Werkhoven ED, Nowee ME, Hart G, Bartelink H, Dorresteijn LD, van Dijk EJ.

BMC Neurol. 2014 Jun 19;14:132. doi: 10.1186/1471-2377-14-132.

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