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Items: 1 to 50 of 55

1.

Health Effects of 12 Weeks of Team-Sport Training and Fitness Training in a Community Health Centre for Sedentary Men with Lifestyle Diseases.

Møller TK, Nielsen TT, Andersen R, Lundager I, Hansen HF, Ottesen L, Krustrup P, Randers MB.

Biomed Res Int. 2018 May 15;2018:1571807. doi: 10.1155/2018/1571807. eCollection 2018.

2.

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.

Hagedorn PH, Pontoppidan M, Bisgaard TS, Berrera M, Dieckmann A, Ebeling M, Møller MR, Hudlebusch H, Jensen ML, Hansen HF, Koch T, Lindow M.

Nucleic Acids Res. 2018 Jun 20;46(11):5366-5380. doi: 10.1093/nar/gky397.

3.

Locked nucleic acid: modality, diversity, and drug discovery.

Hagedorn PH, Persson R, Funder ED, Albæk N, Diemer SL, Hansen DJ, Møller MR, Papargyri N, Christiansen H, Hansen BR, Hansen HF, Jensen MA, Koch T.

Drug Discov Today. 2018 Jan;23(1):101-114. doi: 10.1016/j.drudis.2017.09.018. Epub 2017 Oct 6. Review.

4.

Electronic Structures of LNA Phosphorothioate Oligonucleotides.

Bohr HG, Shim I, Stein C, Ørum H, Hansen HF, Koch T.

Mol Ther Nucleic Acids. 2017 Sep 15;8:428-441. doi: 10.1016/j.omtn.2017.05.011. Epub 2017 Jun 1.

5.

Organisation of evidence-based knowledge production: evidence hierarchies and evidence typologies.

Hansen HF.

Scand J Public Health. 2014 Mar;42(13 Suppl):11-7. doi: 10.1177/1403494813516715.

PMID:
24553850
6.

Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.

Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM.

Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840.

7.

A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys.

Hildebrandt-Eriksen ES, Aarup V, Persson R, Hansen HF, Munk ME, Ørum H.

Nucleic Acid Ther. 2012 Jun;22(3):152-61. doi: 10.1089/nat.2011.0332. Epub 2012 Apr 30.

PMID:
22545703
8.

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

Lindholm MW, Elmén J, Fisker N, Hansen HF, Persson R, Møller MR, Rosenbohm C, Ørum H, Straarup EM, Koch T.

Mol Ther. 2012 Feb;20(2):376-81. doi: 10.1038/mt.2011.260. Epub 2011 Nov 22.

9.

Silencing of microRNA families by seed-targeting tiny LNAs.

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S.

Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786.

10.

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

Straarup EM, Fisker N, Hedtjärn M, Lindholm MW, Rosenbohm C, Aarup V, Hansen HF, Ørum H, Hansen JB, Koch T.

Nucleic Acids Res. 2010 Nov;38(20):7100-11. doi: 10.1093/nar/gkq457. Epub 2010 Jul 8.

11.

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction.

Kocerha J, Faghihi MA, Lopez-Toledano MA, Huang J, Ramsey AJ, Caron MG, Sales N, Willoughby D, Elmen J, Hansen HF, Orum H, Kauppinen S, Kenny PJ, Wahlestedt C.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3507-12. doi: 10.1073/pnas.0805854106. Epub 2009 Feb 5.

12.

SPC3042: a proapoptotic survivin inhibitor.

Hansen JB, Fisker N, Westergaard M, Kjaerulff LS, Hansen HF, Thrue CA, Rosenbohm C, Wissenbach M, Orum H, Koch T.

Mol Cancer Ther. 2008 Sep;7(9):2736-45. doi: 10.1158/1535-7163.MCT-08-0161.

13.

LNA-mediated microRNA silencing in non-human primates.

Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S.

Nature. 2008 Apr 17;452(7189):896-9. doi: 10.1038/nature06783. Epub 2008 Mar 26.

PMID:
18368051
14.

Productive vocabulary size predicts event-related potential correlates of fast mapping in 20-month-olds.

von Koss Torkildsen J, Svangstu JM, Hansen HF, Smith L, Simonsen HG, Moen I, Lindgren M.

J Cogn Neurosci. 2008 Jul;20(7):1266-82. doi: 10.1162/jocn.2008.20087.

PMID:
18284350
15.

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.

Elmén J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thomsen A, Hedtjärn M, Hansen JB, Hansen HF, Straarup EM, McCullagh K, Kearney P, Kauppinen S.

Nucleic Acids Res. 2008 Mar;36(4):1153-62. Epub 2007 Dec 23.

16.

Survivin mRNA antagonists using locked nucleic acid, potential for molecular cancer therapy.

Fisker N, Westergaard M, Hansen HF, Hansen JB.

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1427-30.

PMID:
18066798
17.

Effect of LNA modifications on small molecule binding to nucleic acids.

Marin V, Hansen HF, Koch T, Armitage BA.

J Biomol Struct Dyn. 2004 Jun;21(6):841-50.

PMID:
15107006
18.

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

Frieden M, Christensen SM, Mikkelsen ND, Rosenbohm C, Thrue CA, Westergaard M, Hansen HF, Ørum H, Koch T.

Nucleic Acids Res. 2003 Nov 1;31(21):6365-72.

19.

New standards in LNA synthesis.

Hansen HF, Olsen O, Koch T.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1273-5. No abstract available.

PMID:
14565397
20.

Nuclease stability of LNA oligonucleotides and LNA-DNA chimeras.

Frieden M, Hansen HF, Koch T.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1041-3.

PMID:
14565339
21.

Linker length in podophyllotoxin-acridine conjugates determines potency in vivo and in vitro as well as specificity against MDR cell lines.

Rothenborg-Jensen L, Hansen HF, Wessel I, Nitiss JL, Schmidt G, Jensen PB, Sehested M, Jensen LH.

Anticancer Drug Des. 2001 Dec;16(6):305-15.

PMID:
12375883
22.

PNA synthesis using a novel Boc/acyl protecting group strategy.

Kofoed T, Hansen HF, Orum H, Koch T.

J Pept Sci. 2001 Aug;7(8):402-12.

PMID:
11548056
23.

Inhibition of PNA triplex formation by N4-benzoylated cytosine.

Christensen L, Hansen HF, Koch T, Nielsen PE.

Nucleic Acids Res. 1998 Jun 1;26(11):2735-9.

24.

Increased DNA binding and sequence discrimination of PNA oligomers containing 2,6-diaminopurine.

Haaima G, Hansen HF, Christensen L, Dahl O, Nielsen PE.

Nucleic Acids Res. 1997 Nov 15;25(22):4639-43.

25.

Improvements in automated PNA synthesis using Boc/Z monomers.

Koch T, Hansen HF, Andersen P, Larsen T, Batz HG, Otteson K, Orum H.

J Pept Res. 1997 Jan;49(1):80-8.

PMID:
9128104
26.

Effects of pancreatic spasmolytic Polypeptide (PSP) on epithelial cell function.

Otto WR, Rao J, Cox HM, Kotzian E, Lee CY, Goodlad RA, Lane A, Gorman M, Freemont PA, Hansen HF, Pappin D, Wright NA.

Eur J Biochem. 1996 Jan 15;235(1-2):64-72.

27.

Osmo-expression and fast two-step purification of Escherichia coli translation termination factor RF-3.

Mortensen KK, Hansen HF, Grentzmann G, Buckingham RH, Sperling-Petersen HU.

Eur J Biochem. 1995 Dec 15;234(3):732-6.

28.

Solid-phase synthesis of peptide nucleic acids.

Christensen L, Fitzpatrick R, Gildea B, Petersen KH, Hansen HF, Koch T, Egholm M, Buchardt O, Nielsen PE, Coull J, Berg RH.

J Pept Sci. 1995 May-Jun;1(3):175-83.

PMID:
9222994
29.

Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice.

Playford RJ, Marchbank T, Calnan DP, Calam J, Royston P, Batten JJ, Hansen HF.

Gastroenterology. 1995 Jan;108(1):92-101.

PMID:
7806067
30.

Peptide ladder sequencing by mass spectrometry using a novel, volatile degradation reagent.

Bartlet-Jones M, Jeffery WA, Hansen HF, Pappin DJ.

Rapid Commun Mass Spectrom. 1994 Sep;8(9):737-42.

PMID:
7949336
31.

New compounds related to podophyllotoxin and congeners: synthesis, structure elucidation and biological testing.

Hansen HF, Jensen RB, Willumsen AM, Nørskov-Lauritsen N, Ebbesen P, Nielsen PE, Buchardt O.

Acta Chem Scand. 1993 Dec;47(12):1190-200.

PMID:
8110531
32.

The amino acid sequence of a major protein component in the light harvesting complex of the green photosynthetic bacterium Chlorobium limicola f. thiosulfatophilum.

Højrup P, Gerola P, Hansen HF, Mikkelsen JM, Shahed AE, Knudsen J, Roepstorff P, Olson JM.

Biochim Biophys Acta. 1991 Apr 8;1077(2):220-4.

PMID:
2015294
33.
34.

Acyl-CoA-binding protein in the rat. Purification, binding characteristics, tissue concentrations and amino acid sequence.

Knudsen J, Højrup P, Hansen HO, Hansen HF, Roepstorff P.

Biochem J. 1989 Sep 1;262(2):513-9.

35.

Processing or inactivation of antimicrobial peptides.

Schwartz TW, Hansen HF, Gether U, Aakerlund L.

Nature. 1987 Oct 8-14;329(6139):494. No abstract available.

PMID:
3657973
36.

The protein synthesis initiation factor 2 G-domain. Study of a functionally active C-terminal 65-kilodalton fragment of IF2 from Escherichia coli.

Cenatiempo Y, Deville F, Dondon J, Grunberg-Manago M, Sacerdot C, Hershey JW, Hansen HF, Petersen HU, Clark BF, Kjeldgaard M, et al.

Biochemistry. 1987 Aug 11;26(16):5070-6.

PMID:
2444251
37.

Thermal chemistry of podophyllotoxin in ethanol and a comparison of the cytostatic activity of the thermolysis products.

Buchardt O, Jensen RB, Hansen HF, Nielsen PE, Andersen D, Chinoin I.

J Pharm Sci. 1986 Nov;75(11):1076-80.

PMID:
3820102
39.

Extraction and characterization of IgG Fc receptors from group C and group G streptococci.

Reis KJ, Hansen HF, Björck L.

Mol Immunol. 1986 Apr;23(4):425-31.

PMID:
3724759
40.

Binding of epidermal growth factor from man, rat and mouse to the human epidermal growth factor receptor.

Nexø E, Hansen HF.

Biochim Biophys Acta. 1985 Nov 22;843(1-2):101-6.

PMID:
2998475
41.

Primary structure of glucagon and a partial sequence of oxyntomodulin (glucagon-37) from the guinea pig.

Conlon JM, Hansen HF, Schwartz TW.

Regul Pept. 1985 Aug;11(4):309-20.

PMID:
4048553
42.
43.

Molecular forms of cholecystokinin in the brain and the relationship to neuronal gastrins.

Rehfeld JF, Hansen HF, Marley PD, Stengaard-Pedersen K.

Ann N Y Acad Sci. 1985;448:11-23. Review. No abstract available.

PMID:
3896093
44.

Renal origin of rat urinary epidermal growth factor.

Skov Olsen P, Nexø E, Poulsen SS, Hansen HF, Kirkegaard P.

Regul Pept. 1984 Dec;10(1):37-45.

PMID:
6335757
45.

Isolation of ovine pancreatic icosapeptide: a peptide product containing one cysteine residue.

Schwartz TW, Hansen HF.

FEBS Lett. 1984 Mar 26;168(2):293-8. No abstract available.

46.

Gastrin and cholecystokinin in pituitary neurons.

Rehfeld JF, Hansen HF, Larsson LI, Stengaard-Pedersen K, Thorn NA.

Proc Natl Acad Sci U S A. 1984 Mar;81(6):1902-5.

47.
48.

Generation and reactivity of "nascent" alpha 2-macroglobulin: localization of cross-links in alpha 2-macroglobulin-trypsin complex.

Sottrup-Jensen L, Hansen HF, Christensen U.

Ann N Y Acad Sci. 1983;421:188-208. No abstract available.

PMID:
6202195
49.
50.

Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin.

Mortensen SB, Sottrup-Jensen L, Hansen HF, Petersen TE, Magnusson S.

FEBS Lett. 1981 Dec 7;135(2):295-300. No abstract available.

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