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Items: 1 to 50 of 244

1.

Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.

Findlay AD, Foot JS, Buson A, Deodhar M, Jarnicki AG, Hansbro PM, Liu G, Schilter H, Turner CI, Zhou W, Jarolimek W.

J Med Chem. 2019 Oct 16. doi: 10.1021/acs.jmedchem.9b01283. [Epub ahead of print]

PMID:
31580073
2.

LPS induces steroid-resistant exacerbations in a mouse model of allergic airway disease collectively through IL-13 and pulmonary macrophage activation.

Hadjigol S, Netto KG, Maltby S, Tay HL, Nguyen TH, Hansbro NG, Eyers F, Hansbro PM, Yang M, Foster PS.

Clin Exp Allergy. 2019 Oct 3. doi: 10.1111/cea.13505. [Epub ahead of print]

PMID:
31579973
3.

Epithelial-mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics.

Eapen MS, Sharma P, Gaikwad AV, Lu W, Myers S, Hansbro PM, Sohal SS.

Int J Chron Obstruct Pulmon Dis. 2019 Jul 18;14:1603-1610. doi: 10.2147/COPD.S208428. eCollection 2019.

4.

Microbiome-focused asthma management strategies.

Shukla SD, Shastri MD, Chong WC, Dua K, Budden KF, Mahmood MQ, Hansbro NG, Keely S, Eri R, Patel RP, Peterson GM, Hansbro PM.

Curr Opin Pharmacol. 2019 Jun;46:143-149. doi: 10.1016/j.coph.2019.06.003. Epub 2019 Jul 26. Review.

PMID:
31357048
5.

New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways.

Atto B, Eapen MS, Sharma P, Frey U, Ammit AJ, Markos J, Chia C, Larby J, Haug G, Weber HC, Mabeza G, Tristram S, Myers S, Geraghty DP, Flanagan KL, Hansbro PM, Sohal SS.

Clin Sci (Lond). 2019 Jul 25;133(14):1663-1703. doi: 10.1042/CS20181009. Print 2019 Jul 31. Review.

PMID:
31346069
6.

Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.

Liu G, Cooley MA, Jarnicki AG, Borghuis T, Nair PM, Tjin G, Hsu AC, Haw TJ, Fricker M, Harrison CL, Jones B, Hansbro NG, Wark PA, Horvat JC, Argraves WS, Oliver BG, Knight DA, Burgess JK, Hansbro PM.

JCI Insight. 2019 Jul 25;5. pii: 124529. doi: 10.1172/jci.insight.124529.

7.

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses.

Hayman TJ, Hsu AC, Kolesnik TB, Dagley LF, Willemsen J, Tate MD, Baker PJ, Kershaw NJ, Kedzierski L, Webb AI, Wark PA, Kedzierska K, Masters SL, Belz GT, Binder M, Hansbro PM, Nicola NA, Nicholson SE.

Immunol Cell Biol. 2019 Oct;97(9):840-852. doi: 10.1111/imcb.12284. Epub 2019 Aug 19.

PMID:
31335993
8.

Recent Developments in Alpha-Glucosidase Inhibitors for Management of Type-2 Diabetes: An Update.

Usman B, Sharma N, Satija S, Mehta M, Vyas M, Khatik GL, Khurana N, Hansbro PM, Williams K, Dua K.

Curr Pharm Des. 2019;25(23):2510-2525. doi: 10.2174/1381612825666190717104547.

PMID:
31333110
9.

Interactions between microbiome and lungs: Paving new paths for microbiome based bio-engineered drug delivery systems in chronic respiratory diseases.

Chellappan DK, Sze Ning QL, Su Min SK, Bin SY, Chern PJ, Shi TP, Ee Mei SW, Yee TH, Qi OJ, Thangavelu L, Rajeshkumar S, Negi P, Chellian J, Wadhwa R, Gupta G, Collet T, Hansbro PM, Dua K.

Chem Biol Interact. 2019 Sep 1;310:108732. doi: 10.1016/j.cbi.2019.108732. Epub 2019 Jul 2. Review.

PMID:
31276660
10.

Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production.

Hu M, Schulze KE, Ghildyal R, Henstridge DC, Kolanowski JL, New EJ, Hong Y, Hsu AC, Hansbro PM, Wark PA, Bogoyevitch MA, Jans DA.

Elife. 2019 Jun 27;8. pii: e42448. doi: 10.7554/eLife.42448.

11.

IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis.

Starkey MR, Plank MW, Casolari P, Papi A, Pavlidis S, Guo Y, Cameron GJM, Haw TJ, Tam A, Obiedat M, Donovan C, Hansbro NG, Nguyen DH, Nair PM, Kim RY, Horvat JC, Kaiko GE, Durum SK, Wark PA, Sin DD, Caramori G, Adcock IM, Foster PS, Hansbro PM.

Eur Respir J. 2019 Jul 18;54(1). pii: 1800174. doi: 10.1183/13993003.00174-2018. Print 2019 Jul.

PMID:
31196943
12.

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases.

Mehta M, Deeksha, Tewari D, Gupta G, Awasthi R, Singh H, Pandey P, Chellappan DK, Wadhwa R, Collet T, Hansbro PM, Kumar SR, Thangavelu L, Negi P, Dua K, Satija S.

Chem Biol Interact. 2019 Aug 1;308:206-215. doi: 10.1016/j.cbi.2019.05.028. Epub 2019 May 25. Review.

PMID:
31136735
13.

Chitinase-like protein YKL-40 correlates with inflammatory phenotypes, anti-asthma responsiveness and future exacerbations.

Liu L, Zhang X, Liu Y, Zhang L, Zheng J, Wang J, Hansbro PM, Wang L, Wang G, Hsu AC.

Respir Res. 2019 May 22;20(1):95. doi: 10.1186/s12931-019-1051-9.

14.

Polycomb repressive complex 2 is a critical mediator of allergic inflammation.

Keenan CR, Iannarella N, Garnham AL, Brown AC, Kim RY, Horvat JC, Hansbro PM, Nutt SL, Allan RS.

JCI Insight. 2019 May 16;4(10). pii: 127745. doi: 10.1172/jci.insight.127745. eCollection 2019 May 16.

15.

Molecular links between COPD and lung cancer: new targets for drug discovery?

Caramori G, Ruggeri P, Mumby S, Ieni A, Lo Bello F, Chimankar V, Donovan C, Andò F, Nucera F, Coppolino I, Tuccari G, Hansbro PM, Adcock IM.

Expert Opin Ther Targets. 2019 Jun;23(6):539-553. doi: 10.1080/14728222.2019.1615884. Epub 2019 May 11.

PMID:
31079559
16.

Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury.

Cameron GJM, Cautivo KM, Loering S, Jiang SH, Deshpande AV, Foster PS, McKenzie ANJ, Molofsky AB, Hansbro PM, Starkey MR.

Front Immunol. 2019 Apr 16;10:826. doi: 10.3389/fimmu.2019.00826. eCollection 2019.

17.

Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome.

Liu G, Mateer SW, Hsu A, Goggins BJ, Tay H, Mathe A, Fan K, Neal R, Bruce J, Burns G, Minahan K, Maltby S, Fricker M, Foster PS, Wark PAB, Hansbro PM, Keely S.

Mucosal Immunol. 2019 Jul;12(4):862-873. doi: 10.1038/s41385-019-0163-3. Epub 2019 Apr 11.

PMID:
30976089
18.

Functional effects of the microbiota in chronic respiratory disease.

Budden KF, Shukla SD, Rehman SF, Bowerman KL, Keely S, Hugenholtz P, Armstrong-James DPH, Adcock IM, Chotirmall SH, Chung KF, Hansbro PM.

Lancet Respir Med. 2019 Oct;7(10):907-920. doi: 10.1016/S2213-2600(18)30510-1. Epub 2019 Apr 8. Review.

PMID:
30975495
19.

Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease.

Wadhwa R, Aggarwal T, Malyla V, Kumar N, Gupta G, Chellappan DK, Dureja H, Mehta M, Satija S, Gulati M, Maurya PK, Collet T, Hansbro PM, Dua K.

J Cell Physiol. 2019 Aug;234(10):16703-16723. doi: 10.1002/jcp.28482. Epub 2019 Mar 25. Review.

PMID:
30912142
20.

Evaluating recruitment strategies for AUSPICE, a large Australian community-based randomised controlled trial.

Peel R, Ren S, Hure A, Evans TJ, D'Este CA, Abhayaratna WP, Tonkin AM, Hopper I, Thrift AG, Levi CR, Sturm J, Durrheim D, Hung J, Briffa TG, Chew DP, Anderson P, Moon L, McEvoy M, Hansbro PM, Newby DA, Attia JR.

Med J Aust. 2019 May;210(9):409-415. doi: 10.5694/mja2.50117. Epub 2019 Mar 25.

PMID:
30907001
21.

Current Status on Immunological Therapies for Type 1 Diabetes Mellitus.

Xin GLL, Khee YP, Ying TY, Chellian J, Gupta G, Kunnath AP, Nammi S, Collet T, Hansbro PM, Dua K, Chellappan DK.

Curr Diab Rep. 2019 Mar 23;19(5):22. doi: 10.1007/s11892-019-1144-3. Review.

PMID:
30905013
22.

Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases.

Mehta M, Deeksha, Sharma N, Vyas M, Khurana N, Maurya PK, Singh H, Andreoli de Jesus TP, Dureja H, Chellappan DK, Gupta G, Wadhwa R, Collet T, Hansbro PM, Dua K, Satija S.

Chem Biol Interact. 2019 May 1;304:10-19. doi: 10.1016/j.cbi.2019.02.021. Epub 2019 Mar 5. Review.

PMID:
30849336
23.

Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction.

Hardy SA, Mabotuwana NS, Murtha LA, Coulter B, Sanchez-Bezanilla S, Al-Omary MS, Senanayake T, Loering S, Starkey M, Lee RJ, Rainer PP, Hansbro PM, Boyle AJ.

PLoS One. 2019 Feb 21;14(2):e0212230. doi: 10.1371/journal.pone.0212230. eCollection 2019.

24.

TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis.

Collison AM, Li J, de Siqueira AP, Lv X, Toop HD, Morris JC, Starkey MR, Hansbro PM, Zhang J, Mattes J.

BMC Pulm Med. 2019 Feb 7;19(1):31. doi: 10.1186/s12890-019-0786-x.

25.

Emerging therapeutic potential of group 2 innate lymphoid cells in acute kidney injury.

Cameron GJM, Jiang SH, Loering S, Deshpande AV, Hansbro PM, Starkey MR.

J Pathol. 2019 May;248(1):9-15. doi: 10.1002/path.5242. Epub 2019 Mar 5. Review.

PMID:
30684265
26.

Pulmonary group 2 innate lymphoid cells: surprises and challenges.

Starkey MR, McKenzie AN, Belz GT, Hansbro PM.

Mucosal Immunol. 2019 Mar;12(2):299-311. doi: 10.1038/s41385-018-0130-4. Epub 2019 Jan 21. Review.

27.

Dietary Fatty Acids Amplify Inflammatory Responses to Infection through p38 MAPK Signaling.

Rutting S, Zakarya R, Bozier J, Xenaki D, Horvat JC, Wood LG, Hansbro PM, Oliver BG.

Am J Respir Cell Mol Biol. 2019 May;60(5):554-568. doi: 10.1165/rcmb.2018-0215OC.

PMID:
30648905
28.

STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts.

Waters DW, Blokland KEC, Pathinayake PS, Wei L, Schuliga M, Jaffar J, Westall GP, Hansbro PM, Prele CM, Mutsaers SE, Bartlett NW, Burgess JK, Grainge CL, Knight DA.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):61-73. doi: 10.1165/rcmb.2018-0328OC.

PMID:
30608861
29.

Targeting microRNAs using nanotechnology in pulmonary diseases.

Dua K, Chellappan DK, Singhvi G, de Jesus Andreoli Pinto T, Gupta G, Hansbro PM.

Panminerva Med. 2018 Dec;60(4):230-231. doi: 10.23736/S0031-0808.18.03459-6. No abstract available.

PMID:
30563304
30.

Mechanisms and Management of Asthma Exacerbations.

Ramsahai JM, Hansbro PM, Wark PAB.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):423-432. doi: 10.1164/rccm.201810-1931CI.

PMID:
30562041
31.

Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems.

Dua K, Malyla V, Singhvi G, Wadhwa R, Krishna RV, Shukla SD, Shastri MD, Chellappan DK, Maurya PK, Satija S, Mehta M, Gulati M, Hansbro N, Collet T, Awasthi R, Gupta G, Hsu A, Hansbro PM.

Chem Biol Interact. 2019 Feb 1;299:168-178. doi: 10.1016/j.cbi.2018.12.009. Epub 2018 Dec 13. Review.

PMID:
30553721
32.

Molecular modulators of celastrol as the keystones for its diverse pharmacological activities.

Ng SW, Chan Y, Chellappan DK, Madheswaran T, Zeeshan F, Chan YL, Collet T, Gupta G, Oliver BG, Wark P, Hansbro N, Hsu A, Hansbro PM, Dua K, Panneerselvam J.

Biomed Pharmacother. 2019 Jan;109:1785-1792. doi: 10.1016/j.biopha.2018.11.051. Epub 2018 Nov 26. Review.

33.

TRPA1: A potential target for cold-induced airway disease?

Donovan C, Hansbro PM.

Respirology. 2019 Mar;24(3):193-194. doi: 10.1111/resp.13453. Epub 2018 Dec 13. No abstract available.

34.

Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling.

Schofield ZV, Croker D, Robertson AAB, Massey NL, Donovan C, Tee E, Edwards D, Woodruff TM, Halai R, Hansbro PM, Cooper MA.

Sci Rep. 2018 Dec 13;8(1):17819. doi: 10.1038/s41598-018-36242-1.

35.

Lung development and emerging roles for type 2 immunity.

Loering S, Cameron GJM, Starkey MR, Hansbro PM.

J Pathol. 2019 Apr;247(5):686-696. doi: 10.1002/path.5211. Epub 2019 Jan 16. Review.

PMID:
30506724
36.

The role of environmental exposure to non-cigarette smoke in lung disease.

Kc R, Shukla SD, Gautam SS, Hansbro PM, O'Toole RF.

Clin Transl Med. 2018 Dec 5;7(1):39. doi: 10.1186/s40169-018-0217-2. Review.

37.

Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies.

Eapen MS, Sharma P, Thompson IE, Lu W, Myers S, Hansbro PM, Sohal SS.

Lab Invest. 2019 Feb;99(2):150-157. doi: 10.1038/s41374-018-0146-0. Epub 2018 Nov 19. Review.

PMID:
30451982
38.

Targeting bacterial biofilms in pulmonary diseases in pediatric population.

Dua K, Gupta G, Chellappan DK, Shukla S, Hansbro PM.

Minerva Pediatr. 2019 Jun;71(3):309-310. doi: 10.23736/S0026-4946.18.05256-8. Epub 2018 Nov 7. No abstract available.

PMID:
30419743
39.

Short-chain fatty acids increase TNFα-induced inflammation in primary human lung mesenchymal cells through the activation of p38 MAPK.

Rutting S, Xenaki D, Malouf M, Horvat JC, Wood LG, Hansbro PM, Oliver BG.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L157-L174. doi: 10.1152/ajplung.00306.2018. Epub 2018 Nov 8.

PMID:
30407866
40.

Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD.

Baines KJ, Wright TK, Gibson PG, Powell H, Hansbro PM, Simpson JL.

ERJ Open Res. 2018 Nov 5;4(4). pii: 00031-2018. doi: 10.1183/23120541.00031-2018. eCollection 2018 Oct.

41.

Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis.

Shastri MD, Shukla SD, Chong WC, Dua K, Peterson GM, Patel RP, Hansbro PM, Eri R, O'Toole RF.

Oxid Med Cell Longev. 2018 Oct 11;2018:7695364. doi: 10.1155/2018/7695364. eCollection 2018. Review.

42.

Chronic Obstructive Pulmonary Disease and Lung Cancer: Underlying Pathophysiology and New Therapeutic Modalities.

Eapen MS, Hansbro PM, Larsson-Callerfelt AK, Jolly MK, Myers S, Sharma P, Jones B, Rahman MA, Markos J, Chia C, Larby J, Haug G, Hardikar A, Weber HC, Mabeza G, Cavalheri V, Khor YH, McDonald CF, Sohal SS.

Drugs. 2018 Nov;78(16):1717-1740. doi: 10.1007/s40265-018-1001-8. Review.

PMID:
30392114
43.

Dietary ω-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD.

Rutting S, Papanicolaou M, Xenaki D, Wood LG, Mullin AM, Hansbro PM, Oliver BG.

Respir Res. 2018 Nov 3;19(1):211. doi: 10.1186/s12931-018-0919-4.

44.

Gene therapy and type 1 diabetes mellitus.

Chellappan DK, Sivam NS, Teoh KX, Leong WP, Fui TZ, Chooi K, Khoo N, Yi FJ, Chellian J, Cheng LL, Dahiya R, Gupta G, Singhvi G, Nammi S, Hansbro PM, Dua K.

Biomed Pharmacother. 2018 Dec;108:1188-1200. doi: 10.1016/j.biopha.2018.09.138. Epub 2018 Oct 2. Review.

45.

Dysfunctional Immunity and Microbial Adhesion Molecules in Smoking-induced Pneumonia.

Eapen MS, Sharma P, Moodley YP, Hansbro PM, Sohal SS.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):250-251. doi: 10.1164/rccm.201808-1553LE. No abstract available.

PMID:
30290125
46.

Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease.

Donovan C, Starkey MR, Kim RY, Rana BMJ, Barlow JL, Jones B, Haw TJ, Mono Nair P, Budden K, Cameron GJM, Horvat JC, Wark PA, Foster PS, McKenzie ANJ, Hansbro PM.

J Leukoc Biol. 2019 Jan;105(1):143-150. doi: 10.1002/JLB.3AB0518-178R. Epub 2018 Sep 27.

47.

An Overview of Circular RNAs.

Awasthi R, Singh AK, Mishra G, Maurya A, Chellappan DK, Gupta G, Hansbro PM, Dua K.

Adv Exp Med Biol. 2018;1087:3-14. doi: 10.1007/978-981-13-1426-1_1. Review.

PMID:
30259353
48.

Multi-drug resistant Mycobacterium tuberculosis & oxidative stress complexity: Emerging need for novel drug delivery approaches.

Dua K, Rapalli VK, Shukla SD, Singhvi G, Shastri MD, Chellappan DK, Satija S, Mehta M, Gulati M, Pinto TJA, Gupta G, Hansbro PM.

Biomed Pharmacother. 2018 Nov;107:1218-1229. doi: 10.1016/j.biopha.2018.08.101. Epub 2018 Aug 29. Review.

PMID:
30257336
49.

The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD.

Obeidat M, Dvorkin-Gheva A, Li X, Bossé Y, Brandsma CA, Nickle DC, Hansbro PM, Faner R, Agusti A, Paré PD, Stampfli MR, Sin DD.

Sci Rep. 2018 Aug 8;8(1):11881. doi: 10.1038/s41598-018-30313-z.

50.

Modification of Crocodile Spermatozoa Refutes the Tenet That Post-testicular Sperm Maturation Is Restricted To Mammals.

Nixon B, Johnston SD, Skerrett-Byrne DA, Anderson AL, Stanger SJ, Bromfield EG, Martin JH, Hansbro PM, Dun MD.

Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S59-S76. doi: 10.1074/mcp.RA118.000904. Epub 2018 Aug 2.

PMID:
30072580

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