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Items: 1 to 50 of 272

1.

Glycemic Variability in Diabetes Increases the Severity of Influenza.

Marshall RJ, Armart P, Hulme KD, Chew KY, Brown AC, Hansbro PM, Bloxham CJ, Flint M, Ronacher K, Bielefeldt-Ohmann H, Gallo LA, Short KR.

mBio. 2020 Mar 24;11(2). pii: e02841-19. doi: 10.1128/mBio.02841-19.

2.

Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update.

Mehta M, Dhanjal DS, Paudel KR, Singh B, Gupta G, Rajeshkumar S, Thangavelu L, Tambuwala MM, Bakshi HA, Chellappan DK, Pandey P, Dureja H, Charbe NB, Singh SK, Shukla SD, Nammi S, Aljabali AA, Wich PR, Hansbro PM, Satija S, Dua K.

Inflammopharmacology. 2020 Mar 18. doi: 10.1007/s10787-020-00698-3. [Epub ahead of print] Review.

PMID:
32189104
3.

Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma.

Ali MK, Kim RY, Brown AC, Mayall JR, Karim R, Pinkerton JW, Liu G, Martin KL, Starkey MR, Pillar A, Donovan C, Pathinayake PS, Carroll OR, Trinder D, Tay HL, Badi YE, Kermani NZ, Guo YK, Aryal R, Mumby S, Pavlidis S, Adcock IM, Weaver J, Xenaki D, Oliver BG, Holliday EG, Foster PS, Wark PA, Johnstone DM, Milward EA, Hansbro PM, Horvat JC.

Eur Respir J. 2020 Mar 17. pii: 1901340. doi: 10.1183/13993003.01340-2019. [Epub ahead of print]

PMID:
32184317
4.

Recent advances in experimental animal models of lung cancer.

Malyla V, Paudel KR, Shukla SD, Donovan C, Wadhwa R, Pickles S, Chimankar V, Sahu P, Bielefeldt-Ohmann H, Bebawy M, Hansbro PM, Dua K.

Future Med Chem. 2020 Apr;12(7):567-570. doi: 10.4155/fmc-2019-0338. Epub 2020 Mar 16. No abstract available.

PMID:
32175774
5.

Elastin is a key factor of tumor development in colorectal cancer.

Li J, Xu X, Jiang Y, Hansbro NG, Hansbro PM, Xu J, Liu G.

BMC Cancer. 2020 Mar 14;20(1):217. doi: 10.1186/s12885-020-6686-x.

6.

Role of the mucins in pathogenesis of COPD: implications for therapy.

Lo Bello F, Ieni A, Hansbro PM, Ruggeri P, Di Stefano A, Nucera F, Coppolino I, Monaco F, Tuccari G, Adcock IM, Caramori G.

Expert Rev Respir Med. 2020 Mar 19:1-19. doi: 10.1080/17476348.2020.1739525. [Epub ahead of print]

PMID:
32133884
7.

Critical role for iron accumulation in the pathogenesis of fibrotic lung disease.

Ali MK, Kim RY, Brown AC, Donovan C, Vanka KS, Mayall JR, Liu G, Pillar AL, Jones-Freeman B, Xenaki D, Borghuis T, Karim R, Pinkerton JW, Aryal R, Heidari M, Martin KL, Burgess JK, Oliver BG, Trinder D, Johnstone DM, Milward EA, Hansbro PM, Horvat JC.

J Pathol. 2020 Feb 21. doi: 10.1002/path.5401. [Epub ahead of print]

PMID:
32083318
8.

Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases.

Chellappan DK, Yee LW, Xuan KY, Kunalan K, Rou LC, Jean LS, Ying LY, Wie LX, Chellian J, Mehta M, Satija S, Singh SK, Gulati M, Dureja H, Da Silva MW, Tambuwala MM, Gupta G, Paudel KR, Wadhwa R, Hansbro PM, Dua K.

Drug Dev Res. 2020 Feb 12. doi: 10.1002/ddr.21648. [Epub ahead of print] Review.

PMID:
32048757
9.

Computerized screening of G-protein coupled receptors to identify and characterize olfactory receptors.

Zhang R, Wang P, Yu S, Hansbro P, Wang H.

J Toxicol Environ Health A. 2020;83(1):9-19. doi: 10.1080/15287394.2019.1709305. Epub 2020 Feb 5.

PMID:
32019429
10.

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases.

Tew XN, Xin Lau NJ, Chellappan DK, Madheswaran T, Zeeshan F, Tambuwala MM, Aljabali AA, Balusamy SR, Perumalsamy H, Gupta G, Oliver BG, Hsu A, Wark P, Reddy K, Wadhwa R, Hansbro PM, Dua K.

Chem Biol Interact. 2020 Feb 1;317:108947. doi: 10.1016/j.cbi.2020.108947. Epub 2020 Jan 20. Review.

PMID:
31968208
11.

Blocking Notch3 Signaling Abolishes MUC5AC Production in Airway Epithelial Cells from Individuals with Asthma.

Reid AT, Nichol KS, Chander Veerati P, Moheimani F, Kicic A, Stick SM, Bartlett NW, Grainge CL, Wark PAB, Hansbro PM, Knight DA.

Am J Respir Cell Mol Biol. 2020 Apr;62(4):513-523. doi: 10.1165/rcmb.2019-0069OC.

PMID:
31922915
12.

Enhancing tristetraprolin activity reduces the severity of cigarette smoke-induced experimental chronic obstructive pulmonary disease.

Nair PM, Starkey MR, Haw TJ, Liu G, Collison AM, Mattes J, Wark PA, Morris JC, Verrills NM, Clark AR, Ammit AJ, Hansbro PM.

Clin Transl Immunology. 2019 Oct 28;8(10):e01084. doi: 10.1002/cti2.1084. eCollection 2019.

13.

Emerging Complexity and the Need for Advanced Drug Delivery in Targeting Candida Species.

Wadhwa R, Pandey P, Gupta G, Aggarwal T, Kumar N, Mehta M, Satija S, Gulati M, Madan JR, Dureja H, Balusamy SR, Perumalsamy H, Maurya PK, Collet T, Tambuwala MM, Hansbro PM, Chellappan DK, Dua K.

Curr Top Med Chem. 2019;19(28):2593-2609. doi: 10.2174/1568026619666191026105308. Review.

PMID:
31746290
14.

COPD and the gut-lung axis: the therapeutic potential of fibre.

Vaughan A, Frazer ZA, Hansbro PM, Yang IA.

J Thorac Dis. 2019 Oct;11(Suppl 17):S2173-S2180. doi: 10.21037/jtd.2019.10.40. Review.

15.

The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress.

Dua K, Wadhwa R, Singhvi G, Rapalli V, Shukla SD, Shastri MD, Gupta G, Satija S, Mehta M, Khurana N, Awasthi R, Maurya PK, Thangavelu L, S R, Tambuwala MM, Collet T, Hansbro PM, Chellappan DK.

Drug Dev Res. 2019 Sep;80(6):714-730. doi: 10.1002/ddr.21571. Epub 2019 Jul 16. Review.

PMID:
31691339
16.

Therapeutic potential of Artemisia vulgaris: An insight into underlying immunological mechanisms.

Soon L, Ng PQ, Chellian J, Madheswaran T, Panneerselvam J, Gupta G, Nammi S, Hansbro NG, Hsu A, Dureja H, Mehta M, Satija S, Hansbro PM, Dua K, Collet T, Chellappan DK.

J Environ Pathol Toxicol Oncol. 2019;38(3):205-216. doi: 10.1615/JEnvironPatholToxicolOncol.2019029397. Review.

PMID:
31679308
17.

Hypoxia-inducible factor and bacterial infections in chronic obstructive pulmonary disease.

Shukla SD, Walters EH, Simpson JL, Keely S, Wark PAB, O'Toole RF, Hansbro PM.

Respirology. 2020 Jan;25(1):53-63. doi: 10.1111/resp.13722. Epub 2019 Oct 30. Review.

18.

Cellular mechanisms underlying steroid-resistant asthma.

Wadhwa R, Dua K, Adcock IM, Horvat JC, Kim RY, Hansbro PM.

Eur Respir Rev. 2019 Oct 21;28(153). pii: 190096. doi: 10.1183/16000617.0096-2019. Print 2019 Sep 30. Review. Erratum in: Eur Respir Rev. 2019 Nov 13;28(154):.

19.

Assessment of evidence for or against contributions of Chlamydia pneumoniae infections to Alzheimer's disease etiology.

Woods JJ, Skelding KA, Martin KL, Aryal R, Sontag E, Johnstone DM, Horvat JC, Hansbro PM, Milward EA.

Brain Behav Immun. 2020 Jan;83:22-32. doi: 10.1016/j.bbi.2019.10.014. Epub 2019 Oct 15. Review.

PMID:
31626972
20.

Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.

Findlay AD, Foot JS, Buson A, Deodhar M, Jarnicki AG, Hansbro PM, Liu G, Schilter H, Turner CI, Zhou W, Jarolimek W.

J Med Chem. 2019 Nov 14;62(21):9874-9889. doi: 10.1021/acs.jmedchem.9b01283. Epub 2019 Oct 16.

PMID:
31580073
21.

Lipopolysaccharide induces steroid-resistant exacerbations in a mouse model of allergic airway disease collectively through IL-13 and pulmonary macrophage activation.

Hadjigol S, Netto KG, Maltby S, Tay HL, Nguyen TH, Hansbro NG, Eyers F, Hansbro PM, Yang M, Foster PS.

Clin Exp Allergy. 2020 Jan;50(1):82-94. doi: 10.1111/cea.13505. Epub 2019 Oct 18.

PMID:
31579973
22.

Epithelial-mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics.

Eapen MS, Sharma P, Gaikwad AV, Lu W, Myers S, Hansbro PM, Sohal SS.

Int J Chron Obstruct Pulmon Dis. 2019 Jul 18;14:1603-1610. doi: 10.2147/COPD.S208428. eCollection 2019.

23.

Microbiome-focused asthma management strategies.

Shukla SD, Shastri MD, Chong WC, Dua K, Budden KF, Mahmood MQ, Hansbro NG, Keely S, Eri R, Patel RP, Peterson GM, Hansbro PM.

Curr Opin Pharmacol. 2019 Jun;46:143-149. doi: 10.1016/j.coph.2019.06.003. Epub 2019 Jul 26. Review.

PMID:
31357048
24.

New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways.

Atto B, Eapen MS, Sharma P, Frey U, Ammit AJ, Markos J, Chia C, Larby J, Haug G, Weber HC, Mabeza G, Tristram S, Myers S, Geraghty DP, Flanagan KL, Hansbro PM, Sohal SS.

Clin Sci (Lond). 2019 Jul 25;133(14):1663-1703. doi: 10.1042/CS20181009. Print 2019 Jul 31. Review.

PMID:
31346069
25.

Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.

Liu G, Cooley MA, Jarnicki AG, Borghuis T, Nair PM, Tjin G, Hsu AC, Haw TJ, Fricker M, Harrison CL, Jones B, Hansbro NG, Wark PA, Horvat JC, Argraves WS, Oliver BG, Knight DA, Burgess JK, Hansbro PM.

JCI Insight. 2019 Jul 25;5. pii: 124529. doi: 10.1172/jci.insight.124529.

26.

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses.

Hayman TJ, Hsu AC, Kolesnik TB, Dagley LF, Willemsen J, Tate MD, Baker PJ, Kershaw NJ, Kedzierski L, Webb AI, Wark PA, Kedzierska K, Masters SL, Belz GT, Binder M, Hansbro PM, Nicola NA, Nicholson SE.

Immunol Cell Biol. 2019 Oct;97(9):840-852. doi: 10.1111/imcb.12284. Epub 2019 Aug 19.

PMID:
31335993
27.

Recent Developments in Alpha-Glucosidase Inhibitors for Management of Type-2 Diabetes: An Update.

Usman B, Sharma N, Satija S, Mehta M, Vyas M, Khatik GL, Khurana N, Hansbro PM, Williams K, Dua K.

Curr Pharm Des. 2019;25(23):2510-2525. doi: 10.2174/1381612825666190717104547.

PMID:
31333110
28.

Interactions between microbiome and lungs: Paving new paths for microbiome based bio-engineered drug delivery systems in chronic respiratory diseases.

Chellappan DK, Sze Ning QL, Su Min SK, Bin SY, Chern PJ, Shi TP, Ee Mei SW, Yee TH, Qi OJ, Thangavelu L, Rajeshkumar S, Negi P, Chellian J, Wadhwa R, Gupta G, Collet T, Hansbro PM, Dua K.

Chem Biol Interact. 2019 Sep 1;310:108732. doi: 10.1016/j.cbi.2019.108732. Epub 2019 Jul 2. Review.

PMID:
31276660
29.

Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production.

Hu M, Schulze KE, Ghildyal R, Henstridge DC, Kolanowski JL, New EJ, Hong Y, Hsu AC, Hansbro PM, Wark PA, Bogoyevitch MA, Jans DA.

Elife. 2019 Jun 27;8. pii: e42448. doi: 10.7554/eLife.42448.

30.

IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis.

Starkey MR, Plank MW, Casolari P, Papi A, Pavlidis S, Guo Y, Cameron GJM, Haw TJ, Tam A, Obiedat M, Donovan C, Hansbro NG, Nguyen DH, Nair PM, Kim RY, Horvat JC, Kaiko GE, Durum SK, Wark PA, Sin DD, Caramori G, Adcock IM, Foster PS, Hansbro PM.

Eur Respir J. 2019 Jul 18;54(1). pii: 1800174. doi: 10.1183/13993003.00174-2018. Print 2019 Jul.

PMID:
31196943
31.

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases.

Mehta M, Deeksha, Tewari D, Gupta G, Awasthi R, Singh H, Pandey P, Chellappan DK, Wadhwa R, Collet T, Hansbro PM, Kumar SR, Thangavelu L, Negi P, Dua K, Satija S.

Chem Biol Interact. 2019 Aug 1;308:206-215. doi: 10.1016/j.cbi.2019.05.028. Epub 2019 May 25. Review.

32.

Chitinase-like protein YKL-40 correlates with inflammatory phenotypes, anti-asthma responsiveness and future exacerbations.

Liu L, Zhang X, Liu Y, Zhang L, Zheng J, Wang J, Hansbro PM, Wang L, Wang G, Hsu AC.

Respir Res. 2019 May 22;20(1):95. doi: 10.1186/s12931-019-1051-9.

33.

Polycomb repressive complex 2 is a critical mediator of allergic inflammation.

Keenan CR, Iannarella N, Garnham AL, Brown AC, Kim RY, Horvat JC, Hansbro PM, Nutt SL, Allan RS.

JCI Insight. 2019 May 16;4(10). pii: 127745. doi: 10.1172/jci.insight.127745. eCollection 2019 May 16.

34.

Molecular links between COPD and lung cancer: new targets for drug discovery?

Caramori G, Ruggeri P, Mumby S, Ieni A, Lo Bello F, Chimankar V, Donovan C, Andò F, Nucera F, Coppolino I, Tuccari G, Hansbro PM, Adcock IM.

Expert Opin Ther Targets. 2019 Jun;23(6):539-553. doi: 10.1080/14728222.2019.1615884. Epub 2019 May 11. Review.

PMID:
31079559
35.

Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury.

Cameron GJM, Cautivo KM, Loering S, Jiang SH, Deshpande AV, Foster PS, McKenzie ANJ, Molofsky AB, Hansbro PM, Starkey MR.

Front Immunol. 2019 Apr 16;10:826. doi: 10.3389/fimmu.2019.00826. eCollection 2019.

36.

Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome.

Liu G, Mateer SW, Hsu A, Goggins BJ, Tay H, Mathe A, Fan K, Neal R, Bruce J, Burns G, Minahan K, Maltby S, Fricker M, Foster PS, Wark PAB, Hansbro PM, Keely S.

Mucosal Immunol. 2019 Jul;12(4):862-873. doi: 10.1038/s41385-019-0163-3. Epub 2019 Apr 11.

PMID:
30976089
37.

Functional effects of the microbiota in chronic respiratory disease.

Budden KF, Shukla SD, Rehman SF, Bowerman KL, Keely S, Hugenholtz P, Armstrong-James DPH, Adcock IM, Chotirmall SH, Chung KF, Hansbro PM.

Lancet Respir Med. 2019 Oct;7(10):907-920. doi: 10.1016/S2213-2600(18)30510-1. Epub 2019 Apr 8. Review.

PMID:
30975495
38.

Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease.

Wadhwa R, Aggarwal T, Malyla V, Kumar N, Gupta G, Chellappan DK, Dureja H, Mehta M, Satija S, Gulati M, Maurya PK, Collet T, Hansbro PM, Dua K.

J Cell Physiol. 2019 Aug;234(10):16703-16723. doi: 10.1002/jcp.28482. Epub 2019 Mar 25. Review.

PMID:
30912142
39.

Evaluating recruitment strategies for AUSPICE, a large Australian community-based randomised controlled trial.

Peel R, Ren S, Hure A, Evans TJ, D'Este CA, Abhayaratna WP, Tonkin AM, Hopper I, Thrift AG, Levi CR, Sturm J, Durrheim D, Hung J, Briffa TG, Chew DP, Anderson P, Moon L, McEvoy M, Hansbro PM, Newby DA, Attia JR.

Med J Aust. 2019 May;210(9):409-415. doi: 10.5694/mja2.50117. Epub 2019 Mar 25.

PMID:
30907001
40.

Current Status on Immunological Therapies for Type 1 Diabetes Mellitus.

Xin GLL, Khee YP, Ying TY, Chellian J, Gupta G, Kunnath AP, Nammi S, Collet T, Hansbro PM, Dua K, Chellappan DK.

Curr Diab Rep. 2019 Mar 23;19(5):22. doi: 10.1007/s11892-019-1144-3. Review.

PMID:
30905013
41.

Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases.

Mehta M, Deeksha, Sharma N, Vyas M, Khurana N, Maurya PK, Singh H, Andreoli de Jesus TP, Dureja H, Chellappan DK, Gupta G, Wadhwa R, Collet T, Hansbro PM, Dua K, Satija S.

Chem Biol Interact. 2019 May 1;304:10-19. doi: 10.1016/j.cbi.2019.02.021. Epub 2019 Mar 5. Review.

PMID:
30849336
42.

Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction.

Hardy SA, Mabotuwana NS, Murtha LA, Coulter B, Sanchez-Bezanilla S, Al-Omary MS, Senanayake T, Loering S, Starkey M, Lee RJ, Rainer PP, Hansbro PM, Boyle AJ.

PLoS One. 2019 Feb 21;14(2):e0212230. doi: 10.1371/journal.pone.0212230. eCollection 2019.

43.

TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis.

Collison AM, Li J, de Siqueira AP, Lv X, Toop HD, Morris JC, Starkey MR, Hansbro PM, Zhang J, Mattes J.

BMC Pulm Med. 2019 Feb 7;19(1):31. doi: 10.1186/s12890-019-0786-x.

44.

Emerging therapeutic potential of group 2 innate lymphoid cells in acute kidney injury.

Cameron GJM, Jiang SH, Loering S, Deshpande AV, Hansbro PM, Starkey MR.

J Pathol. 2019 May;248(1):9-15. doi: 10.1002/path.5242. Epub 2019 Mar 5. Review.

PMID:
30684265
45.

Pulmonary group 2 innate lymphoid cells: surprises and challenges.

Starkey MR, McKenzie AN, Belz GT, Hansbro PM.

Mucosal Immunol. 2019 Mar;12(2):299-311. doi: 10.1038/s41385-018-0130-4. Epub 2019 Jan 21. Review.

46.

Dietary Fatty Acids Amplify Inflammatory Responses to Infection through p38 MAPK Signaling.

Rutting S, Zakarya R, Bozier J, Xenaki D, Horvat JC, Wood LG, Hansbro PM, Oliver BG.

Am J Respir Cell Mol Biol. 2019 May;60(5):554-568. doi: 10.1165/rcmb.2018-0215OC.

PMID:
30648905
47.

Beyond the obvious: Environmental health implications of polar polycyclic aromatic hydrocarbons.

Idowu O, Semple KT, Ramadass K, O'Connor W, Hansbro P, Thavamani P.

Environ Int. 2019 Feb;123:543-557. doi: 10.1016/j.envint.2018.12.051. Epub 2019 Jan 5. Review.

48.

STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts.

Waters DW, Blokland KEC, Pathinayake PS, Wei L, Schuliga M, Jaffar J, Westall GP, Hansbro PM, Prele CM, Mutsaers SE, Bartlett NW, Burgess JK, Grainge CL, Knight DA.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):61-73. doi: 10.1165/rcmb.2018-0328OC.

PMID:
30608861
49.

Targeting microRNAs using nanotechnology in pulmonary diseases.

Dua K, Chellappan DK, Singhvi G, de Jesus Andreoli Pinto T, Gupta G, Hansbro PM.

Panminerva Med. 2018 Dec;60(4):230-231. doi: 10.23736/S0031-0808.18.03459-6. No abstract available.

PMID:
30563304
50.

Mechanisms and Management of Asthma Exacerbations.

Ramsahai JM, Hansbro PM, Wark PAB.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):423-432. doi: 10.1164/rccm.201810-1931CI. Review.

PMID:
30562041

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