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Items: 1 to 50 of 65

1.

Initial Characterization of Integrase-Defective Lentiviral Vectors for Pancreatic Cancer Gene Therapy.

Hanoun N, Gayral M, Pointreau A, Buscail L, Cordelier P.

Hum Gene Ther. 2016 Feb;27(2):184-92. doi: 10.1089/hum.2015.151.

2.

First-in-man phase 1 clinical trial of gene therapy for advanced pancreatic cancer: safety, biodistribution, and preliminary clinical findings.

Buscail L, Bournet B, Vernejoul F, Cambois G, Lulka H, Hanoun N, Dufresne M, Meulle A, Vignolle-Vidoni A, Ligat L, Saint-Laurent N, Pont F, Dejean S, Gayral M, Martins F, Torrisani J, Barbey O, Gross F, Guimbaud R, Otal P, Lopez F, Tiraby G, Cordelier P.

Mol Ther. 2015 Apr;23(4):779-89. doi: 10.1038/mt.2015.1. Epub 2015 Jan 14.

3.

Targeted oncolytic herpes simplex virus type 1 eradicates experimental pancreatic tumors.

Gayral M, Lulka H, Hanoun N, Biollay C, Sèlves J, Vignolle-Vidoni A, Berthommé H, Trempat P, Epstein AL, Buscail L, Béjot JL, Cordelier P.

Hum Gene Ther. 2015 Feb;26(2):104-13. doi: 10.1089/hum.2014.072. Epub 2015 Jan 19.

4.

The E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 targets pancreas transcription factor 1a for proteasomal degradation.

Hanoun N, Fritsch S, Gayet O, Gigoux V, Cordelier P, Dusetti N, Torrisani J, Dufresne M.

J Biol Chem. 2014 Dec 19;289(51):35593-604. doi: 10.1074/jbc.M114.620104. Epub 2014 Oct 29.

5.

MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer.

Gayral M, Jo S, Hanoun N, Vignolle-Vidoni A, Lulka H, Delpu Y, Meulle A, Dufresne M, Humeau M, Chalret du Rieu M, Bournet B, Sèlves J, Guimbaud R, Carrère N, Buscail L, Torrisani J, Cordelier P.

World J Gastroenterol. 2014 Aug 28;20(32):11199-209. doi: 10.3748/wjg.v20.i32.11199. Review.

6.

Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled with a KRAS mutation assay using allelic discrimination improves the diagnosis of pancreatic cancer.

Bournet B, Selves J, Grand D, Danjoux M, Hanoun N, Cordelier P, Buscail L.

J Clin Gastroenterol. 2015 Jan;49(1):50-6. doi: 10.1097/MCG.0000000000000053.

PMID:
24798941
7.

The Role of the 3' Untranslated Region in the Post-Transcriptional Regulation of KLF6 Gene Expression in Hepatocellular Carcinoma.

Diab T, Hanoun N, Bureau C, Christol C, Buscail L, Cordelier P, Torrisani J.

Cancers (Basel). 2013 Dec 19;6(1):28-41. doi: 10.3390/cancers6010028.

8.

Oxidative stress induced by inactivation of TP53INP1 cooperates with KrasG12D to initiate and promote pancreatic carcinogenesis in the murine pancreas.

Al Saati T, Clerc P, Hanoun N, Peuget S, Lulka H, Gigoux V, Capilla F, Béluchon B, Couvelard A, Selves J, Buscail L, Carrier A, Dusetti N, Dufresne M.

Am J Pathol. 2013 Jun;182(6):1996-2004. doi: 10.1016/j.ajpath.2013.02.034. Epub 2013 Apr 8.

PMID:
23578383
9.

The rescue of miR-148a expression in pancreatic cancer: an inappropriate therapeutic tool.

Delpu Y, Lulka H, Sicard F, Saint-Laurent N, Lopez F, Hanoun N, Buscail L, Cordelier P, Torrisani J.

PLoS One. 2013;8(1):e55513. doi: 10.1371/journal.pone.0055513. Epub 2013 Jan 31.

10.

Role of endothelial AADC in cardiac synthesis of serotonin and nitrates accumulation.

Rouzaud-Laborde C, Hanoun N, Baysal I, Rech JS, Mias C, Calise D, Sicard P, Frugier C, Seguelas MH, Parini A, Pizzinat N.

PLoS One. 2012;7(7):e34893. doi: 10.1371/journal.pone.0034893. Epub 2012 Jul 19.

11.

Genetic and epigenetic alterations in pancreatic carcinogenesis.

Delpu Y, Hanoun N, Lulka H, Sicard F, Selves J, Buscail L, Torrisani J, Cordelier P.

Curr Genomics. 2011 Mar;12(1):15-24. doi: 10.2174/138920211794520132.

12.

The SV2 variant of KLF6 is down-regulated in hepatocellular carcinoma and displays anti-proliferative and pro-apoptotic functions.

Hanoun N, Bureau C, Diab T, Gayet O, Dusetti N, Selves J, Vinel JP, Buscail L, Cordelier P, Torrisani J.

J Hepatol. 2010 Nov;53(5):880-8. doi: 10.1016/j.jhep.2010.04.038. Epub 2010 Jul 23.

PMID:
20801538
13.

The silencing of microRNA 148a production by DNA hypermethylation is an early event in pancreatic carcinogenesis.

Hanoun N, Delpu Y, Suriawinata AA, Bournet B, Bureau C, Selves J, Tsongalis GJ, Dufresne M, Buscail L, Cordelier P, Torrisani J.

Clin Chem. 2010 Jul;56(7):1107-18. doi: 10.1373/clinchem.2010.144709. Epub 2010 Apr 29.

14.

Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis.

Bureau C, Hanoun N, Torrisani J, Vinel JP, Buscail L, Cordelier P.

Curr Genomics. 2009 Aug;10(5):353-60. doi: 10.2174/138920209788921010.

15.

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy.

Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, Lashuel HA, Haass C, Duyckaerts C, Cohen-Salmon C, Kahle PJ, Hamon M, Brice A, Corti O.

PLoS One. 2009 Aug 14;4(8):e6629. doi: 10.1371/journal.pone.0006629.

16.

Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice.

Kelaï S, Renoir T, Chouchana L, Saurini F, Hanoun N, Hamon M, Lanfumey L.

J Neurochem. 2008 Dec;107(6):1660-70. doi: 10.1111/j.1471-4159.2008.05733.x.

17.

Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice.

Renoir T, Païzanis E, El Yacoubi M, Saurini F, Hanoun N, Melfort M, Lesch KP, Hamon M, Lanfumey L.

Int J Neuropsychopharmacol. 2008 Dec;11(8):1149-62. doi: 10.1017/S1461145708009048. Epub 2008 Jul 9.

PMID:
18611291
18.

Identification of an upstream promoter of the human somatostatin receptor, hSSTR2, which is controlled by epigenetic modifications.

Torrisani J, Hanoun N, Laurell H, Lopez F, Maoret JJ, Souque A, Susini C, Cordelier P, Buscail L.

Endocrinology. 2008 Jun;149(6):3137-47. doi: 10.1210/en.2007-1525. Epub 2008 Mar 6.

PMID:
18325993
19.

The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone.

Gras C, Amilhon B, Lepicard EM, Poirel O, Vinatier J, Herbin M, Dumas S, Tzavara ET, Wade MR, Nomikos GG, Hanoun N, Saurini F, Kemel ML, Gasnier B, Giros B, El Mestikawy S.

Nat Neurosci. 2008 Mar;11(3):292-300. doi: 10.1038/nn2052. Epub 2008 Feb 17.

PMID:
18278042
20.

Microtubule-associated STOP protein deletion triggers restricted changes in dopaminergic neurotransmission.

Bouvrais-Veret C, Weiss S, Hanoun N, Andrieux A, Schweitzer A, Job D, Hamon M, Giros B, Martres MP.

J Neurochem. 2008 Feb;104(3):745-56. doi: 10.1111/j.1471-4159.2007.05025.x.

21.

Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice.

Izikki M, Hanoun N, Marcos E, Savale L, Barlier-Mur AM, Saurini F, Eddahibi S, Hamon M, Adnot S.

Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L1045-52. Epub 2007 Aug 3.

22.

Cannabinoid-serotonin interactions in alcohol-preferring vs. alcohol-avoiding mice.

Kelaï S, Hanoun N, Aufrère G, Beaugé F, Hamon M, Lanfumey L.

J Neurochem. 2006 Oct;99(1):308-20.

23.

Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain.

Mannoury la Cour C, El Mestikawy S, Hanoun N, Hamon M, Lanfumey L.

Mol Pharmacol. 2006 Sep;70(3):1013-21. Epub 2006 Jun 13.

PMID:
16772521
24.

Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension.

Guignabert C, Izikki M, Tu LI, Li Z, Zadigue P, Barlier-Mur AM, Hanoun N, Rodman D, Hamon M, Adnot S, Eddahibi S.

Circ Res. 2006 May 26;98(10):1323-30. Epub 2006 Apr 13.

PMID:
16614302
25.

Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia.

Eddahibi S, Guignabert C, Barlier-Mur AM, Dewachter L, Fadel E, Dartevelle P, Humbert M, Simonneau G, Hanoun N, Saurini F, Hamon M, Adnot S.

Circulation. 2006 Apr 18;113(15):1857-64. Epub 2006 Apr 10.

PMID:
16606791
26.

Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice.

Mekontso-Dessap A, Brouri F, Pascal O, Lechat P, Hanoun N, Lanfumey L, Seif I, Benhaiem-Sigaux N, Kirsch M, Hamon M, Adnot S, Eddahibi S.

Circulation. 2006 Jan 3;113(1):81-9. Epub 2005 Dec 27.

PMID:
16380550
27.

Prepartum chronic ultramild stress increases corticosterone and estradiol levels in gestating mice: implications for postpartum depressive disorders.

Misdrahi D, Pardon MC, Pérez-Diaz F, Hanoun N, Cohen-Salmon C.

Psychiatry Res. 2005 Nov 15;137(1-2):123-30. Epub 2005 Oct 6.

PMID:
16213595
28.

Family-based association study of the 5-HT transporter gene and schizophrenia.

Dubertret C, Hanoun N, Adès J, Hamon M, Gorwood P.

Int J Neuropsychopharmacol. 2005 Mar;8(1):87-92. Epub 2005 Jan 10.

PMID:
15638952
29.

Prevention of diazepam withdrawal syndrome by nifedipine-behavioural and neurochemical studies.

El Ganouni S, Hanoun N, Boni C, Tazi A, Hakkou F, Hamon M.

Pharmacol Biochem Behav. 2004 Oct;79(2):269-77.

PMID:
15501302
30.

Differential effects of the novel antidepressant agomelatine (S 20098) versus fluoxetine on 5-HT1A receptors in the rat brain.

Hanoun N, Mocaër E, Boyer PA, Hamon M, Lanfumey L.

Neuropharmacology. 2004 Sep;47(4):515-26.

PMID:
15380370
31.

Persistent increase in olfactory type G-protein alpha subunit levels may underlie D1 receptor functional hypersensitivity in Parkinson disease.

Corvol JC, Muriel MP, Valjent E, Féger J, Hanoun N, Girault JA, Hirsch EC, Hervé D.

J Neurosci. 2004 Aug 4;24(31):7007-14.

32.

Long-term treatment with the antioxidant drug EGb 761 at senescence restored some neurobehavioral effects of chronic ultramild stress exposure seen in young mice.

Pardon MC, Hanoun N, Perez-Diaz F, Joubert C, Launay JM, Christen Y, Hamon M, Cohen-Salmon C.

Neurobiol Aging. 2004 Sep;25(8):1067-83.

PMID:
15212832
33.

Family-based association studies between 5-HT5A receptor gene and schizophrenia.

Dubertret C, Hanoun N, Adès J, Hamon M, Gorwood P.

J Psychiatr Res. 2004 Jul-Aug;38(4):371-6.

PMID:
15203288
34.

5-HT-mediated inhibition of cardiovagal baroreceptor reflex response during defense reaction in the rat.

Comet MA, Sévoz-Couche C, Hanoun N, Hamon M, Laguzzi R.

Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1641-9. Epub 2004 May 27.

35.

GABA(B) receptors in 5-HT transporter- and 5-HT1A receptor-knock-out mice: further evidence of a transduction pathway shared with 5-HT1A receptors.

Mannoury la Cour C, Hanoun N, Melfort M, Hen R, Lesch KP, Hamon M, Lanfumey L.

J Neurochem. 2004 May;89(4):886-96.

36.

Family-based association study of the serotonin-6 receptor gene (C267T polymorphism) in schizophrenia.

Dubertret C, Hanoun N, Adès J, Hamon M, Gorwood P.

Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):10-5. Review.

PMID:
15048641
37.

Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress.

Froger N, Palazzo E, Boni C, Hanoun N, Saurini F, Joubert C, Dutriez-Casteloot I, Enache M, Maccari S, Barden N, Cohen-Salmon C, Hamon M, Lanfumey L.

J Neurosci. 2004 Mar 17;24(11):2787-96.

38.

Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP.

Rumajogee P, Vergé D, Hanoun N, Brisorgueil MJ, Hen R, Lesch KP, Hamon M, Miquel MC.

Eur J Neurosci. 2004 Feb;19(4):937-44.

PMID:
15009141
39.

Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis.

Brouri F, Hanoun N, Mediani O, Saurini F, Hamon M, Vanhoutte PM, Lechat P.

Eur J Pharmacol. 2004 Feb 6;485(1-3):227-34.

PMID:
14757145
40.

The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia.

Dubertret C, Gouya L, Hanoun N, Deybach JC, Adès J, Hamon M, Gorwood P.

Schizophr Res. 2004 Mar 1;67(1):75-85.

PMID:
14741327
41.

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.

Côté F, Thévenot E, Fligny C, Fromes Y, Darmon M, Ripoche MA, Bayard E, Hanoun N, Saurini F, Lechat P, Dandolo L, Hamon M, Mallet J, Vodjdani G.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13525-30. Epub 2003 Nov 3.

42.

Dihydroergotamine and its metabolite, 8'-hydroxy-dihydroergotamine, as 5-HT1A receptor agonists in the rat brain.

Hanoun N, Saurini F, Lanfumey L, Hamon M, Bourgoin S.

Br J Pharmacol. 2003 May;139(2):424-34.

43.

Toxic cardiac effects of catecholamines: role of beta-adrenoceptor downregulation.

Brouri F, Findji L, Mediani O, Mougenot N, Hanoun N, Le Naour G, Hamon M, Lechat P.

Eur J Pharmacol. 2002 Dec 5;456(1-3):69-75.

PMID:
12450571
44.

Effects of genetic depletion of monoamines on somatosensory cortical development.

Alvarez C, Vitalis T, Fon EA, Hanoun N, Hamon M, Seif I, Edwards R, Gaspar P, Cases O.

Neuroscience. 2002;115(3):753-64.

PMID:
12435414
45.

5-HT(2A) gene promoter polymorphism as a modifying rather than a vulnerability factor in anorexia nervosa.

Kipman A, Bruins-Slot L, Boni C, Hanoun N, Adès J, Blot P, Hamon M, Mouren-Siméoni M, Gorwood P.

Eur Psychiatry. 2002 Jul;17(4):227-9.

PMID:
12231269
46.

Interactions between TrkB signaling and serotonin excess in the developing murine somatosensory cortex: a role in tangential and radial organization of thalamocortical axons.

Vitalis T, Cases O, Gillies K, Hanoun N, Hamon M, Seif I, Gaspar P, Kind P, Price DJ.

J Neurosci. 2002 Jun 15;22(12):4987-5000.

47.

Altered regulation of the 5-HT system in the brain of MAO-A knock-out mice.

Evrard A, Malagié I, Laporte AM, Boni C, Hanoun N, Trillat AC, Seif I, De Maeyer E, Gardier A, Hamon M, Adrien J.

Eur J Neurosci. 2002 Mar;15(5):841-51.

PMID:
11906526
48.

Effects of acetaminophen on monoaminergic systems in the rat central nervous system.

Courade JP, Caussade F, Martin K, Besse D, Delchambre C, Hanoun N, Hamon M, Eschalier A, Cloarec A.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):534-7.

PMID:
11770008
49.

Acetaminophen distribution in the rat central nervous system.

Courad JP, Besse D, Delchambre C, Hanoun N, Hamon M, Eschalier A, Caussade F, Cloarec A.

Life Sci. 2001 Aug 10;69(12):1455-64.

PMID:
11531168
50.

Lipolytic and antilipolytic responses of the Siberian hamster (Phodopus sungorus sungorus) white adipocytes after weight loss induced by short photoperiod exposure.

Atgié C, Le Gouic S, Marti L, Hanoun N, Casteilla L, Pénicaud L, Ambid L, Carpéné C.

Comp Biochem Physiol A Mol Integr Physiol. 1998 Feb;119(2):503-10.

PMID:
11248994

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