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Correction: PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation.

Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA.

Oncogene. 2019 Nov;38(48):7366. doi: 10.1038/s41388-019-1019-8.


PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation.

Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA.

Oncogene. 2019 Nov;38(48):7311-7328. doi: 10.1038/s41388-019-0950-z. Epub 2019 Aug 16. Erratum in: Oncogene. 2019 Oct 1;:.


Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases.

Sakamoto W, Canals D, Salamone S, Allopenna J, Clarke CJ, Snider J, Obeid LM, Hannun YA.

J Lipid Res. 2019 Nov;60(11):1841-1850. doi: 10.1194/jlr.M094722. Epub 2019 Jun 26.


Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma.

Bai A, Liu X, Bielawski J, Hannun YA.

PLoS One. 2019 Apr 19;14(4):e0215770. doi: 10.1371/journal.pone.0215770. eCollection 2019.


Approaches for probing and evaluating mammalian sphingolipid metabolism.

Snider JM, Luberto C, Hannun YA.

Anal Biochem. 2019 Jun 15;575:70-86. doi: 10.1016/j.ab.2019.03.014. Epub 2019 Mar 24. Review.


The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme.

Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA.

J Biol Chem. 2019 May 3;294(18):7488-7502. doi: 10.1074/jbc.RA118.007288. Epub 2019 Mar 19.


Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue.

Schwartz NU, Mileva I, Gurevich M, Snider J, Hannun YA, Obeid LM.

Prostaglandins Other Lipid Mediat. 2019 Apr;141:40-48. doi: 10.1016/j.prostaglandins.2019.02.005. Epub 2019 Feb 19.


Emergence of membrane sphingolipids as a potential therapeutic target.

Sahu SK, Hannun YA, Yao N.

Biochimie. 2019 Mar;158:257-264. doi: 10.1016/j.biochi.2019.01.018. Epub 2019 Jan 28. Review.


RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.

Choi YJ, Laclef C, Yang N, Andreu-Cervera A, Lewis J, Mao X, Li L, Snedecor ER, Takemaru KI, Qin C, Schneider-Maunoury S, Shroyer KR, Hannun YA, Koch PJ, Clark RA, Payne AS, Kowalczyk AP, Chen J.

PLoS Genet. 2019 Jan 28;15(1):e1007914. doi: 10.1371/journal.pgen.1007914. eCollection 2019 Jan.


Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis.

Snider JM, Trayssac M, Clarke CJ, Schwartz N, Snider AJ, Obeid LM, Luberto C, Hannun YA.

J Lipid Res. 2019 Apr;60(4):819-831. doi: 10.1194/jlr.M089714. Epub 2018 Dec 20.


Exploring the Therapeutic Landscape of Sphingomyelinases.

Shanbhogue P, Hannun YA.

Handb Exp Pharmacol. 2018 Nov 27. doi: 10.1007/164_2018_179. [Epub ahead of print]


Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites.

Bai A, Bielawska A, Rahmaniyan M, Kraveka JM, Bielawski J, Hannun YA.

Bioorg Med Chem. 2018 Dec 15;26(23-24):6067-6075. doi: 10.1016/j.bmc.2018.11.012. Epub 2018 Nov 10.


Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer.

Coant N, Hannun YA.

Adv Biol Regul. 2019 Jan;71:141-146. doi: 10.1016/j.jbior.2018.10.005. Epub 2018 Oct 26. Review.


Visualizing bioactive ceramides.

Canals D, Salamone S, Hannun YA.

Chem Phys Lipids. 2018 Nov;216:142-151. doi: 10.1016/j.chemphyslip.2018.09.013. Epub 2018 Sep 25. Review.


Evaluating intrinsic and non-intrinsic cancer risk factors.

Wu S, Zhu W, Thompson P, Hannun YA.

Nat Commun. 2018 Aug 28;9(1):3490. doi: 10.1038/s41467-018-05467-z. Review.


Functions of neutral ceramidase in the Golgi apparatus.

Sakamoto W, Coant N, Canals D, Obeid LM, Hannun YA.

J Lipid Res. 2018 Nov;59(11):2116-2125. doi: 10.1194/jlr.M088187. Epub 2018 Aug 28.


Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway.

Ren J, Saied EM, Zhong A, Snider J, Ruiz C, Arenz C, Obeid LM, Girnun GD, Hannun YA.

J Lipid Res. 2018 Nov;59(11):2126-2139. doi: 10.1194/jlr.M088195. Epub 2018 Aug 28.


Author Correction: Sphingolipids and their metabolism in physiology and disease.

Hannun YA, Obeid LM.

Nat Rev Mol Cell Biol. 2018 Oct;19(10):673. doi: 10.1038/s41580-018-0046-6.


Role of sphingolipids in senescence: implication in aging and age-related diseases.

Trayssac M, Hannun YA, Obeid LM.

J Clin Invest. 2018 Jul 2;128(7):2702-2712. doi: 10.1172/JCI97949. Epub 2018 Jul 2. Review.


Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.

Newcomb B, Rhein C, Mileva I, Ahmad R, Clarke CJ, Snider J, Obeid LM, Hannun YA.

J Lipid Res. 2018 Jul;59(7):1219-1229. doi: 10.1194/jlr.M084202. Epub 2018 May 3.


AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells.

Coant N, García-Barros M, Zhang Q, Obeid LM, Hannun YA.

Oncogene. 2018 Jul;37(28):3852-3863. doi: 10.1038/s41388-018-0236-x. Epub 2018 Apr 17.


The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation.

Ahmad R, Al-Roub A, Kochumon S, Akther N, Thomas R, Kumari M, Koshy MS, Tiss A, Hannun YA, Tuomilehto J, Sindhu S, Rosen ED.

J Immunol. 2018 May 15;200(10):3599-3611. doi: 10.4049/jimmunol.1701552. Epub 2018 Apr 9.


Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry.

Snider JM, Snider AJ, Obeid LM, Luberto C, Hannun YA.

J Lipid Res. 2018 Jun;59(6):1046-1057. doi: 10.1194/jlr.D081646. Epub 2018 Apr 2.


Differentiate and switch, a tale of two heads of a lipid.

Hannun YA.

EMBO J. 2018 Apr 3;37(7). pii: e99221. doi: 10.15252/embj.201899221. Epub 2018 Mar 23. No abstract available.


Acetic acid induces Sch9p-dependent translocation of Isc1p from the endoplasmic reticulum into mitochondria.

Rego A, Cooper KF, Snider J, Hannun YA, Costa V, Côrte-Real M, Chaves SR.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jun;1863(6):576-583. doi: 10.1016/j.bbalip.2018.02.008. Epub 2018 Feb 27.


Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates.

Li F, Xu R, Low BE, Lin CL, Garcia-Barros M, Schrandt J, Mileva I, Snider A, Luo CK, Jiang XC, Li MS, Hannun YA, Obeid LM, Wiles MV, Mao C.

FASEB J. 2018 Jun;32(6):3058-3069. doi: 10.1096/fj.201700445RR. Epub 2018 Jan 22.


Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.

Wang K, Xu R, Schrandt J, Shah P, Gong YZ, Preston C, Wang L, Yi JK, Lin CL, Sun W, Spyropoulos DD, Rhee S, Li M, Zhou J, Ge S, Zhang G, Snider AJ, Hannun YA, Obeid LM, Mao C.

PLoS Genet. 2018 Jan 23;14(1):e1007190. doi: 10.1371/journal.pgen.1007190. eCollection 2018 Jan.


An intrinsic lipid-binding interface controls sphingosine kinase 1 function.

Pulkoski-Gross MJ, Jenkins ML, Truman JP, Salama MF, Clarke CJ, Burke JE, Hannun YA, Obeid LM.

J Lipid Res. 2018 Mar;59(3):462-474. doi: 10.1194/jlr.M081307. Epub 2018 Jan 11.


A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway.

Carroll BL, Bonica J, Shamseddine AA, Hannun YA, Obeid LM.

FEBS Open Bio. 2017 Dec 8;8(1):27-40. doi: 10.1002/2211-5463.12344. eCollection 2018 Jan.


Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment.

Espaillat MP, Snider AJ, Qiu Z, Channer B, Coant N, Schuchman EH, Kew RR, Sheridan BS, Hannun YA, Obeid LM.

FASEB J. 2018 May;32(5):2339-2353. doi: 10.1096/fj.201700585R. Epub 2017 Dec 19.


Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.

Xu R, Garcia-Barros M, Wen S, Li F, Lin CL, Hannun YA, Obeid LM, Mao C.

Cell Death Differ. 2018 May;25(5):841-856. doi: 10.1038/s41418-017-0018-y. Epub 2017 Dec 11.


Sphingosine 1-phosphate activation of ERM contributes to vascular calcification.

Morris TG, Borland SJ, Clarke CJ, Wilson C, Hannun YA, Ohanian V, Canfield AE, Ohanian J.

J Lipid Res. 2018 Jan;59(1):69-78. doi: 10.1194/jlr.M079731. Epub 2017 Nov 22.


Sphingolipids and their metabolism in physiology and disease.

Hannun YA, Obeid LM.

Nat Rev Mol Cell Biol. 2018 Mar;19(3):175-191. doi: 10.1038/nrm.2017.107. Epub 2017 Nov 22. Review. Erratum in: Nat Rev Mol Cell Biol. 2018 Oct;19(10):673.


Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F.

Schwartz NU, Linzer RW, Truman JP, Gurevich M, Hannun YA, Senkal CE, Obeid LM.

FASEB J. 2018 Mar;32(3):1716-1728. doi: 10.1096/fj.201701067R. Epub 2018 Jan 3.


Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae.

Ren J, Snider J, Airola MV, Zhong A, Rana NA, Obeid LM, Hannun YA.

J Lipid Res. 2018 Jan;59(1):162-170. doi: 10.1194/jlr.D078535. Epub 2017 Nov 1.


Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells.

Lin CL, Xu R, Yi JK, Li F, Chen J, Jones EC, Slutsky JB, Huang L, Rigas B, Cao J, Zhong X, Snider AJ, Obeid LM, Hannun YA, Mao C.

Stem Cell Reports. 2017 Nov 14;9(5):1488-1500. doi: 10.1016/j.stemcr.2017.09.015. Epub 2017 Oct 19.


Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.

Furuya H, Tamashiro PM, Shimizu Y, Iino K, Peres R, Chen R, Sun Y, Hannun YA, Obeid LM, Kawamori T.

Carcinogenesis. 2017 Dec 7;38(12):1218-1227. doi: 10.1093/carcin/bgx104.


The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1.

Vilaça R, Barros I, Matmati N, Silva E, Martins T, Teixeira V, Hannun YA, Costa V.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):79-88. doi: 10.1016/j.bbadis.2017.10.010. Epub 2017 Oct 6.


Contributions of the Intrinsic Mutation Process to Cancer Mutation and Risk Burdens.

Zhu W, Wu S, Hannun YA.

EBioMedicine. 2017 Oct;24:5-6. doi: 10.1016/j.ebiom.2017.09.026. Epub 2017 Sep 21. No abstract available.


Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation.

Liu M, Clarke CJ, Salama MF, Choi YJ, Obeid LM, Hannun YA.

PLoS One. 2017 Sep 19;12(9):e0184818. doi: 10.1371/journal.pone.0184818. eCollection 2017.


Wu et al. reply.

Wu S, Zhu W, Hannun YA.

Nature. 2017 Aug 9;548(7666):E15. doi: 10.1038/nature23303. No abstract available.


P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment.

Wada M, Canals D, Adada M, Coant N, Salama MF, Helke KL, Arthur JS, Shroyer KR, Kitatani K, Obeid LM, Hannun YA.

Oncogene. 2017 Nov 23;36(47):6649-6657. doi: 10.1038/onc.2017.274. Epub 2017 Aug 7.


Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation.

Airola MV, Shanbhogue P, Shamseddine AA, Guja KE, Senkal CE, Maini R, Bartke N, Wu BX, Obeid LM, Garcia-Diaz M, Hannun YA.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5549-E5558. doi: 10.1073/pnas.1705134114. Epub 2017 Jun 26.


Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase.

Bai A, Mao C, Jenkins RW, Szulc ZM, Bielawska A, Hannun YA.

PLoS One. 2017 Jun 14;12(6):e0177805. doi: 10.1371/journal.pone.0177805. eCollection 2017.


Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ.

J Lipid Res. 2017 Jul;58(7):1439-1452. doi: 10.1194/jlr.M076745. Epub 2017 May 10.


Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.

Pulkoski-Gross MJ, Uys JD, Orr-Gandy KA, Coant N, Bialkowska AB, Szulc ZM, Bai A, Bielawska A, Townsend DM, Hannun YA, Obeid LM, Snider AJ.

Prostaglandins Other Lipid Mediat. 2017 May;130:47-56. doi: 10.1016/j.prostaglandins.2017.03.006. Epub 2017 Apr 2.


Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets.

Senkal CE, Salama MF, Snider AJ, Allopenna JJ, Rana NA, Koller A, Hannun YA, Obeid LM.

Cell Metab. 2017 Mar 7;25(3):686-697. doi: 10.1016/j.cmet.2017.02.010.


Ceramidases, roles in sphingolipid metabolism and in health and disease.

Coant N, Sakamoto W, Mao C, Hannun YA.

Adv Biol Regul. 2017 Jan;63:122-131. doi: 10.1016/j.jbior.2016.10.002. Epub 2016 Oct 11. Review.


Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations.

Lu S, Cai C, Yan G, Zhou Z, Wan Y, Chen V, Chen L, Cooper GF, Obeid LM, Hannun YA, Lee AV, Lu X.

Cancer Res. 2016 Dec 1;76(23):6785-6794. Epub 2016 Oct 10.


Role of neutral ceramidase in colon cancer.

García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA.

FASEB J. 2016 Dec;30(12):4159-4171. Epub 2016 Sep 8.

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