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Immunotoxicity Considerations for Next Generation Cancer Nanomedicines.

Hannon G, Lysaght J, Liptrott NJ, Prina-Mello A.

Adv Sci (Weinh). 2019 Aug 1;6(19):1900133. doi: 10.1002/advs.201900133. eCollection 2019 Oct 2. Review.


Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.

Kneuss E, Munafò M, Eastwood EL, Deumer US, Preall JB, Hannon GJ, Czech B.

Genes Dev. 2019 Sep 1;33(17-18):1208-1220. doi: 10.1101/gad.328690.119. Epub 2019 Aug 15.


Genetic interactions of G-quadruplexes in humans.

Zyner KG, Mulhearn DS, Adhikari S, Martínez Cuesta S, Di Antonio M, Erard N, Hannon GJ, Tannahill D, Balasubramanian S.

Elife. 2019 Jul 9;8. pii: e46793. doi: 10.7554/eLife.46793.


piRNA-guided co-transcriptional silencing coopts nuclear export factors.

Fabry MH, Ciabrelli F, Munafò M, Eastwood EL, Kneuss E, Falciatori I, Falconio FA, Hannon GJ, Czech B.

Elife. 2019 Jun 20;8. pii: e47999. doi: 10.7554/eLife.47999.


Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery.

Munafò M, Manelli V, Falconio FA, Sawle A, Kneuss E, Eastwood EL, Seah JWE, Czech B, Hannon GJ.

Genes Dev. 2019 Jul 1;33(13-14):844-856. doi: 10.1101/gad.325662.119. Epub 2019 May 23.


lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation.

Delás MJ, Jackson BT, Kovacevic T, Vangelisti S, Munera Maravilla E, Wild SA, Stork EM, Erard N, Knott SRV, Hannon GJ.

Cell Rep. 2019 Apr 16;27(3):719-729.e6. doi: 10.1016/j.celrep.2019.03.080.


piRNA-Guided Genome Defense: From Biogenesis to Silencing.

Czech B, Munafò M, Ciabrelli F, Eastwood EL, Fabry MH, Kneuss E, Hannon GJ.

Annu Rev Genet. 2018 Nov 23;52:131-157. doi: 10.1146/annurev-genet-120417-031441. Review.


Corrigendum to "GoldCLIP: Gel-omitted Ligation-dependent CLIP" [Genomics Proteomics Bioinformatics 16 (2) (2018) 136-143].

Gu J, Wang M, Yang Y, Qiu D, Zhang Y, Ma J, Zhou Y, Hannon GJ, Yu Y.

Genomics Proteomics Bioinformatics. 2018 Jun;16(3):221-222. doi: 10.1016/j.gpb.2018.07.001. Epub 2018 Jul 20. No abstract available.


Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.

Sonzogni O, Haynes J, Seifried LA, Kamel YM, Huang K, BeGora MD, Yeung FA, Robert-Tissot C, Heng YJ, Yuan X, Wulf GM, Kron KJ, Wagenblast E, Lupien M, Kislinger T, Hannon GJ, Muthuswamy SK.

PLoS Biol. 2018 Jun 20;16(6):e2004049. doi: 10.1371/journal.pbio.2004049. eCollection 2018 Jun.


Mycobacterium immunogenum folliculitis on the lower extremities of a healthy young adult.

McNeil EP, Goldfarb N, Hannon GR, Miller DD, Farah RS.

Clin Exp Dermatol. 2019 Apr;44(3):328-330. doi: 10.1111/ced.13703. Epub 2018 Jun 19. No abstract available.


Corrigendum: Evolutionary expansion of DNA hypomethylation in the mammalian germline genome.

Qu J, Hodges E, Molaro A, Gagneux P, Dean MD, Hannon GJ, Smith AD.

Genome Res. 2018 May;28(5):766.2. doi: 10.1101/gr.236885.118. No abstract available.


GoldCLIP: Gel-omitted Ligation-dependent CLIP.

Gu J, Wang M, Yang Y, Qiu D, Zhang Y, Ma J, Zhou Y, Hannon GJ, Yu Y.

Genomics Proteomics Bioinformatics. 2018 Apr;16(2):136-143. doi: 10.1016/j.gpb.2018.04.003. Epub 2018 Apr 28. Erratum in: Genomics Proteomics Bioinformatics. 2018 Jul 20;:.


Erratum: Asparagine bioavailability governs metastasis in a model of breast cancer.

Knott SRV, Wagenblast E, Khan S, Kim SY, Soto M, Wagner M, Turgeon MO, Fish L, Erard N, Gable AL, Maceli AR, Dickopf S, Papachristou EK, D'Santos CS, Carey LA, Wilkinson JE, Harrell JC, Perou CM, Goodarzi H, Poulogiannis G, Hannon GJ.

Nature. 2018 Apr 4;556(7699):135. doi: 10.1038/nature26162.


Asparagine bioavailability governs metastasis in a model of breast cancer.

Knott SRV, Wagenblast E, Khan S, Kim SY, Soto M, Wagner M, Turgeon MO, Fish L, Erard N, Gable AL, Maceli AR, Dickopf S, Papachristou EK, D'Santos CS, Carey LA, Wilkinson JE, Harrell JC, Perou CM, Goodarzi H, Poulogiannis G, Hannon GJ.

Nature. 2018 Feb 15;554(7692):378-381. doi: 10.1038/nature25465. Epub 2018 Feb 7. Erratum in: Nature. 2018 Apr 4;556(7699):135.


COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.

Xie Y, Cao Z, Wong EW, Guan Y, Ma W, Zhang JQ, Walczak EG, Murphy D, Ran L, Sirota I, Wang S, Shukla S, Gao D, Knott SR, Chang K, Leu J, Wongvipat J, Antonescu CR, Hannon G, Chi P, Chen Y.

J Clin Invest. 2018 Apr 2;128(4):1442-1457. doi: 10.1172/JCI94840. Epub 2018 Mar 5.


Evolutionary expansion of DNA hypomethylation in the mammalian germline genome.

Qu J, Hodges E, Molaro A, Gagneux P, Dean MD, Hannon GJ, Smith AD.

Genome Res. 2018 Feb;28(2):145-158. doi: 10.1101/gr.225896.117. Epub 2017 Dec 19. Erratum in: Genome Res. 2018 May;28(5):766.2.


A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

Erard N, Knott SRV, Hannon GJ.

Mol Cell. 2017 Sep 21;67(6):1080. doi: 10.1016/j.molcel.2017.08.027. No abstract available.


Microcytosis is associated with low cognitive outcomes in healthy 2-year-olds in a high-resource setting.

McCarthy EK, Kiely ME, Hannon G, Ahearne C, Kenny LC, Hourihane JO, Irvine AD, Murray DM.

Br J Nutr. 2017 Sep;118(5):360-367. doi: 10.1017/S0007114517001945.


lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.

Delás MJ, Sabin LR, Dolzhenko E, Knott SR, Munera Maravilla E, Jackson BT, Wild SA, Kovacevic T, Stork EM, Zhou M, Erard N, Lee E, Kelley DR, Roth M, Barbosa IA, Zuber J, Rinn JL, Smith AD, Hannon GJ.

Elife. 2017 Sep 6;6. pii: e25607. doi: 10.7554/eLife.25607.


lncRNAs in development and disease: from functions to mechanisms.

Delás MJ, Hannon GJ.

Open Biol. 2017 Jul;7(7). pii: 170121. doi: 10.1098/rsob.170121. Review.


A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

Erard N, Knott SRV, Hannon GJ.

Mol Cell. 2017 Jul 20;67(2):348-354.e4. doi: 10.1016/j.molcel.2017.06.030. Erratum in: Mol Cell. 2017 Sep 21;67(6):1080.


A Model for Epigenetic Inhibition via Transvection in the Mouse.

Rodriguez JD, Myrick DA, Falciatori I, Christopher MA, Lee TW, Hannon GJ, Katz DJ.

Genetics. 2017 Sep;207(1):129-138. doi: 10.1534/genetics.117.201913. Epub 2017 Jul 10.


BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.

Frey WD, Chaudhry A, Slepicka PF, Ouellette AM, Kirberger SE, Pomerantz WCK, Hannon GJ, Dos Santos CO.

Stem Cell Reports. 2017 Jul 11;9(1):23-31. doi: 10.1016/j.stemcr.2017.04.031. Epub 2017 Jun 1.


Thin-for-gestational age infants are at increased risk of neurodevelopmental delay at 2 years.

O'Neill SM, Hannon G, Khashan AS, Hourihane JO, Kenny LC, Kiely M, Murray DM.

Arch Dis Child Fetal Neonatal Ed. 2017 May;102(3):F197-F202. doi: 10.1136/archdischild-2016-310791. Epub 2016 Oct 20.


The evolutionary and phylogeographic history of woolly mammoths: a comprehensive mitogenomic analysis.

Chang D, Knapp M, Enk J, Lippold S, Kircher M, Lister A, MacPhee RD, Widga C, Czechowski P, Sommer R, Hodges E, Stümpel N, Barnes I, Dalén L, Derevianko A, Germonpré M, Hillebrand-Voiculescu A, Constantin S, Kuznetsova T, Mol D, Rathgeber T, Rosendahl W, Tikhonov AN, Willerslev E, Hannon G, Lalueza-Fox C, Joger U, Poinar H, Hofreiter M, Shapiro B.

Sci Rep. 2017 Mar 22;7:44585. doi: 10.1038/srep44585.


TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

Pal D, Pertot A, Shirole NH, Yao Z, Anaparthy N, Garvin T, Cox H, Chang K, Rollins F, Kendall J, Edwards L, Singh VA, Stone GC, Schatz MC, Hicks J, Hannon GJ, Sordella R.

Elife. 2017 Jan 16;6. pii: e21615. doi: 10.7554/eLife.21615.


Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

McFadden DG, Politi K, Bhutkar A, Chen FK, Song X, Pirun M, Santiago PM, Kim-Kiselak C, Platt JT, Lee E, Hodges E, Rosebrock AP, Bronson RT, Socci ND, Hannon GJ, Jacks T, Varmus H.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6409-E6417. Epub 2016 Oct 4.


Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.

Fagegaltier D, Falciatori I, Czech B, Castel S, Perrimon N, Simcox A, Hannon GJ.

Genes Dev. 2016 Jul 15;30(14):1623-35. doi: 10.1101/gad.284927.116.


A Happy 3' Ending to the piRNA Maturation Story.

Czech B, Hannon GJ.

Cell. 2016 Feb 25;164(5):838-40. doi: 10.1016/j.cell.2016.02.012.


One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing.

Czech B, Hannon GJ.

Trends Biochem Sci. 2016 Apr;41(4):324-337. doi: 10.1016/j.tibs.2015.12.008. Epub 2016 Jan 19. Review.


Inducing RNAi in Caenorhabditis elegans by Injection of dsRNA.

Hammell CM, Hannon GJ.

Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.prot086306. doi: 10.1101/pdb.prot086306.


Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation.

Sanchez CG, Teixeira FK, Czech B, Preall JB, Zamparini AL, Seifert JR, Malone CD, Hannon GJ, Lehmann R.

Cell Stem Cell. 2016 Feb 4;18(2):276-90. doi: 10.1016/j.stem.2015.11.004. Epub 2015 Dec 6.


Panoramix enforces piRNA-dependent cotranscriptional silencing.

Yu Y, Gu J, Jin Y, Luo Y, Preall JB, Ma J, Czech B, Hannon GJ.

Science. 2015 Oct 16;350(6258):339-42. doi: 10.1126/science.aab0700.


Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

Dequéant ML, Fagegaltier D, Hu Y, Spirohn K, Simcox A, Hannon GJ, Perrimon N.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12974-9. doi: 10.1073/pnas.1517729112. Epub 2015 Oct 5. Erratum in: Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6408.


Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.

Wasik K, Gurtowski J, Zhou X, Ramos OM, Delás MJ, Battistoni G, El Demerdash O, Falciatori I, Vizoso DB, Smith AD, Ladurner P, Schärer L, McCombie WR, Hannon GJ, Schatz M.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12462-7. doi: 10.1073/pnas.1516718112. Epub 2015 Sep 21.


Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano.

Zhou X, Battistoni G, El Demerdash O, Gurtowski J, Wunderer J, Falciatori I, Ladurner P, Schatz MC, Hannon GJ, Wasik KA.

RNA. 2015 Nov;21(11):1885-97. doi: 10.1261/rna.052456.115. Epub 2015 Aug 31.


The Transgenic RNAi Project at Harvard Medical School: Resources and Validation.

Perkins LA, Holderbaum L, Tao R, Hu Y, Sopko R, McCall K, Yang-Zhou D, Flockhart I, Binari R, Shim HS, Miller A, Housden A, Foos M, Randkelv S, Kelley C, Namgyal P, Villalta C, Liu LP, Jiang X, Huan-Huan Q, Wang X, Fujiyama A, Toyoda A, Ayers K, Blum A, Czech B, Neumuller R, Yan D, Cavallaro A, Hibbard K, Hall D, Cooley L, Hannon GJ, Lehmann R, Parks A, Mohr SE, Ueda R, Kondo S, Ni JQ, Perrimon N.

Genetics. 2015 Nov;201(3):843-52. doi: 10.1534/genetics.115.180208. Epub 2015 Aug 28.


Positive parenting: a randomised controlled trial evaluation of the Parents Plus Adolescent Programme in schools.

Nitsch E, Hannon G, Rickard E, Houghton S, Sharry J.

Child Adolesc Psychiatry Ment Health. 2015 Aug 25;9:43. doi: 10.1186/s13034-015-0077-0. eCollection 2015.


RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.

Wasik KA, Tam OH, Knott SR, Falciatori I, Hammell M, Vagin VV, Hannon GJ.

Genes Dev. 2015 Jul 1;29(13):1403-15. doi: 10.1101/gad.265215.115. Epub 2015 Jun 26.


piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis.

Goh WS, Falciatori I, Tam OH, Burgess R, Meikar O, Kotaja N, Hammell M, Hannon GJ.

Genes Dev. 2015 May 15;29(10):1032-44. doi: 10.1101/gad.260455.115.


An epigenetic memory of pregnancy in the mouse mammary gland.

Dos Santos CO, Dolzhenko E, Hodges E, Smith AD, Hannon GJ.

Cell Rep. 2015 May 19;11(7):1102-9. doi: 10.1016/j.celrep.2015.04.015. Epub 2015 May 7.


ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation.

Teixeira FK, Sanchez CG, Hurd TR, Seifert JR, Czech B, Preall JB, Hannon GJ, Lehmann R.

Nat Cell Biol. 2015 May;17(5):689-96. doi: 10.1038/ncb3165. Epub 2015 Apr 27.


A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.

Wagenblast E, Soto M, Gutiérrez-Ángel S, Hartl CA, Gable AL, Maceli AR, Erard N, Williams AM, Kim SY, Dickopf S, Harrell JC, Smith AD, Perou CM, Wilkinson JE, Hannon GJ, Knott SR.

Nature. 2015 Apr 16;520(7547):358-62. doi: 10.1038/nature14403. Epub 2015 Apr 8.


Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified.

Marinov GK, Wang J, Handler D, Wold BJ, Weng Z, Hannon GJ, Aravin AA, Zamore PD, Brennecke J, Toth KF.

Dev Cell. 2015 Mar 23;32(6):765-71. doi: 10.1016/j.devcel.2015.01.013.


Essential Role for endogenous siRNAs during meiosis in mouse oocytes.

Stein P, Rozhkov NV, Li F, Cárdenas FL, Davydenko O, Vandivier LE, Gregory BD, Hannon GJ, Schultz RM.

PLoS Genet. 2015 Feb 19;11(2):e1005013. doi: 10.1371/journal.pgen.1005013. eCollection 2015 Feb. Erratum in: PLoS Genet. 2015 Apr;11(4):e1005129.


Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil.

Malaspinas AS, Lao O, Schroeder H, Rasmussen M, Raghavan M, Moltke I, Campos PF, Sagredo FS, Rasmussen S, Gonçalves VF, Albrechtsen A, Allentoft ME, Johnson PL, Li M, Reis S, Bernardo DV, DeGiorgio M, Duggan AT, Bastos M, Wang Y, Stenderup J, Moreno-Mayar JV, Brunak S, Sicheritz-Ponten T, Hodges E, Hannon GJ, Orlando L, Price TD, Jensen JD, Nielsen R, Heinemeier J, Olsen J, Rodrigues-Carvalho C, Lahr MM, Neves WA, Kayser M, Higham T, Stoneking M, Pena SD, Willerslev E.

Curr Biol. 2014 Nov 3;24(21):R1035-7. doi: 10.1016/j.cub.2014.09.078. Epub 2014 Oct 23.


A computational algorithm to predict shRNA potency.

Knott SRV, Maceli A, Erard N, Chang K, Marran K, Zhou X, Gordon A, Demerdash OE, Wagenblast E, Kim S, Fellmann C, Hannon GJ.

Mol Cell. 2014 Dec 18;56(6):796-807. doi: 10.1016/j.molcel.2014.10.025. Epub 2014 Nov 26.


MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development.

Deng L, Shang L, Bai S, Chen J, He X, Martin-Trevino R, Chen S, Li XY, Meng X, Yu B, Wang X, Liu Y, McDermott SP, Ariazi AE, Ginestier C, Ibarra I, Ke J, Luther T, Clouthier SG, Xu L, Shan G, Song E, Yao H, Hannon GJ, Weiss SJ, Wicha MS, Liu S.

Cancer Res. 2014 Nov 15;74(22):6648-60. doi: 10.1158/0008-5472.CAN-13-3710. Epub 2014 Sep 12.


Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.

Yang M, Haase AD, Huang FK, Coulis G, Rivera KD, Dickinson BC, Chang CJ, Pappin DJ, Neubert TA, Hannon GJ, Boivin B, Tonks NK.

Mol Cell. 2014 Sep 4;55(5):782-90. doi: 10.1016/j.molcel.2014.07.018. Epub 2014 Aug 28.


A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity.

Fagegaltier D, König A, Gordon A, Lai EC, Gingeras TR, Hannon GJ, Shcherbata HR.

Genetics. 2014 Oct;198(2):647-68. doi: 10.1534/genetics.114.169268. Epub 2014 Jul 31.

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