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Items: 1 to 50 of 109

1.

Migration of Small Ribosomal Subunits on the 5' Untranslated Regions of Capped Messenger RNA.

Shirokikh NE, Dutikova YS, Staroverova MA, Hannan RD, Preiss T.

Int J Mol Sci. 2019 Sep 10;20(18). pii: E4464. doi: 10.3390/ijms20184464.

2.

A functional genetic screen defines the AKT-induced senescence signaling network.

Chan KT, Blake S, Zhu H, Kang J, Trigos AS, Madhamshettiwar PB, Diesch J, Paavolainen L, Horvath P, Hannan RD, George AJ, Sanij E, Hannan KM, Simpson KJ, Pearson RB.

Cell Death Differ. 2019 Jul 8. doi: 10.1038/s41418-019-0384-8. [Epub ahead of print]

PMID:
31285545
3.

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.

Khot A, Brajanovski N, Cameron DP, Hein N, Maclachlan KH, Sanij E, Lim J, Soong J, Link E, Blombery P, Thompson ER, Fellowes A, Sheppard KE, McArthur GA, Pearson RB, Hannan RD, Poortinga G, Harrison SJ.

Cancer Discov. 2019 Aug;9(8):1036-1049. doi: 10.1158/2159-8290.CD-18-1455. Epub 2019 May 15.

PMID:
31092402
4.

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.

Diesch J, Bywater MJ, Sanij E, Cameron DP, Schierding W, Brajanovski N, Son J, Sornkom J, Hein N, Evers M, Pearson RB, McArthur GA, Ganley ARD, O'Sullivan JM, Hannan RD, Poortinga G.

Commun Biol. 2019 Jan 28;2:39. doi: 10.1038/s42003-019-0284-y. eCollection 2019.

5.

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.

Somers K, Wen VW, Middlemiss SMC, Osborne B, Forgham H, Jung M, Karsa M, Clifton M, Bongers A, Gao J, Mayoh C, Raoufi-Rad N, Kusnadi EP, Hannan KM, Scott DA, Kwek A, Liu B, Flemming C, Chudakova DA, Pandher R, Failes TW, Lim J, Angeli A, Osterman AL, Imamura T, Kees UR, Supuran CT, Pearson RB, Hannan RD, Davis TP, McCarroll J, Kavallaris M, Turner N, Gudkov AV, Haber M, Norris MD, Henderson MJ.

Oncogene. 2019 May;38(20):3824-3842. doi: 10.1038/s41388-018-0666-5. Epub 2019 Jan 22.

PMID:
30670779
6.

High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology.

He JS, Soo P, Evers M, Parsons KM, Hein N, Hannan KM, Hannan RD, George AJ.

Assay Drug Dev Technol. 2018 Aug/Sep;16(6):320-332. doi: 10.1089/adt.2018.861.

PMID:
30148664
7.

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy.

Lawrence MG, Obinata D, Sandhu S, Selth LA, Wong SQ, Porter LH, Lister N, Pook D, Pezaro CJ, Goode DL, Rebello RJ, Clark AK, Papargiris M, Van Gramberg J, Hanson AR, Banks P, Wang H, Niranjan B, Keerthikumar S, Hedwards S, Huglo A, Yang R, Henzler C, Li Y, Lopez-Campos F, Castro E, Toivanen R, Azad A, Bolton D, Goad J, Grummet J, Harewood L, Kourambas J, Lawrentschuk N, Moon D, Murphy DG, Sengupta S, Snow R, Thorne H, Mitchell C, Pedersen J, Clouston D, Norden S, Ryan A, Dehm SM, Tilley WD, Pearson RB, Hannan RD, Frydenberg M, Furic L, Taylor RA, Risbridger GP.

Eur Urol. 2018 Nov;74(5):562-572. doi: 10.1016/j.eururo.2018.06.020. Epub 2018 Jul 23.

PMID:
30049486
8.

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers.

Udugama M, Sanij E, Voon HPJ, Son J, Hii L, Henson JD, Chan FL, Chang FTM, Liu Y, Pearson RB, Kalitsis P, Mann JR, Collas P, Hannan RD, Wong LH.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4737-4742. doi: 10.1073/pnas.1720391115. Epub 2018 Apr 18.

9.

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance.

Martin CA, Cullinane C, Kirby L, Abuhammad S, Lelliott EJ, Waldeck K, Young RJ, Brajanovski N, Cameron DP, Walker R, Sanij E, Poortinga G, Hannan RD, Pearson RB, Hicks RJ, McArthur GA, Sheppard KE.

Int J Cancer. 2018 May 15;142(10):2139-2152. doi: 10.1002/ijc.31220. Epub 2018 Jan 3.

10.

Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan anemia patient.

Venugopal P, Moore S, Lawrence DM, George AJ, Hannan RD, Bray SC, To LB, D'Andrea RJ, Feng J, Tirimacco A, Yeoman AL, Young CC, Fine M, Schreiber AW, Hahn CN, Barnett C, Saxon B, Scott HS.

Haematologica. 2017 Dec;102(12):e506-e509. doi: 10.3324/haematol.2017.166678. Epub 2017 Sep 29. No abstract available.

11.

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.

Moily NS, Ormsby AR, Stojilovic A, Ramdzan YM, Diesch J, Hannan RD, Zajac MS, Hannan AJ, Oshlack A, Hatters DM.

Mol Cell Neurosci. 2017 Sep;83:103-112. doi: 10.1016/j.mcn.2017.07.004. Epub 2017 Jul 23.

PMID:
28743452
12.

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.

Hein N, Cameron DP, Hannan KM, Nguyen NN, Fong CY, Sornkom J, Wall M, Pavy M, Cullinane C, Diesch J, Devlin JR, George AJ, Sanij E, Quin J, Poortinga G, Verbrugge I, Baker A, Drygin D, Harrison SJ, Rozario JD, Powell JA, Pitson SM, Zuber J, Johnstone RW, Dawson MA, Guthridge MA, Wei A, McArthur GA, Pearson RB, Hannan RD.

Blood. 2017 May 25;129(21):2882-2895. doi: 10.1182/blood-2016-05-718171. Epub 2017 Mar 10.

13.

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.

Kerry LE, Pegg EE, Cameron DP, Budzak J, Poortinga G, Hannan KM, Hannan RD, Rudenko G.

PLoS Negl Trop Dis. 2017 Mar 6;11(3):e0005432. doi: 10.1371/journal.pntd.0005432. eCollection 2017 Mar.

14.

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene.

Lefebure M, Tothill RW, Kruse E, Hawkins ED, Shortt J, Matthews GM, Gregory GP, Martin BP, Kelly MJ, Todorovski I, Doyle MA, Lupat R, Li J, Schroeder J, Wall M, Craig S, Poortinga G, Cameron D, Bywater M, Kats L, Gearhart MD, Bardwell VJ, Dickins RA, Hannan RD, Papenfuss AT, Johnstone RW.

Nat Commun. 2017 Mar 6;8:14581. doi: 10.1038/ncomms14581.

15.

Therapeutic Approaches Targeting MYC-Driven Prostate Cancer.

Rebello RJ, Pearson RB, Hannan RD, Furic L.

Genes (Basel). 2017 Feb 16;8(2). pii: E71. doi: 10.3390/genes8020071. Review.

16.

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.

Yan S, Frank D, Son J, Hannan KM, Hannan RD, Chan KT, Pearson RB, Sanij E.

Int J Mol Sci. 2017 Jan 20;18(1). pii: E210. doi: 10.3390/ijms18010210. Review.

17.

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription.

Hung SS, Lesmana A, Peck A, Lee R, Tchoubrieva E, Hannan KM, Lin J, Sheppard KE, Jastrzebski K, Quinn LM, Rothblum LI, Pearson RB, Hannan RD, Sanij E.

Gene. 2017 May 15;612:36-48. doi: 10.1016/j.gene.2016.12.015. Epub 2016 Dec 15.

PMID:
27989772
18.

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies.

Colebatch AJ, Di Stefano L, Wong SQ, Hannan RD, Waring PM, Dobrovic A, McArthur GA, Papenfuss AT.

Oncotarget. 2016 Oct 11;7(41):66569-66585. doi: 10.18632/oncotarget.11892.

19.

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.

Chan KT, Paavolainen L, Hannan KM, George AJ, Hannan RD, Simpson KJ, Horvath P, Pearson RB.

Assay Drug Dev Technol. 2016 Sep;14(7):416-28. doi: 10.1089/adt.2016.739.

PMID:
27552145
20.

The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer.

Rebello RJ, Kusnadi E, Cameron DP, Pearson HB, Lesmana A, Devlin JR, Drygin D, Clark AK, Porter L, Pedersen J, Sandhu S, Risbridger GP, Pearson RB, Hannan RD, Furic L.

Clin Cancer Res. 2016 Nov 15;22(22):5539-5552. doi: 10.1158/1078-0432.CCR-16-0124. Epub 2016 Aug 2.

21.

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.

Quin J, Chan KT, Devlin JR, Cameron DP, Diesch J, Cullinane C, Ahern J, Khot A, Hein N, George AJ, Hannan KM, Poortinga G, Sheppard KE, Khanna KK, Johnstone RW, Drygin D, McArthur GA, Pearson RB, Sanij E, Hannan RD.

Oncotarget. 2016 Aug 2;7(31):49800-49818. doi: 10.18632/oncotarget.10452.

22.

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription.

Kang J, Kusnadi EP, Ogden AJ, Hicks RJ, Bammert L, Kutay U, Hung S, Sanij E, Hannan RD, Hannan KM, Pearson RB.

Oncotarget. 2016 Aug 2;7(31):48887-48904. doi: 10.18632/oncotarget.10346.

23.

Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth.

Guo L, Zaysteva O, Nie Z, Mitchell NC, Amanda Lee JE, Ware T, Parsons L, Luwor R, Poortinga G, Hannan RD, Levens DL, Quinn LM.

Nucleic Acids Res. 2016 Sep 19;44(16):7646-58. doi: 10.1093/nar/gkw461. Epub 2016 May 20.

24.

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.

Devlin JR, Hannan KM, Hein N, Cullinane C, Kusnadi E, Ng PY, George AJ, Shortt J, Bywater MJ, Poortinga G, Sanij E, Kang J, Drygin D, O'Brien S, Johnstone RW, McArthur GA, Hannan RD, Pearson RB.

Cancer Discov. 2016 Jan;6(1):59-70. doi: 10.1158/2159-8290.CD-14-0673. Epub 2015 Oct 21.

25.

Genome wide mapping of UBF binding-sites in mouse and human cell lines.

Diesch J, Hannan RD, Sanij E.

Genom Data. 2015 Jan 5;3:103-5. doi: 10.1016/j.gdata.2014.12.005. eCollection 2015 Mar.

26.

Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.

Sjögren SE, Siva K, Soneji S, George AJ, Winkler M, Jaako P, Wlodarski M, Karlsson S, Hannan RD, Flygare J.

Br J Haematol. 2015 Nov;171(4):517-29. doi: 10.1111/bjh.13632. Epub 2015 Aug 25.

27.

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila.

Mitchell NC, Tchoubrieva EB, Chahal A, Woods S, Lee A, Lin JI, Parsons L, Jastrzebski K, Poortinga G, Hannan KM, Pearson RB, Hannan RD, Quinn LM.

Cell Signal. 2015 Oct;27(10):2045-53. doi: 10.1016/j.cellsig.2015.07.018. Epub 2015 Jul 26.

PMID:
26215099
28.

Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.

Lee JE, Mitchell NC, Zaytseva O, Chahal A, Mendis P, Cartier-Michaud A, Parsons LM, Poortinga G, Levens DL, Hannan RD, Quinn LM.

Nat Commun. 2015 Jun 15;6:7404. doi: 10.1038/ncomms8404.

PMID:
26074141
29.

Unexpected role of CDK4 in a G2/M checkpoint.

Sheppard KE, Pearson RB, Hannan RD.

Cell Cycle. 2015;14(9):1351-2. doi: 10.1080/15384101.2015.1022060. No abstract available.

30.

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity.

Gilan O, Diesch J, Amalia M, Jastrzebski K, Chueh AC, Verrills NM, Pearson RB, Mariadason JM, Tulchinsky E, Hannan RD, Dhillon AS.

Oncogene. 2015 Mar 5;34(10):1340. doi: 10.1038/onc.2014.460. No abstract available.

PMID:
25740609
31.

Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer.

Pereira L, Mariadason JM, Hannan RD, Dhillon AS.

Front Oncol. 2015 Feb 2;5:13. doi: 10.3389/fonc.2015.00013. eCollection 2015. Review.

32.

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.

Woods SJ, Hannan KM, Pearson RB, Hannan RD.

Biochim Biophys Acta. 2015 Jul;1849(7):821-9. doi: 10.1016/j.bbagrm.2014.10.007. Epub 2014 Nov 11. Review.

PMID:
25464032
33.

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.

Sanij E, Diesch J, Lesmana A, Poortinga G, Hein N, Lidgerwood G, Cameron DP, Ellul J, Goodall GJ, Wong LH, Dhillon AS, Hamdane N, Rothblum LI, Pearson RB, Haviv I, Moss T, Hannan RD.

Genome Res. 2015 Feb;25(2):201-12. doi: 10.1101/gr.176115.114. Epub 2014 Dec 1.

34.

Regulation of rDNA transcription in response to growth factors, nutrients and energy.

Kusnadi EP, Hannan KM, Hicks RJ, Hannan RD, Pearson RB, Kang J.

Gene. 2015 Feb 1;556(1):27-34. doi: 10.1016/j.gene.2014.11.010. Epub 2014 Nov 8. Review.

PMID:
25447905
35.

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells.

Diesch J, Sanij E, Gilan O, Love C, Tran H, Fleming NI, Ellul J, Amalia M, Haviv I, Pearson RB, Tulchinsky E, Mariadason JM, Sieber OM, Hannan RD, Dhillon AS.

PLoS One. 2014 Mar 21;9(3):e88950. doi: 10.1371/journal.pone.0088950. eCollection 2014.

36.

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity.

Gilan O, Diesch J, Amalia M, Jastrzebski K, Chueh AC, Verrills NM, Pearson RB, Mariadason JM, Tulchinsky E, Hannan RD, Dhillon AS.

Oncogene. 2015 Mar 5;34(10):1333-9. doi: 10.1038/onc.2014.26. Epub 2014 Mar 17. Erratum in: Oncogene. 2015 Mar 5;34(10):1340.

PMID:
24632621
37.

Targeting RNA polymerase I to treat MYC-driven cancer.

Poortinga G, Quinn LM, Hannan RD.

Oncogene. 2015 Jan 22;34(4):403-12. doi: 10.1038/onc.2014.13. Epub 2014 Mar 10. Review.

PMID:
24608428
38.

Targeting the nucleolus for cancer intervention.

Quin JE, Devlin JR, Cameron D, Hannan KM, Pearson RB, Hannan RD.

Biochim Biophys Acta. 2014 Jun;1842(6):802-16. doi: 10.1016/j.bbadis.2013.12.009. Epub 2014 Jan 2. Review.

39.

Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease.

Diesch J, Hannan RD, Sanij E.

Cell Biosci. 2014 Aug 19;4:43. doi: 10.1186/2045-3701-4-43. eCollection 2014. Review.

40.

A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation.

George AJ, Purdue BW, Gould CM, Thomas DW, Handoko Y, Qian H, Quaife-Ryan GA, Morgan KA, Simpson KJ, Thomas WG, Hannan RD.

J Cell Sci. 2013 Dec 1;126(Pt 23):5377-90. doi: 10.1242/jcs.128280. Epub 2013 Sep 17.

41.

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors.

Sheppard KE, Cullinane C, Hannan KM, Wall M, Chan J, Barber F, Foo J, Cameron D, Neilsen A, Ng P, Ellul J, Kleinschmidt M, Kinross KM, Bowtell DD, Christensen JG, Hicks RJ, Johnstone RW, McArthur GA, Hannan RD, Phillips WA, Pearson RB.

Eur J Cancer. 2013 Dec;49(18):3936-44. doi: 10.1016/j.ejca.2013.08.007. Epub 2013 Sep 3.

PMID:
24011934
42.

AKT-independent PI3-K signaling in cancer - emerging role for SGK3.

Bruhn MA, Pearson RB, Hannan RD, Sheppard KE.

Cancer Manag Res. 2013 Aug 26;5:281-92. doi: 10.2147/CMAR.S35178. eCollection 2013. Review.

43.

Targeting the nucleolus for cancer-specific activation of p53.

Drygin D, O'Brien SE, Hannan RD, McArthur GA, Von Hoff DD.

Drug Discov Today. 2014 Mar;19(3):259-65. doi: 10.1016/j.drudis.2013.08.012. Epub 2013 Aug 28. Review.

PMID:
23993916
44.

Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches.

George AJ, Hannan RD, Thomas WG.

FEBS J. 2013 Nov;280(21):5258-68. doi: 10.1111/febs.12509. Epub 2013 Sep 23. Review.

45.

The nucleolus: an emerging target for cancer therapy.

Hein N, Hannan KM, George AJ, Sanij E, Hannan RD.

Trends Mol Med. 2013 Nov;19(11):643-54. doi: 10.1016/j.molmed.2013.07.005. Epub 2013 Aug 15. Review.

PMID:
23953479
46.

Targeting RNA polymerase I transcription and the nucleolus for cancer therapy.

Hannan RD, Drygin D, Pearson RB.

Expert Opin Ther Targets. 2013 Aug;17(8):873-8. doi: 10.1517/14728222.2013.818658.

PMID:
23862680
47.

A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling.

Chen YC, Bui AV, Diesch J, Manasseh R, Hausding C, Rivera J, Haviv I, Agrotis A, Htun NM, Jowett J, Hagemeyer CE, Hannan RD, Bobik A, Peter K.

Circ Res. 2013 Jul 19;113(3):252-65. doi: 10.1161/CIRCRESAHA.113.301562. Epub 2013 Jun 7.

PMID:
23748430
48.

Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart.

Foster SR, Porrello ER, Purdue B, Chan HW, Voigt A, Frenzel S, Hannan RD, Moritz KM, Simmons DG, Molenaar P, Roura E, Boehm U, Meyerhof W, Thomas WG.

PLoS One. 2013 May 15;8(5):e64579. doi: 10.1371/journal.pone.0064579. Print 2013.

49.

Dysregulation of the basal RNA polymerase transcription apparatus in cancer.

Bywater MJ, Pearson RB, McArthur GA, Hannan RD.

Nat Rev Cancer. 2013 May;13(5):299-314. doi: 10.1038/nrc3496. Review.

PMID:
23612459
50.

Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis.

Boglev Y, Badrock AP, Trotter AJ, Du Q, Richardson EJ, Parslow AC, Markmiller SJ, Hall NE, de Jong-Curtain TA, Ng AY, Verkade H, Ober EA, Field HA, Shin D, Shin CH, Hannan KM, Hannan RD, Pearson RB, Kim SH, Ess KC, Lieschke GJ, Stainier DY, Heath JK.

PLoS Genet. 2013;9(2):e1003279. doi: 10.1371/journal.pgen.1003279. Epub 2013 Feb 7.

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