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Items: 21

1.

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.

Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L.

J Hepatol. 2018 Oct;69(4):851-860. doi: 10.1016/j.jhep.2018.05.028. Epub 2018 Jun 5.

2.

Intestinal organoids for modelling intestinal development and disease.

Fair KL, Colquhoun J, Hannan NRF.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170217. doi: 10.1098/rstb.2017.0217. Review.

3.

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images.

Ramsawhook AH, Lewis LC, Eleftheriou M, Abakir A, Durczak P, Markus R, Rajani S, Hannan NRF, Coyle B, Ruzov A.

J Vis Exp. 2017 Sep 7;(127). doi: 10.3791/56318.

4.

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL 3rd, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb-Parsy K, Vallier L.

Nat Med. 2017 Aug;23(8):954-963. doi: 10.1038/nm.4360. Epub 2017 Jul 3.

5.

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.

Sampaziotis F, de Brito MC, Geti I, Bertero A, Hannan NR, Vallier L.

Nat Protoc. 2017 Apr;12(4):814-827. doi: 10.1038/nprot.2017.011. Epub 2017 Mar 23.

6.

Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification.

Lewis LC, Lo PC, Foster JM, Dai N, Corrêa IR, Durczak PM, Duncan G, Ramsawhook A, Aithal GP, Denning C, Hannan NR, Ruzov A.

Epigenetics. 2017 Apr 3;12(4):277-286. doi: 10.1080/15592294.2017.1292189. Epub 2017 Mar 7.

7.

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs.

Bertero A, Pawlowski M, Ortmann D, Snijders K, Yiangou L, Cardoso de Brito M, Brown S, Bernard WG, Cooper JD, Giacomelli E, Gambardella L, Hannan NR, Iyer D, Sampaziotis F, Serrano F, Zonneveld MC, Sinha S, Kotter M, Vallier L.

Development. 2016 Dec 1;143(23):4405-4418.

8.

Generation of Hepatocytes from Pluripotent Stem Cells for Drug Screening and Developmental Modeling.

Gieseck RL 3rd, Vallier L, Hannan NR.

Methods Mol Biol. 2015;1250:123-42. doi: 10.1007/978-1-4939-2074-7_9.

PMID:
26272139
9.

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation.

Sampaziotis F, de Brito MC, Madrigal P, Bertero A, Saeb-Parsy K, Soares FAC, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WT, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L.

Nat Biotechnol. 2015 Aug;33(8):845-852. doi: 10.1038/nbt.3275. Epub 2015 Jul 13.

10.

Generation of Distal Airway Epithelium from Multipotent Human Foregut Stem Cells.

Hannan NR, Sampaziotis F, Segeritz CP, Hanley NA, Vallier L.

Stem Cells Dev. 2015 Jul 15;24(14):1680-90. doi: 10.1089/scd.2014.0512. Epub 2015 Apr 15.

11.

Disease modeling using human induced pluripotent stem cells: lessons from the liver.

Gieseck RL 3rd, Colquhoun J, Hannan NR.

Biochim Biophys Acta. 2015 Jan;1851(1):76-89. doi: 10.1016/j.bbalip.2014.05.010. Epub 2014 Jun 2. Review.

12.

Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture.

Gieseck RL 3rd, Hannan NR, Bort R, Hanley NA, Drake RA, Cameron GW, Wynn TA, Vallier L.

PLoS One. 2014 Jan 22;9(1):e86372. doi: 10.1371/journal.pone.0086372. eCollection 2014.

13.

Generation of multipotent foregut stem cells from human pluripotent stem cells.

Hannan NR, Fordham RP, Syed YA, Moignard V, Berry A, Bautista R, Hanley NA, Jensen KB, Vallier L.

Stem Cell Reports. 2013 Oct 10;1(4):293-306. doi: 10.1016/j.stemcr.2013.09.003. eCollection 2013.

14.

Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury.

Fordham RP, Yui S, Hannan NR, Soendergaard C, Madgwick A, Schweiger PJ, Nielsen OH, Vallier L, Pedersen RA, Nakamura T, Watanabe M, Jensen KB.

Cell Stem Cell. 2013 Dec 5;13(6):734-44. doi: 10.1016/j.stem.2013.09.015. Epub 2013 Oct 17.

15.

Production of hepatocyte-like cells from human pluripotent stem cells.

Hannan NR, Segeritz CP, Touboul T, Vallier L.

Nat Protoc. 2013 Feb;8(2):430-7.

16.

Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells.

Cho CH, Hannan NR, Docherty FM, Docherty HM, Joåo Lima M, Trotter MW, Docherty K, Vallier L.

Diabetologia. 2012 Dec;55(12):3284-95. doi: 10.1007/s00125-012-2687-x. Epub 2012 Sep 26.

17.

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells.

Yusa K, Rashid ST, Strick-Marchand H, Varela I, Liu PQ, Paschon DE, Miranda E, Ordóñez A, Hannan NR, Rouhani FJ, Darche S, Alexander G, Marciniak SJ, Fusaki N, Hasegawa M, Holmes MC, Di Santo JP, Lomas DA, Bradley A, Vallier L.

Nature. 2011 Oct 12;478(7369):391-4. doi: 10.1038/nature10424.

18.

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development.

Touboul T, Hannan NR, Corbineau S, Martinez A, Martinet C, Branchereau S, Mainot S, Strick-Marchand H, Pedersen R, Di Santo J, Weber A, Vallier L.

Hepatology. 2010 May;51(5):1754-65. doi: 10.1002/hep.23506. Erratum in: Hepatology. 2010 Jul;52(1):402.

PMID:
20301097
19.

BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures.

Hannan NR, Jamshidi P, Pera MF, Wolvetang EJ.

Cloning Stem Cells. 2009 Sep;11(3):427-35. doi: 10.1089/clo.2009.0024.

PMID:
19751112
20.

Adipocyte differentiation in human embryonic stem cells transduced with Oct4 shRNA lentivirus.

Hannan NR, Wolvetang EJ.

Stem Cells Dev. 2009 May;18(4):653-60. doi: 10.1089/scd.2008.0160.

PMID:
18764734
21.

Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells.

Gao Y, Hannan NR, Wanyonyi S, Konstantopolous N, Pagnon J, Feng HC, Jowett JB, Kim KH, Walder K, Collier GR.

Cytokine. 2006 Mar 7;33(5):246-51. Epub 2006 Mar 30.

PMID:
16574427

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