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Mining iron: anthrax and heme.

Hanna PC.

Mol Microbiol. 2019 Aug 9. doi: 10.1111/mmi.14363. [Epub ahead of print] No abstract available.


Petrobactin Protects against Oxidative Stress and Enhances Sporulation Efficiency in Bacillus anthracis Sterne.

Hagan AK, Plotnick YM, Dingle RE, Mendel ZI, Cendrowski SR, Sherman DH, Tripathi A, Hanna PC.

MBio. 2018 Nov 6;9(6). pii: e02079-18. doi: 10.1128/mBio.02079-18.


Germinant Synergy Facilitates Clostridium difficile Spore Germination under Physiological Conditions.

Kochan TJ, Shoshiev MS, Hastie JL, Somers MJ, Plotnick YM, Gutierrez-Munoz DF, Foss ED, Schubert AM, Smith AD, Zimmerman SK, Carlson PE Jr, Hanna PC.

mSphere. 2018 Sep 5;3(5). pii: e00335-18. doi: 10.1128/mSphere.00335-18.


Updates to Clostridium difficile Spore Germination.

Kochan TJ, Foley MH, Shoshiev MS, Somers MJ, Carlson PE, Hanna PC.

J Bacteriol. 2018 Jul 25;200(16). pii: e00218-18. doi: 10.1128/JB.00218-18. Print 2018 Aug 15. Review.


Transcriptional response of Clostridium difficile to low iron conditions.

Hastie JL, Hanna PC, Carlson PE.

Pathog Dis. 2018 Mar 1;76(2). doi: 10.1093/femspd/fty009.


Erratum for Hagan et al., "Petrobactin Is Exported from Bacillus anthracis by the RND-Type Exporter ApeX".

Hagan AK, Tripathi A, Berger D, Sherman DH, Hanna PC.

MBio. 2017 Oct 17;8(5). pii: e01686-17. doi: 10.1128/mBio.01686-17. No abstract available.


Petrobactin Is Exported from Bacillus anthracis by the RND-Type Exporter ApeX.

Hagan AK, Tripathi A, Berger D, Sherman DH, Hanna PC.

MBio. 2017 Sep 12;8(5). pii: e01238-17. doi: 10.1128/mBio.01238-17. Erratum in: MBio. 2017 Oct 17;8(5):.


Intestinal calcium and bile salts facilitate germination of Clostridium difficile spores.

Kochan TJ, Somers MJ, Kaiser AM, Shoshiev MS, Hagan AK, Hastie JL, Giordano NP, Smith AD, Schubert AM, Carlson PE Jr, Hanna PC.

PLoS Pathog. 2017 Jul 13;13(7):e1006443. doi: 10.1371/journal.ppat.1006443. eCollection 2017 Jul. Erratum in: PLoS Pathog. 2017 Sep 7;13(9):e1006605.


Flying under the radar: The non-canonical biochemistry and molecular biology of petrobactin from Bacillus anthracis.

Hagan AK, Carlson PE Jr, Hanna PC.

Mol Microbiol. 2016 Oct;102(2):196-206. doi: 10.1111/mmi.13465. Epub 2016 Aug 9. Review.


Global gene expression by Bacillus anthracis during growth in mammalian blood.

Carlson PE Jr, Bourgis AE, Hagan AK, Hanna PC.

Pathog Dis. 2015 Nov;73(8):ftv061. doi: 10.1093/femspd/ftv061. Epub 2015 Aug 26.


Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis.

Green KD, Biswas T, Chang C, Wu R, Chen W, Janes BK, Chalupska D, Gornicki P, Hanna PC, Tsodikov OV, Joachimiak A, Garneau-Tsodikova S.

Biochemistry. 2015 May 26;54(20):3197-206. doi: 10.1021/acs.biochem.5b00244. Epub 2015 May 12.


Variation in germination of Clostridium difficile clinical isolates correlates to disease severity.

Carlson PE Jr, Kaiser AM, McColm SA, Bauer JM, Young VB, Aronoff DM, Hanna PC.

Anaerobe. 2015 Jun;33:64-70. doi: 10.1016/j.anaerobe.2015.02.003. Epub 2015 Feb 11.


Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis.

Tripathi A, Schofield MM, Chlipala GE, Schultz PJ, Yim I, Newmister SA, Nusca TD, Scaglione JB, Hanna PC, Tamayo-Castillo G, Sherman DH.

J Am Chem Soc. 2014 Jan 29;136(4):1579-86. doi: 10.1021/ja4115924. Epub 2014 Jan 17. Erratum in: J Am Chem Soc. 2014 Jul 23;136(29):10541.


Overlapping roles for toxins in Clostridium difficile infection.

Young VB, Hanna PC.

J Infect Dis. 2014 Jan 1;209(1):9-11. doi: 10.1093/infdis/jit461. Epub 2013 Aug 27. No abstract available.


The relationship between phenotype, ribotype, and clinical disease in human Clostridium difficile isolates.

Carlson PE Jr, Walk ST, Bourgis AE, Liu MW, Kopliku F, Lo E, Young VB, Aronoff DM, Hanna PC.

Anaerobe. 2013 Dec;24:109-16. doi: 10.1016/j.anaerobe.2013.04.003. Epub 2013 Apr 20.


Multiple ABC transporters are involved in the acquisition of petrobactin in Bacillus anthracis.

Dixon SD, Janes BK, Bourgis A, Carlson PE Jr, Hanna PC.

Mol Microbiol. 2012 Apr;84(2):370-82. doi: 10.1111/j.1365-2958.2012.08028.x. Epub 2012 Mar 20.


Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from Bacillus anthracis.

Nusca TD, Kim Y, Maltseva N, Lee JY, Eschenfeldt W, Stols L, Schofield MM, Scaglione JB, Dixon SD, Oves-Costales D, Challis GL, Hanna PC, Pfleger BF, Joachimiak A, Sherman DH.

J Biol Chem. 2012 May 4;287(19):16058-72. doi: 10.1074/jbc.M112.359349. Epub 2012 Mar 9.


Membrane topology of the Bacillus anthracis GerH germinant receptor proteins.

Wilson MJ, Carlson PE, Janes BK, Hanna PC.

J Bacteriol. 2012 Mar;194(6):1369-77. doi: 10.1128/JB.06538-11. Epub 2011 Dec 16.


Regulation of petrobactin and bacillibactin biosynthesis in Bacillus anthracis under iron and oxygen variation.

Lee JY, Passalacqua KD, Hanna PC, Sherman DH.

PLoS One. 2011;6(6):e20777. doi: 10.1371/journal.pone.0020777. Epub 2011 Jun 6.


Genetic analysis of petrobactin transport in Bacillus anthracis.

Carlson PE Jr, Dixon SD, Janes BK, Carr KA, Nusca TD, Anderson EC, Keene SE, Sherman DH, Hanna PC.

Mol Microbiol. 2010 Feb;75(4):900-9. doi: 10.1111/j.1365-2958.2009.07025.x. Epub 2010 Jan 13.


Role of the gerP operon in germination and outgrowth of Bacillus anthracis spores.

Carr KA, Janes BK, Hanna PC.

PLoS One. 2010 Feb 9;5(2):e9128. doi: 10.1371/journal.pone.0009128. Erratum in: PLoS One. 2010;5(8) doi: 10.1371/annotation/8f1e2a19-cb97-4680-a6b9-40e0116e7842.


The role of Bacillus anthracis germinant receptors in germination and virulence.

Carr KA, Lybarger SR, Anderson EC, Janes BK, Hanna PC.

Mol Microbiol. 2010 Jan;75(2):365-75. doi: 10.1111/j.1365-2958.2009.06972.x. Epub 2009 Nov 25.


Transcriptional profiling of Bacillus anthracis Sterne (34F2) during iron starvation.

Carlson PE Jr, Carr KA, Janes BK, Anderson EC, Hanna PC.

PLoS One. 2009 Sep 21;4(9):e6988. doi: 10.1371/journal.pone.0006988.


The germination-specific lytic enzymes SleB, CwlJ1, and CwlJ2 each contribute to Bacillus anthracis spore germination and virulence.

Giebel JD, Carr KA, Anderson EC, Hanna PC.

J Bacteriol. 2009 Sep;191(18):5569-76. doi: 10.1128/JB.00408-09. Epub 2009 Jul 6.


Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.

Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17133-8. doi: 10.1073/pnas.0808118105. Epub 2008 Oct 27.


The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis.

Paige C, Reid SD, Hanna PC, Claiborne A.

J Bacteriol. 2008 Sep;190(18):6271-5. doi: 10.1128/JB.00860-08. Epub 2008 Jul 18.


Transcriptional profiling of Bacillus anthracis during infection of host macrophages.

Bergman NH, Anderson EC, Swenson EE, Janes BK, Fisher N, Niemeyer MM, Miyoshi AD, Hanna PC.

Infect Immun. 2007 Jul;75(7):3434-44. Epub 2007 Apr 30.


Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis.

Pfleger BF, Lee JY, Somu RV, Aldrich CC, Hanna PC, Sherman DH.

Biochemistry. 2007 Apr 3;46(13):4147-57. Epub 2007 Mar 9.


Biosynthetic analysis of the petrobactin siderophore pathway from Bacillus anthracis.

Lee JY, Janes BK, Passalacqua KD, Pfleger BF, Bergman NH, Liu H, HÃ¥kansson K, Somu RV, Aldrich CC, Cendrowski S, Hanna PC, Sherman DH.

J Bacteriol. 2007 Mar;189(5):1698-710. Epub 2006 Dec 22.


Adenovirus-based prime-boost immunization for rapid vaccination against anthrax.

McConnell MJ, Hanna PC, Imperiale MJ.

Mol Ther. 2007 Jan;15(1):203-10.


Operon prediction for sequenced bacterial genomes without experimental information.

Bergman NH, Passalacqua KD, Hanna PC, Qin ZS.

Appl Environ Microbiol. 2007 Feb;73(3):846-54. Epub 2006 Nov 22.


Transcriptional profiling of the Bacillus anthracis life cycle in vitro and an implied model for regulation of spore formation.

Bergman NH, Anderson EC, Swenson EE, Niemeyer MM, Miyoshi AD, Hanna PC.

J Bacteriol. 2006 Sep;188(17):6092-100.


Murine macrophage transcriptional responses to Bacillus anthracis infection and intoxication.

Bergman NH, Passalacqua KD, Gaspard R, Shetron-Rama LM, Quackenbush J, Hanna PC.

Infect Immun. 2005 Feb;73(2):1069-80.


Formation and composition of the Bacillus anthracis endospore.

Liu H, Bergman NH, Thomason B, Shallom S, Hazen A, Crossno J, Rasko DA, Ravel J, Read TD, Peterson SN, Yates J 3rd, Hanna PC.

J Bacteriol. 2004 Jan;186(1):164-78.


The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.

Read TD, Peterson SN, Tourasse N, Baillie LW, Paulsen IT, Nelson KE, Tettelin H, Fouts DE, Eisen JA, Gill SR, Holtzapple EK, Okstad OA, Helgason E, Rilstone J, Wu M, Kolonay JF, Beanan MJ, Dodson RJ, Brinkac LM, Gwinn M, DeBoy RT, Madpu R, Daugherty SC, Durkin AS, Haft DH, Nelson WC, Peterson JD, Pop M, Khouri HM, Radune D, Benton JL, Mahamoud Y, Jiang L, Hance IR, Weidman JF, Berry KJ, Plaut RD, Wolf AM, Watkins KL, Nierman WC, Hazen A, Cline R, Redmond C, Thwaite JE, White O, Salzberg SL, Thomason B, Friedlander AM, Koehler TM, Hanna PC, Kolstø AB, Fraser CM.

Nature. 2003 May 1;423(6935):81-6.


Macrophage-enhanced germination of Bacillus anthracis endospores requires gerS.

Ireland JA, Hanna PC.

Infect Immun. 2002 Oct;70(10):5870-2.


Anthrax: a motor protein determines anthrax susceptibility.

Hanna PC.

Curr Biol. 2001 Nov 13;11(22):R905-6. Review.


Early Bacillus anthracis-macrophage interactions: intracellular survival survival and escape.

Dixon TC, Fadl AA, Koehler TM, Swanson JA, Hanna PC.

Cell Microbiol. 2000 Dec;2(6):453-63.



Dixon TC, Meselson M, Guillemin J, Hanna PC.

N Engl J Med. 1999 Sep 9;341(11):815-26. Review. No abstract available.


Understanding Bacillus anthracis pathogenesis.

Hanna PC, Ireland JA.

Trends Microbiol. 1999 May;7(5):180-2. Review. No abstract available.


Coordinate intracellular expression of Salmonella genes induced during infection.

Heithoff DM, Conner CP, Hentschel U, Govantes F, Hanna PC, Mahan MJ.

J Bacteriol. 1999 Feb;181(3):799-807.


Lethal factor active-site mutations affect catalytic activity in vitro.

Hammond SE, Hanna PC.

Infect Immun. 1998 May;66(5):2374-8.


Bacterial infection as assessed by in vivo gene expression.

Heithoff DM, Conner CP, Hanna PC, Julio SM, Hentschel U, Mahan MJ.

Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):934-9.


Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host.

Mahan MJ, Tobias JW, Slauch JM, Hanna PC, Collier RJ, Mekalanos JJ.

Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):669-73.

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