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Items: 1 to 50 of 59

1.

Deciphering the "m6A Code" via Antibody-Independent Quantitative Profiling.

Garcia-Campos MA, Edelheit S, Toth U, Safra M, Shachar R, Viukov S, Winkler R, Nir R, Lasman L, Brandis A, Hanna JH, Rossmanith W, Schwartz S.

Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.

PMID:
31257032
2.

Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation.

Lee H, Bao S, Qian Y, Geula S, Leslie J, Zhang C, Hanna JH, Ding L.

Nat Cell Biol. 2019 Jun;21(6):700-709. doi: 10.1038/s41556-019-0318-1. Epub 2019 May 6.

3.

Universally non-immunogenic iPSCs.

Shani T, Hanna JH.

Nat Biomed Eng. 2019 May;3(5):337-338. doi: 10.1038/s41551-019-0401-8. No abstract available.

PMID:
31036889
4.

Stem Cell-Derived Human Gametes: The Public Engagement Imperative.

Adashi EY, Cohen IG, Hanna JH, Surani AM, Hayashi K.

Trends Mol Med. 2019 Mar;25(3):165-167. doi: 10.1016/j.molmed.2019.01.005. Epub 2019 Feb 6.

PMID:
30738627
5.

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells.

Mitsunaga S, Shioda K, Isselbacher KJ, Hanna JH, Shioda T.

J Vis Exp. 2019 Jan 11;(143). doi: 10.3791/58297.

PMID:
30688291
6.

Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferons.

Winkler R, Gillis E, Lasman L, Safra M, Geula S, Soyris C, Nachshon A, Tai-Schmiedel J, Friedman N, Le-Trilling VTK, Trilling M, Mandelboim M, Hanna JH, Schwartz S, Stern-Ginossar N.

Nat Immunol. 2019 Feb;20(2):243. doi: 10.1038/s41590-019-0314-4.

PMID:
30635652
7.

The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy.

Dorn LE, Lasman L, Chen J, Xu X, Hund TJ, Medvedovic M, Hanna JH, van Berlo JH, Accornero F.

Circulation. 2019 Jan 22;139(4):533-545. doi: 10.1161/CIRCULATIONAHA.118.036146.

8.

m6A modification controls the innate immune response to infection by targeting type I interferons.

Winkler R, Gillis E, Lasman L, Safra M, Geula S, Soyris C, Nachshon A, Tai-Schmiedel J, Friedman N, Le-Trilling VTK, Trilling M, Mandelboim M, Hanna JH, Schwartz S, Stern-Ginossar N.

Nat Immunol. 2019 Feb;20(2):173-182. doi: 10.1038/s41590-018-0275-z. Epub 2018 Dec 17. Erratum in: Nat Immunol. 2019 Jan 11;:.

PMID:
30559377
9.

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules.

Zviran A, Mor N, Rais Y, Gingold H, Peles S, Chomsky E, Viukov S, Buenrostro JD, Scognamiglio R, Weinberger L, Manor YS, Krupalnik V, Zerbib M, Hezroni H, Jaitin DA, Larastiaso D, Gilad S, Benjamin S, Gafni O, Mousa A, Ayyash M, Sheban D, Bayerl J, Aguilera-Castrejon A, Massarwa R, Maza I, Hanna S, Stelzer Y, Ulitsky I, Greenleaf WJ, Tanay A, Trumpp A, Amit I, Pilpel Y, Novershtern N, Hanna JH.

Cell Stem Cell. 2019 Feb 7;24(2):328-341.e9. doi: 10.1016/j.stem.2018.11.014. Epub 2018 Dec 13.

PMID:
30554962
10.

MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells.

Bahat A, Goldman A, Zaltsman Y, Khan DH, Halperin C, Amzallag E, Krupalnik V, Mullokandov M, Silberman A, Erez A, Schimmer AD, Hanna JH, Gross A.

Nat Commun. 2018 Dec 3;9(1):5132. doi: 10.1038/s41467-018-07519-w.

11.

Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency.

Mor N, Rais Y, Sheban D, Peles S, Aguilera-Castrejon A, Zviran A, Elinger D, Viukov S, Geula S, Krupalnik V, Zerbib M, Chomsky E, Lasman L, Shani T, Bayerl J, Gafni O, Hanna S, Buenrostro JD, Hagai T, Masika H, Vainorius G, Bergman Y, Greenleaf WJ, Esteban MA, Elling U, Levin Y, Massarwa R, Merbl Y, Novershtern N, Hanna JH.

Cell Stem Cell. 2018 Sep 6;23(3):412-425.e10. doi: 10.1016/j.stem.2018.07.004. Epub 2018 Aug 16.

12.

The Role of m6A/m-RNA Methylation in Stress Response Regulation.

Engel M, Eggert C, Kaplick PM, Eder M, Röh S, Tietze L, Namendorf C, Arloth J, Weber P, Rex-Haffner M, Geula S, Jakovcevski M, Hanna JH, Leshkowitz D, Uhr M, Wotjak CT, Schmidt MV, Deussing JM, Binder EB, Chen A.

Neuron. 2018 Jul 25;99(2):389-403.e9. doi: 10.1016/j.neuron.2018.07.009.

13.

Modulating cell state to enhance suspension expansion of human pluripotent stem cells.

Lipsitz YY, Woodford C, Yin T, Hanna JH, Zandstra PW.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6369-6374. doi: 10.1073/pnas.1714099115. Epub 2018 Jun 4.

14.

Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies.

Gamliel M, Goldman-Wohl D, Isaacson B, Gur C, Stein N, Yamin R, Berger M, Grunewald M, Keshet E, Rais Y, Bornstein C, David E, Jelinski A, Eisenberg I, Greenfield C, Ben-David A, Imbar T, Gilad R, Haimov-Kochman R, Mankuta D, Elami-Suzin M, Amit I, Hanna JH, Yagel S, Mandelboim O.

Immunity. 2018 May 15;48(5):951-962.e5. doi: 10.1016/j.immuni.2018.03.030.

15.

Human Brain Organoids on a Chip Reveal the Physics of Folding.

Karzbrun E, Kshirsagar A, Cohen SR, Hanna JH, Reiner O.

Nat Phys. 2018 May;14(5):515-522. doi: 10.1038/s41567-018-0046-7. Epub 2018 Feb 19.

16.

m6A deposition: a boost from TGFβ.

Lasman L, Hanna JH.

Cell Res. 2018 May;28(5):505-506. doi: 10.1038/s41422-018-0037-3. No abstract available.

17.

NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.

Glasner A, Levi A, Enk J, Isaacson B, Viukov S, Orlanski S, Scope A, Neuman T, Enk CD, Hanna JH, Sexl V, Jonjic S, Seliger B, Zitvogel L, Mandelboim O.

Immunity. 2018 Feb 20;48(2):396-398. doi: 10.1016/j.immuni.2018.01.010. No abstract available.

18.

RAS Regulates the Transition from Naive to Primed Pluripotent Stem Cells.

Altshuler A, Verbuk M, Bhattacharya S, Abramovich I, Haklai R, Hanna JH, Kloog Y, Gottlieb E, Shalom-Feuerstein R.

Stem Cell Reports. 2018 Mar 13;10(3):1088-1101. doi: 10.1016/j.stemcr.2018.01.004. Epub 2018 Feb 15.

19.

NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.

Glasner A, Levi A, Enk J, Isaacson B, Viukov S, Orlanski S, Scope A, Neuman T, Enk CD, Hanna JH, Sexl V, Jonjic S, Seliger B, Zitvogel L, Mandelboim O.

Immunity. 2018 Jan 16;48(1):107-119.e4. doi: 10.1016/j.immuni.2017.12.007. Epub 2018 Jan 9. Erratum in: Immunity. 2018 Feb 20;48(2):396-398.

20.

Relevance of iPSC-derived human PGC-like cells at the surface of embryoid bodies to prechemotaxis migrating PGCs.

Mitsunaga S, Odajima J, Yawata S, Shioda K, Owa C, Isselbacher KJ, Hanna JH, Shioda T.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9913-E9922. doi: 10.1073/pnas.1707779114. Epub 2017 Oct 30.

21.

OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs.

Sheinboim D, Maza I, Dror I, Parikh S, Krupalnik V, Bell RE, Zviran A, Suita Y, Hakim O, Mandel-Gutfreund Y, Khaled M, Hanna JH, Levy C.

Nat Commun. 2017 Oct 18;8(1):1022. doi: 10.1038/s41467-017-01122-1.

22.

Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression.

Glasner A, Isaacson B, Viukov S, Neuman T, Friedman N, Mandelboim M, Sexl V, Hanna JH, Mandelboim O.

Sci Rep. 2017 Oct 12;7(1):13090. doi: 10.1038/s41598-017-12998-w.

23.

A multiplexed screening method for pluripotency.

Plotnikov A, Kozer N, Krupalnik V, Peles S, Mor N, Rais Y, Hanna JH, Barr HM.

Stem Cell Res. 2017 Aug;23:158-162. doi: 10.1016/j.scr.2017.07.014. Epub 2017 Jul 12.

24.

m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.

Ke S, Pandya-Jones A, Saito Y, Fak JJ, Vågbø CB, Geula S, Hanna JH, Black DL, Darnell JE Jr, Darnell RB.

Genes Dev. 2017 May 15;31(10):990-1006. doi: 10.1101/gad.301036.117.

25.

Quality of patient-centred care: Medical oncology patients' perceptions and characteristics associated with quality of care.

Tzelepis F, Hanna JH, Paul CL, Boyes AW, Carey ML, Regan T.

Psychooncology. 2017 Nov;26(11):1998-2001. doi: 10.1002/pon.4380. Epub 2017 Feb 20. No abstract available.

PMID:
28101971
26.

Transcriptional programs that control expression of the autoimmune regulator gene Aire.

Herzig Y, Nevo S, Bornstein C, Brezis MR, Ben-Hur S, Shkedy A, Eisenberg-Bord M, Levi B, Delacher M, Goldfarb Y, David E, Weinberger L, Viukov S, Ben-Dor S, Giraud M, Hanna JH, Breiling A, Lyko F, Amit I, Feuerer M, Abramson J.

Nat Immunol. 2017 Feb;18(2):161-172. doi: 10.1038/ni.3638. Epub 2016 Dec 12.

PMID:
27941786
27.

Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution.

Weiner A, Lara-Astiaso D, Krupalnik V, Gafni O, David E, Winter DR, Hanna JH, Amit I.

Nat Biotechnol. 2016 Sep;34(9):953-61. doi: 10.1038/nbt.3652. Epub 2016 Jul 25.

PMID:
27454738
28.

Dynamic stem cell states: naive to primed pluripotency in rodents and humans.

Weinberger L, Ayyash M, Novershtern N, Hanna JH.

Nat Rev Mol Cell Biol. 2016 Mar;17(3):155-69. doi: 10.1038/nrm.2015.28. Epub 2016 Feb 10. Review.

PMID:
26860365
29.

Evolutionary analysis across mammals reveals distinct classes of long non-coding RNAs.

Chen J, Shishkin AA, Zhu X, Kadri S, Maza I, Guttman M, Hanna JH, Regev A, Garber M.

Genome Biol. 2016 Feb 2;17:19. doi: 10.1186/s13059-016-0880-9.

30.

An essential role for UTX in resolution and activation of bivalent promoters.

Dhar SS, Lee SH, Chen K, Zhu G, Oh W, Allton K, Gafni O, Kim YZ, Tomoiga AS, Barton MC, Hanna JH, Wang Z, Li W, Lee MG.

Nucleic Acids Res. 2016 May 5;44(8):3659-74. doi: 10.1093/nar/gkv1516. Epub 2016 Jan 13.

31.

Corrigendum: Failure to replicate the STAP cell phenomenon.

De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, Borkent M, Krupalnik V, Lujan E, Wernig M, Hanna JH, Hochedlinger K, Pei D, Jaenisch R, Deng H, Orkin SH, Park PJ, Daley GQ.

Nature. 2016 Mar 17;531(7594):400. doi: 10.1038/nature16479. Epub 2015 Dec 16. No abstract available.

PMID:
26675720
32.

Failure to replicate the STAP cell phenomenon.

De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, Borkent M, Krupalnik V, Lujan E, Wernig M, Hanna JH, Hochedlinger K, Pei D, Jaenisch R, Deng H, Orkin SH, Park PJ, Daley GQ.

Nature. 2015 Sep 24;525(7570):E6-9. doi: 10.1038/nature15513. No abstract available. Erratum in: Nature. 2016 Mar 17;531(7594):400.

PMID:
26399835
33.

Establishing the human naïve pluripotent state.

Manor YS, Massarwa R, Hanna JH.

Curr Opin Genet Dev. 2015 Oct;34:35-45. doi: 10.1016/j.gde.2015.07.005. Epub 2015 Aug 24. Review.

PMID:
26291026
34.

Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors.

Maza I, Caspi I, Zviran A, Chomsky E, Rais Y, Viukov S, Geula S, Buenrostro JD, Weinberger L, Krupalnik V, Hanna S, Zerbib M, Dutton JR, Greenleaf WJ, Massarwa R, Novershtern N, Hanna JH.

Nat Biotechnol. 2015 Jul;33(7):769-74. doi: 10.1038/nbt.3270. Epub 2015 Jun 22.

35.

CD24 tracks divergent pluripotent states in mouse and human cells.

Shakiba N, White CA, Lipsitz YY, Yachie-Kinoshita A, Tonge PD, Hussein SMI, Puri MC, Elbaz J, Morrissey-Scoot J, Li M, Munoz J, Benevento M, Rogers IM, Hanna JH, Heck AJR, Wollscheid B, Nagy A, Zandstra PW.

Nat Commun. 2015 Jun 16;6:7329. doi: 10.1038/ncomms8329.

36.

Lymphatic vessels arise from specialized angioblasts within a venous niche.

Nicenboim J, Malkinson G, Lupo T, Asaf L, Sela Y, Mayseless O, Gibbs-Bar L, Senderovich N, Hashimshony T, Shin M, Jerafi-Vider A, Avraham-Davidi I, Krupalnik V, Hofi R, Almog G, Astin JW, Golani O, Ben-Dor S, Crosier PS, Herzog W, Lawson ND, Hanna JH, Yanai I, Yaniv K.

Nature. 2015 Jun 4;522(7554):56-61.

PMID:
25992545
37.

Corrigendum: Derivation of novel human ground state naive pluripotent stem cells.

Gafni O, Weinberger L, Mansour AA, Manor YS, Chomsky E, Ben-Yosef D, Kalma Y, Viukov S, Maza I, Zviran A, Rais Y, Shipony Z, Mukamel Z, Krupalnik V, Zerbib M, Geula S, Caspi I, Schneir D, Shwartz T, Gilad S, Amann-Zalcenstein D, Benjamin S, Amit I, Tanay A, Massarwa R, Novershtern N, Hanna JH.

Nature. 2015 Apr 30;520(7549):710. doi: 10.1038/nature14370. Epub 2015 Apr 1. No abstract available.

PMID:
25830888
38.

Corrigendum: Deterministic direct reprogramming of somatic cells to pluripotency.

Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, Mansour AA, Caspi I, Krupalnik V, Zerbib M, Maza I, Mor N, Baran D, Weinberger L, Jaitin DA, Lara-Astiaso D, Blecher-Gonen R, Shipony Z, Mukamel Z, Hagai T, Gilad S, Amann-Zalcenstein D, Tanay A, Amit I, Novershtern N, Hanna JH.

Nature. 2015 Apr 30;520(7549):710. doi: 10.1038/nature14369. Epub 2015 Apr 1. No abstract available.

PMID:
25830885
39.

Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.

Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Manor YS, Ben-Haim MS, Eyal E, Yunger S, Pinto Y, Jaitin DA, Viukov S, Rais Y, Krupalnik V, Chomsky E, Zerbib M, Maza I, Rechavi Y, Massarwa R, Hanna S, Amit I, Levanon EY, Amariglio N, Stern-Ginossar N, Novershtern N, Rechavi G, Hanna JH.

Science. 2015 Feb 27;347(6225):1002-6. doi: 10.1126/science.1261417. Epub 2015 Jan 1.

40.

SOX17 is a critical specifier of human primordial germ cell fate.

Irie N, Weinberger L, Tang WW, Kobayashi T, Viukov S, Manor YS, Dietmann S, Hanna JH, Surani MA.

Cell. 2015 Jan 15;160(1-2):253-68. doi: 10.1016/j.cell.2014.12.013. Epub 2014 Dec 24.

41.

Hijacked by an oocyte: hierarchical molecular changes in somatic cell nuclear transfer.

Maza I, Hanna JH.

Mol Cell. 2014 Aug 21;55(4):507-9. doi: 10.1016/j.molcel.2014.08.008.

42.

Stem cells: The quest for the perfect reprogrammed cell.

Krupalnik V, Hanna JH.

Nature. 2014 Jul 10;511(7508):160-2. doi: 10.1038/nature13515. Epub 2014 Jul 2. No abstract available.

PMID:
25008516
43.

Lucky iPSCs.

Zviran A, Hanna JH.

Genome Biol. 2014 Mar 25;15(3):109. doi: 10.1186/gb4167. Review.

44.

Passage number is a major contributor to genomic structural variations in mouse iPSCs.

Liu P, Kaplan A, Yuan B, Hanna JH, Lupski JR, Reiner O.

Stem Cells. 2014 Oct;32(10):2657-67. doi: 10.1002/stem.1779.

45.

Derivation of novel human ground state naive pluripotent stem cells.

Gafni O, Weinberger L, Mansour AA, Manor YS, Chomsky E, Ben-Yosef D, Kalma Y, Viukov S, Maza I, Zviran A, Rais Y, Shipony Z, Mukamel Z, Krupalnik V, Zerbib M, Geula S, Caspi I, Schneir D, Shwartz T, Gilad S, Amann-Zalcenstein D, Benjamin S, Amit I, Tanay A, Massarwa R, Novershtern N, Hanna JH.

Nature. 2013 Dec 12;504(7479):282-6. doi: 10.1038/nature12745. Epub 2013 Oct 30. Erratum in: Nature. 2015 Apr 30;520(7549):710.

PMID:
24172903
46.

Deterministic direct reprogramming of somatic cells to pluripotency.

Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, Mansour AA, Caspi I, Krupalnik V, Zerbib M, Maza I, Mor N, Baran D, Weinberger L, Jaitin DA, Lara-Astiaso D, Blecher-Gonen R, Shipony Z, Mukamel Z, Hagai T, Gilad S, Amann-Zalcenstein D, Tanay A, Amit I, Novershtern N, Hanna JH.

Nature. 2013 Oct 3;502(7469):65-70. doi: 10.1038/nature12587. Epub 2013 Sep 18. Erratum in: Nature. 2015 Apr 30;520(7549):710.

PMID:
24048479
47.

The expression of the beta cell-derived autoimmune ligand for the killer receptor nkp46 is attenuated in type 2 diabetes.

Gur C, Enk J, Weitman E, Bachar E, Suissa Y, Cohen G, Schyr RB, Sabanay H, Horwitz E, Glaser B, Dor Y, Pribluda A, Hanna JH, Leibowitz G, Mandelboim O.

PLoS One. 2013 Aug 29;8(8):e74033. doi: 10.1371/journal.pone.0074033. eCollection 2013.

48.

Oct4 shuffles Sox partners to direct cell fate.

Mansour AA, Hanna JH.

EMBO J. 2013 Apr 3;32(7):917-9. doi: 10.1038/emboj.2013.48. Epub 2013 Mar 8. No abstract available.

49.

Clonal allelic predetermination of immunoglobulin-κ rearrangement.

Farago M, Rosenbluh C, Tevlin M, Fraenkel S, Schlesinger S, Masika H, Gouzman M, Teng G, Schatz D, Rais Y, Hanna JH, Mildner A, Jung S, Mostoslavsky G, Cedar H, Bergman Y.

Nature. 2012 Oct 25;490(7421):561-5. doi: 10.1038/nature11496. Epub 2012 Sep 30.

PMID:
23023124
50.

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.

Mansour AA, Gafni O, Weinberger L, Zviran A, Ayyash M, Rais Y, Krupalnik V, Zerbib M, Amann-Zalcenstein D, Maza I, Geula S, Viukov S, Holtzman L, Pribluda A, Canaani E, Horn-Saban S, Amit I, Novershtern N, Hanna JH.

Nature. 2012 Aug 16;488(7411):409-13. doi: 10.1038/nature11272.

PMID:
22801502

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