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Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin.

Zhang C, Miller DJ, Guibao CD, Donato DM, Hanks SK, Zheng JJ.

J Biol Chem. 2017 Nov 3;292(44):18281-18289. doi: 10.1074/jbc.M117.807271. Epub 2017 Aug 31.


ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility.

Luo W, Janoštiak R, Tolde O, Ryzhova LM, Koudelková L, Dibus M, Brábek J, Hanks SK, Rosel D.

J Cell Sci. 2017 Jul 15;130(14):2382-2393. doi: 10.1242/jcs.197434. Epub 2017 Jun 5.


Podosome dynamics and location in vascular smooth muscle cells require CLASP-dependent microtubule bending.

Zhu X, Efimova N, Arnette C, Hanks SK, Kaverina I.

Cytoskeleton (Hoboken). 2016 Jun;73(6):300-15. doi: 10.1002/cm.21302. Epub 2016 May 20.


Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer.

McKinley ET, Liu H, McDonald WH, Luo W, Zhao P, Coffey RJ, Hanks SK, Manning HC.

PLoS One. 2013 Nov 8;8(11):e80207. doi: 10.1371/journal.pone.0080207. eCollection 2013.


Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.

George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB.

J Clin Invest. 2012 Feb;122(2):674-92. doi: 10.1172/JCI60070. Epub 2012 Jan 17.


Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness.

Janoštiak R, Tolde O, Brůhová Z, Novotný M, Hanks SK, Rösel D, Brábek J.

Mol Biol Cell. 2011 Nov;22(22):4256-67. doi: 10.1091/mbc.E11-03-0207. Epub 2011 Sep 21.


KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1.

Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk DB.

Exp Cell Res. 2011 Feb 15;317(4):452-63. doi: 10.1016/j.yexcr.2010.11.018. Epub 2010 Dec 7.


P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration.

Meenderink LM, Ryzhova LM, Donato DM, Gochberg DF, Kaverina I, Hanks SK.

PLoS One. 2010 Oct 18;5(10):e13412. doi: 10.1371/journal.pone.0013412.


Dynamics and mechanism of p130Cas localization to focal adhesions.

Donato DM, Ryzhova LM, Meenderink LM, Kaverina I, Hanks SK.

J Biol Chem. 2010 Jul 2;285(27):20769-79. doi: 10.1074/jbc.M109.091207. Epub 2010 Apr 29.


Focal adhesion kinase-dependent regulation of adhesive forces involves vinculin recruitment to focal adhesions.

Dumbauld DW, Michael KE, Hanks SK, García AJ.

Biol Cell. 2010 Jan 14;102(4):203-213. doi: 10.1042/BC20090104.


Focal adhesion kinase modulates cell adhesion strengthening via integrin activation.

Michael KE, Dumbauld DW, Burns KL, Hanks SK, García AJ.

Mol Biol Cell. 2009 May;20(9):2508-19. doi: 10.1091/mbc.E08-01-0076. Epub 2009 Mar 18.


Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis.

Ricono JM, Huang M, Barnes LA, Lau SK, Weis SM, Schlaepfer DD, Hanks SK, Cheresh DA.

Cancer Res. 2009 Feb 15;69(4):1383-91. doi: 10.1158/0008-5472.CAN-08-3612. Epub 2009 Feb 10.


p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells.

Cunningham-Edmondson AC, Hanks SK.

Breast Cancer (Dove Med Press). 2009 Dec 7;1:39-52. eCollection 2009.


Quantification of focal adhesion kinase activation loop phosphorylation as a biomarker of Src activity.

Ciccimaro E, Hanks SK, Blair IA.

Mol Pharmacol. 2009 Mar;75(3):658-66. doi: 10.1124/mol.108.052464. Epub 2008 Dec 19.


Src transformation of colonic epithelial cells: enhanced anchorage-independent growth in an Apc(+/min) background.

Constancio-Lund SS, Brabek J, Hanks SK.

Mol Carcinog. 2009 Feb;48(2):156-66. doi: 10.1002/mc.20466.


Global impact of oncogenic Src on a phosphotyrosine proteome.

Luo W, Slebos RJ, Hill S, Li M, Brábek J, Amanchy R, Chaerkady R, Pandey A, Ham AJ, Hanks SK.

J Proteome Res. 2008 Aug;7(8):3447-60. doi: 10.1021/pr800187n. Epub 2008 Jun 19.


The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling.

Kim W, Seok Kang Y, Soo Kim J, Shin NY, Hanks SK, Song WK.

Mol Biol Cell. 2008 May;19(5):2135-46. doi: 10.1091/mbc.E07-10-0991. Epub 2008 Mar 5. Erratum in: Mol Biol Cell. 2011 Oct;22(19):3747.


A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly.

Siesser PM, Meenderink LM, Ryzhova L, Michael KE, Dumbauld DW, García AJ, Kaverina I, Hanks SK.

Cell Motil Cytoskeleton. 2008 Jan;65(1):25-39.


p130CAS is required for netrin signaling and commissural axon guidance.

Liu G, Li W, Gao X, Li X, Jürgensen C, Park HT, Shin NY, Yu J, He ML, Hanks SK, Wu JY, Guan KL, Rao Y.

J Neurosci. 2007 Jan 24;27(4):957-68.


Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.

Rivera GM, Antoku S, Gelkop S, Shin NY, Hanks SK, Pawson T, Mayer BJ.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9536-41. Epub 2006 Jun 12.


The signaling and biological implications of FAK overexpression in cancer.

Siesser PM, Hanks SK.

Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3233-7. Review. No abstract available.


Cellular responses to substrate topography: role of myosin II and focal adhesion kinase.

Frey MT, Tsai IY, Russell TP, Hanks SK, Wang YL.

Biophys J. 2006 May 15;90(10):3774-82. Epub 2006 Feb 24.


Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration.

Bianchi M, De Lucchini S, Marin O, Turner DL, Hanks SK, Villa-Moruzzi E.

Biochem J. 2005 Oct 15;391(Pt 2):359-70.


Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells.

Brábek J, Constancio SS, Siesser PF, Shin NY, Pozzi A, Hanks SK.

Mol Cancer Res. 2005 Jun;3(6):307-15.


CD98 modulates integrin beta1 function in polarized epithelial cells.

Cai S, Bulus N, Fonseca-Siesser PM, Chen D, Hanks SK, Pozzi A, Zent R.

J Cell Sci. 2005 Mar 1;118(Pt 5):889-99. Epub 2005 Feb 15.


CAS promotes invasiveness of Src-transformed cells.

Brábek J, Constancio SS, Shin NY, Pozzi A, Weaver AM, Hanks SK.

Oncogene. 2004 Sep 23;23(44):7406-15.


Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion.

Yano H, Mazaki Y, Kurokawa K, Hanks SK, Matsuda M, Sabe H.

J Cell Biol. 2004 Jul 19;166(2):283-95.


Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration.

Shin NY, Dise RS, Schneider-Mergener J, Ritchie MD, Kilkenny DM, Hanks SK.

J Biol Chem. 2004 Sep 10;279(37):38331-7. Epub 2004 Jul 6.


Assaying protein kinase activity.

Brábek J, Hanks SK.

Methods Mol Biol. 2004;284:79-90.


Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.

Kurenova E, Xu LH, Yang X, Baldwin AS Jr, Craven RJ, Hanks SK, Liu ZG, Cance WG.

Mol Cell Biol. 2004 May;24(10):4361-71.


Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells.

Hecker TP, Ding Q, Rege TA, Hanks SK, Gladson CL.

Oncogene. 2004 May 13;23(22):3962-71.


Biomedical research publication system.

Wang YL, Burridge K, Dembo M, Gabbiani G, Hanks SK, Hosoya H, Janmey P, Karlsson R, Lindberg U, Mabuchi I, Otey C, Rottner K, Small JV, Wang CL, Zigmond S.

Science. 2004 Mar 26;303(5666):1974-6. No abstract available.


Regulation and localization of CAS substrate domain tyrosine phosphorylation.

Fonseca PM, Shin NY, Brábek J, Ryzhova L, Wu J, Hanks SK.

Cell Signal. 2004 May;16(5):621-9.


Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes.

Torsoni AS, Constancio SS, Nadruz W Jr, Hanks SK, Franchini KG.

Circ Res. 2003 Jul 25;93(2):140-7. Epub 2003 Jun 12.


c-Jun is essential for organization of the epidermal leading edge.

Li G, Gustafson-Brown C, Hanks SK, Nason K, Arbeit JM, Pogliano K, Wisdom RM, Johnson RS.

Dev Cell. 2003 Jun;4(6):865-77.


Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility.

Hanks SK, Ryzhova L, Shin NY, Brábek J.

Front Biosci. 2003 May 1;8:d982-96. Review.


An Eph receptor sperm-sensing control mechanism for oocyte meiotic maturation in Caenorhabditis elegans.

Miller MA, Ruest PJ, Kosinski M, Hanks SK, Greenstein D.

Genes Dev. 2003 Jan 15;17(2):187-200.


Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.

Donaldson JC, Dise RS, Ritchie MD, Hanks SK.

J Biol Chem. 2002 Aug 9;277(32):29028-35. Epub 2002 May 10.


Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src.

Ruest PJ, Shin NY, Polte TR, Zhang X, Hanks SK.

Mol Cell Biol. 2001 Nov;21(22):7641-52.


Focal adhesion kinase is involved in mechanosensing during fibroblast migration.

Wang HB, Dembo M, Hanks SK, Wang Y.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11295-300.


Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells.

Donaldson JC, Dempsey PJ, Reddy S, Bouton AH, Coffey RJ, Hanks SK.

Exp Cell Res. 2000 Apr 10;256(1):168-78.


Focal adhesion kinase promotes phospholipase C-gamma1 activity.

Zhang X, Chattopadhyay A, Ji QS, Owen JD, Ruest PJ, Carpenter G, Hanks SK.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9021-6.


Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK.

Yamakita Y, Totsukawa G, Yamashiro S, Fry D, Zhang X, Hanks SK, Matsumura F.

J Cell Biol. 1999 Jan 25;144(2):315-24.

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