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Items: 1 to 50 of 200

1.

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.

Nho K, Kueider-Paisley A, MahmoudianDehkordi S, Arnold M, Risacher SL, Louie G, Blach C, Baillie R, Han X, Kastenmüller G, Jia W, Xie G, Ahmad S, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium.

Alzheimers Dement. 2018 Oct 15. pii: S1552-5260(18)33521-0. doi: 10.1016/j.jalz.2018.08.012. [Epub ahead of print]

PMID:
30337152
2.

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.

MahmoudianDehkordi S, Arnold M, Nho K, Ahmad S, Jia W, Xie G, Louie G, Kueider-Paisley A, Moseley MA, Thompson JW, St John Williams L, Tenenbaum JD, Blach C, Baillie R, Han X, Bhattacharyya S, Toledo JB, Schafferer S, Klein S, Koal T, Risacher SL, Kling MA, Motsinger-Reif A, Rotroff DM, Jack J, Hankemeier T, Bennett DA, De Jager PL, Trojanowski JQ, Shaw LM, Weiner MW, Doraiswamy PM, van Duijn CM, Saykin AJ, Kastenmüller G, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium.

Alzheimers Dement. 2018 Oct 8. pii: S1552-5260(18)33486-1. doi: 10.1016/j.jalz.2018.07.217. [Epub ahead of print]

3.

Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology.

Teitsma XM, Yang W, Jacobs JWG, Pethö-Schramm A, Borm MEA, Harms AC, Hankemeier T, van Laar JM, Bijlsma JWJ, Lafeber FPJG.

Arthritis Res Ther. 2018 Oct 15;20(1):230. doi: 10.1186/s13075-018-1729-2.

4.

Menstrual cycle rhythmicity: metabolic patterns in healthy women.

Draper CF, Duisters K, Weger B, Chakrabarti A, Harms AC, Brennan L, Hankemeier T, Goulet L, Konz T, Martin FP, Moco S, van der Greef J.

Sci Rep. 2018 Oct 1;8(1):14568. doi: 10.1038/s41598-018-32647-0.

5.

Plasma lipid profiling of tissue-specific insulin resistance in human obesity.

van der Kolk BW, Vogelzangs N, Jocken JWE, Valsesia A, Hankemeier T, Astrup A, Saris WHM, Arts ICW, van Greevenbroek MMJ, Blaak EE; DiOGenes consortium.

Int J Obes (Lond). 2018 Sep 21. doi: 10.1038/s41366-018-0189-8. [Epub ahead of print]

PMID:
30242234
6.

Perfused 3D angiogenic sprouting in a high-throughput in vitro platform.

van Duinen V, Zhu D, Ramakers C, van Zonneveld AJ, Vulto P, Hankemeier T.

Angiogenesis. 2018 Aug 31. doi: 10.1007/s10456-018-9647-0. [Epub ahead of print]

PMID:
30171498
7.

Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate.

Kaddurah-Daouk R, Hankemeier T, Scholl EH, Baillie R, Harms A, Stage C, Dalhoff KP, Jűrgens G, Taboureau O, Nzabonimpa GS, Motsinger-Reif AA, Thomsen R, Linnet K, Rasmussen HB; INDICES Consortium; Pharmacometabolomics Research Network.

CPT Pharmacometrics Syst Pharmacol. 2018 Aug;7(8):525-533. doi: 10.1002/psp4.12309.

8.

Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight.

Nahon KJ, Kantae V, den Haan R, Hanssen MJW, Harms AC, van der Stelt M, Hankemeier T, Jazet IM, van Marken Lichtenbelt WD, Rensen PCN, Boon MR.

Obesity (Silver Spring). 2018 Aug;26(8):1332-1337. doi: 10.1002/oby.22245. Epub 2018 Aug 1.

PMID:
30070030
9.

High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor.

van der Aart LT, Spijksma GK, Harms A, Vollmer W, Hankemeier T, van Wezel GP.

J Bacteriol. 2018 Sep 24;200(20). pii: e00290-18. doi: 10.1128/JB.00290-18. Print 2018 Oct 15.

PMID:
30061355
10.

Fusing metabolomics data sets with heterogeneous measurement errors.

Waaijenborg S, Korobko O, Willems van Dijk K, Lips M, Hankemeier T, Wilderjans TF, Smilde AK, Westerhuis JA.

PLoS One. 2018 Apr 26;13(4):e0195939. doi: 10.1371/journal.pone.0195939. eCollection 2018.

11.

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry.

Dubbelman AC, Cuyckens F, Dillen L, Gross G, Vreeken RJ, Hankemeier T.

Anal Chim Acta. 2018 Aug 22;1020:62-75. doi: 10.1016/j.aca.2018.02.055. Epub 2018 Mar 3.

12.

Weight loss moderately affects the mixed meal challenge response of the plasma metabolome and transcriptome of peripheral blood mononuclear cells in abdominally obese subjects.

Fazelzadeh P, Hangelbroek RWJ, Joris PJ, Schalkwijk CG, Esser D, Afman L, Hankemeier T, Jacobs DM, Mihaleva VV, Kersten S, van Duynhoven J, Boekschoten MV.

Metabolomics. 2018;14(4):46. doi: 10.1007/s11306-018-1328-x. Epub 2018 Mar 5.

13.

Strategies to assess and optimize stability of endogenous amines during cerebrospinal fluid sampling.

Noga MJ, Zielman R, van Dongen RM, Bos S, Harms A, Terwindt GM, van den Maagdenberg AMJM, Hankemeier T, Ferrari MD.

Metabolomics. 2018;14(4):44. doi: 10.1007/s11306-018-1333-0. Epub 2018 Mar 5.

14.

Bundling arrows: improving translational CNS drug development by integrated PK/PD-metabolomics.

van den Brink WJ, Hankemeier T, van der Graaf PH, de Lange ECM.

Expert Opin Drug Discov. 2018 Jun;13(6):539-550. doi: 10.1080/17460441.2018.1446935. Epub 2018 Mar 8.

PMID:
29519169
15.

Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.

Schoeman JC, Harms AC, van Weeghel M, Berger R, Vreeken RJ, Hankemeier T.

Anal Bioanal Chem. 2018 Apr;410(10):2551-2568. doi: 10.1007/s00216-018-0912-2. Epub 2018 Mar 2.

16.

A metabolomics study of Qiliqiangxin in a rat model of heart failure: a reverse pharmacology approach.

Fu J, Chang L, Harms AC, Jia Z, Wang H, Wei C, Qiao L, Tian S, Hankemeier T, Wu Y, Wang M.

Sci Rep. 2018 Feb 27;8(1):3688. doi: 10.1038/s41598-018-22074-6.

17.

Pharmacological targeting of ROS reaction network in myeloid leukemia cells monitored by ultra-weak photon emission.

Rossetto Burgos RC, Ramautar R, Van Wijk EPA, Hankemeier T, Der Greef JV, Mashaghi A.

Oncotarget. 2017 Dec 11;9(2):2028-2034. doi: 10.18632/oncotarget.23175. eCollection 2018 Jan 5.

18.

Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes.

van Eyk HJ, van Schinkel LD, Kantae V, Dronkers CEA, Westenberg JJM, de Roos A, Lamb HJ, Jukema JW, Harms AC, Hankemeier T, van der Stelt M, Jazet IM, Rensen PCN, Smit JWA.

Nutr Diabetes. 2018 Jan 17;8(1):6. doi: 10.1038/s41387-017-0016-7.

19.

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.

van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, Melo van Lent D, Tynkkynen J, Fischer K, Hernesniemi J, Haller T, Singh-Manoux A, Verhoeven A, Willemsen G, de Leeuw FA, Wagner H, van Dongen J, Hertel J, Budde K, Willems van Dijk K, Weinhold L, Ikram MA, Pietzner M, Perola M, Wagner M, Friedrich N, Slagboom PE, Scheltens P, Yang Q, Gertzen RE, Egert S, Li S, Hankemeier T, van Beijsterveldt CEM, Vasan RS, Maier W, Peeters CFW, Jörgen Grabe H, Ramirez A, Seshadri S, Metspalu A, Kivimäki M, Salomaa V, Demirkan A, Boomsma DI, van der Flier WM, Amin N, van Duijn CM.

Alzheimers Dement. 2018 Jun;14(6):707-722. doi: 10.1016/j.jalz.2017.11.012. Epub 2018 Jan 6.

20.

96 perfusable blood vessels to study vascular permeability in vitro.

van Duinen V, van den Heuvel A, Trietsch SJ, Lanz HL, van Gils JM, van Zonneveld AJ, Vulto P, Hankemeier T.

Sci Rep. 2017 Dec 22;7(1):18071. doi: 10.1038/s41598-017-14716-y.

21.

The future of metabolomics in ELIXIR.

van Rijswijk M, Beirnaert C, Caron C, Cascante M, Dominguez V, Dunn WB, Ebbels TMD, Giacomoni F, Gonzalez-Beltran A, Hankemeier T, Haug K, Izquierdo-Garcia JL, Jimenez RC, Jourdan F, Kale N, Klapa MI, Kohlbacher O, Koort K, Kultima K, Le Corguillé G, Moreno P, Moschonas NK, Neumann S, O'Donovan C, Reczko M, Rocca-Serra P, Rosato A, Salek RM, Sansone SA, Satagopam V, Schober D, Shimmo R, Spicer RA, Spjuth O, Thévenot EA, Viant MR, Weber RJM, Willighagen EL, Zanetti G, Steinbeck C.

Version 2. F1000Res. 2017 Sep 6 [revised 2017 Jan 1];6. pii: ELIXIR-1649. doi: 10.12688/f1000research.12342.2. eCollection 2017.

22.

Therapy response testing of breast cancer in a 3D high-throughput perfused microfluidic platform.

Lanz HL, Saleh A, Kramer B, Cairns J, Ng CP, Yu J, Trietsch SJ, Hankemeier T, Joore J, Vulto P, Weinshilboum R, Wang L.

BMC Cancer. 2017 Nov 2;17(1):709. doi: 10.1186/s12885-017-3709-3.

23.

Blood-based metabolic signatures in Alzheimer's disease.

de Leeuw FA, Peeters CFW, Kester MI, Harms AC, Struys EA, Hankemeier T, van Vlijmen HWT, van der Lee SJ, van Duijn CM, Scheltens P, Demirkan A, van de Wiel MA, van der Flier WM, Teunissen CE.

Alzheimers Dement (Amst). 2017 Sep 6;8:196-207. doi: 10.1016/j.dadm.2017.07.006. eCollection 2017.

24.

Cellular glutathione levels in HL-60 cells during respiratory burst are not correlated with ultra-weak photon emission.

Burgos RCR, Zhang W, van Wijk EPA, Hankemeier T, Ramautar R, van der Greef J.

J Photochem Photobiol B. 2017 Oct;175:291-296. doi: 10.1016/j.jphotobiol.2017.09.002. Epub 2017 Sep 7.

25.

Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats.

van den Brink WJ, Elassaiss-Schaap J, Gonzalez-Amoros B, Harms AC, van der Graaf PH, Hankemeier T, de Lange ECM.

Eur J Pharm Sci. 2017 Nov 15;109:431-440. doi: 10.1016/j.ejps.2017.08.031. Epub 2017 Sep 4.

26.

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes.

Liu J, van Klinken JB, Semiz S, van Dijk KW, Verhoeven A, Hankemeier T, Harms AC, Sijbrands E, Sheehan NA, van Duijn CM, Demirkan A.

Diabetes. 2017 Nov;66(11):2915-2926. doi: 10.2337/db17-0199. Epub 2017 Aug 28.

27.

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes.

Trietsch SJ, Naumovska E, Kurek D, Setyawati MC, Vormann MK, Wilschut KJ, Lanz HL, Nicolas A, Ng CP, Joore J, Kustermann S, Roth A, Hankemeier T, Moisan A, Vulto P.

Nat Commun. 2017 Aug 15;8(1):262. doi: 10.1038/s41467-017-00259-3.

28.

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study.

Liu J, Semiz S, van der Lee SJ, van der Spek A, Verhoeven A, van Klinken JB, Sijbrands E, Harms AC, Hankemeier T, van Dijk KW, van Duijn CM, Demirkan A.

Metabolomics. 2017;13(9):104. doi: 10.1007/s11306-017-1239-2. Epub 2017 Jul 28.

29.

Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men.

Kantae V, Nahon KJ, Straat ME, Bakker LEH, Harms AC, van der Stelt M, Hankemeier T, Jazet IM, Boon MR, Rensen PCN.

Sci Rep. 2017 Aug 8;7(1):7558. doi: 10.1038/s41598-017-07980-5.

30.

Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants.

Schoeman JC, Moutloatse GP, Harms AC, Vreeken RJ, Scherpbier HJ, Van Leeuwen L, Kuijpers TW, Reinecke CJ, Berger R, Hankemeier T, Bunders MJ.

J Infect Dis. 2017 Aug 15;216(4):436-446. doi: 10.1093/infdis/jix291.

31.

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

van Esbroeck ACM, Janssen APA, Cognetta AB 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M.

Science. 2017 Jun 9;356(6342):1084-1087. doi: 10.1126/science.aaf7497.

32.

Towards personalized treatment of pain using a quantitative systems pharmacology approach.

Goulooze SC, Krekels EHJ, van Dijk M, Tibboel D, van der Graaf PH, Hankemeier T, Knibbe CAJ, van Hasselt JGC.

Eur J Pharm Sci. 2017 Nov 15;109S:S32-S38. doi: 10.1016/j.ejps.2017.05.027. Epub 2017 May 12. Review.

33.

Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine.

Kohler I, Hankemeier T, van der Graaf PH, Knibbe CAJ, van Hasselt JGC.

Eur J Pharm Sci. 2017 Nov 15;109S:S15-S21. doi: 10.1016/j.ejps.2017.05.018. Epub 2017 May 11. Review.

34.

Ultra-weak photon emission as a dynamic tool for monitoring oxidative stress metabolism.

Burgos RCR, Schoeman JC, Winden LJV, Červinková K, Ramautar R, Van Wijk EPA, Cifra M, Berger R, Hankemeier T, Greef JV.

Sci Rep. 2017 Apr 27;7(1):1229. doi: 10.1038/s41598-017-01229-x.

35.

Metabolic network failures in Alzheimer's disease: A biochemical road map.

Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, Risacher SL, Blach C, Lucas JE, Massaro T, Louie G, Zhu H, Dallmann G, Klavins K, Koal T, Kim S, Nho K, Shen L, Casanova R, Varma S, Legido-Quigley C, Moseley MA, Zhu K, Henrion MYR, van der Lee SJ, Harms AC, Demirkan A, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Saykin AJ, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium.

Alzheimers Dement. 2017 Sep;13(9):965-984. doi: 10.1016/j.jalz.2017.01.020. Epub 2017 Mar 22.

36.

Role of amino acids in rheumatoid arthritis studied by metabolomics.

He M, Harms AC, van Wijk E, Wang M, Berger R, Koval S, Hankemeier T, van der Greef J.

Int J Rheum Dis. 2017 Mar 22. doi: 10.1111/1756-185X.13062. [Epub ahead of print]

PMID:
28328075
37.

Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a mouse model of collagen-induced arthritis.

He M, van Wijk E, van Wietmarschen H, Wang M, Sun M, Koval S, van Wijk R, Hankemeier T, van der Greef J.

J Photochem Photobiol B. 2017 Mar;168:98-106. doi: 10.1016/j.jphotobiol.2016.12.036. Epub 2017 Feb 3.

PMID:
28199905
38.

Characterization of the therapeutic properties of Chinese herbal materials by measuring delayed luminescence and dendritic cell-based immunomodulatory response.

Sun M, Chang WT, Van Wijk E, He M, Koval S, Lin MK, Van Wijk R, Hankemeier T, van der Greef J, Wang M.

J Photochem Photobiol B. 2017 Mar;168:1-11. doi: 10.1016/j.jphotobiol.2017.01.018. Epub 2017 Jan 22.

PMID:
28147303
39.

Feasibility of ultra-performance liquid chromatography-ion mobility-time-of-flight mass spectrometry in analyzing oxysterols.

Kylli P, Hankemeier T, Kostiainen R.

J Chromatogr A. 2017 Mar 3;1487:147-152. doi: 10.1016/j.chroma.2017.01.039. Epub 2017 Jan 18.

PMID:
28118975
40.

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy.

Kantae V, Krekels EHJ, Esdonk MJV, Lindenburg P, Harms AC, Knibbe CAJ, Van der Graaf PH, Hankemeier T.

Metabolomics. 2017;13(1):9. doi: 10.1007/s11306-016-1143-1. Epub 2016 Dec 19.

41.

Quantitative profiling of endocannabinoids and related N-acylethanolamines in human CSF using nano LC-MS/MS.

Kantae V, Ogino S, Noga M, Harms AC, van Dongen RM, Onderwater GL, van den Maagdenberg AM, Terwindt GM, van der Stelt M, Ferrari MD, Hankemeier T.

J Lipid Res. 2017 Mar;58(3):615-624. doi: 10.1194/jlr.D070433. Epub 2016 Dec 20.

42.

Measuring ultra-weak photon emission as a non-invasive diagnostic tool for detecting early-stage type 2 diabetes: A step toward personalized medicine.

Sun M, Van Wijk E, Koval S, Van Wijk R, He M, Wang M, Hankemeier T, van der Greef J.

J Photochem Photobiol B. 2017 Jan;166:86-93. doi: 10.1016/j.jphotobiol.2016.11.013. Epub 2016 Nov 17.

PMID:
27888740
43.

Classification for Longevity Potential: The Use of Novel Biomarkers.

Beekman M, Uh HW, van Heemst D, Wuhrer M, Ruhaak LR, Gonzalez-Covarrubias V, Hankemeier T, Houwing-Duistermaat JJ, Slagboom PE.

Front Public Health. 2016 Oct 28;4:233. eCollection 2016.

44.

A novel method for serum lipoprotein profiling using high performance capillary isotachophoresis.

Moreno-Gordaliza E, van der Lee SJ, Demirkan A, van Duijn CM, Kuiper J, Lindenburg PW, Hankemeier T.

Anal Chim Acta. 2016 Nov 9;944:57-69. doi: 10.1016/j.aca.2016.09.038. Epub 2016 Oct 5.

PMID:
27776640
45.

Sheathless Capillary Electrophoresis-Mass Spectrometry for Metabolic Profiling of Biological Samples.

Zhang W, Gulersonmez MC, Hankemeier T, Ramautar R.

J Vis Exp. 2016 Oct 1;(116). doi: 10.3791/54535.

46.

Quantifying Beta-Galactosylceramide Kinetics in Cerebrospinal Fluid of Healthy Subjects Using Deuterium Labeling.

Kanhai K, Goulooze SC, Stevens J, Hay JL, Dent G, Verma A, Hankemeier T, de Boer T, Meijering H, Chavez JC, Cohen AF, Groeneveld GJ.

Clin Transl Sci. 2016 Dec;9(6):321-327. doi: 10.1111/cts.12424. Epub 2016 Oct 15.

47.

Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment.

Fu J, Cuppen BV, Welsing PM, van Wietmarschen H, Harms AC, Berger R, Koval S, Fritsch-Stork RD, Bijlsma JW, Hankemeier T, van der Greef J, Lafeber FP.

Inflammopharmacology. 2016 Dec;24(6):397-402. Epub 2016 Sep 28.

48.

Metabolomics enables precision medicine: "A White Paper, Community Perspective".

Beger RD, Dunn W, Schmidt MA, Gross SS, Kirwan JA, Cascante M, Brennan L, Wishart DS, Oresic M, Hankemeier T, Broadhurst DI, Lane AN, Suhre K, Kastenmüller G, Sumner SJ, Thiele I, Fiehn O, Kaddurah-Daouk R; for “Precision Medicine and Pharmacometabolomics Task Group”-Metabolomics Society Initiative.

Metabolomics. 2016;12(10):149. Epub 2016 Sep 2.

49.

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.

Kantae V, Krekels EH, Ordas A, González O, van Wijk RC, Harms AC, Racz PI, van der Graaf PH, Spaink HP, Hankemeier T.

Zebrafish. 2016 Dec;13(6):504-510. Epub 2016 Sep 15.

50.

Exploring the Inflammatory Metabolomic Profile to Predict Response to TNF-α Inhibitors in Rheumatoid Arthritis.

Cuppen BV, Fu J, van Wietmarschen HA, Harms AC, Koval S, Marijnissen AC, Peeters JJ, Bijlsma JW, Tekstra J, van Laar JM, Hankemeier T, Lafeber FP, van der Greef J; all Society for Rheumatology Research Utrecht investigators.

PLoS One. 2016 Sep 15;11(9):e0163087. doi: 10.1371/journal.pone.0163087. eCollection 2016.

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