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Items: 1 to 50 of 82

1.

Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism.

Fuscoe JC, Vijay V, Hanig JP, Han T, Ren L, Greenhaw JJ, Beger RD, Pence LM, Shi Q.

Drug Metab Dispos. 2020 Mar 19. pii: dmd.119.089367. doi: 10.1124/dmd.119.089367. [Epub ahead of print]

2.

Microglial activation and responses to vasculature that result from an acute LPS exposure.

Bowyer JF, Sarkar S, Burks SM, Hess JN, Tolani S, O'Callaghan JP, Hanig JP.

Neurotoxicology. 2020 Mar;77:181-192. doi: 10.1016/j.neuro.2020.01.014. Epub 2020 Jan 31.

PMID:
32014511
3.

Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-Derived Models.

Liu F, Liu S, Patterson TA, Fogle C, Hanig JP, Wang C, Slikker W Jr.

Mol Neurobiol. 2020 Jan;57(1):200-207. doi: 10.1007/s12035-019-01769-5.

PMID:
31578707
4.

Effects of Xenon-Based Anesthetic Exposure on the Expression Levels of Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) on Human Neural Stem Cell-Derived Neurons.

Liu F, Liu S, Patterson TA, Fogle C, Hanig JP, Slikker W Jr, Wang C.

Mol Neurobiol. 2020 Jan;57(1):217-225. doi: 10.1007/s12035-019-01771-x. Epub 2019 Sep 15.

PMID:
31522383
5.

Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats.

Camacho L, Silva CS, Hanig JP, Schleimer RP, George NI, Bowyer JF.

PLoS One. 2019 Feb 19;14(2):e0210273. doi: 10.1371/journal.pone.0210273. eCollection 2019.

6.

Early life exposure to extended general anesthesia with isoflurane and nitrous oxide reduces responsivity on a cognitive test battery in the nonhuman primate.

Talpos JC, Chelonis JJ, Li M, Hanig JP, Paule MG.

Neurotoxicology. 2019 Jan;70:80-90. doi: 10.1016/j.neuro.2018.11.005. Epub 2018 Nov 14.

PMID:
30445043
7.

Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure.

Wang C, Liu F, Frisch-Daiello JL, Martin S, Patterson TA, Gu Q, Liu S, Paule MG, Hanig JP, Slikker W Jr, Crawford PA, Wang C, Han X.

Anal Chim Acta. 2018 Dec 11;1037:87-96. doi: 10.1016/j.aca.2017.11.052. Epub 2017 Nov 30.

PMID:
30292318
8.

The time course of blood brain barrier leakage and its implications on the progression of methamphetamine-induced seizures.

Bowyer JF, Tranter KM, Robinson BL, Hanig JP, Faubion MG, Sarkar S.

Neurotoxicology. 2018 Dec;69:130-140. doi: 10.1016/j.neuro.2018.09.008. Epub 2018 Sep 30.

PMID:
30282018
9.

Lipid profiling as an effective approach for identifying biomarkers/adverse events associated with pediatric anesthesia.

Wang C, Han X, Liu F, Patterson TA, Hanig JP, Paule MG, Slikker W Jr.

Toxicol Appl Pharmacol. 2018 Sep 1;354:191-195. doi: 10.1016/j.taap.2018.03.017. Epub 2018 Mar 15. Review.

PMID:
29550513
10.

Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency.

Bowyer JF, Tranter KM, Sarkar S, Hanig JP.

Neurotoxicology. 2018 Mar;65:98-110. doi: 10.1016/j.neuro.2018.02.005. Epub 2018 Feb 7.

PMID:
29427613
11.

Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

Imam SZ, He Z, Cuevas E, Rosas-Hernandez H, Lantz SM, Sarkar S, Raymick J, Robinson B, Hanig JP, Herr D, MacMillan D, Smith A, Liachenko S, Ferguson S, O'Callaghan J, Miller D, Somps C, Pardo ID, Slikker W Jr, B Pierson J, Roberts R, Gong B, Tong W, Aschner M, J Kallman M, Calligaro D, Paule MG.

Exp Biol Med (Maywood). 2018 Feb;243(3):228-236. doi: 10.1177/1535370217739859. Epub 2017 Nov 6.

12.

Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine.

Bowyer JF, Tranter KM, Sarkar S, George NI, Hanig JP, Kelly KA, Michalovicz LT, Miller DB, O'Callaghan JP.

J Neurochem. 2017 Oct;143(2):198-213. doi: 10.1111/jnc.14143. Epub 2017 Sep 21.

13.

Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat.

Sarkar S, Liachenko S, Paule MG, Bowyer J, Hanig JP.

Neurotoxicology. 2016 Dec;57:298-309. doi: 10.1016/j.neuro.2016.10.014. Epub 2016 Oct 28.

PMID:
27984051
14.

Longitudinal diffusion tensor imaging of the rat brain after hexachlorophene exposure.

Ramu J, Konak T, Paule MG, Hanig JP, Liachenko S.

Neurotoxicology. 2016 Sep;56:225-232. doi: 10.1016/j.neuro.2016.08.011. Epub 2016 Aug 20.

PMID:
27555423
15.

In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography.

Zhang X, Liu S, Newport GD, Paule MG, Callicott R, Thompson J, Liu F, Patterson TA, Berridge MS, Apana SM, Brown CC, Maisha MP, Hanig JP, Slikker W Jr, Wang C.

Anesthesiology. 2016 Jul;125(1):133-46. doi: 10.1097/ALN.0000000000001154.

PMID:
27183169
16.

Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?

Bowyer JF, Sarkar S, Tranter KM, Hanig JP, Miller DB, O'Callaghan JP.

J Neuroinflammation. 2016 Mar 12;13(1):64. doi: 10.1186/s12974-016-0526-6.

17.

Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward.

Roberts RA, Aschner M, Calligaro D, Guilarte TR, Hanig JP, Herr DW, Hudzik TJ, Jeromin A, Kallman MJ, Liachenko S, Lynch JJ 3rd, Miller DB, Moser VC, O'Callaghan JP, Slikker W Jr, Paule MG.

Toxicol Sci. 2015 Dec;148(2):332-40. doi: 10.1093/toxsci/kfv188. Review.

18.

Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood.

Bowyer JF, Tranter KM, Hanig JP, Crabtree NM, Schleimer RP, George NI.

PLoS One. 2015 Jul 15;10(7):e0133315. doi: 10.1371/journal.pone.0133315. eCollection 2015.

19.

Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells.

Slikker W Jr, Liu F, Rainosek SW, Patterson TA, Sadovova N, Hanig JP, Paule MG, Wang C.

Mol Neurobiol. 2015 Oct;52(2):959-69. doi: 10.1007/s12035-015-9248-5. Epub 2015 Jun 9.

PMID:
26055230
20.

The use of time-lapse optical coherence tomography to image the effects of microapplied toxins on the retina.

Majdi JA, Qian H, Li Y, Langsner RJ, Shea KI, Agrawal A, Hammer DX, Hanig JP, Cohen ED.

Invest Ophthalmol Vis Sci. 2014 Dec 18;56(1):587-97. doi: 10.1167/iovs.14-15594.

21.

Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity.

Bowyer JF, Hanig JP.

Temperature (Austin). 2014 Nov 14;1(3):172-82. doi: 10.4161/23328940.2014.982049. eCollection 2014 Oct-Dec. Review.

22.

Computational identification of a phospholipidosis toxicophore using (13)C and (15)N NMR-distance based fingerprints.

Slavov SH, Wilkes JG, Buzatu DA, Kruhlak NL, Willard JM, Hanig JP, Beger RD.

Bioorg Med Chem. 2014 Dec 1;22(23):6706-6714. doi: 10.1016/j.bmc.2014.08.021. Epub 2014 Aug 27.

23.

Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model.

Sarkar S, Chigurupati S, Raymick J, Mann D, Bowyer JF, Schmitt T, Beger RD, Hanig JP, Schmued LC, Paule MG.

Neurotoxicology. 2014 Sep;44:250-62. doi: 10.1016/j.neuro.2014.07.006. Epub 2014 Jul 23.

PMID:
25064079
24.

Protective effect of acetyl-L-carnitine on propofol-induced toxicity in embryonic neural stem cells.

Liu F, Rainosek SW, Sadovova N, Fogle CM, Patterson TA, Hanig JP, Paule MG, Slikker W Jr, Wang C.

Neurotoxicology. 2014 May;42:49-57. doi: 10.1016/j.neuro.2014.03.011. Epub 2014 Apr 2.

PMID:
24704589
25.

Neurovascular changes in acute, sub-acute and chronic mouse models of Parkinson's disease.

Sarkar S, Raymick J, Mann D, Bowyer JF, Hanig JP, Schmued LC, Paule MG, Chigurupati S.

Curr Neurovasc Res. 2014 Feb;11(1):48-61.

PMID:
24274908
26.

Systemic administration of fluoro-gold for the histological assessment of vascular structure, integrity and damage.

Bowyer JF, Tranter KM, Sarkar S, Raymick J, Hanig JP, Schmued LC.

Curr Neurovasc Res. 2014 Feb;11(1):31-47.

PMID:
24274907
27.

Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity.

Levi MS, Patton RE, Hanig JP, Tranter KM, George NI, James LP, Davis KJ, Bowyer JF.

Neurotoxicology. 2013 Jul;37:40-50. doi: 10.1016/j.neuro.2013.04.003. Epub 2013 Apr 19.

PMID:
23608161
28.

Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity.

Bowyer JF, Patterson TA, Saini UT, Hanig JP, Thomas M, Camacho L, George NI, Chen JJ.

BMC Genomics. 2013 Mar 5;14:147. doi: 10.1186/1471-2164-14-147.

29.

Inhalation Anesthesia-Induced Neuronal Damage and Gene Expression Changes in Developing Rat Brain.

Liu F, Guo L, Zhang J, Rainosek SW, Shi L, Patterson TA, Li QZ, Sadovova N, Hanig JP, Paule MG, Slikker W Jr, Wang C.

Syst Pharmacol. 2013;1:1-9. doi: 10.2478/sph-2012-0001. Epub 2013 Jan 1.

30.

Ketamine-induced neuronal damage and altered N-methyl-D-aspartate receptor function in rat primary forebrain culture.

Liu F, Patterson TA, Sadovova N, Zhang X, Liu S, Zou X, Hanig JP, Paule MG, Slikker W Jr, Wang C.

Toxicol Sci. 2013 Feb;131(2):548-57. doi: 10.1093/toxsci/kfs296. Epub 2012 Oct 11.

31.

A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during the waking (lights off) cycle.

Levi MS, Divine B, Hanig JP, Doerge DR, Vanlandingham MM, George NI, Twaddle NC, Bowyer JF.

Neurotoxicol Teratol. 2012 Mar;34(2):253-62. doi: 10.1016/j.ntt.2012.01.007. Epub 2012 Jan 20.

PMID:
22289608
32.

Biomarkers of endothelial cell activation: candidate markers for drug-induced vasculitis in patients or drug-induced vascular injury in animals.

Zhang J, Hanig JP, De Felice AF.

Vascul Pharmacol. 2012 Jan-Feb;56(1-2):14-25. doi: 10.1016/j.vph.2011.09.002. Epub 2011 Sep 24. Review.

PMID:
21968053
33.

Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey.

Zou X, Liu F, Zhang X, Patterson TA, Callicott R, Liu S, Hanig JP, Paule MG, Slikker W Jr, Wang C.

Neurotoxicol Teratol. 2011 Sep-Oct;33(5):592-7. doi: 10.1016/j.ntt.2011.06.003. Epub 2011 Jun 25.

PMID:
21708249
34.

Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys.

Paule MG, Li M, Allen RR, Liu F, Zou X, Hotchkiss C, Hanig JP, Patterson TA, Slikker W Jr, Wang C.

Neurotoxicol Teratol. 2011 Mar-Apr;33(2):220-30. doi: 10.1016/j.ntt.2011.01.001. Epub 2011 Jan 15.

35.

The use of in situ perfusion of the rat mesentery as a model to investigate vascular injury directly induced by drugs.

Knapton AD, Zhang J, Sistare FD, Hanig JP.

Methods Find Exp Clin Pharmacol. 2010 Sep;32(7):489-97. doi: 10.1358/mf.2010.32.7.1507854.

PMID:
21069100
36.

Biomarkers of endothelial cell activation serve as potential surrogate markers for drug-induced vascular injury.

Zhang J, Defelice AF, Hanig JP, Colatsky T.

Toxicol Pathol. 2010 Oct;38(6):856-71. doi: 10.1177/0192623310378866. Epub 2010 Aug 17. Review.

PMID:
20716788
37.

Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia.

Liu F, Zou X, Sadovova N, Zhang X, Shi L, Guo L, Qian F, Wen Z, Patterson TA, Hanig JP, Paule MG, Slikker W Jr, Wang C.

Int J Dev Neurosci. 2011 May;29(3):351-8. doi: 10.1016/j.ijdevneu.2010.07.234. Epub 2010 Aug 5.

38.

Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure.

Thomas M, George NI, Saini UT, Patterson TA, Hanig JP, Bowyer JF.

Synapse. 2010 Aug;64(8):579-93. doi: 10.1002/syn.20763.

PMID:
20340164
39.

Gene expression profiling in the developing rat brain exposed to ketamine.

Shi Q, Guo L, Patterson TA, Dial S, Li Q, Sadovova N, Zhang X, Hanig JP, Paule MG, Slikker W Jr, Wang C.

Neuroscience. 2010 Mar 31;166(3):852-63. doi: 10.1016/j.neuroscience.2010.01.007. Epub 2010 Jan 18.

40.

A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: microPET Imaging using 18F-annexin V.

Zhang X, Paule MG, Newport GD, Zou X, Sadovova N, Berridge MS, Apana SM, Hanig JP, Slikker W Jr, Wang C.

Toxicol Sci. 2009 Oct;111(2):355-61. doi: 10.1093/toxsci/kfp167. Epub 2009 Jul 28.

PMID:
19638431
41.

Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain.

Zou X, Patterson TA, Divine RL, Sadovova N, Zhang X, Hanig JP, Paule MG, Slikker W Jr, Wang C.

Int J Dev Neurosci. 2009 Nov;27(7):727-31. doi: 10.1016/j.ijdevneu.2009.06.010. Epub 2009 Jul 4.

PMID:
19580862
42.

Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine.

Zhang J, Goering PL, Espandiari P, Shaw M, Bonventre JV, Vaidya VS, Brown RP, Keenan J, Kilty CG, Sadrieh N, Hanig JP.

Toxicol Pathol. 2009 Aug;37(5):629-43. doi: 10.1177/0192623309339605. Epub 2009 Jun 17.

43.

Potential neurotoxicity of ketamine in the developing rat brain.

Zou X, Patterson TA, Sadovova N, Twaddle NC, Doerge DR, Zhang X, Fu X, Hanig JP, Paule MG, Slikker W, Wang C.

Toxicol Sci. 2009 Mar;108(1):149-58. doi: 10.1093/toxsci/kfn270. Epub 2009 Jan 6.

44.

Histopathology of vascular injury in Sprague-Dawley rats treated with phosphodiesterase IV inhibitor SCH 351591 or SCH 534385.

Zhang J, Snyder RD, Herman EH, Knapton A, Honchel R, Miller T, Espandiari P, Goodsaid FM, Rosenblum IY, Hanig JP, Sistare FD, Weaver JL.

Toxicol Pathol. 2008 Oct;36(6):827-39. doi: 10.1177/0192623308322308. Epub 2008 Sep 5.

PMID:
18776163
45.

Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture.

Wang C, Sadovova N, Patterson TA, Zou X, Fu X, Hanig JP, Paule MG, Ali SF, Zhang X, Slikker W Jr.

Neurotoxicology. 2008 Jul;29(4):613-20. doi: 10.1016/j.neuro.2008.03.007. Epub 2008 Mar 29.

PMID:
18456338
46.

Cytochrome c: a non-invasive biomarker of drug-induced liver injury.

Miller TJ, Knapton A, Adeyemo O, Noory L, Weaver J, Hanig JP.

J Appl Toxicol. 2008 Oct;28(7):815-28. doi: 10.1002/jat.1347.

PMID:
18418843
47.

The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex.

Zou X, Sadovova N, Patterson TA, Divine RL, Hotchkiss CE, Ali SF, Hanig JP, Paule MG, Slikker W Jr, Wang C.

Neuroscience. 2008 Feb 19;151(4):1053-65. doi: 10.1016/j.neuroscience.2007.12.013. Epub 2007 Dec 15.

PMID:
18201836
48.

The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals.

Miller TJ, Honchel R, Espandiari P, Knapton A, Zhang J, Sistare FD, Hanig JP.

Regul Toxicol Pharmacol. 2008 Feb;50(1):87-97. Epub 2007 Nov 4.

PMID:
18069108
49.

Age-related differences in susceptibility to toxic effects of valproic acid in rats.

Espandiari P, Zhang J, Schnackenberg LK, Miller TJ, Knapton A, Herman EH, Beger RD, Hanig JP.

J Appl Toxicol. 2008 Jul;28(5):628-37.

PMID:
17994530
50.

Oral treatment with ACCUTANE does not increase measures of anhedonia or depression in rats.

Ferguson SA, Cisneros FJ, Hanig JP, Berry KJ.

Neurotoxicol Teratol. 2007 Nov-Dec;29(6):642-51. Epub 2007 Sep 18.

PMID:
17933491

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