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Modulation of Hematopoietic Chemokine Effects In Vitro and In Vivo by DPP-4/CD26.

Broxmeyer HE, Capitano M, Campbell TB, Hangoc G, Cooper S.

Stem Cells Dev. 2016 Apr 15;25(8):575-85. doi: 10.1089/scd.2016.0026. Epub 2016 Mar 30.


Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo.

Huang W, Dong Z, Chen Y, Wang F, Wang CJ, Peng H, He Y, Hangoc G, Pollok K, Sandusky G, Fu XY, Broxmeyer HE, Zhang ZY, Liu JY, Zhang JT.

Oncogene. 2016 Feb 11;35(6):802. doi: 10.1038/onc.2015.419. No abstract available.


Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression.

Huang X, Lee MR, Cooper S, Hangoc G, Hong KS, Chung HM, Broxmeyer HE.

Leukemia. 2016 Jan;30(1):144-53. doi: 10.1038/leu.2015.189. Epub 2015 Jul 23.


Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.

Mantel CR, O'Leary HA, Chitteti BR, Huang X, Cooper S, Hangoc G, Brustovetsky N, Srour EF, Lee MR, Messina-Graham S, Haas DM, Falah N, Kapur R, Pelus LM, Bardeesy N, Fitamant J, Ivan M, Kim KS, Broxmeyer HE.

Cell. 2015 Jun 18;161(7):1553-65. doi: 10.1016/j.cell.2015.04.054. Epub 2015 Jun 11.


Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo.

Huang W, Dong Z, Chen Y, Wang F, Wang CJ, Peng H, He Y, Hangoc G, Pollok K, Sandusky G, Fu XY, Broxmeyer HE, Zhang ZY, Liu JY, Zhang JT.

Oncogene. 2016 Feb 11;35(6):783-92. doi: 10.1038/onc.2015.215. Epub 2015 Jun 15. Erratum in: Oncogene. 2016 Feb 11;35(6):802.


Mild Heat Treatment Primes Human CD34(+) Cord Blood Cells for Migration Toward SDF-1α and Enhances Engraftment in an NSG Mouse Model.

Capitano ML, Hangoc G, Cooper S, Broxmeyer HE.

Stem Cells. 2015 Jun;33(6):1975-84. doi: 10.1002/stem.1988.


Nonmarrow hematopoiesis occurs in a hyaluronic-acid-rich node and duct system in mice.

Hwang S, Lee SJ, Park SH, Chitteti BR, Srour EF, Cooper S, Hangoc G, Broxmeyer HE, Kwon BS.

Stem Cells Dev. 2014 Nov 1;23(21):2661-71. doi: 10.1089/scd.2014.0075. Epub 2014 Jul 14.


Peroxisome proliferator-activated-γ coactivator-1α-mediated mitochondrial biogenesis is important for hematopoietic recovery in response to stress.

Basu S, Broxmeyer HE, Hangoc G.

Stem Cells Dev. 2013 Jun 1;22(11):1678-92. doi: 10.1089/scd.2012.0466. Epub 2013 Feb 13.


Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.

Broxmeyer HE, Hoggatt J, O'Leary HA, Mantel C, Chitteti BR, Cooper S, Messina-Graham S, Hangoc G, Farag S, Rohrabaugh SL, Ou X, Speth J, Pelus LM, Srour EF, Campbell TB.

Nat Med. 2012 Dec;18(12):1786-96. doi: 10.1038/nm.2991. Epub 2012 Nov 18.


Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function.

Sawant DV, Sehra S, Nguyen ET, Jadhav R, Englert K, Shinnakasu R, Hangoc G, Broxmeyer HE, Nakayama T, Perumal NB, Kaplan MH, Dent AL.

J Immunol. 2012 Nov 15;189(10):4759-69. doi: 10.4049/jimmunol.1201794. Epub 2012 Oct 10.


Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype.

Mantel C, Messina-Graham S, Moh A, Cooper S, Hangoc G, Fu XY, Broxmeyer HE.

Blood. 2012 Sep 27;120(13):2589-99. Epub 2012 Jun 4.


CD1d expression on and regulation of murine hematopoietic stem and progenitor cells.

Broxmeyer HE, Christopherson K, Hangoc G, Cooper S, Mantel C, Renukaradhya GJ, Brutkiewicz RR.

Blood. 2012 Jun 14;119(24):5731-41. doi: 10.1182/blood-2012-01-404012. Epub 2012 Apr 25.


Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors.

Broxmeyer HE, Srour EF, Cooper S, Wallace CT, Hangoc G, Youn BS.

Blood Cells Mol Dis. 2012 Jan 15;48(1):25-9. doi: 10.1016/j.bcmd.2011.09.004. Epub 2011 Oct 7.


DEK regulates hematopoietic stem engraftment and progenitor cell proliferation.

Broxmeyer HE, Kappes F, Mor-Vaknin N, Legendre M, Kinzfogl J, Cooper S, Hangoc G, Markovitz DM.

Stem Cells Dev. 2012 Jun 10;21(9):1449-54. doi: 10.1089/scd.2011.0451. Epub 2011 Oct 27.


Cyclin dependent kinase inhibitors differentially modulate synergistic cytokine responsiveness of hematopoietic progenitor cells.

Broxmeyer HE, Franklin DS, Cooper S, Hangoc G, Mantel C.

Stem Cells Dev. 2012 Jul 1;21(10):1597-603. doi: 10.1089/scd.2011.0476. Epub 2011 Nov 2.


Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells.

Kinzfogl J, Hangoc G, Broxmeyer HE.

Blood. 2011 Jul 21;118(3):565-75. doi: 10.1182/blood-2010-12-325381. Epub 2011 May 31.


STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis.

Kaplan MH, Glosson NL, Stritesky GL, Yeh N, Kinzfogl J, Rohrabaugh SL, Goswami R, Pham D, Levy DE, Brutkiewicz RR, Blum JS, Cooper S, Hangoc G, Broxmeyer HE.

Blood. 2011 Jun 9;117(23):6198-201. doi: 10.1182/blood-2011-02-334367. Epub 2011 Apr 19.


TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC.

Liu Y, Timani K, Mantel C, Fan Y, Hangoc G, Cooper S, He JJ, Broxmeyer HE.

Blood. 2011 May 26;117(21):5643-51. doi: 10.1182/blood-2010-12-325332. Epub 2011 Mar 29.


Ex vivo rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice.

Rohrabaugh SL, Campbell TB, Hangoc G, Broxmeyer HE.

Blood Cells Mol Dis. 2011 Apr 15;46(4):318-20. doi: 10.1016/j.bcmd.2011.02.006.


Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood.

Broxmeyer HE, Lee MR, Hangoc G, Cooper S, Prasain N, Kim YJ, Mallett C, Ye Z, Witting S, Cornetta K, Cheng L, Yoder MC.

Blood. 2011 May 5;117(18):4773-7. doi: 10.1182/blood-2011-01-330514. Epub 2011 Mar 10.


Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro.

Rohrabaugh SL, Hangoc G, Kelley MR, Broxmeyer HE.

Exp Hematol. 2011 Apr;39(4):415-23. doi: 10.1016/j.exphem.2010.12.012. Epub 2011 Jan 7.


Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity.

Ha SP, Klemen ND, Kinnebrew GH, Brandmaier AG, Marsh J, Hangoc G, Palmer DC, Restifo NP, Cornetta K, Broxmeyer HE, Touloukian CE.

J Clin Invest. 2010 Dec;120(12):4273-88. doi: 10.1172/JCI43274. Epub 2010 Nov 15.


Experimental basis of cord blood transplantation.

Broxmeyer HE, Cooper S, Hass DM, Hathaway JK, Stehman FB, Hangoc G.

Bone Marrow Transplant. 2009 Nov;44(10):627-33. doi: 10.1038/bmt.2009.285. Epub 2009 Oct 5. Review.


Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation.

Campbell TB, Basu S, Hangoc G, Tao W, Broxmeyer HE.

Blood. 2009 Oct 15;114(16):3392-401. doi: 10.1182/blood-2008-12-195214. Epub 2009 Aug 18.


Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis.

Stumpo DJ, Broxmeyer HE, Ward T, Cooper S, Hangoc G, Chung YJ, Shelley WC, Richfield EK, Ray MK, Yoder MC, Aplan PD, Blackshear PJ.

Blood. 2009 Sep 17;114(12):2401-10. doi: 10.1182/blood-2009-04-214619. Epub 2009 Jul 24.


Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells.

Liu Y, Hangoc G, Campbell TB, Goodman M, Tao W, Pollok K, Srour EF, Broxmeyer HE.

Exp Hematol. 2008 Aug;36(8):947-56. doi: 10.1016/j.exphem.2008.06.005.


Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist.

Hübel K, Liles WC, Broxmeyer HE, Rodger E, Wood B, Cooper S, Hangoc G, Macfarland R, Bridger GJ, Henson GW, Calandra G, Dale DC.

Support Cancer Ther. 2004 Apr 1;1(3):165-72. doi: 10.3816/SCT.2004.n.008.


SDF-1/CXCL12 enhances in vitro replating capacity of murine and human multipotential and macrophage progenitor cells.

Broxmeyer HE, Mejia JA, Hangoc G, Barese C, Dinauer M, Cooper S.

Stem Cells Dev. 2007 Aug;16(4):589-96.


Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice.

Campbell TB, Hangoc G, Liu Y, Pollok K, Broxmeyer HE.

Stem Cells Dev. 2007 Jun;16(3):347-54.


A role for natural killer T cells and CD1d molecules in counteracting suppression of hematopoiesis in mice induced by infection with murine cytomegalovirus.

Broxmeyer HE, Dent A, Cooper S, Hangoc G, Wang ZY, Du W, Gervay-Haque J, Sriram V, Renukaradhya GJ, Brutkiewicz RR.

Exp Hematol. 2007 Apr;35(4 Suppl 1):87-93.


Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31.

Broxmeyer HE, Li J, Hangoc G, Cooper S, Tao W, Mantel C, Graham-Evans B, Ghilardi N, de Sauvage FJ.

Exp Hematol. 2007 Apr;35(4 Suppl 1):78-86.


AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis.

Broxmeyer HE, Hangoc G, Cooper S, Campbell T, Ito S, Mantel C.

Ann N Y Acad Sci. 2007 Jun;1106:1-19. Epub 2007 Mar 14.


Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-express fluorescent protein is not.

Tao W, Evans BG, Yao J, Cooper S, Cornetta K, Ballas CB, Hangoc G, Broxmeyer HE.

Stem Cells. 2007 Mar;25(3):670-8. Epub 2006 Nov 30.


Enhanced functional response to CXCL12/SDF-1 through retroviral overexpression of CXCR4 on M07e cells: implications for hematopoietic stem cell transplantation.

Porecha NK, English K, Hangoc G, Broxmeyer HE, Christopherson KW 2nd.

Stem Cells Dev. 2006 Jun;15(3):325-33.


SDF-1/CXCL12 enhances survival and chemotaxis of murine embryonic stem cells and production of primitive and definitive hematopoietic progenitor cells.

Guo Y, Hangoc G, Bian H, Pelus LM, Broxmeyer HE.

Stem Cells. 2005 Oct;23(9):1324-32. Erratum in: Stem Cells. 2006 Jan;24(1):211.


Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus.

Patel DR, Li W, Park JS, Sofi MH, Gourley TS, Hangoc G, Kaplan MH, Chang CH.

Cell Immunol. 2005 Jan;233(1):30-40.


Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist.

Broxmeyer HE, Orschell CM, Clapp DW, Hangoc G, Cooper S, Plett PA, Liles WC, Li X, Graham-Evans B, Campbell TB, Calandra G, Bridger G, Dale DC, Srour EF.

J Exp Med. 2005 Apr 18;201(8):1307-18.


Modulation of hematopoietic stem cell homing and engraftment by CD26.

Christopherson KW 2nd, Hangoc G, Mantel CR, Broxmeyer HE.

Science. 2004 Aug 13;305(5686):1000-3.


CD26 is essential for normal G-CSF-induced progenitor cell mobilization as determined by CD26-/- mice.

Christopherson KW, Cooper S, Hangoc G, Broxmeyer HE.

Exp Hematol. 2003 Nov;31(11):1126-34.


Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist.

Liles WC, Broxmeyer HE, Rodger E, Wood B, Hübel K, Cooper S, Hangoc G, Bridger GJ, Henson GW, Calandra G, Dale DC.

Blood. 2003 Oct 15;102(8):2728-30. Epub 2003 Jul 10.


Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20.

Liu L, Ding C, Zeng W, Heuer JG, Tetreault JW, Noblitt TW, Hangoc G, Cooper S, Brune KA, Sharma G, Fox N, Rowlinson SW, Rogers DP, Witcher DR, Lambooy PK, Wroblewski VJ, Miller JR, Broxmeyer HE.

Blood. 2003 Nov 1;102(9):3206-9. Epub 2003 Jul 10.


Profiling of differentially expressed apoptosis-related genes by cDNA arrays in human cord blood CD34+ cells treated with etoposide.

Tao W, Hangoc G, Hawes JW, Si Y, Cooper S, Broxmeyer HE.

Exp Hematol. 2003 Mar;31(3):251-60.


High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years.

Broxmeyer HE, Srour EF, Hangoc G, Cooper S, Anderson SA, Bodine DM.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):645-50. Epub 2003 Jan 7.

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