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Items: 1 to 50 of 92


Translation of peptidoglycan metabolites into immunotherapeutics.

Griffin ME, Hespen CW, Wang YC, Hang HC.

Clin Transl Immunology. 2019 Nov 29;8(12):e1095. doi: 10.1002/cti2.1095. eCollection 2019. Review.


Targeted and proteome-wide analysis of metabolite-protein interactions.

Tsukidate T, Li Q, Hang HC.

Curr Opin Chem Biol. 2019 Nov 29;54:19-27. doi: 10.1016/j.cbpa.2019.10.008. [Epub ahead of print] Review.


Site-specific acylation of a bacterial virulence regulator attenuates infection.

Zhang ZJ, Pedicord VA, Peng T, Hang HC.

Nat Chem Biol. 2019 Nov 18. doi: 10.1038/s41589-019-0392-5. [Epub ahead of print]


Chemical reporters for exploring microbiology and microbiota mechanisms.

Zhang Z, Wang YC, Yang X, Hang HC.

Chembiochem. 2019 Nov 15. doi: 10.1002/cbic.201900535. [Epub ahead of print]


Chemical Proteomic Analysis of S-Fatty Acylated Proteins and Their Modification Sites.

Thinon E, Hang HC.

Methods Mol Biol. 2019;2009:45-57. doi: 10.1007/978-1-4939-9532-5_4.


Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis.

Kim B, Wang YC, Hespen CW, Espinosa J, Salje J, Rangan KJ, Oren DA, Kang JY, Pedicord VA, Hang HC.

Elife. 2019 Apr 10;8. pii: e45343. doi: 10.7554/eLife.45343.


CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.

Zhu XG, Nicholson Puthenveedu S, Shen Y, La K, Ozlu C, Wang T, Klompstra D, Gultekin Y, Chi J, Fidelin J, Peng T, Molina H, Hang HC, Min W, Birsoy K.

Mol Cell. 2019 Apr 4;74(1):45-58.e7. doi: 10.1016/j.molcel.2019.01.037. Epub 2019 Mar 4.


Peptidoglycan Metabolite Photoaffinity Reporters Reveal Direct Binding to Intracellular Pattern Recognition Receptors and Arf GTPases.

Wang YC, Westcott NP, Griffin ME, Hang HC.

ACS Chem Biol. 2019 Mar 15;14(3):405-414. doi: 10.1021/acschembio.8b01038. Epub 2019 Feb 20.


IFITM3 directly engages and shuttles incoming virus particles to lysosomes.

Spence JS, He R, Hoffmann HH, Das T, Thinon E, Rice CM, Peng T, Chandran K, Hang HC.

Nat Chem Biol. 2019 Mar;15(3):259-268. doi: 10.1038/s41589-018-0213-2. Epub 2019 Jan 14.


Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens.

Peng T, Hang HC.

Curr Top Microbiol Immunol. 2019;420:93-110. doi: 10.1007/82_2018_126. Review.


Nε-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function.

Liu W, Zhou Y, Peng T, Zhou P, Ding X, Li Z, Zhong H, Xu Y, Chen S, Hang HC, Shao F.

Nat Microbiol. 2018 Sep;3(9):996-1009. doi: 10.1038/s41564-018-0215-6. Epub 2018 Jul 30.


Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites.

Thinon E, Fernandez JP, Molina H, Hang HC.

J Proteome Res. 2018 May 4;17(5):1907-1922. doi: 10.1021/acs.jproteome.8b00002. Epub 2018 Apr 6.


The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity.

McMichael TM, Zhang L, Chemudupati M, Hach JC, Kenney AD, Hang HC, Yount JS.

J Biol Chem. 2017 Dec 29;292(52):21517-21526. doi: 10.1074/jbc.M117.800482. Epub 2017 Oct 27.


Biochemical Mechanisms of Pathogen Restriction by Intestinal Bacteria.

Rangan KJ, Hang HC.

Trends Biochem Sci. 2017 Nov;42(11):887-898. doi: 10.1016/j.tibs.2017.08.005. Epub 2017 Sep 17. Review.


Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance.

Pedicord VA, Lockhart AAK, Rangan KJ, Craig JW, Loschko J, Rogoz A, Hang HC, Mucida D.

Sci Immunol. 2016 Sep;1(3). pii: eaai7732. doi: 10.1126/sciimmunol.aai7732. Epub 2016 Sep 22.


Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells.

Tsou LK, Yount JS, Hang HC.

Bioorg Med Chem. 2017 Jun 1;25(11):2883-2887. doi: 10.1016/j.bmc.2017.03.023. Epub 2017 Mar 10.


Protein S-palmitoylation in cellular differentiation.

Zhang MM, Hang HC.

Biochem Soc Trans. 2017 Feb 8;45(1):275-285. doi: 10.1042/BST20160236. Review.


Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress.

Westcott NP, Fernandez JP, Molina H, Hang HC.

Nat Chem Biol. 2017 Mar;13(3):302-308. doi: 10.1038/nchembio.2280. Epub 2017 Jan 16.


Site-Specific Bioorthogonal Labeling for Fluorescence Imaging of Intracellular Proteins in Living Cells.

Peng T, Hang HC.

J Am Chem Soc. 2016 Nov 2;138(43):14423-14433. Epub 2016 Oct 21.


A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens.

Rangan KJ, Pedicord VA, Wang YC, Kim B, Lu Y, Shaham S, Mucida D, Hang HC.

Science. 2016 Sep 23;353(6306):1434-1437. Epub 2016 Sep 22.


Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins.

Thinon E, Percher A, Hang HC.

Chembiochem. 2016 Oct 4;17(19):1800-1803. doi: 10.1002/cbic.201600213. Epub 2016 Jul 29.


Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation.

Percher A, Ramakrishnan S, Thinon E, Yuan X, Yount JS, Hang HC.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4302-7. doi: 10.1073/pnas.1602244113. Epub 2016 Apr 4.


Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates.

Tsou LK, Lara-Tejero M, RoseFigura J, Zhang ZJ, Wang YC, Yount JS, Lefebre M, Dossa PD, Kato J, Guan F, Lam W, Cheng YC, Galán JE, Hang HC.

J Am Chem Soc. 2016 Feb 24;138(7):2209-18. doi: 10.1021/jacs.5b11575. Epub 2016 Feb 16.


Proteomic analysis of fatty-acylated proteins.

Peng T, Thinon E, Hang HC.

Curr Opin Chem Biol. 2016 Feb;30:77-86. doi: 10.1016/j.cbpa.2015.11.008. Epub 2015 Dec 2. Review.


A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome.

Santiago-Tirado FH, Peng T, Yang M, Hang HC, Doering TL.

PLoS Pathog. 2015 May 13;11(5):e1004908. doi: 10.1371/journal.ppat.1004908. eCollection 2015 May.


Chemical reporters for exploring protein acylation.

Thinon E, Hang HC.

Biochem Soc Trans. 2015 Apr;43(2):253-61. doi: 10.1042/BST20150004. Review.


Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ.

Burnaevskiy N, Peng T, Reddick LE, Hang HC, Alto NM.

Mol Cell. 2015 Apr 2;58(1):110-22. doi: 10.1016/j.molcel.2015.01.040. Epub 2015 Mar 12.


Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.

Peng T, Hang HC.

J Am Chem Soc. 2015 Jan 21;137(2):556-9. doi: 10.1021/ja502109n. Epub 2015 Jan 12.


Integrative chemical biology approaches for identification and characterization of "erasers" for fatty-acid-acylated lysine residues within proteins.

Liu Z, Yang T, Li X, Peng T, Hang HC, Li XD.

Angew Chem Int Ed Engl. 2015 Jan 19;54(4):1149-52. doi: 10.1002/anie.201408763. Epub 2014 Dec 4.


Chemoproteomics reveals Toll-like receptor fatty acylation.

Chesarino NM, Hach JC, Chen JL, Zaro BW, Rajaram MV, Turner J, Schlesinger LS, Pratt MR, Hang HC, Yount JS.

BMC Biol. 2014 Nov 5;12:91. doi: 10.1186/s12915-014-0091-3.


Turning the spotlight on protein-lipid interactions in cells.

Peng T, Yuan X, Hang HC.

Curr Opin Chem Biol. 2014 Aug;21:144-53. doi: 10.1016/j.cbpa.2014.07.015. Epub 2014 Aug 15. Review.


Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based detection of global pathogen-host AMPylation on self-assembled human protein microarrays.

Yu X, Woolery AR, Luong P, Hao YH, Grammel M, Westcott N, Park J, Wang J, Bian X, Demirkan G, Hang HC, Orth K, LaBaer J.

Mol Cell Proteomics. 2014 Nov;13(11):3164-76. doi: 10.1074/mcp.M114.041103. Epub 2014 Jul 29.


SORTing out cellular proteomes in vivo.

Peng T, Hang HC.

Nat Biotechnol. 2014 May;32(5):445-6. doi: 10.1038/nbt.2898. No abstract available.


Small molecules aimed at type III secretion systems to inhibit bacterial virulence.

Tsou LK, Dossa PD, Hang HC.

Medchemcomm. 2013 Jan 1;4(1):68-79. No abstract available.


Chemical reporters for biological discovery.

Grammel M, Hang HC.

Nat Chem Biol. 2013 Aug;9(8):475-84. doi: 10.1038/nchembio.1296. Review. Erratum in: Nat Chem Biol. 2014 Mar;10(3):239.


Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.

Zhang MM, Wu PY, Kelly FD, Nurse P, Hang HC.

PLoS Biol. 2013 Jul;11(7):e1001597. doi: 10.1371/journal.pbio.1001597. Epub 2013 Jul 2.


Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform.

Charron G, Li MM, MacDonald MR, Hang HC.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11085-90. doi: 10.1073/pnas.1302564110. Epub 2013 Jun 17.


SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.

Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, Du J, Kim R, Ge E, Mostoslavsky R, Hang HC, Hao Q, Lin H.

Nature. 2013 Apr 4;496(7443):110-3. doi: 10.1038/nature12038.


Identification of lysine acetyltransferase substrates using bioorthogonal chemical proteomics.

Grammel M, Hang HC.

Methods Mol Biol. 2013;981:201-10. doi: 10.1007/978-1-62703-305-3_16.


Emerging roles for protein S-palmitoylation in immunity from chemical proteomics.

Yount JS, Zhang MM, Hang HC.

Curr Opin Chem Biol. 2013 Feb;17(1):27-33. doi: 10.1016/j.cbpa.2012.11.008. Epub 2013 Jan 14. Review.


Incorporation of unnatural sugars for the identification of glycoproteins.

Zaro BW, Hang HC, Pratt MR.

Methods Mol Biol. 2013;951:57-67. doi: 10.1007/978-1-62703-146-2_5.


Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.

Zhang X, Abreu JG, Yokota C, MacDonald BT, Singh S, Coburn KL, Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H, He X.

Cell. 2012 Jun 22;149(7):1565-77. doi: 10.1016/j.cell.2012.04.039.


S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus.

Yount JS, Karssemeijer RA, Hang HC.

J Biol Chem. 2012 Jun 1;287(23):19631-41. doi: 10.1074/jbc.M112.362095. Epub 2012 Apr 17.


Cell-selective labeling of bacterial proteomes with an orthogonal phenylalanine amino acid reporter.

Grammel M, Dossa PD, Taylor-Salmon E, Hang HC.

Chem Commun (Camb). 2012 Feb 1;48(10):1473-4. doi: 10.1039/c1cc14939c. Epub 2011 Nov 11.


A chemical reporter for protein AMPylation.

Grammel M, Luong P, Orth K, Hang HC.

J Am Chem Soc. 2011 Nov 2;133(43):17103-5. doi: 10.1021/ja205137d. Epub 2011 Oct 7.


Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding.

Agüera-González S, Gross CC, Fernández-Messina L, Ashiru O, Esteso G, Hang HC, Reyburn HT, Long EO, Valés-Gómez M.

Eur J Immunol. 2011 Dec;41(12):3667-76. doi: 10.1002/eji.201141645. Epub 2011 Nov 3.


Exploring protein lipidation with chemical biology.

Hang HC, Linder ME.

Chem Rev. 2011 Oct 12;111(10):6341-58. doi: 10.1021/cr2001977. Epub 2011 Sep 16. Review. No abstract available.


Subcellular targeting of Salmonella virulence proteins by host-mediated S-palmitoylation.

Hicks SW, Charron G, Hang HC, Galán JE.

Cell Host Microbe. 2011 Jul 21;10(1):9-20. doi: 10.1016/j.chom.2011.06.003.


Bioorthogonal chemical reporters for analyzing protein lipidation and lipid trafficking.

Hang HC, Wilson JP, Charron G.

Acc Chem Res. 2011 Sep 20;44(9):699-708. doi: 10.1021/ar200063v. Epub 2011 Jun 15.

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