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Beyond stereotypes of cerebral palsy: Exploring the lived experiences of young Canadians.

Hanes JE, Hlyva O, Rosenbaum P, Freeman M, Nguyen T, Palisano RJ, Gorter JW.

Child Care Health Dev. 2019 Sep;45(5):613-622. doi: 10.1111/cch.12705. Epub 2019 Jul 24.


Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.

Udupa S, Nguyen S, Hoang G, Nguyen T, Quinones A, Pham K, Asaka R, Nguyen K, Zhang C, Elgogary A, Jung JG, Xu Q, Fu J, Thomas AG, Tsukamoto T, Hanes J, Slusher BS, Cooper AJL, Le A.

Proteomics. 2019 Jun 24:e1800451. doi: 10.1002/pmic.201800451. [Epub ahead of print]


Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD.

Chisholm JF, Shenoy SK, Shade JK, Kim V, Putcha N, Carson KA, Wise R, Hansel NN, Hanes JS, Suk JS, Neptune E.

Eur Respir J. 2019 Aug 1;54(2). pii: 1900088. doi: 10.1183/13993003.00088-2019. Print 2019 Aug.


Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathies.

Majerova P, Michalicova A, Cente M, Hanes J, Vegh J, Kittel A, Kosikova N, Cigankova V, Mihaljevic S, Jadhav S, Kovac A.

PLoS One. 2019 May 23;14(5):e0217216. doi: 10.1371/journal.pone.0217216. eCollection 2019.


A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus.

Fernandez-Petty CM, Hughes GW, Bowers HL, Watson JD, Rosen BH, Townsend SM, Santos C, Ridley CE, Chu KK, Birket SE, Li Y, Leung HM, Mazur M, Garcia BA, Evans TIA, Libby EF, Hathorne H, Hanes J, Tearney GJ, Clancy JP, Engelhardt JF, Swords WE, Thornton DJ, Wiesmann WP, Baker SM, Rowe SM.

JCI Insight. 2019 Apr 18;4(8). pii: 125954. doi: 10.1172/jci.insight.125954. eCollection 2019 Apr 18.


Widespread gene transfer to malignant gliomas with In vitro-to-In vivo correlation.

Negron K, Khalasawi N, Lu B, Ho CY, Lee J, Shenoy S, Mao HQ, Wang TH, Hanes J, Suk JS.

J Control Release. 2019 Jun 10;303:1-11. doi: 10.1016/j.jconrel.2019.04.010. Epub 2019 Apr 9.


Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin.

Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD.

Nat Neurosci. 2019 May;22(5):741-752. doi: 10.1038/s41593-019-0366-7. Epub 2019 Apr 1.


Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?

Price RJ, Fisher DG, Suk JS, Hanes J, Ko HS, Kordower JH.

Mov Disord. 2019 Mar 25. doi: 10.1002/mds.27675. [Epub ahead of print] No abstract available.


Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma.

Park JS, Oh Y, Park YJ, Park O, Yang H, Slania S, Hummers LK, Shah AA, An HT, Jang J, Horton MR, Shin J, Dietz HC, Song E, Na DH, Park EJ, Kim K, Lee KC, Roschke VV, Hanes J, Pomper MG, Lee S.

Nat Commun. 2019 Mar 8;10(1):1128. doi: 10.1038/s41467-019-09101-4.


Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization.

Wang B, Tang Y, Oh Y, Lamb NW, Xia S, Ding Z, Chen B, Suarez MJ, Meng T, Kulkarni V, Eberhart CG, Ensign LM, Stark WJ, Hanes J, Xu Q.

Nanomedicine. 2019 Apr;17:119-123. doi: 10.1016/j.nano.2019.01.001. Epub 2019 Jan 21.


Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis.

Luo L, Yang J, Oh Y, Hartsock MJ, Xia S, Kim YC, Ding Z, Meng T, Eberhart CG, Ensign LM, Thorne JE, Stark WJ, Duh EJ, Xu Q, Hanes J.

J Control Release. 2019 Feb 28;296:68-80. doi: 10.1016/j.jconrel.2019.01.018. Epub 2019 Jan 17.


Development of a mucoinert progesterone nanosuspension for safer and more effective prevention of preterm birth.

Hoang T, Zierden H, Date A, Ortiz J, Gumber S, Anders N, He P, Segars J, Hanes J, Mahendroo M, Ensign LM.

J Control Release. 2019 Feb 10;295:74-86. doi: 10.1016/j.jconrel.2018.12.046. Epub 2018 Dec 28.


Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia.

Huang X, Zhuang J, Chung SW, Huang B, Halpert G, Negron K, Sun X, Yang J, Oh Y, Hwang PM, Hanes J, Suk JS.

ACS Nano. 2019 Jan 22;13(1):236-247. doi: 10.1021/acsnano.8b05399. Epub 2018 Dec 26.


Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease.

Date AA, Halpert G, Babu T, Ortiz J, Kanvinde P, Dimitrion P, Narayan J, Zierden H, Betageri K, Musmanno O, Wiegand H, Huang X, Gumber S, Hanes J, Ensign LM.

Biomaterials. 2018 Dec;185:97-105. doi: 10.1016/j.biomaterials.2018.09.005. Epub 2018 Sep 7.


An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy.

Duncan GA, Kim N, Colon-Cortes Y, Rodriguez J, Mazur M, Birket SE, Rowe SM, West NE, Livraghi-Butrico A, Boucher RC, Hanes J, Aslanidi G, Suk JS.

Mol Ther Methods Clin Dev. 2018 Mar 22;9:296-304. doi: 10.1016/j.omtm.2018.03.006. eCollection 2018 Jun 15.


PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy.

Osman G, Rodriguez J, Chan SY, Chisholm J, Duncan G, Kim N, Tatler AL, Shakesheff KM, Hanes J, Suk JS, Dixon JE.

J Control Release. 2018 Sep 10;285:35-45. doi: 10.1016/j.jconrel.2018.07.001. Epub 2018 Jul 3.


Dendritic Cells as an Alternate Approach for Treatment of Neurodegenerative Disorders.

Brezovakova V, Valachova B, Hanes J, Novak M, Jadhav S.

Cell Mol Neurobiol. 2018 Aug;38(6):1207-1214. doi: 10.1007/s10571-018-0598-1. Epub 2018 Jun 13. Review.


Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis.

Bandeira E, Oliveira H, Silva JD, Menna-Barreto RFS, Takyia CM, Suk JS, Witwer KW, Paulaitis ME, Hanes J, Rocco PRM, Morales MM.

Respir Res. 2018 May 29;19(1):104. doi: 10.1186/s12931-018-0802-3.


Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema.

Hoang T, Date AA, Ortiz JO, Young TW, Bensouda S, Xiao P, Marzinke M, Rohan L, Fuchs EJ, Hendrix C, Gumber S, Villinger F, Cone RA, Hanes J, Ensign LM.

Eur J Pharm Biopharm. 2019 May;138:23-29. doi: 10.1016/j.ejpb.2018.05.030. Epub 2018 May 24.


Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOP-Glaucoma.

Pitha I, Kimball EC, Oglesby EN, Pease ME, Fu J, Schaub J, Kim YC, Hu Q, Hanes J, Quigley HA.

Transl Vis Sci Technol. 2018 Mar 28;7(2):13. doi: 10.1167/tvst.7.2.13. eCollection 2018 Apr.


Pseudomonas aeruginosa pyocyanin production reduced by quorum-sensing inhibiting nanocarriers.

Lu HD, Pearson E, Ristroph KD, Duncan GA, Ensign LM, Suk JS, Hanes J, Prud'homme RK.

Int J Pharm. 2018 Jun 10;544(1):75-82. doi: 10.1016/j.ijpharm.2018.03.058. Epub 2018 Mar 30.


Effects of enzymatic degradation on dynamic mechanical properties of the vitreous and intravitreal nanoparticle mobility.

Huang D, Chen YS, Xu Q, Hanes J, Rupenthal ID.

Eur J Pharm Sci. 2018 Jun 15;118:124-133. doi: 10.1016/j.ejps.2018.03.023. Epub 2018 Mar 21.


Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation.

Patil HP, Freches D, Karmani L, Duncan GA, Ucakar B, Suk JS, Hanes J, Gallez B, Vanbever R.

J Control Release. 2018 Feb 28;272:62-71. doi: 10.1016/j.jconrel.2017.12.009. Epub 2017 Dec 13.


Hypo-osmolar Formulation of Tenofovir (TFV) Enema Promotes Uptake and Metabolism of TFV in Tissues, Leading to Prevention of SHIV/SIV Infection.

Xiao P, Gumber S, Marzinke MA, Date AA, Hoang T, Hanes J, Ensign LM, Wang L, Rohan L, Fuchs EJ, Hendrix C, Villinger F.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01644-17. doi: 10.1128/AAC.01644-17. Print 2018 Jan.


Preclinical Evaluation of Intravesical Cisplatin Nanoparticles for Non-Muscle-Invasive Bladder Cancer.

Kates M, Date A, Yoshida T, Afzal U, Kanvinde P, Babu T, Sopko NA, Matsui H, Hahn NM, McConkey DJ, Baras A, Hanes J, Ensign L, Bivalacqua TJ.

Clin Cancer Res. 2017 Nov 1;23(21):6592-6601. doi: 10.1158/1078-0432.CCR-17-1082. Epub 2017 Aug 14.


Protein nanocages that penetrate airway mucus and tumor tissue.

Huang X, Chisholm J, Zhuang J, Xiao Y, Duncan G, Chen X, Suk JS, Hanes J.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6595-E6602. doi: 10.1073/pnas.1705407114. Epub 2017 Jul 24.


Strategies to enhance the distribution of nanotherapeutics in the brain.

Zhang C, Mastorakos P, Sobral M, Berry S, Song E, Nance E, Eberhart CG, Hanes J, Suk JS.

J Control Release. 2017 Dec 10;267:232-239. doi: 10.1016/j.jconrel.2017.07.028. Epub 2017 Jul 21.


NanoDDS 2016: The 14th International Nanomedicine and Drug Delivery Symposium.

Cui H, Hanes J.

J Control Release. 2017 Oct 10;263:1-3. doi: 10.1016/j.jconrel.2017.07.022. Epub 2017 Jul 20. No abstract available.


Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors.

Mastorakos P, Zhang C, Song E, Kim YE, Park HW, Berry S, Choi WK, Hanes J, Suk JS.

J Control Release. 2017 Sep 28;262:37-46. doi: 10.1016/j.jconrel.2017.07.009. Epub 2017 Jul 8.


Photoactivatable fluorescent probes reveal heterogeneous nanoparticle permeation through biological gels at multiple scales.

Schuster BS, Allan DB, Kays JC, Hanes J, Leheny RL.

J Control Release. 2017 Aug 28;260:124-133. doi: 10.1016/j.jconrel.2017.05.035. Epub 2017 May 31.


Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model.

Mead BP, Kim N, Miller GW, Hodges D, Mastorakos P, Klibanov AL, Mandell JW, Hirsh J, Suk JS, Hanes J, Price RJ.

Nano Lett. 2017 Jun 14;17(6):3533-3542. doi: 10.1021/acs.nanolett.7b00616. Epub 2017 May 18.


Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation.

Schneider CS, Xu Q, Boylan NJ, Chisholm J, Tang BC, Schuster BS, Henning A, Ensign LM, Lee E, Adstamongkonkul P, Simons BW, Wang SS, Gong X, Yu T, Boyle MP, Suk JS, Hanes J.

Sci Adv. 2017 Apr 5;3(4):e1601556. doi: 10.1126/sciadv.1601556. eCollection 2017 Apr.


Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina.

White DT, Sengupta S, Saxena MT, Xu Q, Hanes J, Ding D, Ji H, Mumm JS.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3719-E3728. doi: 10.1073/pnas.1617721114. Epub 2017 Apr 17.


MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound.

Timbie KF, Afzal U, Date A, Zhang C, Song J, Wilson Miller G, Suk JS, Hanes J, Price RJ.

J Control Release. 2017 Oct 10;263:120-131. doi: 10.1016/j.jconrel.2017.03.017. Epub 2017 Mar 11.


Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.

Zhang C, Nance EA, Mastorakos P, Chisholm J, Berry S, Eberhart C, Tyler B, Brem H, Suk JS, Hanes J.

J Control Release. 2017 Oct 10;263:112-119. doi: 10.1016/j.jconrel.2017.03.007. Epub 2017 Mar 7.


Drug Delivery Research for the Future: Expanding the Nano Horizons and Beyond.

Mitragotri S, Lammers T, Bae YH, Schwendeman S, De Smedt S, Leroux JC, Peer D, Kwon IC, Harashima H, Kikuchi A, Oh YK, Torchilin V, Hennink W, Hanes J, Park K.

J Control Release. 2017 Jan 28;246:183-184. doi: 10.1016/j.jconrel.2017.01.011. No abstract available.


Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.

Rodrigues MJ, Windeisen V, Zhang Y, Guédez G, Weber S, Strohmeier M, Hanes JW, Royant A, Evans G, Sinning I, Ealick SE, Begley TP, Tews I.

Nat Chem Biol. 2017 Mar;13(3):290-294. doi: 10.1038/nchembio.2273. Epub 2017 Jan 16.


Development of Absorbable, Antibiotic-Eluting Sutures for Ophthalmic Surgery.

Kashiwabuchi F, Parikh KS, Omiadze R, Zhang S, Luo L, Patel HV, Xu Q, Ensign LM, Mao HQ, Hanes J, McDonnell PJ.

Transl Vis Sci Technol. 2017 Jan 3;6(1):1. doi: 10.1167/tvst.6.1.1. eCollection 2017 Jan.


Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse.

Patel NJ, Wickremsinhe E, Hui YH, Barr A, Masterson N, Ruterbories K, Weller J, Hanes J, Kern T, Perkins E.

J Pharm Pharm Sci. 2016 Oct - Dec;19(4):496-510. doi: 10.18433/J3NK60.


Hyaluronic acid-conjugated lipoplexes for targeted delivery of siRNA in a murine metastatic lung cancer model.

Leite Nascimento T, Hillaireau H, Vergnaud J, Rivano M, Deloménie C, Courilleau D, Arpicco S, Suk JS, Hanes J, Fattal E.

Int J Pharm. 2016 Nov 30;514(1):103-111. doi: 10.1016/j.ijpharm.2016.06.125.


Microstructural alterations of sputum in cystic fibrosis lung disease.

Duncan GA, Jung J, Joseph A, Thaxton AL, West NE, Boyle MP, Hanes J, Suk JS.

JCI Insight. 2016 Nov 3;1(18):e88198. doi: 10.1172/jci.insight.88198.


The Mucus Barrier to Inhaled Gene Therapy.

Duncan GA, Jung J, Hanes J, Suk JS.

Mol Ther. 2016 Dec;24(12):2043-2053. doi: 10.1038/mt.2016.182. Epub 2016 Sep 20. Review.


North America special issue Part II.

Hanes J, Ensign LM, Kannan R, Suk JS.

J Control Release. 2016 Oct 28;240:1. doi: 10.1016/j.jconrel.2016.09.027. No abstract available.


Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces.

Yu T, Chisholm J, Choi WJ, Anonuevo A, Pulicare S, Zhong W, Chen M, Fridley C, Lai SK, Ensign LM, Suk JS, Hanes J.

Adv Healthc Mater. 2016 Nov;5(21):2745-2750. doi: 10.1002/adhm.201600599. Epub 2016 Sep 26.


Enhancing Intracranial Delivery of Clinically Relevant Non-viral Gene Vectors.

Berry S, Mastorakos P, Zhang C, Song E, Patel H, Suk JS, Hanes J.

RSC Adv. 2016;48(6):41665-41674. Epub 2016 Apr 19.


Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography.

Chu KK, Mojahed D, Fernandez CM, Li Y, Liu L, Wilsterman EJ, Diephuis B, Birket SE, Bowers H, Martin Solomon G, Schuster BS, Hanes J, Rowe SM, Tearney GJ.

Biophys J. 2016 Sep 6;111(5):1053-63. doi: 10.1016/j.bpj.2016.07.020.


Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.

Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, Hartung T, Rojas C, Rais R, Tsukamoto T, Semenza GL, Hanes J, Slusher BS, Le A.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5328-36. doi: 10.1073/pnas.1611406113. Epub 2016 Aug 24.


Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits.

Fu J, Sun F, Liu W, Liu Y, Gedam M, Hu Q, Fridley C, Quigley HA, Hanes J, Pitha I.

Mol Pharm. 2016 Sep 6;13(9):2987-95. doi: 10.1021/acs.molpharmaceut.6b00343. Epub 2016 Jul 7.


Nanoparticles for oral delivery: Design, evaluation and state-of-the-art.

Date AA, Hanes J, Ensign LM.

J Control Release. 2016 Oct 28;240:504-526. doi: 10.1016/j.jconrel.2016.06.016. Epub 2016 Jun 9. Review.


Barriers to inhaled gene therapy of obstructive lung diseases: A review.

Kim N, Duncan GA, Hanes J, Suk JS.

J Control Release. 2016 Oct 28;240:465-488. doi: 10.1016/j.jconrel.2016.05.031. Epub 2016 May 16. Review.

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