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Biophysical Characterization of a Nanodisc with and without BAX: An Integrative Study Using Molecular Dynamics Simulations and Cryo-EM.

López CA, Swift MF, Xu XP, Hanein D, Volkmann N, Gnanakaran S.

Structure. 2019 Jun 4;27(6):988-999.e4. doi: 10.1016/j.str.2019.03.013. Epub 2019 Apr 11.


Electron cryo-tomography of vestibular hair-cell stereocilia.

Metlagel Z, Krey JF, Song J, Swift MF, Tivol WJ, Dumont RA, Thai J, Chang A, Seifikar H, Volkmann N, Hanein D, Barr-Gillespie PG, Auer M.

J Struct Biol. 2019 May 1;206(2):149-155. doi: 10.1016/j.jsb.2019.02.006. Epub 2019 Feb 26.


High Rac1 activity is functionally translated into cytosolic structures with unique nanoscale cytoskeletal architecture.

Marston DJ, Anderson KL, Swift MF, Rougie M, Page C, Hahn KM, Volkmann N, Hanein D.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1267-1272. doi: 10.1073/pnas.1808830116. Epub 2019 Jan 10.


Does self-organized criticality drive leading edge protrusion?

Anderson KL, Swift MF, Hanein D, Volkmann N.

Biophys Rev. 2018 Dec;10(6):1571-1575. doi: 10.1007/s12551-018-0484-6. Epub 2018 Nov 17. Review.


Local Tension on Talin in Focal Adhesions Correlates with F-Actin Alignment at the Nanometer Scale.

Kumar A, Anderson KL, Swift MF, Hanein D, Volkmann N, Schwartz MA.

Biophys J. 2018 Oct 16;115(8):1569-1579. doi: 10.1016/j.bpj.2018.08.045. Epub 2018 Sep 10.


Conformational Equilibrium of Human Platelet Integrin Investigated by Three-Dimensional Electron Cryo-Microscopy.

Hanein D, Volkmann N.

Subcell Biochem. 2018;87:353-363. doi: 10.1007/978-981-10-7757-9_12. Review.


Marker-free method for accurate alignment between correlated light, cryo-light, and electron cryo-microscopy data using sample support features.

Anderson KL, Page C, Swift MF, Hanein D, Volkmann N.

J Struct Biol. 2018 Jan;201(1):46-51. doi: 10.1016/j.jsb.2017.11.001. Epub 2017 Nov 4.


Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models.

Bottini M, Mebarek S, Anderson KL, Strzelecka-Kiliszek A, Bozycki L, Simão AMS, Bolean M, Ciancaglini P, Pikula JB, Pikula S, Magne D, Volkmann N, Hanein D, Millán JL, Buchet R.

Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):532-546. doi: 10.1016/j.bbagen.2017.11.005. Epub 2017 Nov 3. Review.


Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions.

Ariazi J, Benowitz A, De Biasi V, Den Boer ML, Cherqui S, Cui H, Douillet N, Eugenin EA, Favre D, Goodman S, Gousset K, Hanein D, Israel DI, Kimura S, Kirkpatrick RB, Kuhn N, Jeong C, Lou E, Mailliard R, Maio S, Okafo G, Osswald M, Pasquier J, Polak R, Pradel G, de Rooij B, Schaeffer P, Skeberdis VA, Smith IF, Tanveer A, Volkmann N, Wu Z, Zurzolo C.

Front Mol Neurosci. 2017 Oct 17;10:333. doi: 10.3389/fnmol.2017.00333. eCollection 2017. Review.


Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-Å resolution and its relevance to the assembly of icosahedral viruses.

Chen Z, Sun L, Zhang Z, Fokine A, Padilla-Sanchez V, Hanein D, Jiang W, Rossmann MG, Rao VB.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8184-E8193. doi: 10.1073/pnas.1708483114. Epub 2017 Sep 11.


Nano-scale actin-network characterization of fibroblast cells lacking functional Arp2/3 complex.

Anderson KL, Page C, Swift MF, Suraneni P, Janssen MEW, Pollard TD, Li R, Volkmann N, Hanein D.

J Struct Biol. 2017 Mar;197(3):312-321. doi: 10.1016/j.jsb.2016.12.010. Epub 2016 Dec 21.


Structure of anthrax lethal toxin prepore complex suggests a pathway for efficient cell entry.

Fabre L, Santelli E, Mountassif D, Donoghue A, Biswas A, Blunck R, Hanein D, Volkmann N, Liddington R, Rouiller I.

J Gen Physiol. 2016 Oct;148(4):313-24. doi: 10.1085/jgp.201611617.


Three-Dimensional Structures of Full-Length, Membrane-Embedded Human α(IIb)β(3) Integrin Complexes.

Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D.

Biophys J. 2016 Feb 23;110(4):798-809. doi: 10.1016/j.bpj.2016.01.016.


Orchestration of ErbB3 signaling through heterointeractions and homointeractions.

McCabe Pryor M, Steinkamp MP, Halasz AM, Chen Y, Yang S, Smith MS, Zahoransky-Kohalmi G, Swift M, Xu XP, Hanein D, Volkmann N, Lidke DS, Edwards JS, Wilson BS.

Mol Biol Cell. 2015 Nov 5;26(22):4109-23. doi: 10.1091/mbc.E14-06-1114. Epub 2015 Sep 16. Erratum in: Mol Biol Cell. 2016 Feb 15;27(4):731. Hanien, Dorit [corrected to Hanein, Dorit].


Metavinculin Tunes the Flexibility and the Architecture of Vinculin-Induced Bundles of Actin Filaments.

Oztug Durer ZA, McGillivary RM, Kang H, Elam WA, Vizcarra CL, Hanein D, De La Cruz EM, Reisler E, Quinlan ME.

J Mol Biol. 2015 Aug 28;427(17):2782-98. doi: 10.1016/j.jmb.2015.07.005. Epub 2015 Jul 10.


Accurate membrane tracing in three-dimensional reconstructions from electron cryotomography data.

Page C, Hanein D, Volkmann N.

Ultramicroscopy. 2015 Aug;155:20-26. doi: 10.1016/j.ultramic.2015.03.021. Epub 2015 Mar 30.


Cellular chirality arising from the self-organization of the actin cytoskeleton.

Tee YH, Shemesh T, Thiagarajan V, Hariadi RF, Anderson KL, Page C, Volkmann N, Hanein D, Sivaramakrishnan S, Kozlov MM, Bershadsky AD.

Nat Cell Biol. 2015 Apr;17(4):445-57. doi: 10.1038/ncb3137. Epub 2015 Mar 23.


A mechanism of leading-edge protrusion in the absence of Arp2/3 complex.

Suraneni P, Fogelson B, Rubinstein B, Noguera P, Volkmann N, Hanein D, Mogilner A, Li R.

Mol Biol Cell. 2015 Mar 1;26(5):901-12. doi: 10.1091/mbc.E14-07-1250. Epub 2015 Jan 7.


Further closing the resolution gap: integrating cryo-soft x-ray and light microscopies.

Hanein D.

Biophys J. 2014 Dec 16;107(12):2745-2746. doi: 10.1016/j.bpj.2014.10.057. No abstract available.


Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force.

Buckley CD, Tan J, Anderson KL, Hanein D, Volkmann N, Weis WI, Nelson WJ, Dunn AR.

Science. 2014 Oct 31;346(6209):1254211. doi: 10.1126/science.1254211.


Holoenzyme structures of endothelial nitric oxide synthase - an allosteric role for calmodulin in pivoting the FMN domain for electron transfer.

Volkmann N, Martásek P, Roman LJ, Xu XP, Page C, Swift M, Hanein D, Masters BS.

J Struct Biol. 2014 Oct;188(1):46-54. doi: 10.1016/j.jsb.2014.08.006. Epub 2014 Aug 28.


Kinome-wide functional analysis highlights the role of cytoskeletal remodeling in somatic cell reprogramming.

Sakurai K, Talukdar I, Patil VS, Dang J, Li Z, Chang KY, Lu CC, Delorme-Walker V, Dermardirossian C, Anderson K, Hanein D, Yang CS, Wu D, Liu Y, Rana TM.

Cell Stem Cell. 2014 Apr 3;14(4):523-34. doi: 10.1016/j.stem.2014.03.001.


Three-dimensional reconstructions of actin filaments capped by Arp2/3 complex.

Volkmann N, Page C, Li R, Hanein D.

Eur J Cell Biol. 2014 May-Jun;93(5-6):179-83. doi: 10.1016/j.ejcb.2014.01.003. Epub 2014 Jan 25.


The rheostat in the membrane: BCL-2 family proteins and apoptosis.

Volkmann N, Marassi FM, Newmeyer DD, Hanein D.

Cell Death Differ. 2014 Feb;21(2):206-15. doi: 10.1038/cdd.2013.153. Epub 2013 Oct 25. Review.


Structural analysis of supramolecular assemblies by hybrid methods.

Hanein D, Milligan R.

J Struct Biol. 2013 Oct;184(1):1. doi: 10.1016/j.jsb.2013.09.014. No abstract available.


αE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factors.

Hansen SD, Kwiatkowski AV, Ouyang CY, Liu H, Pokutta S, Watkins SC, Volkmann N, Hanein D, Weis WI, Mullins RD, Nelson WJ.

Mol Biol Cell. 2013 Dec;24(23):3710-20. doi: 10.1091/mbc.E13-07-0388. Epub 2013 Sep 25.


The architectural relationship of components controlling mast cell endocytosis.

Cleyrat C, Darehshouri A, Anderson KL, Page C, Lidke DS, Volkmann N, Hanein D, Wilson BS.

J Cell Sci. 2013 Nov 1;126(Pt 21):4913-25. doi: 10.1242/jcs.128876. Epub 2013 Aug 28.


Three-dimensional structure of Bax-mediated pores in membrane bilayers.

Xu XP, Zhai D, Kim E, Swift M, Reed JC, Volkmann N, Hanein D.

Cell Death Dis. 2013 Jun 20;4:e683. doi: 10.1038/cddis.2013.210.


Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.

Goult BT, Xu XP, Gingras AR, Swift M, Patel B, Bate N, Kopp PM, Barsukov IL, Critchley DR, Volkmann N, Hanein D.

J Struct Biol. 2013 Oct;184(1):21-32. doi: 10.1016/j.jsb.2013.05.014. Epub 2013 May 30.


Toxofilin upregulates the host cortical actin cytoskeleton dynamics, facilitating Toxoplasma invasion.

Delorme-Walker V, Abrivard M, Lagal V, Anderson K, Perazzi A, Gonzalez V, Page C, Chauvet J, Ochoa W, Volkmann N, Hanein D, Tardieux I.

J Cell Sci. 2012 Sep 15;125(Pt 18):4333-42. doi: 10.1242/jcs.103648. Epub 2012 May 28.


The C-terminal tail domain of metavinculin, vinculin's splice variant, severs actin filaments.

Janssen ME, Liu H, Volkmann N, Hanein D.

J Cell Biol. 2012 May 28;197(5):585-93. doi: 10.1083/jcb.201111046. Epub 2012 May 21.


The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration.

Suraneni P, Rubinstein B, Unruh JR, Durnin M, Hanein D, Li R.

J Cell Biol. 2012 Apr 16;197(2):239-51. doi: 10.1083/jcb.201112113. Epub 2012 Apr 9.


Key structural features of the actin filament Arp2/3 complex branch junction revealed by molecular simulation.

Pfaendtner J, Volkmann N, Hanein D, Dalhaimer P, Pollard TD, Voth GA.

J Mol Biol. 2012 Feb 10;416(1):148-61. doi: 10.1016/j.jmb.2011.12.025. Epub 2011 Dec 17.


The structure of cell-matrix adhesions: the new frontier.

Hanein D, Horwitz AR.

Curr Opin Cell Biol. 2012 Feb;24(1):134-40. doi: 10.1016/ Epub 2011 Dec 22. Review.


Three-dimensional reconstructions of Arp2/3 complex with bound nucleation promoting factors.

Xu XP, Rouiller I, Slaughter BD, Egile C, Kim E, Unruh JR, Fan X, Pollard TD, Li R, Hanein D, Volkmann N.

EMBO J. 2012 Jan 4;31(1):236-47. doi: 10.1038/emboj.2011.343. Epub 2011 Sep 20.


Correlative light-electron microscopy.

Hanein D, Volkmann N.

Adv Protein Chem Struct Biol. 2011;82:91-9. doi: 10.1016/B978-0-12-386507-6.00004-X. Review.


Tomography of actin cytoskeletal networks.

Hanein D.

Methods Enzymol. 2010;483:203-14. doi: 10.1016/S0076-6879(10)83010-1.


Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping.

Hertzog M, Milanesi F, Hazelwood L, Disanza A, Liu H, Perlade E, Malabarba MG, Pasqualato S, Maiolica A, Confalonieri S, Le Clainche C, Offenhauser N, Block J, Rottner K, Di Fiore PP, Carlier MF, Volkmann N, Hanein D, Scita G.

PLoS Biol. 2010 Jun 1;8(6):e1000387. doi: 10.1371/journal.pbio.1000387.


Carboxylated N-glycans on RAGE promote S100A12 binding and signaling.

Srikrishna G, Nayak J, Weigle B, Temme A, Foell D, Hazelwood L, Olsson A, Volkmann N, Hanein D, Freeze HH.

J Cell Biochem. 2010 Jun 1;110(3):645-59. doi: 10.1002/jcb.22575. Erratum in: J Cell Biochem. 2010 Sep 1;111(1):248.


The structural basis of actin filament branching by the Arp2/3 complex.

Rouiller I, Xu XP, Amann KJ, Egile C, Nickell S, Nicastro D, Li R, Pollard TD, Volkmann N, Hanein D.

J Cell Biol. 2008 Mar 10;180(5):887-95. doi: 10.1083/jcb.200709092. Epub 2008 Mar 3.


The structure of the C-terminal actin-binding domain of talin.

Gingras AR, Bate N, Goult BT, Hazelwood L, Canestrelli I, Grossmann JG, Liu H, Putz NS, Roberts GC, Volkmann N, Hanein D, Barsukov IL, Critchley DR.

EMBO J. 2008 Jan 23;27(2):458-69. Epub 2007 Dec 20.


The R403Q myosin mutation implicated in familial hypertrophic cardiomyopathy causes disorder at the actomyosin interface.

Volkmann N, Lui H, Hazelwood L, Trybus KM, Lowey S, Hanein D.

PLoS One. 2007 Nov 7;2(11):e1123.


Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks.

Delorme V, Machacek M, DerMardirossian C, Anderson KL, Wittmann T, Hanein D, Waterman-Storer C, Danuser G, Bokoch GM.

Dev Cell. 2007 Nov;13(5):646-62.


Evidence for an interaction between the SH3 domain and the N-terminal extension of the essential light chain in class II myosins.

Lowey S, Saraswat LD, Liu H, Volkmann N, Hanein D.

J Mol Biol. 2007 Aug 24;371(4):902-13. Epub 2007 Jun 2.


Effect of calcium on calmodulin bound to the IQ motifs of myosin V.

Trybus KM, Gushchin MI, Lui H, Hazelwood L, Krementsova EB, Volkmann N, Hanein D.

J Biol Chem. 2007 Aug 10;282(32):23316-25. Epub 2007 Jun 11.


Structural analysis of supramolecular assemblies by hybrid methods.

Hanein D.

J Struct Biol. 2007 May;158(2):135-6. No abstract available.


Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation.

Faustin B, Lartigue L, Bruey JM, Luciano F, Sergienko E, Bailly-Maitre B, Volkmann N, Hanein D, Rouiller I, Reed JC.

Mol Cell. 2007 Mar 9;25(5):713-24.


The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly.

Luxenburg C, Geblinger D, Klein E, Anderson K, Hanein D, Geiger B, Addadi L.

PLoS One. 2007 Jan 31;2(1):e179.


Efficient automatic noise reduction of electron tomographic reconstructions based on iterative median filtering.

van der Heide P, Xu XP, Marsh BJ, Hanein D, Volkmann N.

J Struct Biol. 2007 May;158(2):196-204. Epub 2006 Nov 21.


Mechanistic differences in actin bundling activity of two mammalian formins, FRL1 and mDia2.

Harris ES, Rouiller I, Hanein D, Higgs HN.

J Biol Chem. 2006 May 19;281(20):14383-92. Epub 2006 Mar 23.

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