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Items: 1 to 50 of 65

1.

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment.

Latacz G, Lubelska A, Jastrzębska-Więsek M, Partyka A, Marć MA, Satała G, Wilczyńska D, Kotańska M, Więcek M, Kamińska K, Wesołowska A, Kieć-Kononowicz K, Handzlik J.

Int J Mol Sci. 2019 Jul 12;20(14). pii: E3420. doi: 10.3390/ijms20143420.

2.

Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6.

Ali W, Więcek M, Łażewska D, Kurczab R, Jastrzębska-Więsek M, Satała G, Kucwaj-Brysz K, Lubelska A, Głuch-Lutwin M, Mordyl B, Siwek A, Nasim MJ, Partyka A, Sudoł S, Latacz G, Wesołowska A, Kieć-Kononowicz K, Handzlik J.

Eur J Med Chem. 2019 Sep 15;178:740-751. doi: 10.1016/j.ejmech.2019.06.022. Epub 2019 Jun 10.

PMID:
31229876
3.

Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors.

Mosolygó T, Kincses A, Csonka A, Tönki ÁS, Witek K, Sanmartín C, Marć MA, Handzlik J, Kieć-Kononowicz K, Domínguez-Álvarez E, Spengler G.

Molecules. 2019 Apr 16;24(8). pii: E1487. doi: 10.3390/molecules24081487.

4.

Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers.

Hogendorf AS, Hogendorf A, Popiołek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ.

Eur J Med Chem. 2019 May 15;170:261-275. doi: 10.1016/j.ejmech.2019.03.017. Epub 2019 Mar 11.

PMID:
30904783
5.

5-Arylideneimidazolones with Amine at Position 3 as Potential Antibiotic Adjuvants against Multidrug Resistant Bacteria.

Kaczor A, Witek K, Podlewska S, Czekajewska J, Lubelska A, Żesławska E, Nitek W, Latacz G, Alibert S, Pagès JM, Karczewska E, Kieć-Kononowicz K, Handzlik J.

Molecules. 2019 Jan 26;24(3). pii: E438. doi: 10.3390/molecules24030438.

6.

Pharmacophoric features for a very potent 5-spirofluorenehydantoin inhibitor of cancer efflux pump ABCB1, based on X-ray analysis.

Żesławska E, Kincses A, Spengler G, Nitek W, Tejchman W, Handzlik J.

Chem Biol Drug Des. 2019 May;93(5):844-853. doi: 10.1111/cbdd.13473. Epub 2019 Jan 29.

PMID:
30586228
7.

Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists.

Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ.

Medchemcomm. 2018 Sep 25;9(11):1882-1890. doi: 10.1039/c8md00313k. eCollection 2018 Nov 1.

8.

Synthesis and computer-aided analysis of the role of linker for novel ligands of the 5-HT6 serotonin receptor among substituted 1,3,5-triazinylpiperazines.

Łażewska D, Kurczab R, Więcek M, Satała G, Kieć-Kononowicz K, Handzlik J.

Bioorg Chem. 2019 Mar;84:319-325. doi: 10.1016/j.bioorg.2018.11.046. Epub 2018 Nov 26.

PMID:
30530073
9.

Influence of 3-{5-[4-(diethylamino)benzylidene]rhodanine}propionic acid on the conformation of 5-(4-chlorobenzylidene)-2-(4-methylpiperazin-1-yl)-3H-imidazol-4(5H)-one.

Żesławska E, Nitek W, Tejchman W, Handzlik J.

Acta Crystallogr C Struct Chem. 2018 Nov 1;74(Pt 11):1427-1433. doi: 10.1107/S2053229618013980. Epub 2018 Oct 19.

PMID:
30398198
10.

Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats.

Alachkar A, Łażewska D, Latacz G, Frank A, Siwek A, Lubelska A, Honkisz-Orzechowska E, Handzlik J, Stark H, Kieć-Kononowicz K, Sadek B.

Int J Mol Sci. 2018 Oct 29;19(11). pii: E3386. doi: 10.3390/ijms19113386.

11.

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT₆ Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo.

Kurczab R, Ali W, Łażewska D, Kotańska M, Jastrzębska-Więsek M, Satała G, Więcek M, Lubelska A, Latacz G, Partyka A, Starek M, Dąbrowska M, Wesołowska A, Jacob C, Kieć-Kononowicz K, Handzlik J.

Molecules. 2018 Oct 3;23(10). pii: E2529. doi: 10.3390/molecules23102529.

12.

The role of aryl-topology in balancing between selective and dual 5-HT7R/5-HT1A actions of 3,5-substituted hydantoins.

Kucwaj-Brysz K, Kurczab R, Żesławska E, Lubelska A, Marć MA, Latacz G, Satała G, Nitek W, Kieć-Kononowicz K, Handzlik J.

Medchemcomm. 2018 May 8;9(6):1033-1044. doi: 10.1039/c8md00168e. eCollection 2018 Jun 1.

13.

Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.

Załuski M, Stanuch K, Karcz T, Hinz S, Latacz G, Szymańska E, Schabikowski J, Doroż-Płonka A, Handzlik J, Drabczyńska A, Müller CE, Kieć-Kononowicz K.

Medchemcomm. 2018 May 14;9(6):951-962. doi: 10.1039/c8md00070k. eCollection 2018 Jun 1.

14.

Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats.

Alachkar A, Latacz G, Siwek A, Lubelska A, Honkisz E, Gryboś A, Łażewska D, Handzlik J, Stark H, Kiec-Kononowicz K, Sadek B.

Pharmacol Biochem Behav. 2018 Jul;170:14-24. doi: 10.1016/j.pbb.2018.04.010. Epub 2018 May 3.

PMID:
29729290
15.

Novel naphthyloxy derivatives - Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation.

Łażewska D, Kaleta M, Hagenow S, Mogilski S, Latacz G, Karcz T, Lubelska A, Honkisz E, Handzlik J, Reiner D, Satała G, Filipek B, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem. 2018 May 15;26(9):2573-2585. doi: 10.1016/j.bmc.2018.04.023. Epub 2018 Apr 11.

PMID:
29681486
16.

Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity.

Álvarez-Pérez M, Ali W, Marć MA, Handzlik J, Domínguez-Álvarez E.

Molecules. 2018 Mar 10;23(3). pii: E628. doi: 10.3390/molecules23030628. Review.

17.

MF-8, a novel promising arylpiperazine-hydantoin based 5-HT7 receptor antagonist: In vitro drug-likeness studies and in vivo pharmacological evaluation.

Latacz G, Lubelska A, Jastrzębska-Więsek M, Partyka A, Kucwaj-Brysz K, Wesołowska A, Kieć-Kononowicz K, Handzlik J.

Bioorg Med Chem Lett. 2018 Mar 1;28(5):878-883. doi: 10.1016/j.bmcl.2018.02.003. Epub 2018 Feb 3.

PMID:
29439902
18.

Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity.

Kucwaj-Brysz K, Kurczab R, Jastrzębska-Więsek M, Żesławska E, Satała G, Nitek W, Partyka A, Siwek A, Jankowska A, Wesołowska A, Kieć-Kononowicz K, Handzlik J.

Eur J Med Chem. 2018 Mar 10;147:102-114. doi: 10.1016/j.ejmech.2018.01.093. Epub 2018 Feb 1.

PMID:
29425815
19.

Selenazolinium Salts as "Small Molecule Catalysts" with High Potency against ESKAPE Bacterial Pathogens.

Witek K, Nasim MJ, Bischoff M, Gaupp R, Arsenyan P, Vasiljeva J, Marć MA, Olejarz A, Latacz G, Kieć-Kononowicz K, Handzlik J, Jacob C.

Molecules. 2017 Dec 8;22(12). pii: E2174. doi: 10.3390/molecules22122174.

20.

Conformational study of (Z)-5-(4-chlorobenzylidene)-2-[4-(2-hydroxyethyl)piperazin-1-yl]-3H-imidazol-4(5H)-one in different environments: insight into the structural properties of bacterial efflux pump inhibitors.

Żesławska E, Nitek W, Handzlik J.

Acta Crystallogr C Struct Chem. 2017 Dec 1;73(Pt 12):1151-1157. doi: 10.1107/S2053229617016461. Epub 2017 Nov 28.

PMID:
29206128
21.

In Vitro Effects of Bromoalkyl Phenytoin Derivatives on Regulated Death, Cell Cycle and Ultrastructure of Leukemia Cells.

Śladowska K, Opydo-Chanek M, Król T, Trybus W, Trybus E, Kopacz-Bednarska A, Handzlik J, Kieć-Kononowicz K, Mazur L.

Anticancer Res. 2017 Nov;37(11):6373-6380.

PMID:
29061822
22.

In the search for a lead structure among series of potent and selective hydantoin 5-HT7 R agents: The drug-likeness in vitro study.

Latacz G, Lubelska A, Jastrzębska-Więsek M, Partyka A, Sobiło A, Olejarz A, Kucwaj-Brysz K, Satała G, Bojarski AJ, Wesołowska A, Kieć-Kononowicz K, Handzlik J.

Chem Biol Drug Des. 2017 Dec;90(6):1295-1306. doi: 10.1111/cbdd.13106. Epub 2017 Oct 3.

PMID:
28886235
23.

Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands.

Łażewska D, Kaleta M, Schwed JS, Karcz T, Mogilski S, Latacz G, Olejarz A, Siwek A, Kubacka M, Lubelska A, Honkisz E, Handzlik J, Filipek B, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem. 2017 Oct 15;25(20):5341-5354. doi: 10.1016/j.bmc.2017.07.058. Epub 2017 Jul 29.

PMID:
28797771
24.

In vitro cytotoxic activity evaluation of phenytoin derivatives against human leukemia cells.

Śladowska K, Handzlik J, Kieć-Kononowicz K, Mazur L.

Indian J Exp Biol. 2016 Sep;54(9):553-9.

PMID:
28699720
25.

Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol.

Hogendorf AS, Hogendorf A, Kurczab R, Satała G, Lenda T, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Wierońska JM, Woźniak M, Cieślik P, Bugno R, Staroń J, Bojarski AJ.

Sci Rep. 2017 May 4;7(1):1444. doi: 10.1038/s41598-017-00822-4.

26.

The computer-aided discovery of novel family of the 5-HT6 serotonin receptor ligands among derivatives of 4-benzyl-1,3,5-triazine.

Łażewska D, Kurczab R, Więcek M, Kamińska K, Satała G, Jastrzębska-Więsek M, Partyka A, Bojarski AJ, Wesołowska A, Kieć-Kononowicz K, Handzlik J.

Eur J Med Chem. 2017 Jul 28;135:117-124. doi: 10.1016/j.ejmech.2017.04.033. Epub 2017 Apr 13.

PMID:
28441580
27.

Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line.

Gajdács M, Spengler G, Sanmartín C, Marć MA, Handzlik J, Domínguez-Álvarez E.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):797-802. doi: 10.1016/j.bmcl.2017.01.033. Epub 2017 Jan 13.

PMID:
28126516
28.

Hydration in silica based mesoporous materials: a DFT model.

Gierada M, Petit I, Handzlik J, Tielens F.

Phys Chem Chem Phys. 2016 Dec 7;18(48):32962-32972.

PMID:
27886289
29.

Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.

Szymańska E, Drabczyńska A, Karcz T, Müller CE, Köse M, Karolak-Wojciechowska J, Fruziński A, Schabikowski J, Doroz-Płonka A, Handzlik J, Kieć-Kononowicz K.

Bioorg Med Chem. 2016 Sep 15;24(18):4347-4362. doi: 10.1016/j.bmc.2016.07.028. Epub 2016 Jul 18.

PMID:
27485602
30.

Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity.

Otręebska-Machaj E, Chevalier J, Handzlik J, Szymańska E, Schabikowski J, Boyer G, Bolla JM, Kieć-Kononowicz K, Pagès JM, Alibert S.

Front Microbiol. 2016 May 3;7:622. doi: 10.3389/fmicb.2016.00622. eCollection 2016.

31.

The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies.

Żesławska E, Kincses A, Spengler G, Nitek W, Wyrzuc K, Kieć-Kononowicz K, Handzlik J.

Bioorg Med Chem. 2016 Jun 15;24(12):2815-22. doi: 10.1016/j.bmc.2016.04.055. Epub 2016 Apr 26.

PMID:
27160056
32.

Identification of selenocompounds with promising properties to reverse cancer multidrug resistance.

Domínguez-Álvarez E, Gajdács M, Spengler G, Palop JA, Marć MA, Kieć-Kononowicz K, Amaral L, Molnár J, Jacob C, Handzlik J, Sanmartín C.

Bioorg Med Chem Lett. 2016 Jun 15;26(12):2821-2824. doi: 10.1016/j.bmcl.2016.04.064. Epub 2016 Apr 22.

PMID:
27156771
33.

Turning Waste into Value: Nanosized Natural Plant Materials of Solanum incanum L. and Pterocarpus erinaceus Poir with Promising Antimicrobial Activities.

Griffin S, Tittikpina NK, Al-Marby A, Alkhayer R, Denezhkin P, Witek K, Gbogbo KA, Batawila K, Duval RE, Nasim MJ, Awadh-Ali NA, Kirsch G, Chaimbault P, Schäfer KH, Keck CM, Handzlik J, Jacob C.

Pharmaceutics. 2016 Apr 19;8(2). pii: E11. doi: 10.3390/pharmaceutics8020011.

34.

Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.

Kucwaj-Brysz K, Warszycki D, Podlewska S, Witek J, Witek K, González Izquierdo A, Satała G, Loza MI, Lubelska A, Latacz G, Bojarski AJ, Castro M, Kieć-Kononowicz K, Handzlik J.

Eur J Med Chem. 2016 Apr 13;112:258-269. doi: 10.1016/j.ejmech.2016.02.024. Epub 2016 Feb 9.

PMID:
26900658
35.

Natural selenium particles from Staphylococcus carnosus: Hazards or particles with particular promise?

Estevam EC, Griffin S, Nasim MJ, Denezhkin P, Schneider R, Lilischkis R, Dominguez-Alvarez E, Witek K, Latacz G, Keck C, Schäfer KH, Kieć-Kononowicz K, Handzlik J, Jacob C.

J Hazard Mater. 2017 Feb 15;324(Pt A):22-30. doi: 10.1016/j.jhazmat.2016.02.001. Epub 2016 Feb 2.

PMID:
26897703
36.

Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay.

Bohnert JA, Schuster S, Kern WV, Karcz T, Olejarz A, Kaczor A, Handzlik J, Kieć-Kononowicz K.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):1974-83. doi: 10.1128/AAC.01995-15. Print 2016 Apr.

37.

Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design.

Estevam EC, Witek K, Faulstich L, Nasim MJ, Latacz G, Domínguez-Álvarez E, Kieć-Kononowicz K, Demasi M, Handzlik J, Jacob C.

Molecules. 2015 Jul 31;20(8):13894-912. doi: 10.3390/molecules200813894.

38.

Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: synthesis, biological evaluation and molecular modeling studies.

Matys A, Podlewska S, Witek K, Witek J, Bojarski AJ, Schabikowski J, Otrębska-Machaj E, Latacz G, Szymańska E, Kieć-Kononowicz K, Molnar J, Amaral L, Handzlik J.

Eur J Med Chem. 2015 Aug 28;101:313-25. doi: 10.1016/j.ejmech.2015.06.013. Epub 2015 Jun 24.

PMID:
26160112
39.

Characterization of molybdenum monomeric oxide species supported on hydroxylated silica: a DFT study.

Guesmi H, Gryboś R, Handzlik J, Tielens F.

Phys Chem Chem Phys. 2014 Sep 14;16(34):18253-60. doi: 10.1039/c4cp02296c.

PMID:
25058667
40.

SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.

Handzlik J, Bojarski AJ, Satała G, Kubacka M, Sadek B, Ashoor A, Siwek A, Więcek M, Kucwaj K, Filipek B, Kieć-Kononowicz K.

Eur J Med Chem. 2014 May 6;78:324-39. doi: 10.1016/j.ejmech.2014.01.065. Epub 2014 Mar 18.

PMID:
24691057
41.

Temperature dependence of the interaction of prazosin with lipid Langmuir monolayers.

Gzyl-Malcher B, Handzlik J, Klekowska E.

Colloids Surf B Biointerfaces. 2013 Dec 1;112:171-6. doi: 10.1016/j.colsurfb.2013.07.030. Epub 2013 Aug 2.

PMID:
23973675
42.

Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones.

Drabczyńska A, Karcz T, Szymańska E, Köse M, Müller CE, Paskaleva M, Karolak-Wojciechowska J, Handzlik J, Yuzlenko O, Kieć-Kononowicz K.

Purinergic Signal. 2013 Sep;9(3):395-414. doi: 10.1007/s11302-013-9358-3. Epub 2013 Apr 2.

43.

Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus.

Handzlik J, Matys A, Kieć-Kononowicz K.

Antibiotics (Basel). 2013 Feb 5;2(1):28-45. doi: 10.3390/antibiotics2010028. Review.

44.

Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin.

Handzlik J, Szymańska E, Alibert S, Chevalier J, Otrębska E, Pękala E, Pagès JM, Kieć-Kononowicz K.

Bioorg Med Chem. 2013 Jan 1;21(1):135-45. doi: 10.1016/j.bmc.2012.10.053. Epub 2012 Nov 15.

PMID:
23218781
45.

Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.

Amaral L, Spengler G, Martins A, Armada A, Handzlik J, Kiec-Kononowicz K, Molnar J.

Anticancer Res. 2012 Jul;32(7):2947-57. Review.

PMID:
22753759
46.

Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α₁-adrenoceptor antagonistic properties.

Handzlik J, Szymańska E, Wójcik R, Dela A, Jastrzębska-Więsek M, Karolak-Wojciechowska J, Fruziński A, Siwek A, Filipek B, Kieć-Kononowicz K.

Bioorg Med Chem. 2012 Jul 15;20(14):4245-57. doi: 10.1016/j.bmc.2012.05.064. Epub 2012 Jun 5.

PMID:
22739084
47.

5-arylidene(thio)hydantoin derivatives as modulators of cancer efflux pump.

Handzlik J, Spengler G, Mastek B, Dela A, Molnar J, Amaral L, Kieć-Kononowicz K.

Acta Pol Pharm. 2012 Jan-Feb;69(1):149-56. No abstract available.

48.

Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with α₁-adrenoceptor affinities.

Handzlik J, Bajda M, Zygmunt M, Maciąg D, Dybała M, Bednarski M, Filipek B, Malawska B, Kieć-Kononowicz K.

Bioorg Med Chem. 2012 Apr 1;20(7):2290-303. doi: 10.1016/j.bmc.2012.02.009. Epub 2012 Feb 13.

PMID:
22381672
49.

Activity of fourteen new hydantoin compounds on the human ABCB1 efflux pump.

Martins A, Dymek A, Handzlik J, Spengler G, Armada A, Molnar J, Kiéc-Kononowicz K, Amaral L.

In Vivo. 2012 Mar-Apr;26(2):293-7.

PMID:
22351672
50.

The activity of 16 new hydantoin compounds on the intrinsic and overexpressed efflux pump system of Staphylococcus aureus.

Dymek A, Armada A, Handzlik J, Viveiros M, Spengler G, Molnar J, Kieć-Kononowicz K, Amaral L.

In Vivo. 2012 Mar-Apr;26(2):223-9.

PMID:
22351662

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