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How Epigenetic Modifications Drive the Expression and Mediate the Action of PGC-1α in the Regulation of Metabolism.

Krämer AI, Handschin C.

Int J Mol Sci. 2019 Oct 31;20(21). pii: E5449. doi: 10.3390/ijms20215449. Review.


PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice.

Panajatovic MV, Singh F, Roos NJ, Duthaler U, Handschin C, Krähenbühl S, Bouitbir J.

Acta Physiol (Oxf). 2019 Oct 12:e13402. doi: 10.1111/apha.13402. [Epub ahead of print]


JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms.

Rao TN, Hansen N, Hilfiker J, Rai S, Majewska JM, Leković D, Gezer D, Andina N, Galli S, Cassel T, Geier F, Delezie J, Nienhold R, Hao-Shen H, Beisel C, Di Palma S, Dimeloe S, Trebicka J, Wolf D, Gassmann M, Fan TW, Lane AN, Handschin C, Dirnhofer S, Kröger N, Hess C, Radimerski T, Koschmieder S, Čokić VP, Skoda RC.

Blood. 2019 Nov 21;134(21):1832-1846. doi: 10.1182/blood.2019000162.


BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle.

Delezie J, Weihrauch M, Maier G, Tejero R, Ham DJ, Gill JF, Karrer-Cardel B, Rüegg MA, Tabares L, Handschin C.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16111-16120. doi: 10.1073/pnas.1900544116. Epub 2019 Jul 18.


Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle.

Furrer R, Handschin C.

In: Spiegelman B, editor. Hormones, Metabolism and the Benefits of Exercise [Internet]. Cham (CH): Springer; 2017.
2018 Mar 8.


Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging.

Gill JF, Delezie J, Santos G, McGuirk S, Schnyder S, Frank S, Rausch M, St-Pierre J, Handschin C.

Aging Cell. 2019 Oct;18(5):e12993. doi: 10.1111/acel.12993. Epub 2019 Jul 10.


Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.

Agudelo LZ, Ferreira DMS, Dadvar S, Cervenka I, Ketscher L, Izadi M, Zhengye L, Furrer R, Handschin C, Venckunas T, Brazaitis M, Kamandulis S, Lanner JT, Ruas JL.

Nat Commun. 2019 Jun 24;10(1):2767. doi: 10.1038/s41467-019-10712-0.


Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics.

Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB.

Cell Rep. 2019 Apr 30;27(5):1551-1566.e5. doi: 10.1016/j.celrep.2019.04.012.


Pharmacological targeting of age-related changes in skeletal muscle tissue.

Leuchtmann AB, Handschin C.

Pharmacol Res. 2019 Mar 4:104191. doi: 10.1016/j.phrs.2019.02.030. [Epub ahead of print] Review.


Endocrine Crosstalk Between Skeletal Muscle and the Brain.

Delezie J, Handschin C.

Front Neurol. 2018 Aug 24;9:698. doi: 10.3389/fneur.2018.00698. eCollection 2018. Review.


Muscle Wasting Diseases: Novel Targets and Treatments.

Furrer R, Handschin C.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:315-339. doi: 10.1146/annurev-pharmtox-010818-021041. Epub 2018 Aug 27.


Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice.

Baum O, Aaldijk D, Engeli AL, Spree M, Summermatter S, Handschin C, Zakrzewicz A.

Nitric Oxide. 2018 Jul 1;77:35-43. doi: 10.1016/j.niox.2018.04.005. Epub 2018 Apr 17.


Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart.

Whitehead N, Gill JF, Brink M, Handschin C.

Front Physiol. 2018 Mar 21;9:242. doi: 10.3389/fphys.2018.00242. eCollection 2018.


Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma.

Haralampieva D, Salemi S, Betzel T, Dinulovic I, Krämer SD, Schibli R, Sulser T, Handschin C, Ametamey SM, Eberli D.

Stem Cells Int. 2018 Jan 21;2018:4658503. doi: 10.1155/2018/4658503. eCollection 2018.


Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance.

Ruiz A, Dror E, Handschin C, Furrer R, Perez-Schindler J, Bachmann C, Treves S, Zorzato F.

Sci Rep. 2018 Jan 12;8(1):636. doi: 10.1038/s41598-017-18844-3.


Plasticity of the Muscle Stem Cell Microenvironment.

Dinulovic I, Furrer R, Handschin C.

Adv Exp Med Biol. 2017;1041:141-169. doi: 10.1007/978-3-319-69194-7_8. Review.


PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice.

Gill JF, Santos G, Schnyder S, Handschin C.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12697. Epub 2017 Oct 25.


Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls.

Weihrauch M, Handschin C.

Biochem Pharmacol. 2018 Jan;147:211-220. doi: 10.1016/j.bcp.2017.10.006. Epub 2017 Oct 20. Review.


Giant Valley-Isospin Conductance Oscillations in Ballistic Graphene.

Handschin C, Makk P, Rickhaus P, Maurand R, Watanabe K, Taniguchi T, Richter K, Liu MH, Schönenberger C.

Nano Lett. 2017 Sep 13;17(9):5389-5393. doi: 10.1021/acs.nanolett.7b01964. Epub 2017 Aug 17.


Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations.

Kupr B, Schnyder S, Handschin C.

Cold Spring Harb Perspect Med. 2017 Jun 1;7(6). pii: a029835. doi: 10.1101/cshperspect.a029835. Review.


Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice.

Schnyder S, Svensson K, Cardel B, Handschin C.

Am J Physiol Endocrinol Metab. 2017 May 1;312(5):E437-E446. doi: 10.1152/ajpendo.00361.2016. Epub 2017 Feb 21.


Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Early Skeletal Muscle Tissue Formation.

Haralampieva D, Salemi S, Dinulovic I, Sulser T, Ametamey SM, Handschin C, Eberli D.

Cell Transplant. 2017 Jun 9;26(6):1103-1114. doi: 10.3727/096368917X694868. Epub 2017 Feb 3.


Taking advantage of acoustic inhomogeneities in photoacoustic measurements.

Da Silva A, Handschin C, Metwally K, Garci H, Riedinger C, Mensah S, Akhouayri H.

J Biomed Opt. 2017 Apr 1;22(4):41012. doi: 10.1117/1.JBO.22.4.041012.


Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP.

Furrer R, Eisele PS, Schmidt A, Beer M, Handschin C.

Sci Rep. 2017 Jan 16;7:40789. doi: 10.1038/srep40789.


Coregulator-mediated control of skeletal muscle plasticity - A mini-review.

Schnyder S, Kupr B, Handschin C.

Biochimie. 2017 May;136:49-54. doi: 10.1016/j.biochi.2016.12.011. Epub 2017 Jan 3. Review.


Fabry-Pérot Resonances in a Graphene/hBN Moiré Superlattice.

Handschin C, Makk P, Rickhaus P, Liu MH, Watanabe K, Taniguchi T, Richter K, Schönenberger C.

Nano Lett. 2017 Jan 11;17(1):328-333. doi: 10.1021/acs.nanolett.6b04137. Epub 2016 Dec 16.


Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche.

Dinulovic I, Furrer R, Beer M, Ferry A, Cardel B, Handschin C.

Skelet Muscle. 2016 Dec 2;6(1):39.


Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres.

Ross JA, Pearson A, Levy Y, Cardel B, Handschin C, Ochala J.

J Cell Physiol. 2017 Jun;232(6):1270-1274. doi: 10.1002/jcp.25678. Epub 2016 Dec 29.


PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle.

Dinulovic I, Furrer R, Di Fulvio S, Ferry A, Beer M, Handschin C.

Skelet Muscle. 2016 Nov 8;6:38. eCollection 2016.


Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice.

Svensson K, Schnyder S, Cardel B, Handschin C.

PLoS One. 2016 Jul 27;11(7):e0158716. doi: 10.1371/journal.pone.0158716. eCollection 2016.


PGC-1α expression in murine AgRP neurons regulates food intake and energy balance.

Gill JF, Delezie J, Santos G, Handschin C.

Mol Metab. 2016 May 18;5(7):580-588. doi: 10.1016/j.molmet.2016.05.008. eCollection 2016 Jul.


Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering.

Haralampieva D, Betzel T, Dinulovic I, Salemi S, Stoelting M, Krämer SD, Schibli R, Sulser T, Handschin C, Eberli D, Ametamey SM.

J Nucl Med. 2016 Sep;57(9):1467-73. doi: 10.2967/jnumed.115.170548. Epub 2016 May 19.


The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells.

Salatino S, Kupr B, Baresic M, Omidi S, van Nimwegen E, Handschin C.

Mol Endocrinol. 2016 Jul;30(7):809-25. doi: 10.1210/me.2016-1036. Epub 2016 May 16. Erratum in: Endocrinology. 2018 Jul 1;159(7):2703.


Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice.

Svensson K, Albert V, Cardel B, Salatino S, Handschin C.

FASEB J. 2016 May;30(5):1976-86. doi: 10.1096/fj.201500128. Epub 2016 Feb 5.


mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.

Albert V, Svensson K, Shimobayashi M, Colombi M, Muñoz S, Jimenez V, Handschin C, Bosch F, Hall MN.

EMBO Mol Med. 2016 Mar 1;8(3):232-46. doi: 10.15252/emmm.201505610.


Caloric restriction and exercise "mimetics'': Ready for prime time?

Handschin C.

Pharmacol Res. 2016 Jan;103:158-66. doi: 10.1016/j.phrs.2015.11.009. Epub 2015 Dec 2. Review.


Complex Coordination of Cell Plasticity by a PGC-1α-controlled Transcriptional Network in Skeletal Muscle.

Kupr B, Handschin C.

Front Physiol. 2015 Nov 9;6:325. doi: 10.3389/fphys.2015.00325. eCollection 2015. Review.


Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise.

Schnyder S, Handschin C.

Bone. 2015 Nov;80:115-125. doi: 10.1016/j.bone.2015.02.008. Review.


Magnetic stimulation supports muscle and nerve regeneration after trauma in mice.

Stölting MN, Arnold AS, Haralampieva D, Handschin C, Sulser T, Eberli D.

Muscle Nerve. 2016 Apr;53(4):598-607. doi: 10.1002/mus.24780.


The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo.

Eisele PS, Furrer R, Beer M, Handschin C.

Biochem Biophys Res Commun. 2015 Aug 28;464(3):692-7. doi: 10.1016/j.bbrc.2015.06.166. Epub 2015 Jul 6.


Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α).

Svensson K, Schnyder S, Albert V, Cardel B, Quagliata L, Terracciano LM, Handschin C.

J Biol Chem. 2015 Jun 26;290(26):16059-76. doi: 10.1074/jbc.M114.590653. Epub 2015 May 18.


External physical and biochemical stimulation to enhance skeletal muscle bioengineering.

Handschin C, Mortezavi A, Plock J, Eberli D.

Adv Drug Deliv Rev. 2015 Mar;82-83:168-175. doi: 10.1016/j.addr.2014.10.021. Epub 2014 Oct 22. Review.


PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects.

Soler F, Fernández-Belda F, Pérez-Schindler J, Handschin C, Fuente T, Hernandez-Cascales J.

Exp Biol Med (Maywood). 2015 Sep;240(9):1205-13. doi: 10.1177/1535370214560969. Epub 2014 Nov 27.


The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet.

Pérez-Schindler J, Svensson K, Vargas-Fernández E, Santos G, Wahli W, Handschin C.

Diabetologia. 2014 Nov;57(11):2405-12. doi: 10.1007/s00125-014-3352-3. Epub 2014 Aug 13.


Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program.

Baresic M, Salatino S, Kupr B, van Nimwegen E, Handschin C.

Mol Cell Biol. 2014 Aug;34(16):2996-3012. doi: 10.1128/MCB.01710-13. Epub 2014 Jun 9.


MicroRNAs emerge as modulators of NAD+-dependent energy metabolism in skeletal muscle.

Svensson K, Handschin C.

Diabetes. 2014 May;63(5):1451-3. doi: 10.2337/db14-0166. No abstract available.


Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α.

Arnold AS, Gill J, Christe M, Ruiz R, McGuirk S, St-Pierre J, Tabares L, Handschin C.

Nat Commun. 2014 Apr 1;5:3569. doi: 10.1038/ncomms4569.


Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases.

Svensson K, Handschin C.

Drug Discov Today. 2014 Jul;19(7):1024-9. doi: 10.1016/j.drudis.2014.02.013. Epub 2014 Mar 12. Review. No abstract available.


Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice.

Morand R, Bouitbir J, Felser A, Hench J, Handschin C, Frank S, Krähenbühl S.

Eur J Nutr. 2014 Sep;53(6):1313-25. doi: 10.1007/s00394-013-0631-6. Epub 2013 Dec 11.


The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling.

Pérez-Schindler J, Summermatter S, Santos G, Zorzato F, Handschin C.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20314-9. doi: 10.1073/pnas.1312039110. Epub 2013 Nov 25.

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