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Items: 47

1.

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis.

Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL Jr, Orchard RC, McCune BT, Kim KW, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW.

Cell Host Microbe. 2019 Jun 12;25(6):845-857.e5. doi: 10.1016/j.chom.2019.04.005. Epub 2019 May 23.

PMID:
31130511
2.

Drowning in Viruses.

Handley SA, Virgin HW.

Cell. 2019 May 16;177(5):1084-1085. doi: 10.1016/j.cell.2019.04.045.

PMID:
31100262
3.

Going Viral: a Novel Role for Bacteriophage in Colorectal Cancer.

Handley SA, Devkota S.

MBio. 2019 Jan 22;10(1). pii: e02626-18. doi: 10.1128/mBio.02626-18.

4.

Plasma and Urine Levamisole in Clinical Samples Containing Benzoylecgonine: Absence of Aminorex.

Handley SA, Belsey SL, Couchman L, Flanagan RJ.

J Anal Toxicol. 2019 May 1;43(4):299-306. doi: 10.1093/jat/bky102.

PMID:
30590551
5.

Virome biogeography in the lower gastrointestinal tract of rhesus macaques with chronic diarrhea.

Zhao G, Droit L, Gilbert MH, Schiro FR, Didier PJ, Si X, Paredes A, Handley SA, Virgin HW, Bohm RP, Wang D.

Virology. 2019 Jan 15;527:77-88. doi: 10.1016/j.virol.2018.10.001. Epub 2018 Nov 20.

PMID:
30468938
6.

Effect of Antibiotic-Mediated Microbiome Modulation on Rotavirus Vaccine Immunogenicity: A Human, Randomized-Control Proof-of-Concept Trial.

Harris VC, Haak BW, Handley SA, Jiang B, Velasquez DE, Hykes BL Jr, Droit L, Berbers GAM, Kemper EM, van Leeuwen EMM, Boele van Hensbroek M, Wiersinga WJ.

Cell Host Microbe. 2018 Aug 8;24(2):197-207.e4. doi: 10.1016/j.chom.2018.07.005.

PMID:
30092197
7.

Alterations in the oral microbiome in HIV-infected participants after antiretroviral therapy administration are influenced by immune status.

Presti RM, Handley SA, Droit L, Ghannoum M, Jacobson M, Shiboski CH, Webster-Cyriaque J, Brown T, Yin MT, Overton ET.

AIDS. 2018 Jun 19;32(10):1279-1287. doi: 10.1097/QAD.0000000000001811.

8.

Tropism for tuft cells determines immune promotion of norovirus pathogenesis.

Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW.

Science. 2018 Apr 13;360(6385):204-208. doi: 10.1126/science.aar3799.

9.

Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections.

Thackray LB, Handley SA, Gorman MJ, Poddar S, Bagadia P, Briseño CG, Theisen DJ, Tan Q, Hykes BL Jr, Lin H, Lucas TM, Desai C, Gordon JI, Murphy KM, Virgin HW, Diamond MS.

Cell Rep. 2018 Mar 27;22(13):3440-3453.e6. doi: 10.1016/j.celrep.2018.03.001.

10.

LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.

Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, Hwang S, Viehmann Milam A, Chen E, Kerrinnes T, Starnbach MN, Handley SA, Mysorekar IU, Allen PM, Monack DM, Dinauer MC, Doering TL, Tsolis RM, Dworkin JE, Stallings CL, Amarasinghe GK, Micchelli CA, Virgin HW.

J Biol Chem. 2018 Apr 20;293(16):6022-6038. doi: 10.1074/jbc.RA117.001246. Epub 2018 Mar 1.

11.

Clozapine and Norclozapine Concentrations in Paired Human Plasma and Serum Samples.

Sa H, Fisher SS, K S, Rj F.

Ther Drug Monit. 2018 Feb;40(1):148-150. doi: 10.1097/FTD.0000000000000478.

PMID:
29240616
12.

Ultra-fast LC-MS/MS in therapeutic drug monitoring: Quantification of clozapine and norclozapine in human plasma.

Couchman L, Fisher DS, Subramaniam K, Handley SA, Boughtflower RJ, Benton CM, Flanagan RJ.

Drug Test Anal. 2018 Feb;10(2):323-329. doi: 10.1002/dta.2223. Epub 2017 Jul 19.

PMID:
28585411
13.

Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.

Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung'u T, Ghebremichael MS, Wesemann DR, Mitchell C, Dong KL, Huttenhower C, Walker BD, Virgin HW, Kwon DS.

Immunity. 2017 Jan 17;46(1):29-37. doi: 10.1016/j.immuni.2016.12.013. Epub 2017 Jan 10.

14.

The virome: a missing component of biological interaction networks in health and disease.

Handley SA.

Genome Med. 2016 Apr 1;8(1):32. doi: 10.1186/s13073-016-0287-y. Review.

15.

SIV Infection-Mediated Changes in Gastrointestinal Bacterial Microbiome and Virome Are Associated with Immunodeficiency and Prevented by Vaccination.

Handley SA, Desai C, Zhao G, Droit L, Monaco CL, Schroeder AC, Nkolola JP, Norman ME, Miller AD, Wang D, Barouch DH, Virgin HW.

Cell Host Microbe. 2016 Mar 9;19(3):323-35. doi: 10.1016/j.chom.2016.02.010.

16.

Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome.

Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kwon DS, Virgin HW.

Cell Host Microbe. 2016 Mar 9;19(3):311-22. doi: 10.1016/j.chom.2016.02.011.

17.

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.

Park S, Buck MD, Desai C, Zhang X, Loginicheva E, Martinez J, Freeman ML, Saitoh T, Akira S, Guan JL, He YW, Blackman MA, Handley SA, Levine B, Green DR, Reese TA, Artyomov MN, Virgin HW.

Cell Host Microbe. 2016 Jan 13;19(1):91-101. doi: 10.1016/j.chom.2015.12.010.

18.

Automated Analysis of Clozapine and Norclozapine in Human Plasma Using Novel Extraction Plate Technology and Flow-Injection Tandem Mass Spectrometry.

Couchman L, Subramaniam K, Fisher DS, Belsey SL, Handley SA, Flanagan RJ.

Ther Drug Monit. 2016 Feb;38(1):42-9. doi: 10.1097/FTD.0000000000000231.

PMID:
26349082
19.

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys.

Barouch DH, Alter G, Broge T, Linde C, Ackerman ME, Brown EP, Borducchi EN, Smith KM, Nkolola JP, Liu J, Shields J, Parenteau L, Whitney JB, Abbink P, Ng'ang'a DM, Seaman MS, Lavine CL, Perry JR, Li W, Colantonio AD, Lewis MG, Chen B, Wenschuh H, Reimer U, Piatak M, Lifson JD, Handley SA, Virgin HW, Koutsoukos M, Lorin C, Voss G, Weijtens M, Pau MG, Schuitemaker H.

Science. 2015 Jul 17;349(6245):320-4. doi: 10.1126/science.aab3886. Epub 2015 Jul 2.

20.

Disease-specific alterations in the enteric virome in inflammatory bowel disease.

Norman JM, Handley SA, Baldridge MT, Droit L, Liu CY, Keller BC, Kambal A, Monaco CL, Zhao G, Fleshner P, Stappenbeck TS, McGovern DP, Keshavarzian A, Mutlu EA, Sauk J, Gevers D, Xavier RJ, Wang D, Parkes M, Virgin HW.

Cell. 2015 Jan 29;160(3):447-60. doi: 10.1016/j.cell.2015.01.002. Epub 2015 Jan 22.

21.

Construction and evaluation of novel rhesus monkey adenovirus vaccine vectors.

Abbink P, Maxfield LF, Ng'ang'a D, Borducchi EN, Iampietro MJ, Bricault CA, Teigler JE, Blackmore S, Parenteau L, Wagh K, Handley SA, Zhao G, Virgin HW, Korber B, Barouch DH.

J Virol. 2015 Feb;89(3):1512-22. doi: 10.1128/JVI.02950-14. Epub 2014 Nov 19.

22.

Kingdom-agnostic metagenomics and the importance of complete characterization of enteric microbial communities.

Norman JM, Handley SA, Virgin HW.

Gastroenterology. 2014 May;146(6):1459-69. doi: 10.1053/j.gastro.2014.02.001. Epub 2014 Feb 5. Review.

23.

Drugs and other chemicals involved in fatal poisoning in England and Wales during 2000 – 2011.

Handley SA, Flanagan RJ.

Clin Toxicol (Phila). 2014 Jan;52(1):1-12. doi: 10.3109/15563650.2013.872791.

PMID:
24397714
24.

Plasma quetiapine in relation to prescribed dose and other factors: data from a therapeutic drug monitoring service, 2000-2011.

Handley SA, Bowskill SV, Patel MX, Flanagan RJ.

Ther Adv Psychopharmacol. 2013 Jun;3(3):129-37. doi: 10.1177/2045125312470677.

25.

A novel approach to quantitative LC-MS/MS: therapeutic drug monitoring of clozapine and norclozapine using isotopic internal calibration.

Couchman L, Belsey SL, Handley SA, Flanagan RJ.

Anal Bioanal Chem. 2013 Nov;405(29):9455-66. doi: 10.1007/s00216-013-7361-8. Epub 2013 Oct 4.

PMID:
24091736
26.

A mouse model for human norovirus.

Taube S, Kolawole AO, Höhne M, Wilkinson JE, Handley SA, Perry JW, Thackray LB, Akkina R, Wobus CE.

MBio. 2013 Jul 16;4(4). pii: e00450-13. doi: 10.1128/mBio.00450-13.

27.

Stability of some atypical antipsychotics in human plasma, haemolysed whole blood, oral fluid, human serum and calf serum.

Fisher DS, Partridge SJ, Handley SA, Flanagan RJ.

Forensic Sci Int. 2013 Jun 10;229(1-3):151-6. doi: 10.1016/j.forsciint.2013.03.021. Epub 2013 Apr 6.

PMID:
23570966
28.

LC-MS/MS of some atypical antipsychotics in human plasma, serum, oral fluid and haemolysed whole blood.

Fisher DS, Partridge SJ, Handley SA, Couchman L, Morgan PE, Flanagan RJ.

Forensic Sci Int. 2013 Jun 10;229(1-3):145-50. doi: 10.1016/j.forsciint.2013.02.010. Epub 2013 Mar 9.

PMID:
23477803
29.

Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome.

Handley SA, Thackray LB, Zhao G, Presti R, Miller AD, Droit L, Abbink P, Maxfield LF, Kambal A, Duan E, Stanley K, Kramer J, Macri SC, Permar SR, Schmitz JE, Mansfield K, Brenchley JM, Veazey RS, Stappenbeck TS, Wang D, Barouch DH, Virgin HW.

Cell. 2012 Oct 12;151(2):253-66. doi: 10.1016/j.cell.2012.09.024.

30.

Plasma amisulpride in relation to prescribed dose, clozapine augmentation, and other factors: data from a therapeutic drug monitoring service, 2002-2010.

Bowskill SV, Patel MX, Handley SA, Flanagan RJ.

Hum Psychopharmacol. 2012 Sep;27(5):507-13. doi: 10.1002/hup.2256.

PMID:
22996618
31.
32.

Risperidone and total 9-hydroxyrisperidone in relation to prescribed dose and other factors: data from a therapeutic drug monitoring service, 2002-2010.

Bowskill SV, Handley SA, Fisher DS, Flanagan RJ, Patel MX.

Ther Drug Monit. 2012 Jun;34(3):349-55. doi: 10.1097/FTD.0b013e3182577c43.

PMID:
22569353
33.

Measurement of quetiapine and four quetiapine metabolites in human plasma by LC-MS/MS.

Fisher DS, Handley SA, Taylor D, Flanagan RJ.

Biomed Chromatogr. 2012 Sep;26(9):1125-32. doi: 10.1002/bmc.2672. Epub 2012 Jan 12.

PMID:
22241669
34.

Measurement of serum lanthanum in patients treated with lanthanum carbonate by inductively coupled plasma-mass spectrometry.

Handley SA, Raja KB, Sharpe C, Flanagan RJ.

Ann Clin Biochem. 2011 Mar;48(Pt 2):178-82. doi: 10.1258/acb.2010.010162. Epub 2011 Mar 2.

PMID:
21367883
35.

Identification and sequencing of a novel rodent gammaherpesvirus that establishes acute and latent infection in laboratory mice.

Loh J, Zhao G, Nelson CA, Coder P, Droit L, Handley SA, Johnson LS, Vachharajani P, Guzman H, Tesh RB, Wang D, Fremont DH, Virgin HW.

J Virol. 2011 Mar;85(6):2642-56. doi: 10.1128/JVI.01661-10. Epub 2011 Jan 5.

37.

Comparison of the host responses to wild-type and cpsB mutant Klebsiella pneumoniae infections.

Lawlor MS, Handley SA, Miller VL.

Infect Immun. 2006 Sep;74(9):5402-7.

38.

Histamine signaling through the H(2) receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection.

Handley SA, Dube PH, Miller VL.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9268-73. Epub 2006 May 22.

39.
40.

Population genetic analysis of Bartonella bacilliformis isolates from areas of peru where Carrion's disease is endemic and epidemic.

Hambuch TM, Handley SA, Ellis B, Chamberlin J, Romero S, Regnery R.

J Clin Microbiol. 2004 Aug;42(8):3675-80.

41.

The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae.

Alsmark CM, Frank AC, Karlberg EO, Legault BA, Ardell DH, Canbäck B, Eriksson AS, Näslund AK, Handley SA, Huvet M, La Scola B, Holmberg M, Andersson SG.

Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9716-21. Epub 2004 Jun 21.

42.
43.

Characterization of oral Yersinia enterocolitica infection in three different strains of inbred mice.

Handley SA, Dube PH, Revell PA, Miller VL.

Infect Immun. 2004 Mar;72(3):1645-56.

44.

Comparing bootstrap and posterior probability values in the four-taxon case.

Cummings MP, Handley SA, Myers DS, Reed DL, Rokas A, Winka K.

Syst Biol. 2003 Aug;52(4):477-87.

PMID:
12857639
45.
46.
47.

Differentiation of pathogenic Bartonella species by infrequent restriction site PCR.

Handley SA, Regnery RL.

J Clin Microbiol. 2000 Aug;38(8):3010-5.

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