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Items: 1 to 50 of 102

1.

Somatic mutant clones colonize the human esophagus with age.

Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones PH.

Science. 2018 Oct 18. pii: eaau3879. doi: 10.1126/science.aau3879. [Epub ahead of print]

PMID:
30337457
2.

Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling.

Takeuchi H, Schneider M, Williamson DB, Ito A, Takeuchi M, Handford PA, Haltiwanger RS.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8395-E8402. doi: 10.1073/pnas.1804005115. Epub 2018 Aug 20.

PMID:
30127001
3.

Structural Insights into Notch Receptor-Ligand Interactions.

Handford PA, Korona B, Suckling R, Redfield C, Lea SM.

Adv Exp Med Biol. 2018;1066:33-46. doi: 10.1007/978-3-319-89512-3_2.

PMID:
30030820
4.

The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1.

Robertson IB, Dias HF, Osuch IH, Lowe ED, Jensen SA, Redfield C, Handford PA.

Structure. 2017 Aug 1;25(8):1208-1221.e5. doi: 10.1016/j.str.2017.06.003. Epub 2017 Jun 29.

5.

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.

Suckling RJ, Korona B, Whiteman P, Chillakuri C, Holt L, Handford PA, Lea SM.

EMBO J. 2017 Aug 1;36(15):2204-2215. doi: 10.15252/embj.201796632. Epub 2017 Jun 1.

6.

New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies.

Jensen SA, Handford PA.

Biochem J. 2016 Apr 1;473(7):827-38. doi: 10.1042/BJ20151108. Review.

PMID:
27026396
7.

Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.

Weisshuhn PC, Sheppard D, Taylor P, Whiteman P, Lea SM, Handford PA, Redfield C.

Structure. 2016 Apr 5;24(4):555-566. doi: 10.1016/j.str.2016.02.010. Epub 2016 Mar 17.

8.

A microfibril assembly assay identifies different mechanisms of dominance underlying Marfan syndrome, stiff skin syndrome and acromelic dysplasias.

Jensen SA, Iqbal S, Bulsiewicz A, Handford PA.

Hum Mol Genet. 2015 Aug 1;24(15):4454-63. doi: 10.1093/hmg/ddv181. Epub 2015 May 15.

9.

(1)H, (13)C and (15)N assignments of EGF domains 8-11 of human Notch-1.

Weisshuhn PC, Handford PA, Redfield C.

Biomol NMR Assign. 2015 Oct;9(2):375-9. doi: 10.1007/s12104-015-9613-3. Epub 2015 May 1.

PMID:
25930016
10.

Validity of the decoding-encoding screener for dyslexia.

Handford P, Borsting E.

Optom Vis Sci. 2015 Apr;92(4):487-93. doi: 10.1097/OPX.0000000000000560.

PMID:
25785525
11.

(1)H, (13)C and (15)N assignments of EGF domains 4 to 7 of human Notch-1.

Weisshuhn PC, Handford PA, Redfield C.

Biomol NMR Assign. 2015 Oct;9(2):275-9. doi: 10.1007/s12104-014-9591-x. Epub 2014 Dec 13.

PMID:
25503468
12.

Bacterial expression and in vitro refolding of limited fragments of the Notch receptor and its ligands.

Whiteman P, Redfield C, Handford PA.

Methods Mol Biol. 2014;1187:193-208. doi: 10.1007/978-1-4939-1139-4_15.

PMID:
25053491
13.

C-terminal propeptide is required for fibrillin-1 secretion and blocks premature assembly through linkage to domains cbEGF41-43.

Jensen SA, Aspinall G, Handford PA.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10155-60. doi: 10.1073/pnas.1401697111. Epub 2014 Jun 30.

14.

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands.

Taylor P, Takeuchi H, Sheppard D, Chillakuri C, Lea SM, Haltiwanger RS, Handford PA.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7290-5. doi: 10.1073/pnas.1319683111. Epub 2014 May 6.

15.

NMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation.

Robertson IB, Handford PA, Redfield C.

PLoS One. 2014 Jan 29;9(1):e87125. doi: 10.1371/journal.pone.0087125. eCollection 2014.

16.

Structural analysis uncovers lipid-binding properties of Notch ligands.

Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM.

Cell Rep. 2013 Nov 27;5(4):861-7. doi: 10.1016/j.celrep.2013.10.029. Epub 2013 Nov 14.

17.

Structure of the fibrillin-1 N-terminal domains suggests that heparan sulfate regulates the early stages of microfibril assembly.

Yadin DA, Robertson IB, McNaught-Davis J, Evans P, Stoddart D, Handford PA, Jensen SA, Redfield C.

Structure. 2013 Oct 8;21(10):1743-56. doi: 10.1016/j.str.2013.08.004. Epub 2013 Sep 12.

18.

Juvenile idiopathic arthritis, mitral valve prolapse and a familial variant involving the integrin-binding fragment of FBN1.

Wilson BT, Jensen SA, McAnulty CP, Brennan P, Handford PA.

Am J Med Genet A. 2013 Aug;161A(8):2047-51. doi: 10.1002/ajmg.a.36011. Epub 2013 Jun 21.

PMID:
23794388
19.

¹H, ¹³C and ¹⁵N resonance assignments for the fibrillin-1 EGF2-EGF3-hybrid1-cbEGF1 four-domain fragment.

Robertson IB, Osuch I, Yadin DA, Handford PA, Jensen SA, Redfield C.

Biomol NMR Assign. 2014 Apr;8(1):189-94. doi: 10.1007/s12104-013-9481-7. Epub 2013 May 7.

20.

Backbone ¹H, ¹³C and ¹⁵N resonance assignment of the C-terminal EGF-cbEGF pair of LTBP1 and flanking residues.

Robertson IB, Handford PA, Redfield C.

Biomol NMR Assign. 2014 Apr;8(1):159-63. doi: 10.1007/s12104-013-9474-6. Epub 2013 Mar 14.

PMID:
23494870
21.

Continental phylogeography of an ecologically and morphologically diverse Neotropical songbird, Zonotrichia capensis.

Lougheed SC, Campagna L, Dávila JA, Tubaro PL, Lijtmaer DA, Handford P.

BMC Evol Biol. 2013 Mar 1;13:58. doi: 10.1186/1471-2148-13-58.

22.

Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor.

Whiteman P, de Madrid BH, Taylor P, Li D, Heslop R, Viticheep N, Tan JZ, Shimizu H, Callaghan J, Masiero M, Li JL, Banham AH, Harris AL, Lea SM, Redfield C, Baron M, Handford PA.

J Biol Chem. 2013 Mar 8;288(10):7305-12. doi: 10.1074/jbc.M112.428854. Epub 2013 Jan 21.

23.

¹H, ¹³C and ¹⁵N assignments of the four N-terminal domains of human fibrillin-1.

Yadin DA, Robertson IB, Jensen SA, Handford PA, Redfield C.

Biomol NMR Assign. 2014 Apr;8(1):75-80. doi: 10.1007/s12104-012-9456-0. Epub 2012 Dec 23.

24.

The CD46-Jagged1 interaction is critical for human TH1 immunity.

Le Friec G, Sheppard D, Whiteman P, Karsten CM, Shamoun SA, Laing A, Bugeon L, Dallman MJ, Melchionna T, Chillakuri C, Smith RA, Drouet C, Couzi L, Fremeaux-Bacchi V, Köhl J, Waddington SN, McDonnell JM, Baker A, Handford PA, Lea SM, Kemper C.

Nat Immunol. 2012 Dec;13(12):1213-21. doi: 10.1038/ni.2454. Epub 2012 Oct 21.

25.

Notch receptor-ligand binding and activation: insights from molecular studies.

Chillakuri CR, Sheppard D, Lea SM, Handford PA.

Semin Cell Dev Biol. 2012 Jun;23(4):421-8. doi: 10.1016/j.semcdb.2012.01.009. Epub 2012 Feb 4. Review.

26.

Dissecting the fibrillin microfibril: structural insights into organization and function.

Jensen SA, Robertson IB, Handford PA.

Structure. 2012 Feb 8;20(2):215-25. doi: 10.1016/j.str.2011.12.008. Review.

27.

A molecular phylogeny of the Sierra-Finches (Phrygilus, Passeriformes): extreme polyphyly in a group of Andean specialists.

Campagna L, Geale K, Handford P, Lijtmaer DA, Tubaro PL, Lougheed SC.

Mol Phylogenet Evol. 2011 Nov;61(2):521-33. doi: 10.1016/j.ympev.2011.07.011. Epub 2011 Jul 23.

PMID:
21807104
28.

Mutations in the TGFβ binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias.

Le Goff C, Mahaut C, Wang LW, Allali S, Abhyankar A, Jensen S, Zylberberg L, Collod-Beroud G, Bonnet D, Alanay Y, Brady AF, Cordier MP, Devriendt K, Genevieve D, Kiper PÖ, Kitoh H, Krakow D, Lynch SA, Le Merrer M, Mégarbane A, Mortier G, Odent S, Polak M, Rohrbach M, Sillence D, Stolte-Dijkstra I, Superti-Furga A, Rimoin DL, Topouchian V, Unger S, Zabel B, Bole-Feysot C, Nitschke P, Handford P, Casanova JL, Boileau C, Apte SS, Munnich A, Cormier-Daire V.

Am J Hum Genet. 2011 Jul 15;89(1):7-14. doi: 10.1016/j.ajhg.2011.05.012. Epub 2011 Jun 16.

29.

TB domain proteins: evolutionary insights into the multifaceted roles of fibrillins and LTBPs.

Robertson I, Jensen S, Handford P.

Biochem J. 2011 Jan 15;433(2):263-76. doi: 10.1042/BJ20101320. Review.

PMID:
21175431
30.

Biophysical characterisation of fibulin-5 proteins associated with disease.

Schneider R, Jensen SA, Whiteman P, McCullagh JS, Redfield C, Handford PA.

J Mol Biol. 2010 Aug 27;401(4):605-17. doi: 10.1016/j.jmb.2010.06.039. Epub 2010 Jun 25.

PMID:
20599547
31.

Mutations in fibrillin-1 cause congenital scleroderma: stiff skin syndrome.

Loeys BL, Gerber EE, Riegert-Johnson D, Iqbal S, Whiteman P, McConnell V, Chillakuri CR, Macaya D, Coucke PJ, De Paepe A, Judge DP, Wigley F, Davis EC, Mardon HJ, Handford P, Keene DR, Sakai LY, Dietz HC.

Sci Transl Med. 2010 Mar 17;2(23):23ra20. doi: 10.1126/scitranslmed.3000488.

32.

Structure and interdomain interactions of a hybrid domain: a disulphide-rich module of the fibrillin/LTBP superfamily of matrix proteins.

Jensen SA, Iqbal S, Lowe ED, Redfield C, Handford PA.

Structure. 2009 May 13;17(5):759-68. doi: 10.1016/j.str.2009.03.014.

33.

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.

Cordle J, Johnson S, Tay JZ, Roversi P, Wilkin MB, de Madrid BH, Shimizu H, Jensen S, Whiteman P, Jin B, Redfield C, Baron M, Lea SM, Handford PA.

Nat Struct Mol Biol. 2008 Aug;15(8):849-57. doi: 10.1038/nsmb.1457. Epub 2008 Jul 27.

34.

Pleistocene climatic cycling and diversification of the Andean treefrog, Hypsiboas andinus.

Koscinski D, Handford P, Tubaro PL, Sharp S, Lougheed SC.

Mol Ecol. 2008 Apr;17(8):2012-25. doi: 10.1111/j.1365-294X.2008.03733.x. Epub 2008 Mar 25.

PMID:
18373535
35.

Fibrillin-integrin interactions in health and disease.

Jovanović J, Iqbal S, Jensen S, Mardon H, Handford P.

Biochem Soc Trans. 2008 Apr;36(Pt 2):257-62. doi: 10.1042/BST0360257. Review.

PMID:
18363569
36.

Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity.

Cordle J, Redfieldz C, Stacey M, van der Merwe PA, Willis AC, Champion BR, Hambleton S, Handford PA.

J Biol Chem. 2008 Apr 25;283(17):11785-93. doi: 10.1074/jbc.M708424200. Epub 2008 Feb 22.

37.
38.

Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.

Abbott RJ, Spendlove I, Roversi P, Fitzgibbon H, Knott V, Teriete P, McDonnell JM, Handford PA, Lea SM.

J Biol Chem. 2007 Jul 27;282(30):22023-32. Epub 2007 Apr 20.

39.

Microfibrils, elastin fibres and collagen fibres in the human intervertebral disc and bovine tail disc.

Yu J, Tirlapur U, Fairbank J, Handford P, Roberts S, Winlove CP, Cui Z, Urban J.

J Anat. 2007 Apr;210(4):460-71.

40.

Cellular and molecular studies of Marfan syndrome mutations identify co-operative protein folding in the cbEGF12-13 region of fibrillin-1.

Whiteman P, Willis AC, Warner A, Brown J, Redfield C, Handford PA.

Hum Mol Genet. 2007 Apr 15;16(8):907-18. Epub 2007 Feb 26.

PMID:
17324963
41.

alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity.

Jovanovic J, Takagi J, Choulier L, Abrescia NG, Stuart DI, van der Merwe PA, Mardon HJ, Handford PA.

J Biol Chem. 2007 Mar 2;282(9):6743-51. Epub 2006 Dec 11.

42.

Fibrillin-1 misfolding and disease.

Whiteman P, Hutchinson S, Handford PA.

Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):338-46. Review.

PMID:
16677079
43.

The molecular genetics of Marfan syndrome and related disorders.

Robinson PN, Arteaga-Solis E, Baldock C, Collod-Béroud G, Booms P, De Paepe A, Dietz HC, Guo G, Handford PA, Judge DP, Kielty CM, Loeys B, Milewicz DM, Ney A, Ramirez F, Reinhardt DP, Tiedemann K, Whiteman P, Godfrey M.

J Med Genet. 2006 Oct;43(10):769-87. Epub 2006 Mar 29. Review.

44.

Calcium binding activity of the epidermal growth factor-like domains of the apicomplexan microneme protein EtMIC4.

Periz J, Gill AC, Knott V, Handford PA, Tomley FM.

Mol Biochem Parasitol. 2005 Oct;143(2):192-9.

PMID:
16024103
45.

Molecular effects of homocysteine on cbEGF domain structure: insights into the pathogenesis of homocystinuria.

Hutchinson S, Aplin RT, Webb H, Kettle S, Timmermans J, Boers GH, Handford PA.

J Mol Biol. 2005 Feb 25;346(3):833-44. Epub 2005 Jan 22.

PMID:
15713466
46.

Ca2+-dependent interface formation in fibrillin-1.

Jensen SA, Corbett AR, Knott V, Redfield C, Handford PA.

J Biol Chem. 2005 Apr 8;280(14):14076-84. Epub 2005 Jan 13.

47.

Structural and functional properties of the human notch-1 ligand binding region.

Hambleton S, Valeyev NV, Muranyi A, Knott V, Werner JM, McMichael AJ, Handford PA, Downing AK.

Structure. 2004 Dec;12(12):2173-83.

48.

CRB1 mutation spectrum in inherited retinal dystrophies.

den Hollander AI, Davis J, van der Velde-Visser SD, Zonneveld MN, Pierrottet CO, Koenekoop RK, Kellner U, van den Born LI, Heckenlively JR, Hoyng CB, Handford PA, Roepman R, Cremers FP.

Hum Mutat. 2004 Nov;24(5):355-69. Review.

PMID:
15459956
49.

Structural consequences of cysteine substitutions C1977Y and C1977R in calcium-binding epidermal growth factor-like domain 30 of human fibrillin-1.

Suk JY, Jensen S, McGettrick A, Willis AC, Whiteman P, Redfield C, Handford PA.

J Biol Chem. 2004 Dec 3;279(49):51258-65. Epub 2004 Sep 14.

50.

1H, 13C, and 15N resonance assignments of human Notch-1 calcium binding EGF domains 11-13.

Muranyi A, Hambleton S, Knott V, McMichael A, Handford PA, Downing AK.

J Biomol NMR. 2004 Jul;29(3):443-4. No abstract available.

PMID:
15213460

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