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Items: 1 to 50 of 126


Leukocyte Adhesion: Reconceptualizing Chemokine Presentation by Glycosaminoglycans.

Graham GJ, Handel TM, Proudfoot AEI.

Trends Immunol. 2019 Jun;40(6):472-481. doi: 10.1016/ Epub 2019 Apr 18. Review.


Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on 13C-methyl methionine labeling of the atypical chemokine receptor ACKR3.

Kleist AB, Peterson F, Tyler RC, Gustavsson M, Handel TM, Volkman BF.

Methods Cell Biol. 2019;149:259-288. doi: 10.1016/bs.mcb.2018.09.004. Epub 2018 Nov 15.


A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.

Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J.

Cell Rep. 2018 Sep 18;24(12):3312-3323.e5. doi: 10.1016/j.celrep.2018.08.061.


Editorial: Chemokines - beyond chemotaxis.

Proudfoot AE, Handel TM, Graham G.

Cytokine. 2018 Sep;109:1. doi: 10.1016/j.cyto.2018.04.036. Epub 2018 Jun 1. No abstract available.


Intracellular Receptor Modulation: Novel Approach to Target GPCRs.

Ortiz Zacarías NV, Lenselink EB, IJzerman AP, Handel TM, Heitman LH.

Trends Pharmacol Sci. 2018 Jun;39(6):547-559. doi: 10.1016/ Epub 2018 Apr 10. Review.


Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System.

Proudfoot AEI, Johnson Z, Bonvin P, Handel TM.

Pharmaceuticals (Basel). 2017 Aug 9;10(3). pii: E70. doi: 10.3390/ph10030070. Review.


Heparan Sulfate Microarray Reveals That Heparan Sulfate-Protein Binding Exhibits Different Ligand Requirements.

Zong C, Venot A, Li X, Lu W, Xiao W, Wilkes JL, Salanga CL, Handel TM, Wang L, Wolfert MA, Boons GJ.

J Am Chem Soc. 2017 Jul 19;139(28):9534-9543. doi: 10.1021/jacs.7b01399. Epub 2017 Jul 7.


Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV.

Zheng Y, Han GW, Abagyan R, Wu B, Stevens RC, Cherezov V, Kufareva I, Handel TM.

Immunity. 2017 Jun 20;46(6):1005-1017.e5. doi: 10.1016/j.immuni.2017.05.002.


What Do Structures Tell Us About Chemokine Receptor Function and Antagonism?

Kufareva I, Gustavsson M, Zheng Y, Stephens BS, Handel TM.

Annu Rev Biophys. 2017 May 22;46:175-198. doi: 10.1146/annurev-biophys-051013-022942. Review.


Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization.

Dyer DP, Migliorini E, Salanga CL, Thakar D, Handel TM, Richter RP.

Open Biol. 2017 Jan;7(1). pii: 160286. doi: 10.1098/rsob.160286.


Structural basis of ligand interaction with atypical chemokine receptor 3.

Gustavsson M, Wang L, van Gils N, Stephens BS, Zhang P, Schall TJ, Yang S, Abagyan R, Chance MR, Kufareva I, Handel TM.

Nat Commun. 2017 Jan 18;8:14135. doi: 10.1038/ncomms14135.


Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, Heitman LH, Tebben A, Kufareva I, Handel TM.

Nature. 2016 Dec 15;540(7633):458-461. doi: 10.1038/nature20605. Epub 2016 Dec 7.


Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices.

Wescott MP, Kufareva I, Paes C, Goodman JR, Thaker Y, Puffer BA, Berdougo E, Rucker JB, Handel TM, Doranz BJ.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9928-33. doi: 10.1073/pnas.1601278113. Epub 2016 Aug 19.


The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

Dyer DP, Salanga CL, Johns SC, Valdambrini E, Fuster MM, Milner CM, Day AJ, Handel TM.

J Biol Chem. 2016 Jun 10;291(24):12627-40. doi: 10.1074/jbc.M116.720953. Epub 2016 Apr 4.



Handel TM.

Methods Enzymol. 2016;570:xxi-xxii. doi: 10.1016/S0076-6879(16)00083-5. No abstract available.


Disulfide Trapping for Modeling and Structure Determination of Receptor: Chemokine Complexes.

Kufareva I, Gustavsson M, Holden LG, Qin L, Zheng Y, Handel TM.

Methods Enzymol. 2016;570:389-420. doi: 10.1016/bs.mie.2015.12.001. Epub 2016 Jan 13.


Examining Roles of Glycans in Chemokine-Mediated Dendritic-Endothelial Cell Interactions.

Yin X, Johns SC, El Ghazal R, Salanga CL, Handel TM, Fuster MM.

Methods Enzymol. 2016;570:335-55. doi: 10.1016/bs.mie.2015.09.017. Epub 2015 Nov 14.


Production of Chemokine/Chemokine Receptor Complexes for Structural Biophysical Studies.

Gustavsson M, Zheng Y, Handel TM.

Methods Enzymol. 2016;570:233-60. doi: 10.1016/bs.mie.2015.10.003. Epub 2015 Dec 14.


Examination of Glycosaminoglycan Binding Sites on the XCL1 Dimer.

Fox JC, Tyler RC, Peterson FC, Dyer DP, Zhang F, Linhardt RJ, Handel TM, Volkman BF.

Biochemistry. 2016 Mar 1;55(8):1214-25. doi: 10.1021/acs.biochem.5b01329. Epub 2016 Feb 17.


The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization.

Dyer DP, Salanga CL, Volkman BF, Kawamura T, Handel TM.

Glycobiology. 2016 Mar;26(3):312-26. doi: 10.1093/glycob/cwv100. Epub 2015 Nov 17.


Cytokines and growth factors cross-link heparan sulfate.

Migliorini E, Thakar D, Kühnle J, Sadir R, Dyer DP, Li Y, Sun C, Volkman BF, Handel TM, Coche-Guerente L, Fernig DG, Lortat-Jacob H, Richter RP.

Open Biol. 2015 Aug;5(8). pii: 150046. doi: 10.1098/rsob.150046.


Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRs.

Kufareva I, Handel TM, Abagyan R.

Methods Mol Biol. 2015;1335:295-311. doi: 10.1007/978-1-4939-2914-6_19.


Dual targeting of the chemokine receptors CXCR4 and ACKR3 with novel engineered chemokines.

Hanes MS, Salanga CL, Chowdry AB, Comerford I, McColl SR, Kufareva I, Handel TM.

J Biol Chem. 2015 Sep 11;290(37):22385-97. doi: 10.1074/jbc.M115.675108. Epub 2015 Jul 27.


The Structure of a CXCR4:Chemokine Complex.

Handel TM.

Front Immunol. 2015 Jun 5;6:282. doi: 10.3389/fimmu.2015.00282. eCollection 2015. Review. No abstract available.


Interactions of the Chemokine CCL5/RANTES with Medium-Sized Chondroitin Sulfate Ligands.

Deshauer C, Morgan AM, Ryan EO, Handel TM, Prestegard JH, Wang X.

Structure. 2015 Jun 2;23(6):1066-77. doi: 10.1016/j.str.2015.03.024. Epub 2015 May 14.


Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies.

Kufareva I, Salanga CL, Handel TM.

Immunol Cell Biol. 2015 Apr;93(4):372-83. doi: 10.1038/icb.2015.15. Epub 2015 Feb 24. Review.


Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine.

Qin L, Kufareva I, Holden LG, Wang C, Zheng Y, Zhao C, Fenalti G, Wu H, Han GW, Cherezov V, Abagyan R, Stevens RC, Handel TM.

Science. 2015 Mar 6;347(6226):1117-22. doi: 10.1126/science.1261064. Epub 2015 Jan 22.


Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: molecular modeling and experimental validation.

Kufareva I, Stephens BS, Holden LG, Qin L, Zhao C, Kawamura T, Abagyan R, Handel TM.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5363-72. doi: 10.1073/pnas.1417037111. Epub 2014 Dec 2.


Identification of the pharmacophore of the CC chemokine-binding proteins Evasin-1 and -4 using phage display.

Bonvin P, Dunn SM, Rousseau F, Dyer DP, Shaw J, Power CA, Handel TM, Proudfoot AE.

J Biol Chem. 2014 Nov 14;289(46):31846-55. doi: 10.1074/jbc.M114.599233. Epub 2014 Sep 29.


Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine.

Salanga CL, Dyer DP, Kiselar JG, Gupta S, Chance MR, Handel TM.

J Biol Chem. 2014 May 23;289(21):14896-912. doi: 10.1074/jbc.M114.547737. Epub 2014 Apr 11.


Chemokine cooperativity is caused by competitive glycosaminoglycan binding.

Verkaar F, van Offenbeek J, van der Lee MMC, van Lith LHCJ, Watts AO, Rops ALWMM, Aguilar DC, Ziarek JJ, van der Vlag J, Handel TM, Volkman BF, Proudfoot AEI, Vischer HF, Zaman GJR, Smit MJ.

J Immunol. 2014 Apr 15;192(8):3908-3914. doi: 10.4049/jimmunol.1302159. Epub 2014 Mar 17.


TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8.

Dyer DP, Thomson JM, Hermant A, Jowitt TA, Handel TM, Proudfoot AE, Day AJ, Milner CM.

J Immunol. 2014 Mar 1;192(5):2177-85. doi: 10.4049/jimmunol.1300194. Epub 2014 Feb 5.


Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node.

Yin X, Johns SC, Kim D, Mikulski Z, Salanga CL, Handel TM, Macal M, Zúñiga EI, Fuster MM.

J Immunol. 2014 Mar 1;192(5):2133-42. doi: 10.4049/jimmunol.1301286. Epub 2014 Feb 3.


A general method for site specific fluorescent labeling of recombinant chemokines.

Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM.

PLoS One. 2014 Jan 28;9(1):e81454. doi: 10.1371/journal.pone.0081454. eCollection 2014.


The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization.

Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM.

J Biol Chem. 2013 Nov 8;288(45):32194-210. doi: 10.1074/jbc.M113.503797. Epub 2013 Sep 20.


Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery.

Ziarek JJ, Getschman AE, Butler SJ, Taleski D, Stephens B, Kufareva I, Handel TM, Payne RJ, Volkman BF.

ACS Chem Biol. 2013 Sep 20;8(9):1955-63. doi: 10.1021/cb400274z. Epub 2013 Jun 26.


Distinct chemokine receptor axes regulate Th9 cell trafficking to allergic and autoimmune inflammatory sites.

Kara EE, Comerford I, Bastow CR, Fenix KA, Litchfield W, Handel TM, McColl SR.

J Immunol. 2013 Aug 1;191(3):1110-7. doi: 10.4049/jimmunol.1203089. Epub 2013 Jun 24.


MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma.

Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller YI.

J Lipid Res. 2013 Jul;54(7):1877-83. doi: 10.1194/jlr.M036343. Epub 2013 May 10. Erratum in: J Lipid Res. 2014 Jul;55(7):1549.


Chemokine oligomerization in cell signaling and migration.

Wang X, Sharp JS, Handel TM, Prestegard JH.

Prog Mol Biol Transl Sci. 2013;117:531-78. doi: 10.1016/B978-0-12-386931-9.00020-9. Review.


The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.

O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS.

Nat Rev Cancer. 2013 Jun;13(6):412-24. doi: 10.1038/nrc3521. Epub 2013 May 3. Review.


A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer.

Kufareva I, Stephens B, Gilliland CT, Wu B, Fenalti G, Hamel D, Stevens RC, Abagyan R, Handel TM.

Methods Mol Biol. 2013;1013:93-127. doi: 10.1007/978-1-62703-426-5_7.


Chemokine receptor oligomerization and allostery.

Stephens B, Handel TM.

Prog Mol Biol Transl Sci. 2013;115:375-420. doi: 10.1016/B978-0-12-394587-7.00009-9. Review.


Opportunities for functional selectivity in GPCR antibodies.

Webb DR, Handel TM, Kretz-Rommel A, Stevens RC.

Biochem Pharmacol. 2013 Jan 15;85(2):147-52. doi: 10.1016/j.bcp.2012.08.021. Epub 2012 Sep 10. Review.


Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice.

Axelsson J, Xu D, Kang BN, Nussbacher JK, Handel TM, Ley K, Sriramarao P, Esko JD.

Blood. 2012 Aug 23;120(8):1742-51. doi: 10.1182/blood-2012-03-417139. Epub 2012 Jul 12.


Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL).

O'Hayre M, Niederst M, Fecteau JF, Nguyen VM, Kipps TJ, Messmer D, Newton AC, Handel TM.

Leukemia. 2012 Jul;26(7):1689-92. doi: 10.1038/leu.2012.6. Epub 2012 Jan 12. No abstract available.


Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1).

Fecteau JF, Bharati IS, O'Hayre M, Handel TM, Kipps TJ, Messmer D.

Mol Med. 2012 Feb 10;18:19-28. doi: 10.2119/molmed.2011.00164.


Oligomeric structure of the chemokine CCL5/RANTES from NMR, MS, and SAXS data.

Wang X, Watson C, Sharp JS, Handel TM, Prestegard JH.

Structure. 2011 Aug 10;19(8):1138-48. doi: 10.1016/j.str.2011.06.001.


Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins.

Kulig P, Kantyka T, Zabel BA, Banas M, Chyra A, Stefanska A, Tu H, Allen SJ, Handel TM, Kozik A, Potempa J, Butcher EC, Cichy J.

J Immunol. 2011 Aug 1;187(3):1403-10. doi: 10.4049/jimmunol.1002352. Epub 2011 Jun 29.


A rapid and efficient way to obtain modified chemokines for functional and biophysical studies.

Allen SJ, Hamel DJ, Handel TM.

Cytokine. 2011 Aug;55(2):168-73. doi: 10.1016/j.cyto.2011.05.002. Epub 2011 May 31.


Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function.

Laborde E, Macsata RW, Meng F, Peterson BT, Robinson L, Schow SR, Simon RJ, Xu H, Baba K, Inagaki H, Ishiwata Y, Jomori T, Matsumoto Y, Miyachi A, Nakamura T, Okamoto M, Handel TM, Bernard CC.

J Med Chem. 2011 Mar 24;54(6):1667-81. doi: 10.1021/jm1012903. Epub 2011 Feb 22.

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