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Items: 1 to 50 of 60

1.

Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells".

Handel AE, Holländer GA.

J Immunol. 2019 Nov 1;203(9):2355. doi: 10.4049/jimmunol.1900948. No abstract available.

PMID:
31636132
2.

Keratinocyte growth factor impairs human thymic recovery from lymphopenia.

Coles AJ, Azzopardi L, Kousin-Ezewu O, Mullay HK, Thompson SA, Jarvis L, Davies J, Howlett S, Rainbow D, Babar J, Sadler TJ, Brown JWL, Needham E, May K, Georgieva ZG, Handel AE, Maio S, Deadman M, Rota I, Holländer G, Dawson S, Jayne D, Seggewiss-Bernhardt R, Douek DC, Isaacs JD, Jones JL.

JCI Insight. 2019 May 7;5. pii: 125377. doi: 10.1172/jci.insight.125377.

3.

The role of thymic tolerance in CNS autoimmune disease.

Handel AE, Irani SR, Holländer GA.

Nat Rev Neurol. 2018 Dec;14(12):723-734. doi: 10.1038/s41582-018-0095-7. Review.

PMID:
30451970
4.

Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development.

Handel AE, Shikama-Dorn N, Zhanybekova S, Maio S, Graedel AN, Zuklys S, Ponting CP, Holländer GA.

Front Immunol. 2018 Sep 19;9:2120. doi: 10.3389/fimmu.2018.02120. eCollection 2018.

5.

Most brain disease-associated and eQTL haplotypes are not located within transcription factor DNase-seq footprints in brain.

Handel AE, Gallone G, Zameel Cader M, Ponting CP.

Hum Mol Genet. 2017 Jan 1;26(1):79-89. doi: 10.1093/hmg/ddw369.

6.

Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics.

Handel AE, Chintawar S, Lalic T, Whiteley E, Vowles J, Giustacchini A, Argoud K, Sopp P, Nakanishi M, Bowden R, Cowley S, Newey S, Akerman C, Ponting CP, Cader MZ.

Hum Mol Genet. 2016 Mar 1;25(5):989-1000. doi: 10.1093/hmg/ddv637. Epub 2016 Jan 5.

7.

Erratum to: Bioinformatics Analysis of Estrogen-Responsive Genes.

Handel AE.

Methods Mol Biol. 2016;1366:E3. doi: 10.1007/978-1-4939-3127-9_45. No abstract available.

8.

Bioinformatics Analysis of Estrogen-Responsive Genes.

Handel AE.

Methods Mol Biol. 2016;1366:29-39. doi: 10.1007/978-1-4939-3127-9_4. Erratum in: Methods Mol Biol. 2016;1366:E3.

9.

EBNA2 binds to genomic intervals associated with multiple sclerosis and overlaps with vitamin D receptor occupancy.

Ricigliano VA, Handel AE, Sandve GK, Annibali V, Ristori G, Mechelli R, Cader MZ, Salvetti M.

PLoS One. 2015 Apr 8;10(4):e0119605. doi: 10.1371/journal.pone.0119605. eCollection 2015.

10.

National survey of UK medical students on the perception of neurology.

Pakpoor J, Handel AE, Disanto G, Davenport RJ, Giovannoni G, Ramagopalan SV; Association of British Neurologists.

BMC Med Educ. 2014 Oct 21;14:225. doi: 10.1186/1472-6920-14-225.

11.

Integrating multiple oestrogen receptor alpha ChIP studies: overlap with disease susceptibility regions, DNase I hypersensitivity peaks and gene expression.

Handel AE, Sandve GK, Disanto G, Handunnetthi L, Giovannoni G, Ramagopalan SV.

BMC Med Genomics. 2013 Oct 30;6:45. doi: 10.1186/1755-8794-6-45.

12.

DNase hypersensitive sites and association with multiple sclerosis.

Disanto G, Kjetil Sandve G, Ricigliano VA, Pakpoor J, Berlanga-Taylor AJ, Handel AE, Kuhle J, Holden L, Watson CT, Giovannoni G, Handunnetthi L, Ramagopalan SV.

Hum Mol Genet. 2014 Feb 15;23(4):942-8. doi: 10.1093/hmg/ddt489. Epub 2013 Oct 2.

PMID:
24092328
13.

Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease.

Handel AE, Sandve GK, Disanto G, Berlanga-Taylor AJ, Gallone G, Hanwell H, Drabløs F, Giovannoni G, Ebers GC, Ramagopalan SV.

BMC Med. 2013 Jul 12;11:163. doi: 10.1186/1741-7015-11-163.

14.

Vitamin D supplementation and antibodies against the Epstein-Barr virus in multiple sclerosis patients.

Disanto G, Handel AE, Damoiseaux J, Hupperts R, Giovannoni G, Smolders J, Ramagopalan SV.

Mult Scler. 2013 Oct;19(12):1679-80. doi: 10.1177/1352458513494494. Epub 2013 Jul 4. No abstract available.

PMID:
23828870
15.

Next-generation sequencing in understanding complex neurological disease.

Handel AE, Disanto G, Ramagopalan SV.

Expert Rev Neurother. 2013 Feb;13(2):215-27. doi: 10.1586/ern.12.165. Review.

16.

Weekend admissions as an independent predictor of mortality: an analysis of Scottish hospital admissions.

Handel AE, Patel SV, Skingsley A, Bramley K, Sobieski R, Ramagopalan SV.

BMJ Open. 2012 Nov 6;2(6). pii: e001789. doi: 10.1136/bmjopen-2012-001789. Print 2012.

17.

Meta-analysis of the relationship between multiple sclerosis and migraine.

Pakpoor J, Handel AE, Giovannoni G, Dobson R, Ramagopalan SV.

PLoS One. 2012;7(9):e45295. Epub 2012 Sep 14. Erratum in: PLoS One. 2013;8(4). doi: 10.1371/annotation/274e5ef1-79aa-48f7-af62-0594d5c1354e.

18.

High reprint orders in medical journals and pharmaceutical industry funding: case-control study.

Handel AE, Patel SV, Pakpoor J, Ebers GC, Goldacre B, Ramagopalan SV.

BMJ. 2012 Jun 28;344:e4212. doi: 10.1136/bmj.e4212.

19.

Vitamin D and multiple sclerosis: an interaction between genes and environment.

Handel AE, Ramagopalan SV.

Mult Scler. 2012 Jan;18(1):2-4. doi: 10.1177/1352458511418353. No abstract available.

PMID:
22247498
20.

Concealed effects of gene-environment interactions in genome-wide association.

Handel AE, Williamson AJ, Ramagopalan SV.

Mult Scler Relat Disord. 2012 Jan;1(1):39-42. doi: 10.1016/j.msard.2011.08.005. Epub 2011 Sep 9.

PMID:
25876449
21.

Smoking and multiple sclerosis: a matter of global importance.

Handel AE, Ramagopalan SV.

Neuroepidemiology. 2011;37(3-4):243-4. doi: 10.1159/000333241. Epub 2011 Dec 7. No abstract available.

22.

Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis.

Babron MC, Perdry H, Handel AE, Ramagopalan SV, Damotte V, Fontaine B, Müller-Myhsok B, Ebers GC, Clerget-Darpoux F.

Eur J Hum Genet. 2012 Mar;20(3):321-5. doi: 10.1038/ejhg.2011.197. Epub 2011 Nov 16.

23.

Seasonality of admissions with multiple sclerosis in Scotland.

Handel AE, Disanto G, Jarvis L, McLaughlin R, Fries A, Ebers GC, Ramagopalan SV.

Eur J Neurol. 2011 Aug;18(8):1109-11. doi: 10.1111/j.1468-1331.2010.03318.x. Epub 2010 Dec 29.

PMID:
21749578
24.

Vitamin D and multiple sclerosis hospital admissions in Scotland.

Disanto G, Handel AE, Morahan JM, Deluca GC, Kimball SM, Hypponen E, Giovannoni G, Ebers GC, Ramagopalan SV.

QJM. 2011 Nov;104(11):1001-3. doi: 10.1093/qjmed/hcr101. Epub 2011 Jun 29. No abstract available.

25.

Relationship of UV exposure to prevalence of multiple sclerosis in England.

Ramagopalan SV, Handel AE, Giovannoni G, Rutherford Siegel S, Ebers GC, Chaplin G.

Neurology. 2011 Apr 19;76(16):1410-4. doi: 10.1212/WNL.0b013e318216715e. Erratum in: Neurology. 2011 May 17;76(20):1773.

26.

Epigenetic mechanisms in multiple sclerosis and the major histocompatibility complex (MHC).

Burrell AM, Handel AE, Ramagopalan SV, Ebers GC, Morahan JM.

Discov Med. 2011 Mar;11(58):187-96. Review.

27.

Comment on "Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice".

Disanto G, Handel AE, Morahan JM, Ramagopalan SV.

J Immunol. 2011 Apr 1;186(7):3803-4. doi: 10.4049/jimmunol.1190005. No abstract available.

28.

Of mice and men: experimental autoimmune encephalitis and multiple sclerosis.

Handel AE, Lincoln MR, Ramagopalan SV.

Eur J Clin Invest. 2011 Nov;41(11):1254-8. doi: 10.1111/j.1365-2362.2011.02519.x. Epub 2011 Mar 21. Review.

PMID:
21418205
29.

Season of birth and anorexia nervosa.

Disanto G, Handel AE, Para AE, Ramagopalan SV, Handunnetthi L.

Br J Psychiatry. 2011 May;198(5):404-5. doi: 10.1192/bjp.bp.110.085944. Epub 2011 Mar 17.

30.

The epidemiology of multiple sclerosis in Scotland: inferences from hospital admissions.

Handel AE, Jarvis L, McLaughlin R, Fries A, Ebers GC, Ramagopalan SV.

PLoS One. 2011 Jan 27;6(1):e14606. doi: 10.1371/journal.pone.0014606.

31.

HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination.

Disanto G, Magalhaes S, Handel AE, Morrison KM, Sadovnick AD, Ebers GC, Banwell B, Bar-Or A; Canadian Pediatric Demyelinating Disease Network.

Neurology. 2011 Mar 1;76(9):781-6. doi: 10.1212/WNL.0b013e31820ee1cd. Epub 2011 Feb 2.

32.

Revisiting the T-cell receptor alpha/delta locus and possible associations with multiple sclerosis.

Watson CT, Para AE, Lincoln MR, Ramagopalan SV, Orton SM, Morrison KM, Handunnetthi L, Handel AE, Chao MJ, Morahan J, Sadovnick AD, Breden F, Ebers GC.

Genes Immun. 2011 Mar;12(2):59-66. doi: 10.1038/gene.2010.65. Epub 2011 Jan 27. Review.

PMID:
21270827
33.

Inequities in advice on vitamin D?

Handel AE, Gillie O, Ramagopalan SV.

QJM. 2011 Jun;104(6):547-9. doi: 10.1093/qjmed/hcq255. Epub 2011 Jan 23. No abstract available.

PMID:
21262738
34.

Smoking and multiple sclerosis: an updated meta-analysis.

Handel AE, Williamson AJ, Disanto G, Dobson R, Giovannoni G, Ramagopalan SV.

PLoS One. 2011 Jan 13;6(1):e16149. doi: 10.1371/journal.pone.0016149.

35.

Risk of venous thromboembolism in people admitted to hospital with selected immune-mediated diseases: record-linkage study.

Ramagopalan SV, Wotton CJ, Handel AE, Yeates D, Goldacre MJ.

BMC Med. 2011 Jan 10;9:1. doi: 10.1186/1741-7015-9-1.

36.

Comment on "Gender differences in 1,25 dihydroxyvitamin D3 immunomodulatory effects in multiple sclerosis patients and healthy subjects".

Handel AE, De Luca GC, Ramagopalan SV.

J Immunol. 2011 Jan 15;186(2):647; author reply 648. doi: 10.4049/jimmunol.1090123. No abstract available.

37.

Heterogeneity in multiple sclerosis: scratching the surface of a complex disease.

Disanto G, Berlanga AJ, Handel AE, Para AE, Burrell AM, Fries A, Handunnetthi L, De Luca GC, Morahan JM.

Autoimmune Dis. 2010 Dec 9;2011:932351. doi: 10.4061/2011/932351.

38.

Estrogen-vitamin D interaction in multiple sclerosis.

Disanto G, Handel AE, Ramagopalan SV.

Fertil Steril. 2011 Jan;95(1):e3; author reply e4. doi: 10.1016/j.fertnstert.2010.09.047. Epub 2010 Nov 5. No abstract available.

PMID:
21055742
39.

Visceral obesity and brain volume.

Handel AE, Disanto G, Ramagopalan SV.

Ann Neurol. 2010 Nov;68(5):770-1; author reply 771-2. doi: 10.1002/ana.22151. No abstract available.

PMID:
21031593
40.

An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis.

Handel AE, Williamson AJ, Disanto G, Handunnetthi L, Giovannoni G, Ramagopalan SV.

PLoS One. 2010 Sep 1;5(9). pii: e12496. doi: 10.1371/journal.pone.0012496.

41.

Contribution of genetic, epigenetic and transcriptomic differences to twin discordance in multiple sclerosis.

Handunnetthi L, Handel AE, Ramagopalan SV.

Expert Rev Neurother. 2010 Sep;10(9):1379-81. doi: 10.1586/ern.10.116.

PMID:
20819009
42.

Tuberculosis and diabetes mellitus: is vitamin D the missing link?

Handel AE, Ramagopalan SV.

Lancet Infect Dis. 2010 Sep;10(9):596. doi: 10.1016/S1473-3099(10)70185-7. No abstract available.

PMID:
20797643
43.

A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.

Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, Handunnetthi L, Handel AE, Disanto G, Orton SM, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC.

Genome Res. 2010 Oct;20(10):1352-60. doi: 10.1101/gr.107920.110. Epub 2010 Aug 24.

44.

Multiple sclerosis and risk of cancer: a meta-analysis.

Handel AE, Ramagopalan SV.

J Neurol Neurosurg Psychiatry. 2010 Dec;81(12):1413-4. doi: 10.1136/jnnp.2009.195776. Epub 2010 Aug 19. No abstract available.

PMID:
20724517
45.

Association between maternal height and childhood outcomes.

Handel AE, Handunnetthi L, Ramagopalan SV.

JAMA. 2010 Aug 11;304(6):638; author reply 638-9. doi: 10.1001/jama.2010.1107. No abstract available.

PMID:
20699453
46.

Chronic cerebrospinal venous insufficiency and multiple sclerosis.

Handel AE, Lincoln MR, Ramagopalan SV.

Ann Neurol. 2010 Aug;68(2):270. doi: 10.1002/ana.22067. No abstract available.

PMID:
20695021
47.

GPC5 and lung cancer in multiple sclerosis.

Handel AE, Ramagopalan SV.

Lancet Oncol. 2010 Aug;11(8):714. doi: 10.1016/S1470-2045(10)70177-7. No abstract available.

PMID:
20688271
48.

Haiti: the potential transgenerational effect of disasters.

Handel AE, Handel CE, Ramagopalan SV.

QJM. 2011 Jan;104(1):69-71. doi: 10.1093/qjmed/hcq118. Epub 2010 Jul 22. No abstract available.

PMID:
20650972
49.

The questionable effectiveness of sunscreen.

Handel AE, Ramagopalan SV.

Lancet. 2010 Jul 17;376(9736):161-2; author reply 162. doi: 10.1016/S0140-6736(10)61104-X. No abstract available.

PMID:
20638560
50.

The potential role of major histocompatibility complex class I in schizophrenia.

Handel AE, Ramagopalan SV.

Biol Psychiatry. 2010 Oct 1;68(7):e29-30; author reply e31. doi: 10.1016/j.biopsych.2010.03.039. No abstract available.

PMID:
20619398

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