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Items: 1 to 50 of 134

1.

Genome-Wide Transcriptome Analysis Reveals Intermittent Fasting-Induced Metabolic Rewiring in the Liver.

Ng GY, Kang SW, Kim J, Alli-Shaik A, Baik SH, Jo DG, Hande MP, Sobey CG, Gunaratne J, Fann DY, Arumugam TV.

Dose Response. 2019 Sep 25;17(3):1559325819876780. doi: 10.1177/1559325819876780. eCollection 2019 Jul-Sep.

2.

Combined treatment with cisplatin and the tankyrase inhibitor XAV-939 increases cytotoxicity, abrogates cancer-stem-like cell phenotype and increases chemosensitivity of head-and-neck squamous-cell carcinoma cells.

Roy S, Roy S, Kar M, Chakraborty A, Kumar A, Delogu F, Asthana S, Hande MP, Banerjee B.

Mutat Res. 2019 Oct;846:503084. doi: 10.1016/j.mrgentox.2019.503084. Epub 2019 Aug 17.

PMID:
31585633
3.

Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells.

Kandilya D, Maskomani S, Shyamasundar S, Tambyah PA, Shiao Yng C, Lee RCH, Hande MP, Mallilankaraman K, Chu JJH, Dheen ST.

Epigenomics. 2019 Aug;11(10):1143-1161. doi: 10.2217/epi-2018-0180. Epub 2019 Jun 25.

PMID:
31234652
4.

A Child with Partial Trisomy 4 (q26 - qterminal) Resulting from Paternally Inherited Translocation (4:18) Associated with Multiple Congenital Anomalies and Death.

Chakraborty A, Panda SK, Mohakud NK, Roy D, Padhi S, Koh SW, Hande MP, Banerjee B.

Genome Integr. 2019 May 24;10:1. doi: 10.4103/genint.genint_4_18. eCollection 2019.

5.

Effects of rapamycin on the mechanistic target of rapamycin (mTOR) pathway and telomerase in breast cancer cells.

Gopalakrishnan K, Venkatesan S, Low ESH, Hande MP.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Dec;836(Pt B):103-113. doi: 10.1016/j.mrgentox.2018.03.008. Epub 2018 Mar 28.

PMID:
30442335
6.

Assessment of genomic instability and proliferation index in cultured lymphocytes of patients with Down syndrome, congenital anomalies and aplastic anaemia.

George A, Venkatesan S, Ashok N, Saraswathy R, Hande MP.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Dec;836(Pt A):98-103. doi: 10.1016/j.mrgentox.2018.06.015. Epub 2018 Jun 8.

PMID:
30389169
7.

The role of p38 MAPK pathway in p53 compromised state and telomere mediated DNA damage response.

Roy S, Roy S, Rana A, Akhter Y, Hande MP, Banerjee B.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Dec;836(Pt A):89-97. doi: 10.1016/j.mrgentox.2018.05.018. Epub 2018 May 26. Review.

PMID:
30389168
8.

History and evolution of cytogenetic techniques: Current and future applications in basic and clinical research.

Balajee AS, Hande MP.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Dec;836(Pt A):3-12. doi: 10.1016/j.mrgentox.2018.08.008. Epub 2018 Aug 30. Review.

PMID:
30389159
9.

In Memory of Professor Adayapalam T Natarajan.

Balajee AS, Palitti F, Surrallés J, Hande MP.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Dec;836(Pt A):1-2. doi: 10.1016/j.mrgentox.2018.04.008. Epub 2018 May 7. No abstract available.

PMID:
30389151
10.

DNA-dependent protein kinase modulates the anti-cancer properties of silver nanoparticles in human cancer cells.

Lim HK, Gurung RL, Hande MP.

Mutat Res. 2017 Dec;824:32-41. doi: 10.1016/j.mrgentox.2017.10.001. Epub 2017 Oct 13.

PMID:
29150048
11.

Telomere Biology-Insights into an Intriguing Phenomenon.

Venkatesan S, Khaw AK, Hande MP.

Cells. 2017 Jun 19;6(2). pii: E15. doi: 10.3390/cells6020015. Review.

12.

Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster.

Ng CT, Yong LQ, Hande MP, Ong CN, Yu LE, Bay BH, Baeg GH.

Int J Nanomedicine. 2017 Feb 28;12:1621-1637. doi: 10.2147/IJN.S124403. eCollection 2017.

13.

Biomarkers of Ionizing Radiation Exposure: A Multiparametric Approach.

Zeegers D, Venkatesan S, Koh SW, Low GK, Srivastava P, Sundaram N, Sethu S, Banerjee B, Jayapal M, Belyakov O, Baskar R, Balajee AS, Hande MP.

Genome Integr. 2017 Jan 23;8:6. doi: 10.4103/2041-9414.198911. eCollection 2017.

14.

Plumbagin triggers DNA damage response, telomere dysfunction and genome instability of human breast cancer cells.

Sameni S, Hande MP.

Biomed Pharmacother. 2016 Aug;82:256-68. doi: 10.1016/j.biopha.2016.05.007. Epub 2016 May 14.

PMID:
27470362
15.

Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.

Ghamrasni SE, Cardoso R, Li L, Guturi KK, Bjerregaard VA, Liu Y, Venkatesan S, Hande MP, Henderson JT, Sanchez O, Hickson ID, Hakem A, Hakem R.

Oncogene. 2016 Sep 15;35(37):4836-45. doi: 10.1038/onc.2016.16. Epub 2016 Feb 15.

PMID:
26876210
16.

Trans-dichlorooxovandium (IV) complex as a novel photoinducible DNA interstrand crosslinker for cancer therapy.

Somyajit K, Banik B, Saxena S, Babu S, Hande MP, Chakravarty AR, Nagaraju G.

Carcinogenesis. 2016 Feb;37(2):145-156. doi: 10.1093/carcin/bgv173. Epub 2015 Dec 17.

PMID:
26678223
17.

Chromosomal instability--mechanisms and consequences.

Venkatesan S, Natarajan AT, Hande MP.

Mutat Res Genet Toxicol Environ Mutagen. 2015 Nov;793:176-84. doi: 10.1016/j.mrgentox.2015.08.008. Epub 2015 Aug 28. Review.

PMID:
26520388
18.

Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells.

Khaw AK, Sameni S, Venkatesan S, Kalthur G, Hande MP.

Mutat Res Genet Toxicol Environ Mutagen. 2015 Nov;793:86-95. doi: 10.1016/j.mrgentox.2015.06.004. Epub 2015 Jun 9. Erratum in: Mutat Res Genet Toxicol Environ Mutagen. 2016 Mar;798-799():55-6.

PMID:
26520377
19.

Distribution pattern of cytoplasmic organelles, spindle integrity, oxidative stress, octamer-binding transcription factor 4 (Oct4) expression and developmental potential of oocytes following multiple superovulation.

Kalthur G, Salian SR, Nair R, Mathew J, Adiga SK, Kalthur SG, Zeegers D, Hande MP.

Reprod Fertil Dev. 2016 Oct;28(12):2027-2038. doi: 10.1071/RD15184.

PMID:
26173898
20.

Differential resistance of human embryonic stem cells and somatic cell types to hydrogen peroxide-induced genotoxicity may be dependent on innate basal intracellular ROS levels.

Vinoth KJ, Manikandan J, Sethu S, Balakrishnan L, Heng A, Lu K, Poonepalli A, Hande MP, Cao T.

Folia Histochem Cytobiol. 2015;53(2):169-74. doi: 10.5603/FHC.a2015.0016. Epub 2015 Jul 9.

21.

MST-312 Alters Telomere Dynamics, Gene Expression Profiles and Growth in Human Breast Cancer Cells.

Gurung RL, Lim SN, Low GK, Hande MP.

J Nutrigenet Nutrigenomics. 2014;7(4-6):283-98. doi: 10.1159/000381346. Epub 2015 May 27.

22.

Clinico-Pathological Correlation of β-Catenin and Telomere Dysfunction in Head and Neck Squamous Cell Carcinoma Patients.

Padhi S, Saha A, Kar M, Ghosh C, Adhya A, Baisakh M, Mohapatra N, Venkatesan S, Hande MP, Banerjee B.

J Cancer. 2015 Jan 15;6(2):192-202. doi: 10.7150/jca.9558. eCollection 2015.

23.

Targeting DNA-PKcs and telomerase in brain tumour cells.

Gurung RL, Lim HK, Venkatesan S, Lee PS, Hande MP.

Mol Cancer. 2014 Oct 13;13:232. doi: 10.1186/1476-4598-13-232.

24.

Evaluation of human embryonic stem cells and their differentiated fibroblastic progenies as cellular models for in vitro genotoxicity screening.

Vinoth KJ, Manikandan J, Sethu S, Balakrishnan L, Heng A, Lu K, Hande MP, Cao T.

J Biotechnol. 2014 Aug 20;184:154-68. doi: 10.1016/j.jbiotec.2014.05.009. Epub 2014 May 23.

PMID:
24862194
25.

Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.

El Ghamrasni S, Cardoso R, Halaby MJ, Zeegers D, Harding S, Kumareswaran R, Yavorska T, Chami N, Jurisicova A, Sanchez O, Hande MP, Bristow R, Hakem R, Hakem A.

Oncogene. 2015 Apr 2;34(14):1780-9. doi: 10.1038/onc.2014.121. Epub 2014 May 26.

PMID:
24858046
26.

Folate deficiency induces dysfunctional long and short telomeres; both states are associated with hypomethylation and DNA damage in human WIL2-NS cells.

Bull CF, Mayrhofer G, O'Callaghan NJ, Au AY, Pickett HA, Low GK, Zeegers D, Hande MP, Fenech MF.

Cancer Prev Res (Phila). 2014 Jan;7(1):128-38. doi: 10.1158/1940-6207.CAPR-13-0264. Epub 2013 Nov 19.

27.

Toxicological profile of small airway epithelial cells exposed to gold nanoparticles.

Ng CT, Li JJ, Gurung RL, Hande MP, Ong CN, Bay BH, Yung LY.

Exp Biol Med (Maywood). 2013 Dec;238(12):1355-61. doi: 10.1177/1535370213505964. Epub 2013 Oct 24.

PMID:
24157586
28.

Age-independent telomere shortening and ion-channel defects in SCD.

Banerjee B, Hande MP.

Nat Rev Cardiol. 2013 Jun;10(6):362. doi: 10.1038/nrcardio.2013.30-c1. Epub 2013 Apr 30. No abstract available.

PMID:
23629439
29.

Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.

Khaw AK, Hande MP, Kalthur G, Hande MP.

J Cell Biochem. 2013 Jun;114(6):1257-70. doi: 10.1002/jcb.24466.

PMID:
23192708
30.

Physicochemical and toxicological characteristics of urban aerosols during a recent Indonesian biomass burning episode.

Pavagadhi S, Betha R, Venkatesan S, Balasubramanian R, Hande MP.

Environ Sci Pollut Res Int. 2013 Apr;20(4):2569-78. doi: 10.1007/s11356-012-1157-9. Epub 2012 Sep 13.

PMID:
22972615
32.

Genistein induces growth arrest and suppresses telomerase activity in brain tumor cells.

Khaw AK, Yong JW, Kalthur G, Hande MP.

Genes Chromosomes Cancer. 2012 Oct;51(10):961-74. doi: 10.1002/gcc.21979. Epub 2012 Jun 27.

PMID:
22736505
33.

Enhanced genotoxicity of silver nanoparticles in DNA repair deficient Mammalian cells.

Lim HK, Asharani PV, Hande MP.

Front Genet. 2012 Jun 13;3:104. doi: 10.3389/fgene.2012.00104. eCollection 2012.

34.

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.

Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Gurung RL, Hande MP, d'Adda di Fagagna F, Herbig U.

EMBO J. 2012 Jun 29;31(13):2839-51. doi: 10.1038/emboj.2012.132. Epub 2012 May 8.

35.

Folate deficiency is associated with the formation of complex nuclear anomalies in the cytokinesis-block micronucleus cytome assay.

Bull CF, Mayrhofer G, Zeegers D, Mun GL, Hande MP, Fenech MF.

Environ Mol Mutagen. 2012 May;53(4):311-23. doi: 10.1002/em.21688. Epub 2012 Mar 19.

PMID:
22430981
36.

Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells.

Asharani P, Sethu S, Lim HK, Balaji G, Valiyaveettil S, Hande MP.

Genome Integr. 2012 Feb 10;3(1):2. doi: 10.1186/2041-9414-3-2.

37.

Biochemical response of diverse organs in adult Danio rerio (zebrafish) exposed to sub-lethal concentrations of microcystin-LR and microcystin-RR: a balneation study.

Pavagadhi S, Gong Z, Hande MP, Dionysiou DD, de la Cruz AA, Balasubramanian R.

Aquat Toxicol. 2012 Mar;109:1-10. doi: 10.1016/j.aquatox.2011.11.009. Epub 2011 Nov 26.

PMID:
22207040
38.

Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm.

Manikandan J, Kothandaraman N, Hande MP, Pushparaj PN.

Cell Mol Life Sci. 2012 Jun;69(12):1917-29. doi: 10.1007/s00018-011-0886-0. Epub 2011 Dec 7. Review.

PMID:
22146792
39.

Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.

El Ghamrasni S, Pamidi A, Halaby MJ, Bohgaki M, Cardoso R, Li L, Venkatesan S, Sethu S, Hirao A, Mak TW, Hande MP, Hakem A, Hakem R.

PLoS Genet. 2011 May;7(5):e1001385. doi: 10.1371/journal.pgen.1001385. Epub 2011 May 19.

40.

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande MP, Durocher D, Hakem A, Hakem R.

PLoS Genet. 2011 Apr;7(4):e1001381. doi: 10.1371/journal.pgen.1001381. Epub 2011 Apr 28.

41.

Genomic instability of gold nanoparticle treated human lung fibroblast cells.

Li JJ, Lo SL, Ng CT, Gurung RL, Hartono D, Hande MP, Ong CN, Bay BH, Yung LY.

Biomaterials. 2011 Aug;32(23):5515-23. doi: 10.1016/j.biomaterials.2011.04.023. Epub 2011 May 2.

PMID:
21543115
42.

Health impact and safety of engineered nanomaterials.

Teow Y, Asharani PV, Hande MP, Valiyaveettil S.

Chem Commun (Camb). 2011 Jul 7;47(25):7025-38. doi: 10.1039/c0cc05271j. Epub 2011 Apr 11. Review.

PMID:
21479319
43.

Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells.

Gopalakrishnan K, Low GKM, Ting APL, Srikanth P, Slijepcevic P, Hande MP.

Genome Integr. 2010 Dec 22;1(1):16. doi: 10.1186/2041-9414-1-16.

44.

hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells.

Indran IR, Hande MP, Pervaiz S.

Cancer Res. 2011 Jan 1;71(1):266-76. doi: 10.1158/0008-5472.CAN-10-1588. Epub 2010 Nov 11.

45.

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo.

Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw AK, Banerjee B, Hande MP, Miyamoto T, Miyoshi I, Shirai T, Motoyama N, Delhase M, Appella E, Nakanishi M.

EMBO J. 2010 Oct 20;29(20):3558-70. doi: 10.1038/emboj.2010.218. Epub 2010 Sep 10.

46.

A positive role for c-Abl in Atm and Atr activation in DNA damage response.

Wang X, Zeng L, Wang J, Chau JF, Lai KP, Jia D, Poonepalli A, Hande MP, Liu H, He G, He L, Li B.

Cell Death Differ. 2011 Jan;18(1):5-15. doi: 10.1038/cdd.2010.106. Epub 2010 Aug 27.

47.

Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells.

Gurung RL, Lim SN, Khaw AK, Soon JF, Shenoy K, Mohamed Ali S, Jayapal M, Sethu S, Baskar R, Hande MP.

PLoS One. 2010 Aug 12;5(8):e12124. doi: 10.1371/journal.pone.0012124.

48.

Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.

Bhattacharjee RN, Banerjee B, Akira S, Hande MP.

PLoS One. 2010 Jul 29;5(7):e11873. doi: 10.1371/journal.pone.0011873.

49.

UHRF1 is a genome caretaker that facilitates the DNA damage response to gamma-irradiation.

Mistry H, Tamblyn L, Butt H, Sisgoreo D, Gracias A, Larin M, Gopalakrishnan K, Hande MP, McPherson JP.

Genome Integr. 2010 Jun 8;1(1):7. doi: 10.1186/2041-9414-1-7.

50.

Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability.

Gurung RL, Balakrishnan L, Bhattacharjee RN, Manikandan J, Swaminathan S, Hande MP.

Genome Integr. 2010 May 26;1(1):5. doi: 10.1186/2041-9414-1-5.

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