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Items: 1 to 50 of 406

1.

Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells.

Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Cole PA, Dent SYR, Hancock WW.

Cancers (Basel). 2019 Apr 18;11(4). pii: E554. doi: 10.3390/cancers11040554.

2.

Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage.

Reed HO, Wang L, Sonett J, Chen M, Yang J, Li L, Aradi P, Jakus Z, D'Armiento J, Hancock WW, Kahn ML.

J Clin Invest. 2019 Apr 4;130:2514-2526. doi: 10.1172/JCI125044.

3.

Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer.

Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM, Eruslanov EB.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaat1500. doi: 10.1126/scitranslmed.aat1500.

PMID:
30760579
4.

Sirtuin-1 in immunotherapy: A Janus-headed target.

Chadha S, Wang L, Hancock WW, Beier UH.

J Leukoc Biol. 2019 Jan 3. doi: 10.1002/JLB.2RU1118-422R. [Epub ahead of print] Review.

PMID:
30605226
5.

Loss of HDAC6 alters gut microbiota and worsens obesity.

Lieber AD, Beier UH, Xiao H, Wilkins BJ, Jiao J, Li XS, Schugar RC, Strauch CM, Wang Z, Brown JM, Hazen SL, Bokulich NA, Ruggles KV, Akimova T, Hancock WW, Blaser MJ.

FASEB J. 2019 Jan;33(1):1098-1109. doi: 10.1096/fj.201701586R. Epub 2018 Aug 13.

PMID:
30102568
6.

How little is known about the role of human FOXP3+ Tregs in tumors.

Akimova T, Hancock WW.

Expert Opin Ther Targets. 2018 Aug;22(8):655-658. doi: 10.1080/14728222.2018.1499728. Epub 2018 Jul 19. No abstract available.

PMID:
29989842
7.

MEF2 and the tumorigenic process, hic sunt leones.

Di Giorgio E, Hancock WW, Brancolini C.

Biochim Biophys Acta Rev Cancer. 2018 Dec;1870(2):261-273. doi: 10.1016/j.bbcan.2018.05.007. Epub 2018 Jun 5. Review.

8.

Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function posttransplantation.

Wang L, Beier UH, Akimova T, Dahiya S, Han R, Samanta A, Levine MH, Hancock WW.

Am J Transplant. 2018 Jul;18(7):1596-1603. doi: 10.1111/ajt.14749. Epub 2018 Apr 21. Review.

9.

Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms.

Negorev D, Beier UH, Zhang T, Quatromoni JG, Bhojnagarwala P, Albelda SM, Singhal S, Eruslanov E, Lohoff FW, Levine MH, Diamond JM, Christie JD, Hancock WW, Akimova T.

Sci Rep. 2018 Feb 16;8(1):3135. doi: 10.1038/s41598-018-21450-6.

10.

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.

Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA.

Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4.

11.

Utility of IL-2 Complexes in Promoting the Survival of Murine Orthotopic Forelimb Vascularized Composite Allografts.

Xu H, Dahiya S, Wang L, Akimova T, Han R, Zhang T, Zhang Y, Qin L, Levine MH, Hancock WW, Levin LS.

Transplantation. 2018 Jan;102(1):70-78. doi: 10.1097/TP.0000000000001852.

12.

Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60.

Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, Weinstock J, Mattern M, Bezsonova I, Hancock WW, Kumar S.

PLoS One. 2017 Dec 13;12(12):e0189744. doi: 10.1371/journal.pone.0189744. eCollection 2017.

13.

Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function.

Huang J, Wang L, Dahiya S, Beier UH, Han R, Samanta A, Bergman J, Sotomayor EM, Seto E, Kozikowski AP, Hancock WW.

Sci Rep. 2017 Aug 17;7(1):8626. doi: 10.1038/s41598-017-09211-3.

14.

Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors.

Akimova T, Zhang T, Negorev D, Singhal S, Stadanlick J, Rao A, Annunziata M, Levine MH, Beier UH, Diamond JM, Christie JD, Albelda SM, Eruslanov EB, Hancock WW.

JCI Insight. 2017 Aug 17;2(16). pii: 94075. doi: 10.1172/jci.insight.94075. eCollection 2017 Aug 17.

15.

The Effects of Tacrolimus on T-Cell Proliferation Are Short-Lived: A Pilot Analysis of Immune Function Testing.

Laskin BL, Jiao J, Baluarte HJ, Amaral S, Furth SL, Akimova T, Hancock WW, Levine MH, Reese PP, Beier UH.

Transplant Direct. 2017 Jul 19;3(8):e199. doi: 10.1097/TXD.0000000000000715. eCollection 2017 Aug.

16.

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model.

Woods DM, Woan KV, Cheng F, Sodré AL, Wang D, Wu Y, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Zhang Y, Wu X, Zheng X, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM.

Blood. 2017 Jul 13;130(2):146-155. doi: 10.1182/blood-2016-08-731505. Epub 2017 May 26.

17.

Regulatory T cell signatures in liver transplant recipients successfully weaned from immunosuppression: Getting from here to there.

Levine MH, Akimova T, Murken DR, Hancock WW.

Liver Transpl. 2017 Jul;23(7):875-877. doi: 10.1002/lt.24786. No abstract available.

18.

Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.

Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR.

JCI Insight. 2017 May 4;2(9). pii: 93121. doi: 10.1172/jci.insight.93121. eCollection 2017 May 4. Review.

19.

Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.

Angelin A, Gil-de-Gómez L, Dahiya S, Jiao J, Guo L, Levine MH, Wang Z, Quinn WJ 3rd, Kopinski PK, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Laskin BL, Baur JA, Blair IA, Wallace DC, Hancock WW, Beier UH.

Cell Metab. 2017 Jun 6;25(6):1282-1293.e7. doi: 10.1016/j.cmet.2016.12.018. Epub 2017 Apr 13.

20.

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity.

Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, Han R, Samanta A, Beier UH, Akimova T, Bhatti TR, Nicholson B, Kodrasov MP, Agarwal S, Sterner DE, Gu W, Weinstock J, Butt TR, Albelda SM, Hancock WW.

EBioMedicine. 2016 Nov;13:99-112. doi: 10.1016/j.ebiom.2016.10.018. Epub 2016 Oct 15.

21.

Proximity Ligation Assay to Quantify Foxp3 Acetylation in Regulatory T Cells.

Jiao J, Han R, Hancock WW, Beier UH.

Methods Mol Biol. 2017;1510:287-293.

22.

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.

Singhal S, Bhojnagarwala PS, O'Brien S, Moon EK, Garfall AL, Rao AS, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman MD, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB.

Cancer Cell. 2016 Jul 11;30(1):120-135. doi: 10.1016/j.ccell.2016.06.001. Epub 2016 Jun 30.

23.

Isoform-Selective HDAC Inhibitor Therapy for Transplantation: Are We Ready for HDAC6?

Hancock WW.

Transplantation. 2016 Aug;100(8):1597-8. doi: 10.1097/TP.0000000000001209. No abstract available.

24.

Improved renal ischemia tolerance in females influences kidney transplantation outcomes.

Aufhauser DD Jr, Wang Z, Murken DR, Bhatti TR, Wang Y, Ge G, Redfield RR 3rd, Abt PL, Wang L, Svoronos N, Thomasson A, Reese PP, Hancock WW, Levine MH.

J Clin Invest. 2016 May 2;126(5):1968-77. doi: 10.1172/JCI84712. Epub 2016 Apr 18.

25.

Targeting Sirtuin-1 prolongs murine renal allograft survival and function.

Levine MH, Wang Z, Xiao H, Jiao J, Wang L, Bhatti TR, Hancock WW, Beier UH.

Kidney Int. 2016 May;89(5):1016-1026. doi: 10.1016/j.kint.2015.12.051. Epub 2016 Mar 16.

26.

HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells.

Xiao H, Jiao J, Wang L, O'Brien S, Newick K, Wang LC, Falkensammer E, Liu Y, Han R, Kapoor V, Hansen FK, Kurz T, Hancock WW, Beier UH.

Int J Cancer. 2016 May 15;138(10):2477-86. doi: 10.1002/ijc.29979. Epub 2016 Jan 19.

27.

Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function.

Segretti MC, Vallerini GP, Brochier C, Langley B, Wang L, Hancock WW, Kozikowski AP.

ACS Med Chem Lett. 2015 Oct 5;6(11):1156-61. doi: 10.1021/acsmedchemlett.5b00303. eCollection 2015 Nov 12.

28.

Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function.

Akimova T, Levine MH, Beier UH, Hancock WW.

Methods Mol Biol. 2016;1371:43-78. doi: 10.1007/978-1-4939-3139-2_4.

29.

Mesenchymal Stromal Cell-Derived Factors Promote Tissue Repair in a Small-for-Size Ischemic Liver Model but Do Not Protect against Early Effects of Ischemia and Reperfusion Injury.

Fouraschen SM, Wolf JH, van der Laan LJ, de Ruiter PE, Hancock WW, van Kooten JP, Verstegen MM, Olthoff KM, de Jonge J.

J Immunol Res. 2015;2015:202975. doi: 10.1155/2015/202975. Epub 2015 Aug 24.

30.

FOXP3⁺ regulatory T cell development and function require histone/protein deacetylase 3.

Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Akimova T, Greene MI, Hiebert SW, Hancock WW.

J Clin Invest. 2015 Aug 3;125(8):3304. doi: 10.1172/JCI83084. Epub 2015 Aug 3. No abstract available.

31.

Class-specific histone/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation.

Levine MH, Wang Z, Bhatti TR, Wang Y, Aufhauser DD, McNeal S, Liu Y, Cheraghlou S, Han R, Wang L, Hancock WW.

Am J Transplant. 2015 Apr;15(4):965-73. doi: 10.1111/ajt.13106. Epub 2015 Feb 23.

32.

Essential role of mitochondrial energy metabolism in Foxp3⁺ T-regulatory cell function and allograft survival.

Beier UH, Angelin A, Akimova T, Wang L, Liu Y, Xiao H, Koike MA, Hancock SA, Bhatti TR, Han R, Jiao J, Veasey SC, Sims CA, Baur JA, Wallace DC, Hancock WW.

FASEB J. 2015 Jun;29(6):2315-26. doi: 10.1096/fj.14-268409. Epub 2015 Feb 13.

33.

FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.

Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Akimova T, Greene MI, Hiebert SW, Hancock WW.

J Clin Invest. 2015 Mar 2;125(3):1111-23. doi: 10.1172/JCI77088. Epub 2015 Feb 2. Erratum in: J Clin Invest. 2015 Aug 3;125(8):3304.

34.

The inflammatory phenotype of the fibrous plate is distinct from the liver and correlates with clinical outcome in biliary atresia.

Arva NC, Russo PA, Erlichman J, Hancock WW, Haber BA, Bhatti TR.

Pathol Res Pract. 2015 Mar;211(3):252-60. doi: 10.1016/j.prp.2014.12.003. Epub 2015 Jan 6.

PMID:
25624184
35.

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer.

Eruslanov EB, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, Akimova T, Vachani A, Litzky L, Hancock WW, Conejo-Garcia JR, Feldman M, Albelda SM, Singhal S.

J Clin Invest. 2014 Dec;124(12):5466-80. doi: 10.1172/JCI77053. Epub 2014 Nov 10.

36.

An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells.

Quatromoni JG, Singhal S, Bhojnagarwala P, Hancock WW, Albelda SM, Eruslanov E.

J Leukoc Biol. 2015 Jan;97(1):201-9. doi: 10.1189/jlb.5TA0814-373. Epub 2014 Oct 30.

37.

Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function.

Liu Y, Wang L, Han R, Beier UH, Akimova T, Bhatti T, Xiao H, Cole PA, Brindle PK, Hancock WW.

Mol Cell Biol. 2014 Nov;34(21):3993-4007. doi: 10.1128/MCB.00919-14. Epub 2014 Aug 25.

38.

Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60.

Xiao Y, Nagai Y, Deng G, Ohtani T, Zhu Z, Zhou Z, Zhang H, Ji MQ, Lough JW, Samanta A, Hancock WW, Greene MI.

Cell Rep. 2014 Jun 12;7(5):1471-1480. doi: 10.1016/j.celrep.2014.04.021. Epub 2014 May 15.

39.

Blunted expression of miR-199a-5p in regulatory T cells of patients with chronic obstructive pulmonary disease compared to unaffected smokers.

Chatila WM, Criner GJ, Hancock WW, Akimova T, Moldover B, Chang JK, Cornwell W, Santerre M, Rogers TJ.

Clin Exp Immunol. 2014 Jul;177(1):341-52. doi: 10.1111/cei.12325.

40.

Regulation of T cell differentiation and alloimmunity by the cyclin-dependent kinase inhibitor p18ink4c.

Rowell EA, Wang L, Chunder N, Hancock WW, Wells AD.

PLoS One. 2014 Mar 10;9(3):e91587. doi: 10.1371/journal.pone.0091587. eCollection 2014.

41.

Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells.

Akimova T, Xiao H, Liu Y, Bhatti TR, Jiao J, Eruslanov E, Singhal S, Wang L, Han R, Zacharia K, Hancock WW, Beier UH.

Mucosal Immunol. 2014 Sep;7(5):1209-20. doi: 10.1038/mi.2014.10. Epub 2014 Feb 19.

42.

Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.

Diamond JM, Akimova T, Kazi A, Shah RJ, Cantu E, Feng R, Levine MH, Kawut SM, Meyer NJ, Lee JC, Hancock WW, Aplenc R, Ware LB, Palmer SM, Bhorade S, Lama VN, Weinacker A, Orens J, Wille K, Crespo M, Lederer DJ, Arcasoy S, Demissie E, Christie JD; Lung Transplant Outcomes Group.

Am J Respir Crit Care Med. 2014 Mar 1;189(5):567-75. doi: 10.1164/rccm.201307-1283OC.

43.

Heat shock protein 70 is required for optimal liver regeneration after partial hepatectomy in mice.

Wolf JH, Bhatti TR, Fouraschen S, Chakravorty S, Wang L, Kurian S, Salomon D, Olthoff KM, Hancock WW, Levine MH.

Liver Transpl. 2014 Mar;20(3):376-85. doi: 10.1002/lt.23813.

44.

Effects of histone deacetylase inhibitors on alloresponses.

Hancock WW.

Lancet Oncol. 2014 Jan;15(1):10-1. doi: 10.1016/S1470-2045(13)70537-0. Epub 2013 Nov 30. No abstract available.

PMID:
24295573
45.

Mbd2 promotes foxp3 demethylation and T-regulatory-cell function.

Wang L, Liu Y, Han R, Beier UH, Thomas RM, Wells AD, Hancock WW.

Mol Cell Biol. 2013 Oct;33(20):4106-15. doi: 10.1128/MCB.00144-13. Epub 2013 Aug 26.

46.

Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.

Liu Y, Wang L, Predina J, Han R, Beier UH, Wang LC, Kapoor V, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW.

Nat Med. 2013 Sep;19(9):1173-7. doi: 10.1038/nm.3286. Epub 2013 Aug 18.

47.

Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity.

Wang L, Liu Y, Beier UH, Han R, Bhatti TR, Akimova T, Hancock WW.

Blood. 2013 May 2;121(18):3631-9. doi: 10.1182/blood-2012-08-451765. Epub 2013 Feb 26.

48.

Cyclin-dependent kinase 2 controls peripheral immune tolerance.

Chunder N, Wang L, Chen C, Hancock WW, Wells AD.

J Immunol. 2012 Dec 15;189(12):5659-66. doi: 10.4049/jimmunol.1202313. Epub 2012 Nov 7.

49.

Differing effects of rapamycin or calcineurin inhibitor on T-regulatory cells in pediatric liver and kidney transplant recipients.

Akimova T, Kamath BM, Goebel JW, Meyers KE, Rand EB, Hawkins A, Levine MH, Bucuvalas JC, Hancock WW.

Am J Transplant. 2012 Dec;12(12):3449-61. doi: 10.1111/j.1600-6143.2012.04269.x. Epub 2012 Sep 20.

50.

Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function.

Beier UH, Wang L, Hancock WW.

Cell Cycle. 2012 Sep 15;11(18):3351-2. doi: 10.4161/cc.21876. Epub 2012 Aug 23.

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