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Aurein-derived antimicrobial peptides formulated with pegylated phospholipid micelles to target methicillin-resistant Staphylococcus aureus skin infections.

Kumar P, Pletzer D, Haney E, Rahanjam N, Cheng JJT, Yue M, Aljehani W, Hancock REW, Kizhakkedathu JN, Straus SK.

ACS Infect Dis. 2018 Dec 19. doi: 10.1021/acsinfecdis.8b00319. [Epub ahead of print]


Bone Environment Influences Irreversible Adhesion of a Methicillin-Susceptible Staphylococcus aureus Strain.

Reffuveille F, Josse J, Velard F, Lamret F, Varin-Simon J, Dubus M, Haney EF, Hancock REW, Mongaret C, Gangloff SC.

Front Microbiol. 2018 Nov 27;9:2865. doi: 10.3389/fmicb.2018.02865. eCollection 2018.


S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies.

Brown KL, Lubieniecka JM, Armaroli G, Kessel K, Gibson KM, Graham J, Liu D, Hancock REW, Ross CJ, Benseler SM, Luqmani RA, Cabral DA, Foell D, Kessel C.

Front Pediatr. 2018 Nov 23;6:341. doi: 10.3389/fped.2018.00341. eCollection 2018.


Is synergy the key to treating high-density infections?

Pletzer D, Hancock RE.

Future Microbiol. 2018 Nov 14. doi: 10.2217/fmb-2018-0216. [Epub ahead of print] No abstract available.


Characterization of Host Responses during Pseudomonas aeruginosa Acute Infection in the Lungs and Blood and after Treatment with the Synthetic Immunomodulatory Peptide IDR-1002.

Wuerth K, Lee AHY, Falsafi R, Gill EE, Hancock REW.

Infect Immun. 2018 Dec 19;87(1). pii: e00661-18. doi: 10.1128/IAI.00661-18. Print 2019 Jan.


Antimicrobial Effect of Peptide DJK-5 Used Alone or Mixed with EDTA on Mono- and Multispecies Biofilms in Dentin Canals.

Wang D, Shen Y, Hancock REW, Ma J, Haapasalo M.

J Endod. 2018 Nov;44(11):1709-1713. doi: 10.1016/j.joen.2018.07.018. Epub 2018 Sep 19.


Surfing Motility: a Conserved yet Diverse Adaptation among Motile Bacteria.

Sun E, Liu S, Hancock REW.

J Bacteriol. 2018 Nov 6;200(23). pii: e00394-18. doi: 10.1128/JB.00394-18. Print 2018 Dec 1.


Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells.

Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A, Speak A, Clare S, Coomber EL, Mukhopadhyay S, Kraiczy J, Schreiber F, Lawley TD, Hancock REW, Uhlig HH, Zilbauer M, Powrie F, Dougan G.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10118-10123. doi: 10.1073/pnas.1811866115. Epub 2018 Sep 14.


Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application.

Dostert M, Belanger CR, Hancock REW.

J Innate Immun. 2018 Aug 22:1-12. doi: 10.1159/000491497. [Epub ahead of print] Review.


Broad-Spectrum Adaptive Antibiotic Resistance Associated with Pseudomonas aeruginosa Mucin-Dependent Surfing Motility.

Sun E, Gill EE, Falsafi R, Yeung A, Liu S, Hancock REW.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00848-18. doi: 10.1128/AAC.00848-18. Print 2018 Sep.


Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting α-Type Phenol-Soluble Modulins and α-Hemolysin.

Wolfmeier H, Mansour SC, Liu LT, Pletzer D, Draeger A, Babiychuk EB, Hancock REW.

EBioMedicine. 2018 Jul;33:211-217. doi: 10.1016/j.ebiom.2018.06.016. Epub 2018 Jun 20.


Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens.

Pletzer D, Mansour SC, Hancock REW.

PLoS Pathog. 2018 Jun 21;14(6):e1007084. doi: 10.1371/journal.ppat.1007084. eCollection 2018 Jun.


Critical Assessment of Methods to Quantify Biofilm Growth and Evaluate Antibiofilm Activity of Host Defence Peptides.

Haney EF, Trimble MJ, Cheng JT, Vallé Q, Hancock REW.

Biomolecules. 2018 May 21;8(2). pii: E29. doi: 10.3390/biom8020029.


Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines.

Mwanza-Lisulo M, Chomba MS, Chama M, Besa EC, Funjika E, Zyambo K, Banda R, Imikendu M, Sianongo S, Hancock REW, Lee A, Chilengi R, Stagg AJ, Namangala B, Kelly PM.

Vaccine. 2018 Jun 27;36(28):4134-4141. doi: 10.1016/j.vaccine.2018.04.083. Epub 2018 May 22.


Development of Molecularly Imprinted Polymers To Block Quorum Sensing and Inhibit Bacterial Biofilm Formation.

Ma L, Feng S, Fuente-Núñez C, Hancock REW, Lu X.

ACS Appl Mater Interfaces. 2018 Jun 6;10(22):18450-18457. doi: 10.1021/acsami.8b01584. Epub 2018 May 25.


Helicobacter pylori Biofilm Formation Is Differentially Affected by Common Culture Conditions, and Proteins Play a Central Role in the Biofilm Matrix.

Windham IH, Servetas SL, Whitmire JM, Pletzer D, Hancock REW, Merrell DS.

Appl Environ Microbiol. 2018 Jul 2;84(14). pii: e00391-18. doi: 10.1128/AEM.00391-18. Print 2018 Jul 15.


In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design.

Porto WF, Irazazabal L, Alves ESF, Ribeiro SM, Matos CO, Pires ÁS, Fensterseifer ICM, Miranda VJ, Haney EF, Humblot V, Torres MDT, Hancock REW, Liao LM, Ladram A, Lu TK, de la Fuente-Nunez C, Franco OL.

Nat Commun. 2018 Apr 16;9(1):1490. doi: 10.1038/s41467-018-03746-3.


High-throughput detection of RNA processing in bacteria.

Gill EE, Chan LS, Winsor GL, Dobson N, Lo R, Ho Sui SJ, Dhillon BK, Taylor PK, Shrestha R, Spencer C, Hancock REW, Unrau PJ, Brinkman FSL.

BMC Genomics. 2018 Mar 27;19(1):223. doi: 10.1186/s12864-018-4538-8.


Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms.

Haney EF, Brito-Sánchez Y, Trimble MJ, Mansour SC, Cherkasov A, Hancock REW.

Sci Rep. 2018 Jan 30;8(1):1871. doi: 10.1038/s41598-018-19669-4.


Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment.

Marin-Luevano P, Trujillo V, Rodriguez-Carlos A, González-Curiel I, Enciso-Moreno JA, Hancock REW, Rivas-Santiago B.

Peptides. 2018 Mar;101:135-144. doi: 10.1016/j.peptides.2018.01.010. Epub 2018 Jan 17.


New Perspectives in Biofilm Eradication.

Wolfmeier H, Pletzer D, Mansour SC, Hancock REW.

ACS Infect Dis. 2018 Feb 9;4(2):93-106. doi: 10.1021/acsinfecdis.7b00170. Epub 2017 Dec 27.


Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection.

Wuerth KC, Falsafi R, Hancock REW.

PLoS One. 2017 Nov 6;12(11):e0187565. doi: 10.1371/journal.pone.0187565. eCollection 2017.


Synthetic Peptides to Target Stringent Response-Controlled Virulence in a Pseudomonas aeruginosa Murine Cutaneous Infection Model.

Pletzer D, Wolfmeier H, Bains M, Hancock REW.

Front Microbiol. 2017 Sep 27;8:1867. doi: 10.3389/fmicb.2017.01867. eCollection 2017.


Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model.

Wu BC, Lee AH, Hancock REW.

J Immunol. 2017 Nov 15;199(10):3592-3603. doi: 10.4049/jimmunol.1700985. Epub 2017 Oct 9.


Antibiofilm Effect of D-enantiomeric Peptide Alone and Combined with EDTA In Vitro.

Wang D, Shen Y, Ma J, Hancock REW, Haapasalo M.

J Endod. 2017 Nov;43(11):1862-1867. doi: 10.1016/j.joen.2017.06.037. Epub 2017 Sep 23.


Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides.

Haney EF, Wu BC, Lee K, Hilchie AL, Hancock REW.

Cell Chem Biol. 2017 Aug 17;24(8):969-980.e4. doi: 10.1016/j.chembiol.2017.07.010. Epub 2017 Aug 10.


Sensing Mg2+ contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis.

Qadi M, Izquierdo-Rabassa S, Mateu Borrás M, Doménech-Sánchez A, Juan C, Goldberg JB, Hancock REW, Albertí S.

Environ Microbiol. 2017 Oct;19(10):4278-4286. doi: 10.1111/1462-2920.13889. Epub 2017 Sep 15.


A novel small RNA is important for biofilm formation and pathogenicity in Pseudomonas aeruginosa.

Taylor PK, Van Kessel ATM, Colavita A, Hancock REW, Mah TF.

PLoS One. 2017 Aug 3;12(8):e0182582. doi: 10.1371/journal.pone.0182582. eCollection 2017.


Ciprofloxacin-nitroxide hybrids with potential for biofilm control.

Verderosa AD, de la Fuente-Núñez C, Mansour SC, Cao J, Lu TK, Hancock REW, Fairfull-Smith KE.

Eur J Med Chem. 2017 Sep 29;138:590-601. doi: 10.1016/j.ejmech.2017.06.058. Epub 2017 Jun 28.


An Immunomodulatory Peptide Confers Protection in an Experimental Candidemia Murine Model.

Freitas CG, Lima SMF, Freire MS, Cantuária APC, Júnior NGO, Santos TS, Folha JS, Ribeiro SM, Dias SC, Rezende TMB, Albuquerque P, Nicola AM, de la Fuente-Núñez C, Hancock REW, Franco OL, Felipe MSS.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e02518-16. doi: 10.1128/AAC.02518-16. Print 2017 Aug.


Return to Play After Shoulder Instability Surgery in National Collegiate Athletic Association Division I Intercollegiate Football Athletes.

Robins RJ, Daruwalla JH, Gamradt SC, McCarty EC, Dragoo JL, Hancock RE, Guy JA, Cotsonis GA, Xerogeanes JW; ASP Collaborative Group, Tuman JM, Tibone JE, Javernick MA, Yochem EM, Boden SA, Pilato A, Miley JH, Greis PE.

Am J Sports Med. 2017 Aug;45(10):2329-2335. doi: 10.1177/0363546517705635. Epub 2017 May 30.


Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

Yeung ATY, Hale C, Lee AH, Gill EE, Bushell W, Parry-Smith D, Goulding D, Pickard D, Roumeliotis T, Choudhary J, Thomson N, Skarnes WC, Dougan G, Hancock REW.

Nat Commun. 2017 Apr 25;8:15013. doi: 10.1038/ncomms15013.


Exosomes, your body's answer to immune health.

Baquir B, Hancock RE.

Ann Transl Med. 2017 Feb;5(4):81. doi: 10.21037/atm.2017.01.50. No abstract available.


An alternative approach to treating antibiotic-resistant infections.

Trimble MJ, Hancock RE.

Future Microbiol. 2017 Mar;12:201-204. doi: 10.2217/fmb-2016-0222. Epub 2017 Feb 15. No abstract available.


Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum.

Crabbé A, Liu Y, Matthijs N, Rigole P, De La Fuente-Nùñez C, Davis R, Ledesma MA, Sarker S, Van Houdt R, Hancock RE, Coenye T, Nickerson CA.

Sci Rep. 2017 Mar 3;7:43321. doi: 10.1038/srep43321.


New Mouse Model for Chronic Infections by Gram-Negative Bacteria Enabling the Study of Anti-Infective Efficacy and Host-Microbe Interactions.

Pletzer D, Mansour SC, Wuerth K, Rahanjam N, Hancock RE.

MBio. 2017 Feb 28;8(1). pii: e00140-17. doi: 10.1128/mBio.00140-17.


Anticancer activities of bovine and human lactoferricin-derived peptides.

Arias M, Hilchie AL, Haney EF, Bolscher JG, Hyndman ME, Hancock RE, Vogel HJ.

Biochem Cell Biol. 2017 Feb;95(1):91-98. doi: 10.1139/bcb-2016-0175. Epub 2016 Nov 3.


High-Performance Liquid Chromatography and Mass Spectrometry-Based Design of Proteolytically Stable Antimicrobial Peptides.

Bagheri M, Hancock RE.

Methods Mol Biol. 2017;1548:61-71. doi: 10.1007/978-1-4939-6737-7_5.


Antimicrobial Peptides: An Introduction.

Haney EF, Mansour SC, Hancock RE.

Methods Mol Biol. 2017;1548:3-22. doi: 10.1007/978-1-4939-6737-7_1. Review.


Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model.

Yu K, Lo JC, Yan M, Yang X, Brooks DE, Hancock RE, Lange D, Kizhakkedathu JN.

Biomaterials. 2017 Feb;116:69-81. doi: 10.1016/j.biomaterials.2016.11.047. Epub 2016 Nov 24.


Treatment of Oral Biofilms by a D-Enantiomeric Peptide.

Zhang T, Wang Z, Hancock RE, de la Fuente-Núñez C, Haapasalo M.

PLoS One. 2016 Nov 23;11(11):e0166997. doi: 10.1371/journal.pone.0166997. eCollection 2016.


Two Isoforms of Clp Peptidase in Pseudomonas aeruginosa Control Distinct Aspects of Cellular Physiology.

Hall BM, Breidenstein EBM, de la Fuente-Núñez C, Reffuveille F, Mawla GD, Hancock REW, Baker TA.

J Bacteriol. 2017 Jan 12;199(3). pii: e00568-16. doi: 10.1128/JB.00568-16. Print 2017 Feb 1.


Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma.

Hilchie AL, Sharon AJ, Haney EF, Hoskin DW, Bally MB, Franco OL, Corcoran JA, Hancock REW.

Biochim Biophys Acta. 2016 Dec;1858(12):3195-3204. doi: 10.1016/j.bbamem.2016.09.021. Epub 2016 Oct 18.


An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities.

Silva ON, de la Fuente-Núñez C, Haney EF, Fensterseifer IC, Ribeiro SM, Porto WF, Brown P, Faria-Junior C, Rezende TM, Moreno SE, Lu TK, Hancock RE, Franco OL.

Sci Rep. 2016 Nov 2;6:35465. doi: 10.1038/srep35465.


Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically.

Mansour SC, Pletzer D, de la Fuente-Núñez C, Kim P, Cheung GYC, Joo HS, Otto M, Hancock REW.

EBioMedicine. 2016 Oct;12:219-226. doi: 10.1016/j.ebiom.2016.09.015. Epub 2016 Sep 17.


Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells.

Yang H, Kozicky L, Saferali A, Fung SY, Afacan N, Cai B, Falsafi R, Gill E, Liu M, Kollmann TR, Hancock RE, Sly LM, Turvey SE.

Biomaterials. 2016 Dec;111:90-102. doi: 10.1016/j.biomaterials.2016.09.032. Epub 2016 Oct 3.


Anti-biofilm peptides as a new weapon in antimicrobial warfare.

Pletzer D, Coleman SR, Hancock RE.

Curr Opin Microbiol. 2016 Oct;33:35-40. doi: 10.1016/j.mib.2016.05.016. Epub 2016 Jun 16. Review.


Polymyxin: Alternative Mechanisms of Action and Resistance.

Trimble MJ, Mlynárčik P, Kolář M, Hancock RE.

Cold Spring Harb Perspect Med. 2016 Oct 3;6(10). pii: a025288. doi: 10.1101/cshperspect.a025288. Review.


Corrigendum: A polyalanine peptide derived from polar fish with anti-infectious activities.

Cardoso MH, Ribeiro SM, Nolasco DO, de la Fuente-Núñez C, Felício MR, Gonçalves S, Matos CO, Liao LM, Santos NC, Hancock RE, Franco OL, Migliolo L.

Sci Rep. 2016 Jul 20;6:28216. doi: 10.1038/srep28216. No abstract available.

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