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Items: 1 to 50 of 185

1.

Acylpeptide hydrolase is a novel regulator of KRAS plasma membrane localization and function.

Tan L, Cho KJ, Kattan WE, Garrido CM, Zhou Y, Neupane P, Capon RJ, Hancock JF.

J Cell Sci. 2019 Jul 2. pii: jcs.232132. doi: 10.1242/jcs.232132. [Epub ahead of print]

PMID:
31266814
2.

Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells.

Dent P, Booth L, Roberts JL, Liu J, Poklepovic A, Lalani AS, Tuveson D, Martinez J, Hancock JF.

Oncogene. 2019 Jun 28. doi: 10.1038/s41388-019-0849-8. [Epub ahead of print]

PMID:
31253872
3.

Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding.

McCarthy MJ, Pagba CV, Prakash P, Naji AK, van der Hoeven D, Liang H, Gupta AK, Zhou Y, Cho KJ, Hancock JF, Gorfe AA.

ACS Omega. 2019 Feb 28;4(2):2921-2930. doi: 10.1021/acsomega.8b03308. Epub 2019 Feb 8.

4.

HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.

Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K.

EMBO Rep. 2019 Apr;20(4). pii: e46685. doi: 10.15252/embr.201846685. Epub 2019 Feb 20.

PMID:
30787043
5.

Three distinct regions of cRaf kinase domain interact with membrane.

Prakash P, Hancock JF, Gorfe AA.

Sci Rep. 2019 Feb 14;9(1):2057. doi: 10.1038/s41598-019-38770-w.

6.

Dynamics of Membrane-Bound G12V-KRAS from Simulations and Single-Molecule FRET in Native Nanodiscs.

Prakash P, Litwin D, Liang H, Sarkar-Banerjee S, Dolino D, Zhou Y, Hancock JF, Jayaraman V, Gorfe AA.

Biophys J. 2019 Jan 22;116(2):179-183. doi: 10.1016/j.bpj.2018.12.011. Epub 2018 Dec 20.

PMID:
30616834
7.
8.

Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Gαq and Gα11 and kill uveal melanoma cells.

Booth L, Roberts JL, Sander C, Lalani AS, Kirkwood JM, Hancock JF, Poklepovic A, Dent P.

Cancer Biol Ther. 2019;20(5):700-710. doi: 10.1080/15384047.2018.1551747. Epub 2018 Dec 20.

PMID:
30571927
9.

Neratinib augments the lethality of [regorafenib + sildenafil].

Booth L, Roberts JL, Rais R, Cutler RE Jr, Diala I, Lalani AS, Hancock JF, Poklepovic A, Dent P.

J Cell Physiol. 2019 Apr;234(4):4874-4887. doi: 10.1002/jcp.27276. Epub 2018 Sep 10.

PMID:
30203445
10.

An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth.

Tan L, Cho KJ, Neupane P, Capon RJ, Hancock JF.

J Biol Chem. 2018 Aug 31;293(35):13696-13706. doi: 10.1074/jbc.RA118.003907. Epub 2018 Jul 3.

PMID:
29970615
11.

Rac1 Nanoscale Organization on the Plasma Membrane Is Driven by Lipid Binding Specificity Encoded in the Membrane Anchor.

Maxwell KN, Zhou Y, Hancock JF.

Mol Cell Biol. 2018 Aug 28;38(18). pii: e00186-18. doi: 10.1128/MCB.00186-18. Print 2018 Sep 15.

12.

Influence of intergenotypic competition on multigenerational persistence of abiotic stress resistance transgenes in populations of Arabidopsis thaliana.

Bigelow PJ, Loescher W, Hancock JF, Grumet R.

Evol Appl. 2018 Mar 5;11(6):950-962. doi: 10.1111/eva.12610. eCollection 2018 Jul.

13.

A novel prenyl-polybasic domain code determines lipid-binding specificity of the K-Ras membrane anchor.

Zhou Y, Hancock JF.

Small GTPases. 2018 Jan 15:1-5. doi: 10.1080/21541248.2017.1379583. [Epub ahead of print]

PMID:
29239694
14.

Ras and the Plasma Membrane: A Complicated Relationship.

Zhou Y, Prakash P, Gorfe AA, Hancock JF.

Cold Spring Harb Perspect Med. 2018 Oct 1;8(10). pii: a031831. doi: 10.1101/cshperspect.a031831. Review.

PMID:
29229665
15.

Clustering of Rac1: Selective Lipid Sorting Drives Signaling.

Maxwell KN, Zhou Y, Hancock JF.

Trends Biochem Sci. 2018 Feb;43(2):75-77. doi: 10.1016/j.tibs.2017.11.007. Epub 2017 Nov 30.

PMID:
29198968
16.

Sphingomyelin Metabolism Is a Regulator of K-Ras Function.

van der Hoeven D, Cho KJ, Zhou Y, Ma X, Chen W, Naji A, Montufar-Solis D, Zuo Y, Kovar SE, Levental KR, Frost JA, van der Hoeven R, Hancock JF.

Mol Cell Biol. 2018 Jan 16;38(3). pii: e00373-17. doi: 10.1128/MCB.00373-17. Print 2018 Feb 1.

17.

Clarifying sub-genomic positions of QTLs for flowering habit and fruit quality in U.S. strawberry (Fragaria×ananassa) breeding populations using pedigree-based QTL analysis.

Verma S, Zurn JD, Salinas N, Mathey MM, Denoyes B, Hancock JF, Finn CE, Bassil NV, Whitaker VM.

Hortic Res. 2017 Nov 8;4:17062. doi: 10.1038/hortres.2017.62. eCollection 2017.

18.

ω-3 polyunsaturated fatty acids direct differentiation of the membrane phenotype in mesenchymal stem cells to potentiate osteogenesis.

Levental KR, Surma MA, Skinkle AD, Lorent JH, Zhou Y, Klose C, Chang JT, Hancock JF, Levental I.

Sci Adv. 2017 Nov 8;3(11):eaao1193. doi: 10.1126/sciadv.aao1193. eCollection 2017 Nov.

19.

Deciphering lipid codes: K-Ras as a paradigm.

Zhou Y, Hancock JF.

Traffic. 2018 Mar;19(3):157-165. doi: 10.1111/tra.12541. Epub 2017 Dec 10. Review.

20.

Lipid sorting and the activity of Arf signaling complexes.

Zhou Y, Hancock JF.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11266-11267. doi: 10.1073/pnas.1715502114. Epub 2017 Oct 12. No abstract available.

21.

Spatiotemporal Analysis of K-Ras Plasma Membrane Interactions Reveals Multiple High Order Homo-oligomeric Complexes.

Sarkar-Banerjee S, Sayyed-Ahmad A, Prakash P, Cho KJ, Waxham MN, Hancock JF, Gorfe AA.

J Am Chem Soc. 2017 Sep 27;139(38):13466-13475. doi: 10.1021/jacs.7b06292. Epub 2017 Sep 18.

22.

The G protein-coupled receptor GPR31 promotes membrane association of KRAS.

Fehrenbacher N, Tojal da Silva I, Ramirez C, Zhou Y, Cho KJ, Kuchay S, Shi J, Thomas S, Pagano M, Hancock JF, Bar-Sagi D, Philips MR.

J Cell Biol. 2017 Aug 7;216(8):2329-2338. doi: 10.1083/jcb.201609096. Epub 2017 Jun 15.

23.

Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.

Mustachio LM, Lu Y, Tafe LJ, Memoli V, Rodriguez-Canales J, Mino B, Villalobos PA, Wistuba I, Katayama H, Hanash SM, Roszik J, Kawakami M, Cho KJ, Hancock JF, Chinyengetere F, Hu S, Liu X, Freemantle SJ, Dmitrovsky E.

Mol Cancer Res. 2017 Jul;15(7):905-914. doi: 10.1158/1541-7786.MCR-16-0369. Epub 2017 Feb 27.

24.

Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers.

Prakash P, Sayyed-Ahmad A, Cho KJ, Dolino DM, Chen W, Li H, Grant BJ, Hancock JF, Gorfe AA.

Sci Rep. 2017 Jan 9;7:40109. doi: 10.1038/srep40109.

25.

Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output.

Zhou Y, Prakash P, Liang H, Cho KJ, Gorfe AA, Hancock JF.

Cell. 2017 Jan 12;168(1-2):239-251.e16. doi: 10.1016/j.cell.2016.11.059. Epub 2016 Dec 29.

26.

A High-Density Linkage Map of the Ancestral Diploid Strawberry, , Constructed with Single Nucleotide Polymorphism Markers from the IStraw90 Array and Genotyping by Sequencing.

Mahoney LL, Sargent DJ, Abebe-Akele F, Wood DJ, Ward JA, Bassil NV, Hancock JF, Folta KM, Davis TM.

Plant Genome. 2016 Jul;9(2). doi: 10.3835/plantgenome2015.08.0071.

27.

Corrigendum to "Ras nanoclusters: Versatile lipid-based signaling platforms" [Biochim. Biophys. Acta 1853/4 (2015) 841-849].

Zhou Y, Hancock JF.

Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):449. doi: 10.1016/j.bbamcr.2016.11.016. Epub 2016 Nov 23. No abstract available.

28.

Inhibition of RAS function through targeting an allosteric regulatory site.

Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP.

Nat Chem Biol. 2017 Jan;13(1):62-68. doi: 10.1038/nchembio.2231. Epub 2016 Nov 7.

29.

Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.

Baameur F, Singhmar P, Zhou Y, Hancock JF, Cheng X, Heijnen CJ, Kavelaars A.

Sci Rep. 2016 Nov 3;6:36370. doi: 10.1038/srep36370.

30.

AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.

Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF.

Mol Cell Biol. 2016 Nov 28;36(24):3086-3099. Print 2016 Dec 15.

31.

VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking.

Zhou M, Wiener H, Su W, Zhou Y, Liot C, Ahearn I, Hancock JF, Philips MR.

J Cell Biol. 2016 Aug 15;214(4):445-58. doi: 10.1083/jcb.201604061. Epub 2016 Aug 8.

32.

Public Availability of a Genotyped Segregating Population May Foster Marker Assisted Breeding (MAB) and Quantitative Trait Loci (QTL) Discovery: An Example Using Strawberry.

Hancock JF, Sooriyapathirana SS, Bassil NV, Stegmeir T, Cai L, Finn CE, Van de Weg E, Weebadde CK.

Front Plant Sci. 2016 May 9;7:619. doi: 10.3389/fpls.2016.00619. eCollection 2016.

33.

Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization through an Effector Binding Surface Suggests Limited Functional Role.

Sayyed-Ahmad A, Cho KJ, Hancock JF, Gorfe AA.

J Phys Chem B. 2016 Aug 25;120(33):8547-56. doi: 10.1021/acs.jpcb.6b02403. Epub 2016 May 11.

34.

Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.

Prakash P, Zhou Y, Liang H, Hancock JF, Gorfe AA.

Biophys J. 2016 Mar 8;110(5):1125-38. doi: 10.1016/j.bpj.2016.01.019.

35.

Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane.

Cho KJ, van der Hoeven D, Zhou Y, Maekawa M, Ma X, Chen W, Fairn GD, Hancock JF.

Mol Cell Biol. 2015 Nov 16;36(2):363-74. doi: 10.1128/MCB.00719-15. Print 2016 Jan 15.

36.

Oligomycins as inhibitors of K-Ras plasma membrane localisation.

Salim AA, Tan L, Huang XC, Cho KJ, Lacey E, Hancock JF, Capon RJ.

Org Biomol Chem. 2016 Jan 14;14(2):711-715. doi: 10.1039/c5ob02020d.

37.

Relevance of Crop Biology for Environmental Risk Assessment of Genetically Modified Crops in Africa.

Akinbo O, Hancock JF, Makinde D.

Front Bioeng Biotechnol. 2015 Oct 9;3:150. doi: 10.3389/fbioe.2015.00150. eCollection 2015. Review.

38.

Breeding blueberries for a changing global environment: a review.

Lobos GA, Hancock JF.

Front Plant Sci. 2015 Sep 30;6:782. doi: 10.3389/fpls.2015.00782. eCollection 2015. Review.

39.

SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.

Zhou Y, Wong CO, Cho KJ, van der Hoeven D, Liang H, Thakur DP, Luo J, Babic M, Zinsmaier KE, Zhu MX, Hu H, Venkatachalam K, Hancock JF.

Science. 2015 Aug 21;349(6250):873-6. doi: 10.1126/science.aaa5619.

40.

Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.

Šolman M, Ligabue A, Blaževitš O, Jaiswal A, Zhou Y, Liang H, Lectez B, Kopra K, Guzmán C, Härmä H, Hancock JF, Aittokallio T, Abankwa D.

Elife. 2015 Aug 14;4:e08905. doi: 10.7554/eLife.08905.

41.

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.

Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE.

Oncogene. 2016 Apr 28;35(17):2186-96. doi: 10.1038/onc.2015.279. Epub 2015 Jul 27.

42.

Binding hotspots on K-ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis.

Prakash P, Hancock JF, Gorfe AA.

Proteins. 2015 May;83(5):898-909. doi: 10.1002/prot.24786. Epub 2015 Mar 25.

43.

Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras.

Salim AA, Cho KJ, Tan L, Quezada M, Lacey E, Hancock JF, Capon RJ.

Org Lett. 2014 Oct 3;16(19):5036-9. doi: 10.1021/ol502376e. Epub 2014 Sep 19.

44.

Ras nanoclusters: Versatile lipid-based signaling platforms.

Zhou Y, Hancock JF.

Biochim Biophys Acta. 2015 Apr;1853(4):841-9. doi: 10.1016/j.bbamcr.2014.09.008. Epub 2014 Sep 16. Review. Erratum in: Biochim Biophys Acta. 2017 Feb;1864(2):449.

45.

Rare Streptomyces sp. polyketides as modulators of K-Ras localisation.

Salim AA, Xiao X, Cho KJ, Piggott AM, Lacey E, Hancock JF, Capon RJ.

Org Biomol Chem. 2014 Jul 21;12(27):4872-8. doi: 10.1039/c4ob00745j.

46.

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling.

Ariotti N, Fernández-Rojo MA, Zhou Y, Hill MM, Rodkey TL, Inder KL, Tanner LB, Wenk MR, Hancock JF, Parton RG.

J Cell Biol. 2014 Mar 3;204(5):777-92. doi: 10.1083/jcb.201307055. Epub 2014 Feb 24.

47.

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae.

Gambin Y, Ariotti N, McMahon KA, Bastiani M, Sierecki E, Kovtun O, Polinkovsky ME, Magenau A, Jung W, Okano S, Zhou Y, Leneva N, Mureev S, Johnston W, Gaus K, Hancock JF, Collins BM, Alexandrov K, Parton RG.

Elife. 2013 Jan 1;3:e01434. doi: 10.7554/eLife.01434.

48.

Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters.

Zhou Y, Liang H, Rodkey T, Ariotti N, Parton RG, Hancock JF.

Mol Cell Biol. 2014 Mar;34(5):862-76. doi: 10.1128/MCB.01227-13. Epub 2013 Dec 23.

49.

Bile acids modulate signaling by functional perturbation of plasma membrane domains.

Zhou Y, Maxwell KN, Sezgin E, Lu M, Liang H, Hancock JF, Dial EJ, Lichtenberger LM, Levental I.

J Biol Chem. 2013 Dec 13;288(50):35660-70. doi: 10.1074/jbc.M113.519116. Epub 2013 Oct 28.

50.

Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells.

Zhang F, Wang Z, Lu M, Yonekubo Y, Liang X, Zhang Y, Wu P, Zhou Y, Grinstein S, Hancock JF, Du G.

Mol Cell Biol. 2014 Jan;34(1):84-95. doi: 10.1128/MCB.00987-13. Epub 2013 Oct 28.

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