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Items: 1 to 50 of 77

1.

Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.

Sheets MF, Fozzard HA, Hanck DA.

Biophys J. 2015 Dec 1;109(11):2277-86. doi: 10.1016/j.bpj.2015.10.012.

2.

Outward stabilization of the voltage sensor in domain II but not domain I speeds inactivation of voltage-gated sodium channels.

Sheets MF, Chen T, Hanck DA.

Am J Physiol Heart Circ Physiol. 2013 Oct 15;305(8):H1213-21. doi: 10.1152/ajpheart.00225.2013. Epub 2013 Jul 26.

3.

The sodium channel as a target for local anesthetic drugs.

Fozzard HA, Sheets MF, Hanck DA.

Front Pharmacol. 2011 Nov 1;2:68. doi: 10.3389/fphar.2011.00068. eCollection 2011.

4.

A molecular model of the inner pore of the Ca channel in its open state.

Lipkind GM, Fozzard HA, Hanck DA.

Channels (Austin). 2011 Nov-Dec;5(6):482-8. doi: 10.4161/chan.5.6.18354. Epub 2011 Nov 1.

5.

Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation.

Li D, Herrera S, Bubula N, Nikitina E, Palmer AA, Hanck DA, Loweth JA, Vezina P.

J Neurochem. 2011 Jul;118(2):237-47. doi: 10.1111/j.1471-4159.2011.07308.x. Epub 2011 Jun 6.

6.

Verapamil block of T-type calcium channels.

Bergson P, Lipkind G, Lee SP, Duban ME, Hanck DA.

Mol Pharmacol. 2011 Mar;79(3):411-9. doi: 10.1124/mol.110.069492. Epub 2010 Dec 13.

7.

Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel.

Sheets MF, Chen T, Hanck DA.

Pflugers Arch. 2011 Jan;461(1):91-7. doi: 10.1007/s00424-010-0894-1. Epub 2010 Oct 28.

8.

Sodium channel molecular conformations and antiarrhythmic drug affinity.

Sheets MF, Fozzard HA, Lipkind GM, Hanck DA.

Trends Cardiovasc Med. 2010 Jan;20(1):16-21. doi: 10.1016/j.tcm.2010.03.002. Review.

9.

Inhibition of the activation pathway of the T-type calcium channel Ca(V)3.1 by ProTxII.

Edgerton GB, Blumenthal KM, Hanck DA.

Toxicon. 2010 Sep 15;56(4):624-36. doi: 10.1016/j.toxicon.2010.06.009. Epub 2010 Jun 23.

10.

Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.

Hanck DA, Nikitina E, McNulty MM, Fozzard HA, Lipkind GM, Sheets MF.

Circ Res. 2009 Aug 28;105(5):492-9. doi: 10.1161/CIRCRESAHA.109.198572. Epub 2009 Aug 6.

11.

The N terminus of connexin37 contains an alpha-helix that is required for channel function.

Kyle JW, Berthoud VM, Kurutz J, Minogue PJ, Greenspan M, Hanck DA, Beyer EC.

J Biol Chem. 2009 Jul 24;284(30):20418-27. doi: 10.1074/jbc.M109.016907. Epub 2009 May 28.

12.

An intact connexin N-terminus is required for function but not gap junction formation.

Kyle JW, Minogue PJ, Thomas BC, Domowicz DA, Berthoud VM, Hanck DA, Beyer EC.

J Cell Sci. 2008 Aug 15;121(Pt 16):2744-50. doi: 10.1242/jcs.032482. Epub 2008 Jul 29.

13.

Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5.

Edgerton GB, Blumenthal KM, Hanck DA.

Toxicon. 2008 Sep 1;52(3):489-500. doi: 10.1016/j.toxicon.2008.06.023. Epub 2008 Jul 9.

14.

The relationship between single-channel and whole-cell conductance in the T-type Ca2+ channel CaV3.1.

Bittner KC, Hanck DA.

Biophys J. 2008 Jul;95(2):931-41. doi: 10.1529/biophysj.107.128124. Epub 2008 Mar 28.

15.

Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.

Sheets MF, Hanck DA.

J Physiol. 2007 Jul 1;582(Pt 1):317-34. Epub 2007 May 17.

16.

Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.

McNulty MM, Edgerton GB, Shah RD, Hanck DA, Fozzard HA, Lipkind GM.

J Physiol. 2007 Jun 1;581(Pt 2):741-55. Epub 2007 Mar 15.

17.

Site-3 toxins and cardiac sodium channels.

Hanck DA, Sheets MF.

Toxicon. 2007 Feb;49(2):181-93. Epub 2006 Sep 27. Review.

18.

An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels.

McNulty MM, Kyle JW, Lipkind GM, Hanck DA.

Mol Pharmacol. 2006 Nov;70(5):1514-23. Epub 2006 Aug 2.

PMID:
16885209
19.

Isoform-dependent interaction of voltage-gated sodium channels with protons.

Khan A, Kyle JW, Hanck DA, Lipkind GM, Fozzard HA.

J Physiol. 2006 Oct 15;576(Pt 2):493-501. Epub 2006 Jul 27.

20.

State-dependent verapamil block of the cloned human Ca(v)3.1 T-type Ca(2+) channel.

Freeze BS, McNulty MM, Hanck DA.

Mol Pharmacol. 2006 Aug;70(2):718-26. Epub 2006 May 12.

PMID:
16699084
21.
22.

A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies.

Zhong X, Liu JR, Kyle JW, Hanck DA, Agnew WS.

Hum Mol Genet. 2006 May 1;15(9):1497-512. Epub 2006 Mar 24.

PMID:
16565161
23.

Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels.

Lam AD, Chikina MD, McNulty MM, Glaaser IW, Hanck DA.

Pflugers Arch. 2005 Nov;451(2):349-61. Epub 2005 Aug 26.

PMID:
16133267
24.

Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.

Sunami A, Tracey A, Glaaser IW, Lipkind GM, Hanck DA, Fozzard HA.

J Physiol. 2004 Dec 1;561(Pt 2):403-13. Epub 2004 Oct 7.

25.

Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation.

Sheets MF, Hanck DA.

J Physiol. 2005 Feb 15;563(Pt 1):83-93. Epub 2004 Dec 2.

26.

State-dependent mibefradil block of Na+ channels.

McNulty MM, Hanck DA.

Mol Pharmacol. 2004 Dec;66(6):1652-61.

PMID:
15562257
27.

Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels.

Puljung MC, Berthoud VM, Beyer EC, Hanck DA.

J Gen Physiol. 2004 Nov;124(5):587-603.

28.

Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3.

Seibert AL, Liu J, Hanck DA, Blumenthal KM.

Biochemistry. 2004 Jun 8;43(22):7082-9.

PMID:
15170345
29.

Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity.

Seibert AL, Liu J, Hanck DA, Blumenthal KM.

Biochemistry. 2003 Dec 16;42(49):14515-21.

PMID:
14661964
30.

Molecular action of lidocaine on the voltage sensors of sodium channels.

Sheets MF, Hanck DA.

J Gen Physiol. 2003 Feb;121(2):163-75.

31.
32.

Mibefradil block of cloned T-type calcium channels.

Martin RL, Lee JH, Cribbs LL, Perez-Reyes E, Hanck DA.

J Pharmacol Exp Ther. 2000 Oct;295(1):302-8.

PMID:
10991994
33.

Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin.

Martin RL, Pittendrigh B, Liu J, Reenan R, ffrench-Constant R, Hanck DA.

Insect Biochem Mol Biol. 2000 Nov;30(11):1051-9.

PMID:
10989292
34.

Lidocaine alters activation gating of cardiac Na channels.

Hanck DA, Makielski JC, Sheets MF.

Pflugers Arch. 2000 Apr;439(6):814-21.

PMID:
10784357
35.

The role of the putative inactivation lid in sodium channel gating current immobilization.

Sheets MF, Kyle JW, Hanck DA.

J Gen Physiol. 2000 May;115(5):609-20.

36.
37.
38.

Gating of skeletal and cardiac muscle sodium channels in mammalian cells.

Sheets MF, Hanck DA.

J Physiol. 1999 Jan 15;514 ( Pt 2):425-36.

39.

A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.

Benzinger GR, Kyle JW, Blumenthal KM, Hanck DA.

J Biol Chem. 1998 Jan 2;273(1):80-4.

40.
41.

Differences in the binding sites of two site-3 sodium channel toxins.

Benzinger GR, Drum CL, Chen LQ, Kallen RG, Hanck DA, Hanck D.

Pflugers Arch. 1997 Nov;434(6):742-9.

PMID:
9306007
42.

Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel.

Kelso GJ, Drum CL, Hanck DA, Blumenthal KM.

Biochemistry. 1996 Nov 12;35(45):14157-64.

PMID:
8916901
43.

The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B.

Dias-Kadambi BL, Combs KA, Drum CL, Hanck DA, Blumenthal KM.

J Biol Chem. 1996 Sep 27;271(39):23828-35.

44.

Optimization of a mammalian expression system for the measurement of sodium channel gating currents.

Sheets MF, Kyle JW, Krueger S, Hanck DA.

Am J Physiol. 1996 Sep;271(3 Pt 1):C1001-6.

PMID:
8843731
45.
46.

Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8.

Zeng D, Kyle JW, Martin RL, Ambler KS, Hanck DA.

Am J Physiol. 1996 May;270(5 Pt 1):C1522-31.

PMID:
8967455
47.

Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel.

Dias-Kadambi BL, Drum CL, Hanck DA, Blumenthal KM.

J Biol Chem. 1996 Apr 19;271(16):9422-8.

49.
50.

A structural motif for the voltage-gated potassium channel pore.

Lipkind GM, Hanck DA, Fozzard HA.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9215-9.

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