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Items: 1 to 50 of 284

1.

Cutting-edge perspectives in genomic maintenance VI.

Hanawalt PC, Wilson SH.

DNA Repair (Amst). 2019 Aug 5:102677. doi: 10.1016/j.dnarep.2019.102677. [Epub ahead of print] No abstract available.

PMID:
31427173
2.

Cutting-edge perspectives in genomic maintenance V.

Hanawalt PC, Wilson SH.

DNA Repair (Amst). 2018 Nov;71:1-2. doi: 10.1016/j.dnarep.2018.09.012. Epub 2018 Sep 25. No abstract available.

PMID:
30314737
3.

R-loop generation during transcription: Formation, processing and cellular outcomes.

Belotserkovskii BP, Tornaletti S, D'Souza AD, Hanawalt PC.

DNA Repair (Amst). 2018 Nov;71:69-81. doi: 10.1016/j.dnarep.2018.08.009. Epub 2018 Aug 25. Review.

PMID:
30190235
4.

A novel mode for transcription inhibition mediated by PNA-induced R-loops with a model in vitro system.

D'Souza AD, Belotserkovskii BP, Hanawalt PC.

Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):158-166. doi: 10.1016/j.bbagrm.2017.12.008. Epub 2018 Jan 31.

5.

Cutting-edge perspectives in genomic maintenance IV.

Hanawalt PC, Wilson SH.

DNA Repair (Amst). 2017 Aug;56:1-3. doi: 10.1016/j.dnarep.2017.06.025. Epub 2017 Jun 24. No abstract available.

PMID:
28705538
6.

Strong transcription blockage mediated by R-loop formation within a G-rich homopurine-homopyrimidine sequence localized in the vicinity of the promoter.

Belotserkovskii BP, Soo Shin JH, Hanawalt PC.

Nucleic Acids Res. 2017 Jun 20;45(11):6589-6599. doi: 10.1093/nar/gkx403.

7.

Modulation of Cytotoxicity by Transcription-Coupled Nucleotide Excision Repair Is Independent of the Requirement for Bioactivation of Acylfulvene.

Otto C, Spivak G, Aloisi CM, Menigatti M, Naegeli H, Hanawalt PC, Tanasova M, Sturla SJ.

Chem Res Toxicol. 2017 Mar 20;30(3):769-776. doi: 10.1021/acs.chemrestox.6b00240. Epub 2017 Feb 16.

PMID:
28076683
8.

When transcription goes on Holliday: Double Holliday junctions block RNA polymerase II transcription in vitro.

Pipathsouk A, Belotserkovskii BP, Hanawalt PC.

Biochim Biophys Acta Gene Regul Mech. 2017 Feb;1860(2):282-288. doi: 10.1016/j.bbagrm.2016.12.002. Epub 2016 Dec 5.

9.

Cutting-edge Perspectives in Genomic Maintenance III: Preface.

Hanawalt PC, Wilson SH.

DNA Repair (Amst). 2016 Aug;44:1-3. doi: 10.1016/j.dnarep.2016.05.033. Epub 2016 May 31. No abstract available.

PMID:
27342790
10.

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair.

Haradhvala NJ, Polak P, Stojanov P, Covington KR, Shinbrot E, Hess JM, Rheinbay E, Kim J, Maruvka YE, Braunstein LZ, Kamburov A, Hanawalt PC, Wheeler DA, Koren A, Lawrence MS, Getz G.

Cell. 2016 Jan 28;164(3):538-49. doi: 10.1016/j.cell.2015.12.050. Epub 2016 Jan 21.

11.

Historical perspective on the DNA damage response.

Hanawalt PC.

DNA Repair (Amst). 2015 Dec;36:2-7. doi: 10.1016/j.dnarep.2015.10.001. Epub 2015 Oct 22. Review.

12.

Photosensitive human syndromes.

Spivak G, Hanawalt PC.

Mutat Res. 2015 Jun;776:24-30. doi: 10.1016/j.mrfmmm.2014.11.003. Epub 2014 Nov 14. Review.

13.

Thymineless Death Lives On: New Insights into a Classic Phenomenon.

Khodursky A, Guzmán EC, Hanawalt PC.

Annu Rev Microbiol. 2015;69:247-63. doi: 10.1146/annurev-micro-092412-155749. Epub 2015 Aug 7. Review.

PMID:
26253395
14.

Cutting-edge Perspectives in Genomic Maintenance. Preface.

Hanawalt PC, Wilson SH.

DNA Repair (Amst). 2015 Aug;32:1-2. doi: 10.1016/j.dnarep.2015.06.001. Epub 2015 Jun 16. No abstract available.

PMID:
26163976
15.

Transcription blockage by stable H-DNA analogs in vitro.

Pandey S, Ogloblina AM, Belotserkovskii BP, Dolinnaya NG, Yakubovskaya MG, Mirkin SM, Hanawalt PC.

Nucleic Acids Res. 2015 Aug 18;43(14):6994-7004. doi: 10.1093/nar/gkv622. Epub 2015 Jun 22.

16.

A balanced perspective on unbalanced growth and thymineless death.

Hanawalt PC.

Front Microbiol. 2015 Jun 5;6:504. doi: 10.3389/fmicb.2015.00504. eCollection 2015. Review.

17.

Altered minor-groove hydrogen bonds in DNA block transcription elongation by T7 RNA polymerase.

Tanasova M, Goeldi S, Meyer F, Hanawalt PC, Spivak G, Sturla SJ.

Chembiochem. 2015 May 26;16(8):1212-8. doi: 10.1002/cbic.201500077. Epub 2015 Apr 16.

PMID:
25881991
18.

PNA binding to the non-template DNA strand interferes with transcription, suggesting a blockage mechanism mediated by R-loop formation.

Belotserkovskii BP, Hanawalt PC.

Mol Carcinog. 2015 Nov;54(11):1508-12. doi: 10.1002/mc.22209. Epub 2014 Aug 30.

19.

Coincidentally, this first issue marks the 50th anniversary of the seminal discovery of the excision-repair of damaged DNA. Preface.

Hanawalt PC, Wilson SH.

DNA Repair (Amst). 2014 Jul;19:1-2. doi: 10.1016/j.dnarep.2014.05.004. No abstract available.

PMID:
24909491
20.

In memory of John Bruce Hays (1937-2014).

de Wind N, Buermeyer AB, Hanawalt PC.

DNA Repair (Amst). 2014 Apr;16:vi-vii. doi: 10.1016/S1568-7864(14)00071-8. No abstract available.

PMID:
24674631
21.

The awakening of DNA repair at Yale.

Hanawalt PC.

Yale J Biol Med. 2013 Dec 13;86(4):517-23.

22.

DNA sequences that interfere with transcription: implications for genome function and stability.

Belotserkovskii BP, Mirkin SM, Hanawalt PC.

Chem Rev. 2013 Nov 13;113(11):8620-37. doi: 10.1021/cr400078y. Epub 2013 Aug 23. Review. No abstract available.

PMID:
23972098
23.

Comet-FISH with strand-specific probes reveals transcription-coupled repair of 8-oxoGuanine in human cells.

Guo J, Hanawalt PC, Spivak G.

Nucleic Acids Res. 2013 Sep;41(16):7700-12. doi: 10.1093/nar/gkt524. Epub 2013 Jun 17.

24.

Building on the past, shaping the future: the Environmental Mutagenesis and Genomics Society.

Wilson TE, DeMarini DM, Dertinger SD, Engelward BP, Hanawalt PC, MacGregor JT, Smith-Roe SL, Witt KL, Yauk CL, Ljungman M, Schwartz JL, Klein CB.

Environ Mol Mutagen. 2013 Apr;54(3):153-7. doi: 10.1002/em.21765. Epub 2013 Feb 26.

25.

Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks.

Belotserkovskii BP, Neil AJ, Saleh SS, Shin JH, Mirkin SM, Hanawalt PC.

Nucleic Acids Res. 2013 Feb 1;41(3):1817-28. doi: 10.1093/nar/gks1333. Epub 2012 Dec 28.

26.

Transcription blockage by bulky end termini at single-strand breaks in the DNA template: differential effects of 5' and 3' adducts.

Neil AJ, Belotserkovskii BP, Hanawalt PC.

Biochemistry. 2012 Nov 6;51(44):8964-70. doi: 10.1021/bi301240y. Epub 2012 Oct 24.

27.

A novel XPD mutation in a compound heterozygote; the mutation in the second allele is present in three homozygous patients with mild sun sensitivity.

Falik-Zaccai TC, Erel-Segal R, Horev L, Bitterman-Deutsch O, Koka S, Chaim S, Keren Z, Kalfon L, Gross B, Segal Z, Orgal S, Shoval Y, Slor H, Spivak G, Hanawalt PC.

Environ Mol Mutagen. 2012 Aug;53(7):505-14. doi: 10.1002/em.21716. Epub 2012 Jul 23.

PMID:
22826098
28.

Transcription-coupled DNA repair in prokaryotes.

Ganesan A, Spivak G, Hanawalt PC.

Prog Mol Biol Transl Sci. 2012;110:25-40. doi: 10.1016/B978-0-12-387665-2.00002-X. Review.

PMID:
22749141
29.

DNA slip-outs cause RNA polymerase II arrest in vitro: potential implications for genetic instability.

Salinas-Rios V, Belotserkovskii BP, Hanawalt PC.

Nucleic Acids Res. 2011 Sep 1;39(17):7444-54. doi: 10.1093/nar/gkr429. Epub 2011 Jun 11.

30.

Anchoring nascent RNA to the DNA template could interfere with transcription.

Belotserkovskii BP, Hanawalt PC.

Biophys J. 2011 Feb 2;100(3):675-684. doi: 10.1016/j.bpj.2010.12.3709.

31.

Transcription-coupled nucleotide excision repair of a gene transcribed by bacteriophage T7 RNA polymerase in Escherichia coli.

Ganesan AK, Hanawalt PC.

DNA Repair (Amst). 2010 Sep 4;9(9):958-63. doi: 10.1016/j.dnarep.2010.06.007. Epub 2010 Jul 17.

32.

Mechanisms and implications of transcription blockage by guanine-rich DNA sequences.

Belotserkovskii BP, Liu R, Tornaletti S, Krasilnikova MM, Mirkin SM, Hanawalt PC.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12816-21. doi: 10.1073/pnas.1007580107. Epub 2010 Jun 28.

33.

Role of RecA and the SOS response in thymineless death in Escherichia coli.

Fonville NC, Bates D, Hastings PJ, Hanawalt PC, Rosenberg SM.

PLoS Genet. 2010 Mar 5;6(3):e1000865. doi: 10.1371/journal.pgen.1000865.

34.

Thymineless death is associated with loss of essential genetic information from the replication origin.

Sangurdekar DP, Hamann BL, Smirnov D, Srienc F, Hanawalt PC, Khodursky AB.

Mol Microbiol. 2010 Mar;75(6):1455-67. doi: 10.1111/j.1365-2958.2010.07072.x. Epub 2010 Feb 1.

35.

A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage.

Nardo T, Oneda R, Spivak G, Vaz B, Mortier L, Thomas P, Orioli D, Laugel V, Stary A, Hanawalt PC, Sarasin A, Stefanini M.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6209-14. doi: 10.1073/pnas.0902113106. Epub 2009 Mar 27.

36.

Peptide nucleic acid (PNA) binding and its effect on in vitro transcription in friedreich's ataxia triplet repeats.

Belotserkovskii BP, Liu R, Hanawalt PC.

Mol Carcinog. 2009 Apr;48(4):299-308. doi: 10.1002/mc.20486.

37.

Intrinsic genomic instability from naturally occurring DNA structures: An introduction to the special issue.

Vasquez KM, Hanawalt PC.

Mol Carcinog. 2009 Apr;48(4):271-2. doi: 10.1002/mc.20519. No abstract available.

PMID:
19306307
38.

Transcription-coupled DNA repair: two decades of progress and surprises.

Hanawalt PC, Spivak G.

Nat Rev Mol Cell Biol. 2008 Dec;9(12):958-70. doi: 10.1038/nrm2549. Review.

PMID:
19023283
39.

Emerging links between premature ageing and defective DNA repair.

Hanawalt PC.

Mech Ageing Dev. 2008 Jul-Aug;129(7-8):503-5. doi: 10.1016/j.mad.2008.03.007. Epub 2008 Mar 25. No abstract available.

40.

Inhibitory effect of a short Z-DNA forming sequence on transcription elongation by T7 RNA polymerase.

Ditlevson JV, Tornaletti S, Belotserkovskii BP, Teijeiro V, Wang G, Vasquez KM, Hanawalt PC.

Nucleic Acids Res. 2008 Jun;36(10):3163-70. doi: 10.1093/nar/gkn136. Epub 2008 Apr 9.

41.

G4-forming sequences in the non-transcribed DNA strand pose blocks to T7 RNA polymerase and mammalian RNA polymerase II.

Tornaletti S, Park-Snyder S, Hanawalt PC.

J Biol Chem. 2008 May 9;283(19):12756-62. doi: 10.1074/jbc.M705003200. Epub 2008 Feb 20.

42.

New applications of the Comet assay: Comet-FISH and transcription-coupled DNA repair.

Spivak G, Cox RA, Hanawalt PC.

Mutat Res. 2009 Jan-Feb;681(1):44-50. doi: 10.1016/j.mrrev.2007.12.003. Epub 2008 Jan 17. Review.

43.

Paradigms for the three rs: DNA replication, recombination, and repair.

Hanawalt PC.

Mol Cell. 2007 Dec 14;28(5):702-7. Review.

44.

A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcription.

Belotserkovskii BP, De Silva E, Tornaletti S, Wang G, Vasquez KM, Hanawalt PC.

J Biol Chem. 2007 Nov 2;282(44):32433-41. Epub 2007 Sep 4.

45.

Transcription coupled nucleotide excision repair in Escherichia coli can be affected by changing the arginine at position 529 of the beta subunit of RNA polymerase.

Ganesan AK, Smith AJ, Savery NJ, Zamos P, Hanawalt PC.

DNA Repair (Amst). 2007 Oct 1;6(10):1434-40. Epub 2007 May 25.

46.

Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme.

Nouspikel T, Hanawalt PC.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16188-93. Epub 2006 Oct 23.

47.

Transcription domain-associated repair in human cells.

Nouspikel TP, Hyka-Nouspikel N, Hanawalt PC.

Mol Cell Biol. 2006 Dec;26(23):8722-30. Epub 2006 Oct 2.

48.

Transcription arrest at an abasic site in the transcribed strand of template DNA.

Tornaletti S, Maeda LS, Hanawalt PC.

Chem Res Toxicol. 2006 Sep;19(9):1215-20.

PMID:
16978026
49.

Research collaborations: trial, trust, and truth.

Hanawalt PC.

Cell. 2006 Sep 8;126(5):823-5.

50.

DNA repair: from molecular mechanism to human disease.

Friedberg EC, Aguilera A, Gellert M, Hanawalt PC, Hays JB, Lehmann AR, Lindahl T, Lowndes N, Sarasin A, Wood RD.

DNA Repair (Amst). 2006 Aug 13;5(8):986-96. No abstract available.

PMID:
16955546

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