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Items: 1 to 50 of 401

1.

Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress.

Kurashima K, Sekimoto T, Oda T, Kawabata T, Hanaoka F, Yamashita T.

J Cell Sci. 2018 Jun 25;131(12). pii: jcs212183. doi: 10.1242/jcs.212183.

PMID:
29777036
2.

Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites.

Yasuda T, Kagawa W, Ogi T, Kato TA, Suzuki T, Dohmae N, Takizawa K, Nakazawa Y, Genet MD, Saotome M, Hama M, Konishi T, Nakajima NI, Hazawa M, Tomita M, Koike M, Noshiro K, Tomiyama K, Obara C, Gotoh T, Ui A, Fujimori A, Nakayama F, Hanaoka F, Sugasawa K, Okayasu R, Jeggo PA, Tajima K.

PLoS Genet. 2018 Mar 28;14(3):e1007277. doi: 10.1371/journal.pgen.1007277. eCollection 2018 Mar.

3.

Hypersensitivity of mouse embryonic fibroblast cells defective for DNA polymerases η, ι and κ to various genotoxic compounds: Its potential for application in chemical genotoxic screening.

Akagi J, Yokoi M, Cho YM, Toyoda T, Ohmori H, Hanaoka F, Ogawa K.

DNA Repair (Amst). 2018 Jan;61:76-85. doi: 10.1016/j.dnarep.2017.11.006. Epub 2017 Nov 26.

4.

The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing.

Izumi M, Mizuno T, Yanagi KI, Sugimura K, Okumura K, Imamoto N, Abe T, Hanaoka F.

J Biol Chem. 2017 Aug 4;292(31):13008-13021. doi: 10.1074/jbc.M117.779371. Epub 2017 Jun 22.

5.

Direct single-molecule observations of DNA unwinding by SV40 large tumor antigen under a negative DNA supercoil state.

Takahashi S, Motooka S, Kawasaki S, Kurita H, Mizuno T, Matsuura SI, Hanaoka F, Mizuno A, Oshige M, Katsura S.

J Biomol Struct Dyn. 2018 Jan;36(1):32-44. doi: 10.1080/07391102.2016.1269689. Epub 2017 Jan 5.

PMID:
27928933
6.

Two mammalian homologs of yeast Rad23, HR23A and HR23B, as multifunctional proteins.

Yokoi M, Hanaoka F.

Gene. 2017 Jan 15;597:1-9. doi: 10.1016/j.gene.2016.10.027. Epub 2016 Oct 20. Review.

PMID:
27771451
7.

USP7 Is a Suppressor of PCNA Ubiquitination and Oxidative-Stress-Induced Mutagenesis in Human Cells.

Kashiwaba S, Kanao R, Masuda Y, Kusumoto-Matsuo R, Hanaoka F, Masutani C.

Cell Rep. 2015 Dec 15;13(10):2072-80. doi: 10.1016/j.celrep.2015.11.014. Epub 2015 Dec 8.

8.

Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome.

Osakabe A, Tachiwana H, Kagawa W, Horikoshi N, Matsumoto S, Hasegawa M, Matsumoto N, Toga T, Yamamoto J, Hanaoka F, Thomä NH, Sugasawa K, Iwai S, Kurumizaka H.

Sci Rep. 2015 Nov 17;5:16330. doi: 10.1038/srep16330.

9.

Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases.

Masuda Y, Kanao R, Kaji K, Ohmori H, Hanaoka F, Masutani C.

Nucleic Acids Res. 2015 Sep 18;43(16):7898-910. doi: 10.1093/nar/gkv712. Epub 2015 Jul 13.

10.

The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regulated during the Cell Cycle and after DNA Damage.

Uchiyama M, Terunuma J, Hanaoka F.

PLoS One. 2015 Jul 6;10(7):e0130000. doi: 10.1371/journal.pone.0130000. eCollection 2015.

11.

SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair.

Akita M, Tak YS, Shimura T, Matsumoto S, Okuda-Shimizu Y, Shimizu Y, Nishi R, Saitoh H, Iwai S, Mori T, Ikura T, Sakai W, Hanaoka F, Sugasawa K.

Sci Rep. 2015 Jun 4;5:10984. doi: 10.1038/srep10984.

12.

Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions.

Tsaalbi-Shtylik A, Ferrás C, Pauw B, Hendriks G, Temviriyanukul P, Carlée L, Calléja F, van Hees S, Akagi J, Iwai S, Hanaoka F, Jansen JG, de Wind N.

J Cell Biol. 2015 Apr 13;209(1):33-46. doi: 10.1083/jcb.201408017.

13.

UV-induced mutations in epidermal cells of mice defective in DNA polymerase η and/or ι.

Kanao R, Yokoi M, Ohkumo T, Sakurai Y, Dotsu K, Kura S, Nakatsu Y, Tsuzuki T, Masutani C, Hanaoka F.

DNA Repair (Amst). 2015 May;29:139-46. doi: 10.1016/j.dnarep.2015.02.006. Epub 2015 Feb 16.

PMID:
25733082
14.

Relevance of simultaneous mono-ubiquitinations of multiple units of PCNA homo-trimers in DNA damage tolerance.

Kanao R, Masuda Y, Deguchi S, Yumoto-Sugimoto M, Hanaoka F, Masutani C.

PLoS One. 2015 Feb 18;10(2):e0118775. doi: 10.1371/journal.pone.0118775. eCollection 2015.

15.

Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein.

Matsumoto S, Fischer ES, Yasuda T, Dohmae N, Iwai S, Mori T, Nishi R, Yoshino K, Sakai W, Hanaoka F, Thomä NH, Sugasawa K.

Nucleic Acids Res. 2015 Feb 18;43(3):1700-13. doi: 10.1093/nar/gkv038. Epub 2015 Jan 27.

16.

Association of the winged helix motif of the TFIIEα subunit of TFIIE with either the TFIIEβ subunit or TFIIB distinguishes its functions in transcription.

Tanaka A, Akimoto Y, Kobayashi S, Hisatake K, Hanaoka F, Ohkuma Y.

Genes Cells. 2015 Mar;20(3):203-16. doi: 10.1111/gtc.12212. Epub 2014 Dec 10.

17.

Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication.

Sekimoto T, Oda T, Kurashima K, Hanaoka F, Yamashita T.

Mol Cell Biol. 2015 Feb;35(4):699-715. doi: 10.1128/MCB.01153-14. Epub 2014 Dec 8.

18.

Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE.

Akimoto Y, Yamamoto S, Iida S, Hirose Y, Tanaka A, Hanaoka F, Ohkuma Y.

Genes Cells. 2014 Dec;19(12):879-90. doi: 10.1111/gtc.12187. Epub 2014 Oct 13.

19.

Remarkable induction of UV-signature mutations at the 3'-cytosine of dipyrimidine sites except at 5'-TCG-3' in the UVB-exposed skin epidermis of xeroderma pigmentosum variant model mice.

Ikehata H, Chang Y, Yokoi M, Yamamoto M, Hanaoka F.

DNA Repair (Amst). 2014 Oct;22:112-22. doi: 10.1016/j.dnarep.2014.07.012. Epub 2014 Aug 14.

PMID:
25128761
20.

Sphingosine, a modulator of human translesion DNA polymerase activity.

Kamath-Loeb AS, Balakrishna S, Whittington D, Shen JC, Emond MJ, Okabe T, Masutani C, Hanaoka F, Nishimura S, Loeb LA.

J Biol Chem. 2014 Aug 1;289(31):21663-72. doi: 10.1074/jbc.M114.570242. Epub 2014 Jun 13.

21.

Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication.

Shibutani T, Ito S, Toda M, Kanao R, Collins LB, Shibata M, Urabe M, Koseki H, Masuda Y, Swenberg JA, Masutani C, Hanaoka F, Iwai S, Kuraoka I.

Sci Rep. 2014 Jun 9;4:5220. doi: 10.1038/srep05220.

22.

A cyclobutane thymine-N4-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis.

Yamamoto J, Oyama T, Kunishi T, Masutani C, Hanaoka F, Iwai S.

Nucleic Acids Res. 2014 Feb;42(3):2075-84. doi: 10.1093/nar/gkt1039. Epub 2013 Oct 31.

23.

Structure-function analysis of the EF-hand protein centrin-2 for its intracellular localization and nucleotide excision repair.

Nishi R, Sakai W, Tone D, Hanaoka F, Sugasawa K.

Nucleic Acids Res. 2013 Aug;41(14):6917-29. doi: 10.1093/nar/gkt434. Epub 2013 May 28.

24.

Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.

Zhao Y, Gregory MT, Biertümpfel C, Hua YJ, Hanaoka F, Yang W.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8146-51. doi: 10.1073/pnas.1303126110. Epub 2013 Apr 29.

25.

Trapping DNA replication origins from the human genome.

Eki T, Murakami Y, Hanaoka F.

Genes (Basel). 2013 Apr 17;4(2):198-225. doi: 10.3390/genes4020198.

27.

Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin.

Zhao Y, Biertümpfel C, Gregory MT, Hua YJ, Hanaoka F, Yang W.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7269-74. doi: 10.1073/pnas.1202681109. Epub 2012 Apr 23.

28.

A DNA oligomer containing 2,2,4-triamino-5(2H)-oxazolone is incised by human NEIL1 and NTH1.

Kino K, Takao M, Miyazawa H, Hanaoka F.

Mutat Res. 2012 Jun 1;734(1-2):73-7. doi: 10.1016/j.mrfmmm.2012.03.007. Epub 2012 Mar 23.

PMID:
22465744
29.

The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.

Hashimoto K, Cho Y, Yang IY, Akagi J, Ohashi E, Tateishi S, de Wind N, Hanaoka F, Ohmori H, Moriya M.

J Biol Chem. 2012 Mar 16;287(12):9613-22. doi: 10.1074/jbc.M111.331728. Epub 2012 Feb 2.

30.

Stalled Polη at its cognate substrate initiates an alternative translesion synthesis pathway via interaction with REV1.

Ito W, Yokoi M, Sakayoshi N, Sakurai Y, Akagi J, Mitani H, Hanaoka F.

Genes Cells. 2012 Feb;17(2):98-108. doi: 10.1111/j.1365-2443.2011.01576.x.

31.
32.

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

Fischer ES, Scrima A, Böhm K, Matsumoto S, Lingaraju GM, Faty M, Yasuda T, Cavadini S, Wakasugi M, Hanaoka F, Iwai S, Gut H, Sugasawa K, Thomä NH.

Cell. 2011 Nov 23;147(5):1024-39. doi: 10.1016/j.cell.2011.10.035.

33.

NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.

Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K.

Mol Cell. 2011 Sep 2;43(5):788-97. doi: 10.1016/j.molcel.2011.07.026.

34.

Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis.

Pozo FM, Oda T, Sekimoto T, Murakumo Y, Masutani C, Hanaoka F, Yamashita T.

Mol Cell Biol. 2011 Aug;31(16):3396-409. doi: 10.1128/MCB.05117-11. Epub 2011 Jun 20.

35.

Hst3 and Hst4 histone deacetylases regulate replicative lifespan by preventing genome instability in Saccharomyces cerevisiae.

Hachinohe M, Hanaoka F, Masumoto H.

Genes Cells. 2011 Apr;16(4):467-77. doi: 10.1111/j.1365-2443.2011.01493.x. Epub 2011 Mar 15.

36.

Genetic analyses using a mouse cell cycle mutant identifies magoh as a novel gene involved in Cdk regulation.

Inaki M, Kato D, Utsugi T, Onoda F, Hanaoka F, Murakami Y.

Genes Cells. 2011 Feb;16(2):166-78. doi: 10.1111/j.1365-2443.2010.01479.x. Epub 2011 Jan 7.

37.

Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.

Hirota K, Sonoda E, Kawamoto T, Motegi A, Masutani C, Hanaoka F, Szüts D, Iwai S, Sale JE, Lehmann A, Takeda S.

PLoS Genet. 2010 Oct 7;6(10). pii: e1001151. doi: 10.1371/journal.pgen.1001151.

38.

Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana.

Kashiwagi S, Kuraoka I, Fujiwara Y, Hitomi K, Cheng QJ, Fuss JO, Shin DS, Masutani C, Tainer JA, Hanaoka F, Iwai S.

J Nucleic Acids. 2010 Sep 20;2010. pii: 701472. doi: 10.4061/2010/701472.

39.

Photosensitized [2 + 2] cycloaddition of N-acetylated cytosine affords stereoselective formation of cyclobutane pyrimidine dimer.

Yamamoto J, Nishiguchi K, Manabe K, Masutani C, Hanaoka F, Iwai S.

Nucleic Acids Res. 2011 Feb;39(3):1165-75. doi: 10.1093/nar/gkq855. Epub 2010 Sep 29.

40.

Stimulation of DNA Glycosylase Activities by XPC Protein Complex: Roles of Protein-Protein Interactions.

Shimizu Y, Uchimura Y, Dohmae N, Saitoh H, Hanaoka F, Sugasawa K.

J Nucleic Acids. 2010 Jul 25;2010. pii: 805698. doi: 10.4061/2010/805698.

41.

Structure and mechanism of human DNA polymerase eta.

Biertümpfel C, Zhao Y, Kondo Y, Ramón-Maiques S, Gregory M, Lee JY, Masutani C, Lehmann AR, Hanaoka F, Yang W.

Nature. 2010 Jun 24;465(7301):1044-8. doi: 10.1038/nature09196. Erratum in: Nature. 2011 Aug 18;476(7360):360.

42.

Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.

Jee J, Mizuno T, Kamada K, Tochio H, Chiba Y, Yanagi K, Yasuda G, Hiroaki H, Hanaoka F, Shirakawa M.

J Biol Chem. 2010 May 21;285(21):15931-40. doi: 10.1074/jbc.M109.075333. Epub 2010 Mar 24.

43.

The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells.

Sekimoto T, Oda T, Pozo FM, Murakumo Y, Masutani C, Hanaoka F, Yamashita T.

Mol Cell. 2010 Jan 15;37(1):79-89. doi: 10.1016/j.molcel.2009.12.015. Epub 2010 Jan 14.

44.

Polymerization by DNA polymerase eta is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: implications for cytotoxic effects in nucleotide excision repair-negative tumor cells.

Chijiwa S, Masutani C, Hanaoka F, Iwai S, Kuraoka I.

Carcinogenesis. 2010 Mar;31(3):388-93. doi: 10.1093/carcin/bgp316. Epub 2009 Dec 16.

PMID:
20015866
45.

Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning.

Sugasawa K, Akagi J, Nishi R, Iwai S, Hanaoka F.

Mol Cell. 2009 Nov 25;36(4):642-53. doi: 10.1016/j.molcel.2009.09.035.

46.

Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides.

Katafuchi A, Sassa A, Niimi N, Grúz P, Fujimoto H, Masutani C, Hanaoka F, Ohta T, Nohmi T.

Nucleic Acids Res. 2010 Jan;38(3):859-67. doi: 10.1093/nar/gkp1095. Epub 2009 Nov 25.

47.

The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.

Takemoto A, Maeshima K, Ikehara T, Yamaguchi K, Murayama A, Imamura S, Imamoto N, Yokoyama S, Hirano T, Watanabe Y, Hanaoka F, Yanagisawa J, Kimura K.

Nat Struct Mol Biol. 2009 Dec;16(12):1302-8. doi: 10.1038/nsmb.1708. Epub 2009 Nov 15.

PMID:
19915589
48.

Eukaryotic DNA polymerases alpha, beta and epsilon incorporate guanine opposite 2,2,4-triamino-5(2H)-oxazolone.

Kino K, Sugasawa K, Mizuno T, Bando T, Sugiyama H, Akita M, Miyazawa H, Hanaoka F.

Chembiochem. 2009 Nov 2;10(16):2613-6. doi: 10.1002/cbic.200900492. No abstract available.

PMID:
19780077
49.

Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus.

Eichinger CS, Mizuno T, Mizuno K, Miyake Y, Yanagi K, Imamoto N, Hanaoka F.

J Biol Chem. 2009 Oct 30;284(44):30604-14. doi: 10.1074/jbc.M109.024760. Epub 2009 Sep 2.

50.

A novel interaction between human DNA polymerase eta and MutLalpha.

Kanao R, Hanaoka F, Masutani C.

Biochem Biophys Res Commun. 2009 Nov 6;389(1):40-5. doi: 10.1016/j.bbrc.2009.08.090. Epub 2009 Aug 22.

PMID:
19703417

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