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Items: 1 to 50 of 330

1.

TDP2 negatively regulates axon regeneration by inducing SUMOylation of an Ets transcription factor.

Sakai Y, Hanafusa H, Pastuhov SI, Shimizu T, Li C, Hisamoto N, Matsumoto K.

EMBO Rep. 2019 Aug 8:e47517. doi: 10.15252/embr.201847517. [Epub ahead of print]

PMID:
31393064
2.

A girl with CLOVES syndrome with a recurrent PIK3CA somatic mutation and pancreatic steatosis.

Hanafusa H, Morisada N, Nomura T, Kobayashi D, Akasaka Y, Ye MJ, Nozu K, Nishimura N, Iijima K, Nakao H.

Hum Genome Var. 2019 Jun 24;6:31. doi: 10.1038/s41439-019-0063-9. eCollection 2019.

3.

C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.

Hisamoto N, Shimizu T, Asai K, Sakai Y, Pastuhov SI, Hanafusa H, Matsumoto K.

J Neurosci. 2019 Jul 17;39(29):5662-5672. doi: 10.1523/JNEUROSCI.2059-18.2019. Epub 2019 May 20.

PMID:
31109965
4.

LRRK1 phosphorylation of Rab7 at S72 links trafficking of EGFR-containing endosomes to its effector RILP.

Hanafusa H, Yagi T, Ikeda H, Hisamoto N, Nishioka T, Kaibuchi K, Shirakabe K, Matsumoto K.

J Cell Sci. 2019 Jun 3;132(11). pii: jcs228809. doi: 10.1242/jcs.228809.

PMID:
31085713
5.

The C. elegans BRCA2-ALP/Enigma Complex Regulates Axon Regeneration via a Rho GTPase-ROCK-MLC Phosphorylation Pathway.

Shimizu T, Pastuhov SI, Hanafusa H, Matsumoto K, Hisamoto N.

Cell Rep. 2018 Aug 14;24(7):1880-1889. doi: 10.1016/j.celrep.2018.07.049.

6.

Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration.

Hisamoto N, Tsuge A, Pastuhov SI, Shimizu T, Hanafusa H, Matsumoto K.

Nat Commun. 2018 Aug 6;9(1):3099. doi: 10.1038/s41467-018-05478-w.

7.

Portal Venous Gas Following Ingestion of Hydrogen Peroxide Successfully Treated with Hyperbaric Oxygen Therapy.

Tsuboi C, Naito H, Hagioka S, Hanafusa H, Hirayama T, Kosaki Y, Iida A, Yumoto T, Tsukahara K, Morimoto N, Nakao A.

Acta Med Okayama. 2018 Apr;72(2):181-183. doi: 10.18926/AMO/55859.

8.

[Regulation of cellular function by ROCO family kinase LRRK1 in a manner dependent on its substrates].

Hanafusa H, Matsumoto K.

Seikagaku. 2017 Apr;89(2):286-9. Review. Japanese. No abstract available.

PMID:
29624999
9.

The smallest de novo 20q11.2 microdeletion causing intellectual disability and dysmorphic features.

Hanafusa H, Morisada N, Ishida Y, Sakata R, Morita K, Miura S, Ye MJ, Yamamoto T, Okamoto N, Nozu K, Iijima K.

Hum Genome Var. 2017 Nov 30;4:17050. doi: 10.1038/hgv.2017.50. eCollection 2017.

10.

TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus.

Sai K, Morioka S, Takaesu G, Muthusamy N, Ghashghaei HT, Hanafusa H, Matsumoto K, Ninomiya-Tsuji J.

J Cell Sci. 2016 May 1;129(9):1855-65. doi: 10.1242/jcs.180505. Epub 2016 Mar 16.

11.

Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi.

Fukuzono T, Pastuhov SI, Fukushima O, Li C, Hattori A, Iemura S, Natsume T, Shibuya H, Hanafusa H, Matsumoto K, Hisamoto N.

Genes Cells. 2016 Apr;21(4):311-24. doi: 10.1111/gtc.12338. Epub 2016 Feb 8.

12.

LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.

Hanafusa H, Matsumoto K.

Cell Cycle. 2015;14(21):3349-50. doi: 10.1080/15384101.2015.1093446. No abstract available.

13.

Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression.

Yamamoto K, Ito S, Hanafusa H, Shimizu K, Ouchida M.

PLoS One. 2015 Sep 14;10(9):e0137887. doi: 10.1371/journal.pone.0137887. eCollection 2015.

14.

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.

Hanafusa H, Kedashiro S, Tezuka M, Funatsu M, Usami S, Toyoshima F, Matsumoto K.

Nat Cell Biol. 2015 Aug;17(8):1024-35. doi: 10.1038/ncb3204. Epub 2015 Jul 20.

PMID:
26192437
15.

LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends.

Kedashiro S, Pastuhov SI, Nishioka T, Watanabe T, Kaibuchi K, Matsumoto K, Hanafusa H.

J Cell Sci. 2015 Feb 15;128(4):829. doi: 10.1242/jcs.169102. No abstract available.

16.

LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends.

Kedashiro S, Pastuhov SI, Nishioka T, Watanabe T, Kaibuchi K, Matsumoto K, Hanafusa H.

J Cell Sci. 2015 Jan 15;128(2):385-96. doi: 10.1242/jcs.161547. Epub 2014 Nov 20. Erratum in: J Cell Sci. 2015 Feb 15;128(4):829.

17.

Diagnostic and predictive performance and standardized threshold of traditional biomarkers for drug-induced liver injury in rats.

Tonomura Y, Kato Y, Hanafusa H, Morikawa Y, Matsuyama K, Uehara T, Ueno M, Torii M.

J Appl Toxicol. 2015 Feb;35(2):165-72. doi: 10.1002/jat.3053. Epub 2014 Sep 4.

PMID:
25186495
18.

Comparative gene and protein expression analyses of a panel of cytokines in acute and chronic drug-induced liver injury in rats.

Hanafusa H, Morikawa Y, Uehara T, Kaneto M, Ono A, Yamada H, Ohno Y, Urushidani T.

Toxicology. 2014 Oct 3;324:43-54. doi: 10.1016/j.tox.2014.07.005. Epub 2014 Jul 19.

PMID:
25051504
19.

Direct observation of grain growth from molten silicon formed by micro-thermal-plasma-jet irradiation.

Hayashi S, Fujita Y, Kamikura T, Sakaike K, Akazawa M, Ikeda M, Hanafusa H, Higashi S.

Appl Phys Lett. 2012 Oct 22;101(17):172111. Epub 2012 Oct 26.

20.

Toxicogenomic biomarkers for renal papillary injury in rats.

Uehara T, Kondo C, Morikawa Y, Hanafusa H, Ueda S, Minowa Y, Nakatsu N, Ono A, Maruyama T, Kato I, Yamate J, Yamada H, Ohno Y, Urushidani T.

Toxicology. 2013 Jan 7;303:1-8. doi: 10.1016/j.tox.2012.09.012. Epub 2012 Nov 8.

PMID:
23142791
21.

Novel direct targets of miR-19a identified in breast cancer cells by a quantitative proteomic approach.

Ouchida M, Kanzaki H, Ito S, Hanafusa H, Jitsumori Y, Tamaru S, Shimizu K.

PLoS One. 2012;7(8):e44095. doi: 10.1371/journal.pone.0044095. Epub 2012 Aug 30.

22.

[Regulation of intracellular trafficking of the EGF receptor by ROCO family kinase LRRK1].

Hanafusa H, Matsumoto K.

Seikagaku. 2011 Dec;83(12):1127-31. Review. Japanese. No abstract available.

PMID:
22352044
23.

EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR.

Ishikawa K, Nara A, Matsumoto K, Hanafusa H.

Mol Biol Cell. 2012 Apr;23(7):1294-306. doi: 10.1091/mbc.E11-09-0780. Epub 2012 Feb 15.

24.

Expression and inducibility of UDP-glucuronosyltransferase 1As in MCF-7 human breast carcinoma cells.

Hanioka N, Iwabu H, Hanafusa H, Nakada S, Narimatsu S.

Basic Clin Pharmacol Toxicol. 2012 Mar;110(3):253-8. doi: 10.1111/j.1742-7843.2011.00790.x. Epub 2011 Oct 10.

25.

Identification of direct targets for the miR-17-92 cluster by proteomic analysis.

Kanzaki H, Ito S, Hanafusa H, Jitsumori Y, Tamaru S, Shimizu K, Ouchida M.

Proteomics. 2011 Sep;11(17):3531-9. doi: 10.1002/pmic.201000501. Epub 2011 Aug 1.

PMID:
21751348
26.

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor.

Hanafusa H, Ishikawa K, Kedashiro S, Saigo T, Iemura S, Natsume T, Komada M, Shibuya H, Nara A, Matsumoto K.

Nat Commun. 2011 Jan 18;2:158.

27.

Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning.

Hanafusa H, Matsumoto K, Nishida E.

Nat Cell Biol. 2009 Jan;11(1):106-9. doi: 10.1038/ncb1820.

PMID:
19122596
28.

Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos.

Ishibashi H, Matsumura N, Hanafusa H, Matsumoto K, De Robertis EM, Kuroda H.

Mech Dev. 2008 Jan-Feb;125(1-2):58-66. Epub 2007 Oct 12.

29.

Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population.

Kanzaki H, Ouchida M, Hanafusa H, Sakai A, Yamamoto H, Suzuki H, Yano M, Aoe M, Imai K, Date H, Nakachi K, Shimizu K.

Oncol Rep. 2007 Nov;18(5):1171-5.

PMID:
17914568
30.

The association between RAD18 Arg302Gln polymorphism and the risk of human non-small-cell lung cancer.

Kanzaki H, Ouchida M, Hanafusa H, Yamamoto H, Suzuki H, Yano M, Aoe M, Imai K, Date H, Nakachi K, Shimizu K.

J Cancer Res Clin Oncol. 2008 Feb;134(2):211-7. Epub 2007 Jul 12.

PMID:
17624554
31.
32.

Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population.

Kanzaki H, Ouchida M, Hanafusa H, Yano M, Suzuki H, Aoe M, Imai K, Shimizu N, Nakachi K, Shimizu K.

Int J Mol Med. 2006 Aug;18(2):279-84.

PMID:
16820935
33.

FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.

Kakumoto K, Sasai K, Sukezane T, Oneyama C, Ishimaru S, Shibutani K, Mizushima H, Mekada E, Hanafusa H, Akagi T.

Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5490-5. Epub 2006 Mar 28.

34.

Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk.

Kanzaki H, Hanafusa H, Yamamoto H, Yasuda Y, Imai K, Yano M, Aoe M, Shimizu N, Nakachi K, Ouchida M, Shimizu K.

Cancer Lett. 2006 Jul 8;238(1):128-34. Epub 2005 Aug 25.

PMID:
16125301
35.

Human diploid fibroblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras.

Sukezane T, Oneyama C, Kakumoto K, Shibutani K, Hanafusa H, Akagi T.

Oncogene. 2005 Aug 25;24(36):5648-55. Erratum in: Oncogene. 2005 Dec 8;24(55):8216.

PMID:
16007212
36.

Xenopus ILK (integrin-linked kinase) is required for morphogenetic movements during gastrulation.

Yasunaga T, Kusakabe M, Yamanaka H, Hanafusa H, Masuyama N, Nishida E.

Genes Cells. 2005 Apr;10(4):369-79.

37.

CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas.

Iwahara T, Akagi T, Fujitsuka Y, Hanafusa H.

Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17693-8. Epub 2004 Dec 14.

38.

Single nucleotide polymorphisms in the EXO1 gene and risk of colorectal cancer in a Japanese population.

Yamamoto H, Hanafusa H, Ouchida M, Yano M, Suzuki H, Murakami M, Aoe M, Shimizu N, Nakachi K, Shimizu K.

Carcinogenesis. 2005 Feb;26(2):411-6. Epub 2004 Nov 18.

PMID:
15550454
39.

PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis.

Ishimaru S, Ueda R, Hinohara Y, Ohtani M, Hanafusa H.

EMBO J. 2004 Oct 13;23(20):3984-94. Epub 2004 Sep 30.

40.

Loss of c-abl facilitates anchorage-independent growth of p53- and RB- deficient primary mouse embryonic fibroblasts.

Suzuki J, Sukezane T, Akagi T, Georgescu MM, Ohtani M, Inoue H, Jat PS, Goff SP, Hanafusa H, Shishido T.

Oncogene. 2004 Nov 4;23(52):8527-34.

PMID:
15378021
41.

Crk associates with ERM proteins and promotes cell motility toward hyaluronic acid.

Tsuda M, Makino Y, Iwahara T, Nishihara H, Sawa H, Nagashima K, Hanafusa H, Tanaka S.

J Biol Chem. 2004 Nov 5;279(45):46843-50. Epub 2004 Aug 23.

42.
43.

Human diploid fibroblasts are refractory to oncogene-mediated transformation.

Akagi T, Hanafusa H.

Cell Cycle. 2004 Mar;3(3):257-8. Epub 2004 Mar 1.

PMID:
14726647
44.

Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation.

Akagi T, Sasai K, Hanafusa H.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13567-72. Epub 2003 Nov 3.

45.

CrkII induces serum response factor activation and cellular transformation through its function in Rho activation.

Iwahara T, Akagi T, Shishido T, Hanafusa H.

Oncogene. 2003 Sep 4;22(38):5946-57.

PMID:
12955073
46.

PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

Radu A, Neubauer V, Akagi T, Hanafusa H, Georgescu MM.

Mol Cell Biol. 2003 Sep;23(17):6139-49.

47.

Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.

Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T.

J Biol Chem. 2003 Jun 13;278(24):21685-92. Epub 2003 Apr 2.

48.

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

Hanafusa H, Torii S, Yasunaga T, Nishida E.

Nat Cell Biol. 2002 Nov;4(11):850-8.

PMID:
12402043
49.

v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras.

Akagi T, Murata K, Shishido T, Hanafusa H.

Mol Cell Biol. 2002 Oct;22(20):7015-23.

50.

Genetic alterations of the ornithine decarboxylase gene in human colorectal cancers.

Matsubara N, Yoshitaka T, Hanafusa H, Tanaka N, Shimizu K.

J Exp Clin Cancer Res. 2002 Jun;21(2):191-5.

PMID:
12148577

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