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Items: 1 to 50 of 54

1.

Moringa oleifera from Cambodia Ameliorates Oxidative Stress, Hyperglycemia, and Kidney Dysfunction in Type 2 Diabetic Mice.

Tang Y, Choi EJ, Han WC, Oh M, Kim J, Hwang JY, Park PJ, Moon SH, Kim YS, Kim EK.

J Med Food. 2017 May;20(5):502-510. doi: 10.1089/jmf.2016.3792. Epub 2017 May 3.

PMID:
28467233
2.

Posttraumatic administration of a sub-anesthetic dose of ketamine exerts neuroprotection via attenuating inflammation and autophagy.

Wang CQ, Ye Y, Chen F, Han WC, Sun JM, Lu X, Guo R, Cao K, Zheng MJ, Liao LC.

Neuroscience. 2017 Feb 20;343:30-38. doi: 10.1016/j.neuroscience.2016.11.029. Epub 2016 Dec 1.

PMID:
27916727
3.

Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury.

Bao HJ, Qiu HY, Kuai JX, Song CJ, Wang SX, Wang CQ, Peng HB, Han WC, Wu YP.

Neural Regen Res. 2016 Jul;11(7):1128-33. doi: 10.4103/1673-5374.187049.

4.

Effect of Enterococcus faecalis EF-2001 on experimentally induced atopic eczema in mice.

Choi EJ, Iwasa M, Han KI, Kim WJ, Tang Y, Han WC, Kim EK, Park ZY.

Food Sci Biotechnol. 2016 Aug 31;25(4):1087-1093. doi: 10.1007/s10068-016-0175-7. eCollection 2016.

5.

Primary Retroperitoneal Mucinous Cystadenoma.

Lee SY, Han WC.

Ann Coloproctol. 2016 Feb;32(1):33-7. doi: 10.3393/ac.2016.32.1.33. Epub 2016 Feb 29.

6.

Heat-Killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine Model.

Choi EJ, Iwasa M, Han KI, Kim WJ, Tang Y, Hwang YJ, Chae JR, Han WC, Shin YS, Kim EK.

Nutrients. 2016 Mar 5;8(3):146. doi: 10.3390/nu8030146.

7.

[The absorption and metabolism of oxymatrine in rat intestine].

Cai LY, Wu LL, Yu XM, Liu JJ, Han WC, Wei Q, Tang L.

Yao Xue Xue Bao. 2015 Oct;50(10):1336-41. Chinese.

PMID:
26837183
8.

Correction to N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent.

Misra RN, Xiao HY, Kim KS, Lu S, Han WC, Barbosa SA, Hunt JT, Rawlins DB, Shan W, Ahmed SZ, Qian L, Chen BC, Zhao R, Bednarz MS, Kellar KA, Mulheron JG, Batorsky R, Roongta U, Kamath A, Marathe P, Ranadive SA, Sack JS, Tokarski JS, Pavletich NP, Lee FY, Webster KR, Kimball SD.

J Med Chem. 2015 Sep 24;58(18):7609. doi: 10.1021/acs.jmedchem.5b01294. Epub 2015 Sep 2. No abstract available.

PMID:
26328598
9.

Artemisia asiatica Nakai Attenuates the Expression of Proinflammatory Mediators in Stimulated Macrophages Through Modulation of Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathways.

Kim EK, Tang Y, Cha KS, Choi H, Lee CB, Yoon JH, Kim SB, Kim JS, Kim JM, Han WC, Choi SJ, Lee S, Choi EJ, Kim SH.

J Med Food. 2015 Aug;18(8):921-8. doi: 10.1089/jmf.2014.3344. Epub 2015 May 19.

10.

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

Gavai AV, Quesnelle C, Norris D, Han WC, Gill P, Shan W, Balog A, Chen K, Tebben A, Rampulla R, Wu DR, Zhang Y, Mathur A, White R, Rose A, Wang H, Yang Z, Ranasinghe A, D'Arienzo C, Guarino V, Xiao L, Su C, Everlof G, Arora V, Shen DR, Cvijic ME, Menard K, Wen ML, Meredith J, Trainor G, Lombardo LJ, Olson R, Baran PS, Hunt JT, Vite GD, Fischer BS, Westhouse RA, Lee FY.

ACS Med Chem Lett. 2015 Mar 11;6(5):523-7. doi: 10.1021/acsmedchemlett.5b00001. eCollection 2015 May 14.

11.

BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.

Shan W, Balog A, Quesnelle C, Gill P, Han WC, Norris D, Mandal S, Thiruvenkadam R, Gona KB, Thiyagarajan K, Kandula S, McGlinchey K, Menard K, Wen ML, Rose A, White R, Guarino V, Shen DR, Cvijic ME, Ranasinghe A, Dai J, Zhang Y, Wu DR, Mathur A, Rampulla R, Trainor G, Hunt JT, Vite GD, Westhouse R, Lee FY, Gavai AV.

Bioorg Med Chem Lett. 2015 May 1;25(9):1905-9. doi: 10.1016/j.bmcl.2015.03.038. Epub 2015 Mar 23.

PMID:
25857941
12.

Phytocomponent 4-hydroxy-3-methoxycinnamaldehyde ablates T-cell activation by targeting protein kinase C-θ and its downstream pathways.

Akber U, Na BR, Ko YS, Lee HS, Kim HR, Kwon MS, Park ZY, Choi EJ, Han WC, Lee SH, Oh HM, Jun CD.

Int Immunopharmacol. 2015 Mar;25(1):130-40. doi: 10.1016/j.intimp.2015.01.020. Epub 2015 Jan 28. Erratum in: Int Immunopharmacol. 2015 Jun;26(2):439. Ko, You-Seung [corrected to Ko, Yoo-Seung].

PMID:
25637768
13.

Intravascular papillary endothelial hyperplasia as an aneurysm of the brachial artery.

Kwon JN, Han WC.

Ann Vasc Surg. 2015;29(4):837.e17-20. doi: 10.1016/j.avsg.2014.10.045. Epub 2015 Jan 28.

PMID:
25637575
14.

Apelin-13 attenuates traumatic brain injury-induced damage by suppressing autophagy.

Bao HJ, Zhang L, Han WC, Dai DK.

Neurochem Res. 2015 Jan;40(1):89-97. doi: 10.1007/s11064-014-1469-x. Epub 2014 Nov 2.

PMID:
25362565
15.

A patient with eosinophilic gastroenteritis presenting with acute pancreatitis and ascites.

Baek MS, Mok YM, Han WC, Kim YS.

Gut Liver. 2014 Mar;8(2):224-7. doi: 10.5009/gnl.2014.8.2.224. Epub 2014 Mar 11.

16.

Aplotaxene blocks T cell activation by modulation of protein kinase C-θ-dependent pathway.

Na BR, Kim HR, Kwon MS, Lee HS, Piragyte I, Choi EJ, Choi HK, Han WC, Lee SH, Jun CD.

Food Chem Toxicol. 2013 Dec;62:23-31. doi: 10.1016/j.fct.2013.08.016. Epub 2013 Aug 11.

PMID:
23941771
17.

Dynamic motile T cells highly respond to the T cell stimulation via PI3K-Akt and NF-κB pathways.

Kim HR, Na BR, Kwon MS, Ko YS, Han WC, Jun CD.

PLoS One. 2013;8(3):e59793. doi: 10.1371/journal.pone.0059793. Epub 2013 Mar 26.

18.

Peripheral lymphadenopathy as the initial manifestation of malignant mesothelioma in a child.

Gong YS, Rong YT, Han WC, Zhang YC.

Hum Pathol. 2013 Apr;44(4):664-9. doi: 10.1016/j.humpath.2012.09.011. Epub 2013 Jan 11.

PMID:
23313308
19.

Identifying Polymorphisms in IL-31 and Their Association with Susceptibility to Asthma.

Yu JI, Han WC, Yun KJ, Moon HB, Oh GJ, Chae SC.

Korean J Pathol. 2012 Apr;46(2):162-8. doi: 10.4132/KoreanJPathol.2012.46.2.162. Epub 2012 Apr 25.

20.

Phytocomponent p-Hydroxycinnamic acid inhibits T-cell activation by modulation of protein kinase C-θ-dependent pathway.

Lee HS, Kim YD, Na BR, Kim HR, Choi EJ, Han WC, Choi HK, Lee SH, Jun CD.

Int Immunopharmacol. 2012 Jan;12(1):131-8. doi: 10.1016/j.intimp.2011.11.001. Epub 2011 Nov 17.

PMID:
22101249
21.

Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists.

Xiao HY, Balog A, Attar RM, Fairfax D, Fleming LB, Holst CL, Martin GS, Rossiter LM, Chen J, Cvjic ME, Dell-John J, Geng J, Gottardis MM, Han WC, Nation A, Obermeier M, Rizzo CA, Schweizer L, Spires T Jr, Shan W, Gavai A, Salvati ME, Vite G.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4491-5. doi: 10.1016/j.bmcl.2010.06.034. Epub 2010 Jun 10.

PMID:
20584610
22.

Production of lactosucrose from sucrose and lactose by a levansucrase from Zymomonas mobilis.

Han WC, Byun SH, Kim MH, Sohn EH, Lim JD, Um BH, Kim CH, Kang SA, Jang KH.

J Microbiol Biotechnol. 2009 Oct;19(10):1153-60.

23.

Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.

Gavai AV, Fink BE, Fairfax DJ, Martin GS, Rossiter LM, Holst CL, Kim SH, Leavitt KJ, Mastalerz H, Han WC, Norris D, Goyal B, Swaminathan S, Patel B, Mathur A, Vyas DM, Tokarski JS, Yu C, Oppenheimer S, Zhang H, Marathe P, Fargnoli J, Lee FY, Wong TW, Vite GD.

J Med Chem. 2009 Nov 12;52(21):6527-30. doi: 10.1021/jm9010065.

PMID:
19821562
24.

Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells.

Choi EJ, Oh HM, Wee H, Choi CS, Choi SC, Kim KH, Han WC, Oh TY, Kim SH, Jun CD.

Differentiation. 2009 Apr;77(4):412-23. doi: 10.1016/j.diff.2008.12.004. Epub 2009 Feb 10.

PMID:
19281788
25.

Ammonium glycyrrhizinate protects gastric epithelial cells from hydrogen peroxide-induced cell death.

Oh HM, Lee S, Park YN, Choi EJ, Choi JY, Kim JA, Kweon JH, Han WC, Choi SC, Han JK, Son JK, Lee SH, Jun CD.

Exp Biol Med (Maywood). 2009 Mar;234(3):263-77. doi: 10.3181/0805-RM-178. Epub 2009 Jan 14.

PMID:
19144869
26.

5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Mastalerz H, Chang M, Chen P, Fink BE, Gavai A, Han WC, Johnson W, Langley D, Lee FY, Leavitt K, Marathe P, Norris D, Oppenheimer S, Sleczka B, Tarrant J, Tokarski JS, Vite GD, Vyas DM, Wong H, Wong TW, Zhang H, Zhang G.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4947-54. Epub 2007 Jun 10.

PMID:
17606372
27.

New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Mastalerz H, Chang M, Chen P, Dextraze P, Fink BE, Gavai A, Goyal B, Han WC, Johnson W, Langley D, Lee FY, Marathe P, Mathur A, Oppenheimer S, Ruediger E, Tarrant J, Tokarski JS, Vite GD, Vyas DM, Wong H, Wong TW, Zhang H, Zhang G.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):2036-42. Epub 2007 Jan 12.

PMID:
17270437
28.

Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.

Fink BE, Gavai AV, Tokarski JS, Goyal B, Misra R, Xiao HY, Kimball SD, Han WC, Norris D, Spires TE, You D, Gottardis MM, Lorenzi MV, Vite GD.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1532-6. Epub 2006 Jan 4.

PMID:
16386902
29.

Increased expression of MIP-3alpha/CCL20 in peripheral blood mononuclear cells from patients with ulcerative colitis and its down-regulation by sulfasalazine and glucocorticoid treatment.

Lee HJ, Choi SC, Lee MH, Oh HM, Choi EY, Choi EJ, Yun KJ, Seo GS, Kim SW, Lee JG, Han WC, Park KI, Jun CD.

Inflamm Bowel Dis. 2005 Dec;11(12):1070-9.

PMID:
16306769
30.

Induction and localization of NOD2 protein in human endothelial cells.

Oh HM, Lee HJ, Seo GS, Choi EY, Kweon SH, Chun CH, Han WC, Lee KM, Lee MS, Choi SC, Jun CD.

Cell Immunol. 2005 Sep;237(1):37-44. Epub 2005 Nov 8.

PMID:
16288731
31.

Paratesticular mucinous cystadenocarcinoma: metastasis from pancreatic cancer.

Seo IY, Kim SG, Han WC, Rim JS.

Int J Urol. 2004 Dec;11(12):1147-9.

32.

Discovery of the pyrrolo[2,1-f][1,2,4]triazine nucleus as a new kinase inhibitor template.

Hunt JT, Mitt T, Borzilleri R, Gullo-Brown J, Fargnoli J, Fink B, Han WC, Mortillo S, Vite G, Wautlet B, Wong T, Yu C, Zheng X, Bhide R.

J Med Chem. 2004 Jul 29;47(16):4054-9.

PMID:
15267243
33.

Combined action of extracellular signal-regulated kinase and p38 kinase rescues Molt4 T cells from nitric oxide-induced apoptotic and necrotic cell death.

Oh HM, Choi SC, Lee HS, Chun CH, Seo GS, Choi EY, Lee HJ, Lee MS, Yeom JJ, Choi SJ, Han WC, Oh JM, Chung YT, Chun JS, Lee KM, Jun CD.

Free Radic Biol Med. 2004 Aug 15;37(4):463-79.

PMID:
15256218
34.

Iron chelator triggers inflammatory signals in human intestinal epithelial cells: involvement of p38 and extracellular signal-regulated kinase signaling pathways.

Choi EY, Kim EC, Oh HM, Kim S, Lee HJ, Cho EY, Yoon KH, Kim EA, Han WC, Choi SC, Hwang JY, Park C, Oh BS, Kim Y, Kimm KC, Park KI, Chung HT, Jun CD.

J Immunol. 2004 Jun 1;172(11):7069-77.

35.

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.

Misra RN, Xiao HY, Kim KS, Lu S, Han WC, Barbosa SA, Hunt JT, Rawlins DB, Shan W, Ahmed SZ, Qian L, Chen BC, Zhao R, Bednarz MS, Kellar KA, Mulheron JG, Batorsky R, Roongta U, Kamath A, Marathe P, Ranadive SA, Sack JS, Tokarski JS, Pavletich NP, Lee FY, Webster KR, Kimball SD.

J Med Chem. 2004 Mar 25;47(7):1719-28. Erratum in: J Med Chem. 2015 Sep 24;58(18):7609.

PMID:
15027863
36.

Soluble factor from murine bladder tumor-2 cell elevates nitric oxide production in macrophages and enhances the taxol-mediated macrophage cytotoxicity on tumor cells.

Choi SC, Oh HM, Park JS, Han WC, Yoon KH, Kim TH, Yun KJ, Kim EC, Nah YH, Cha YN, Chung HT, Jun CD.

Cancer Invest. 2003;21(5):708-19.

PMID:
14628429
37.

Downregulation of p38 kinase pathway by cAMP response element-binding protein protects HL-60 cells from iron chelator-induced apoptosis.

Choi SC, Kim BS, Song MY, Choi EY, Oh HM, Lyou JH, Han WC, Moon HB, Kim TH, Oh JM, Chung HT, Jun CD.

Free Radic Biol Med. 2003 Nov 15;35(10):1171-84.

PMID:
14607516
38.

An efficient method for the rapid establishment of Epstein-Barr virus immortalization of human B lymphocytes.

Oh HM, Oh JM, Choi SC, Kim SW, Han WC, Kim TH, Park DS, Jun CD.

Cell Prolif. 2003 Aug;36(4):191-7.

PMID:
12950388
39.

Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death.

Kim BS, Yoon KH, Oh HM, Choi EY, Kim SW, Han WC, Kim EA, Choi SC, Kim TH, Yun KJ, Kim EC, Lyou JH, Nah YH, Chung HT, Cha YN, Jun CD.

Cell Immunol. 2002 Dec;220(2):96-106.

PMID:
12657244
40.

Soluble factor from tumor cells induces heme oxygenase-1 by a nitric oxide-independent mechanism in murine peritoneal macrophages.

Kim SW, Oh HM, Kim BS, Chung HT, Han WC, Kim EC, Kim TH, Seo GS, Lyou JH, Nah YH, Jung JC, Choi SC, Jun CD.

Exp Mol Med. 2003 Feb 28;35(1):53-9.

PMID:
12642904
41.

Oxidative activation of acylguanidine prodrugs: intestinal presystemic activation in rats limits absorption and can be inhibited by co-administration of ketoconazole.

Humphreys WG, Obermeier MT, Chong S, Kimball SD, Das J, Chen P, Moquin R, Han WC, Gedamke R, White RE, Morrison RA.

Xenobiotica. 2003 Jan;33(1):93-106.

PMID:
12519697
42.

Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity.

Iwanowicz EJ, Kimball SD, Lin J, Lau W, Han WC, Wang TC, Roberts DG, Schumacher WA, Ogletree ML, Seiler SM.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3183-6.

PMID:
12372529
43.

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.

Kim KS, Kimball SD, Misra RN, Rawlins DB, Hunt JT, Xiao HY, Lu S, Qian L, Han WC, Shan W, Mitt T, Cai ZW, Poss MA, Zhu H, Sack JS, Tokarski JS, Chang CY, Pavletich N, Kamath A, Humphreys WG, Marathe P, Bursuker I, Kellar KA, Roongta U, Batorsky R, Mulheron JG, Bol D, Fairchild CR, Lee FY, Webster KR.

J Med Chem. 2002 Aug 29;45(18):3905-27.

PMID:
12190313
44.

Immunohistochemical Study for CD44v6 in Hepatocellular Carcinoma and Cholangiocarcinoma.

Yun KJ, Yoon KH, Han WC.

Cancer Res Treat. 2002 Jun;34(3):170-4. doi: 10.4143/crt.2002.34.3.170.

PMID:
26680859
45.

Immunohistochemical Study of beta-catenin Expression between Hepatocellular Carcinoma and Cholangiocarcinoma.

Yun KJ, Han WC, Choi SC, Kim TH.

Cancer Res Treat. 2002 Apr;34(2):117-21. doi: 10.4143/crt.2002.34.2.117.

PMID:
26680852
46.

Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664.

Das J, Kimball SD, Hall SE, Han WC, Iwanowicz E, Lin J, Moquin RV, Reid JA, Sack JS, Malley MF, Chang CY, Chong S, Wang-Iverson DB, Roberts DG, Seiler SM, Schumacher WA, Ogletree ML.

Bioorg Med Chem Lett. 2002 Jan 7;12(1):45-9.

PMID:
11738570
47.

Proximal extracranial vertebral artery disease in the New England Medical Center Posterior Circulation Registry.

Wityk RJ, Chang HM, Rosengart A, Han WC, DeWitt LD, Pessin MS, Caplan LR.

Arch Neurol. 1998 Apr;55(4):470-8.

PMID:
9561974
48.

Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.

Tabernero L, Chang CY, Ohringer SL, Lau WF, Iwanowicz EJ, Han WC, Wang TC, Seiler SM, Roberts DG, Sack JS.

J Mol Biol. 1995 Feb 10;246(1):14-20.

PMID:
7853394
49.

Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists.

Misra RN, Brown BR, Sher PM, Patel MM, Hall SE, Han WC, Barrish JC, Kocy O, Harris DN, Goldenberg HJ, et al.

J Med Chem. 1993 May 14;36(10):1401-17.

PMID:
8496908
50.

Pharmacological characterization of potent, long-acting thromboxane receptor antagonists, SQ 33,261 and SQ 33,552.

Harris DN, Michel IM, Goldenberg HJ, Hartl KS, Allen GT, Steinbacher TE, Schumacher WA, Han WC, Hall SE, Floyd DM, et al.

J Pharmacol Exp Ther. 1992 Apr;261(1):131-7.

PMID:
1532833

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