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The social determinants of chronic disease management: perspectives of elderly patients with hypertension from low socio-economic background in Singapore.

Tan ST, Quek RYC, Haldane V, Koh JJK, Han EKL, Ong SE, Chuah FLH, Legido-Quigley H.

Int J Equity Health. 2019 Jan 3;18(1):1. doi: 10.1186/s12939-018-0897-7.


Development of 26 microsatellite markers in Bupleurum latissimum (Apiaceae), an endangered plant endemic to Ulleung Island, Korea.

Lee JH, Yoon CY, Han EK, Kim JH.

Appl Plant Sci. 2018 May 2;6(4):e1144. doi: 10.1002/aps3.1144. eCollection 2018 Apr.


ABBV-399, a c-Met Antibody-Drug Conjugate that Targets Both MET-Amplified and c-Met-Overexpressing Tumors, Irrespective of MET Pathway Dependence.

Wang J, Anderson MG, Oleksijew A, Vaidya KS, Boghaert ER, Tucker L, Zhang Q, Han EK, Palma JP, Naumovski L, Reilly EB.

Clin Cancer Res. 2017 Feb 15;23(4):992-1000. doi: 10.1158/1078-0432.CCR-16-1568. Epub 2016 Aug 29.


Aminopyrimidinone cdc7 kinase inhibitors.

Woods KW, Lai C, Miyashiro JM, Tong Y, Florjancic AS, Han EK, Soni N, Shi Y, Lasko L, Leverson JD, Johnson EF, Shoemaker AR, Penning TD.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1940-3. doi: 10.1016/j.bmcl.2012.01.041. Epub 2012 Jan 25.


Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.

Tao ZF, Hasvold LA, Leverson JD, Han EK, Guan R, Johnson EF, Stoll VS, Stewart KD, Stamper G, Soni N, Bouska JJ, Luo Y, Sowin TJ, Lin NH, Giranda VS, Rosenberg SH, Penning TD.

J Med Chem. 2009 Nov 12;52(21):6621-36. doi: 10.1021/jm900943h.


Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways.

Liu X, Han EK, Anderson M, Shi Y, Semizarov D, Wang G, McGonigal T, Roberts L, Lasko L, Palma J, Zhu GD, Penning T, Rosenberg S, Giranda VL, Luo Y, Leverson J, Johnson EF, Shoemaker AR.

Mol Cancer Res. 2009 Oct;7(10):1686-92. doi: 10.1158/1541-7786.MCR-09-0299. Epub 2009 Oct 13.


Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract.

Ham SS, Kim SH, Moon SY, Chung MJ, Cui CB, Han EK, Chung CK, Choe M.

Mutat Res. 2009 Jan;672(1):55-9. doi: 10.1016/j.mrgentox.2008.10.002. Epub 2008 Oct 17.


Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells.

Han EK, Mcgonigal T, Butler C, Giranda VL, Luo Y.

Anticancer Res. 2008 Mar-Apr;28(2A):957-63.


Role of focal adhesion kinase in human cancer: a potential target for drug discovery.

Han EK, McGonigal T.

Anticancer Agents Med Chem. 2007 Nov;7(6):681-4. Review.


Prevalence of narcolepsy-cataplexy in Korean adolescents.

Shin YK, Yoon IY, Han EK, No YM, Hong MC, Yun YD, Jung BK, Chung SH, Choi JB, Cyn JG, Lee YJ, Hong SC.

Acta Neurol Scand. 2008 Apr;117(4):273-8. Epub 2007 Oct 8.


ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models.

Donawho CK, Luo Y, Luo Y, Penning TD, Bauch JL, Bouska JJ, Bontcheva-Diaz VD, Cox BF, DeWeese TL, Dillehay LE, Ferguson DC, Ghoreishi-Haack NS, Grimm DR, Guan R, Han EK, Holley-Shanks RR, Hristov B, Idler KB, Jarvis K, Johnson EF, Kleinberg LR, Klinghofer V, Lasko LM, Liu X, Marsh KC, McGonigal TP, Meulbroek JA, Olson AM, Palma JP, Rodriguez LE, Shi Y, Stavropoulos JA, Tsurutani AC, Zhu GD, Rosenberg SH, Giranda VL, Frost DJ.

Clin Cancer Res. 2007 May 1;13(9):2728-37.


Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition.

Han EK, Leverson JD, McGonigal T, Shah OJ, Woods KW, Hunter T, Giranda VL, Luo Y.

Oncogene. 2007 Aug 16;26(38):5655-61. Epub 2007 Mar 5.


Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors.

Woods KW, Fischer JP, Claiborne A, Li T, Thomas SA, Zhu GD, Diebold RB, Liu X, Shi Y, Klinghofer V, Han EK, Guan R, Magnone SR, Johnson EF, Bouska JJ, Olson AM, de Jong R, Oltersdorf T, Luo Y, Rosenberg SH, Giranda VL, Li Q.

Bioorg Med Chem. 2006 Oct 15;14(20):6832-46. Epub 2006 Jul 14.


Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo.

Shi Y, Liu X, Han EK, Guan R, Shoemaker AR, Oleksijew A, Woods KW, Fisher JP, Klinghofer V, Lasko L, McGonigal T, Li Q, Rosenberg SH, Giranda VL, Luo Y.

Neoplasia. 2005 Nov;7(11):992-1000.


Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.

Luo Y, Shoemaker AR, Liu X, Woods KW, Thomas SA, de Jong R, Han EK, Li T, Stoll VS, Powlas JA, Oleksijew A, Mitten MJ, Shi Y, Guan R, McGonigal TP, Klinghofer V, Johnson EF, Leverson JD, Bouska JJ, Mamo M, Smith RA, Gramling-Evans EE, Zinker BA, Mika AK, Nguyen PT, Oltersdorf T, Rosenberg SH, Li Q, Giranda VL.

Mol Cancer Ther. 2005 Jun;4(6):977-86.


Chkl binds and phosphorylates BAD protein.

Han EK, Butler C, Zhang H, Severin JM, Qin W, Holzman TF, Gubbins EJ, Simmer RL, Rosenberg S, Giranda VL, Ng SC, Luo Y.

Anticancer Res. 2004 Nov-Dec;24(6):3907-10. Erratum in: Anticancer Res. 2005 Jan-Feb;25(1b):681. Severin, Jean M [added]; Qin, Wenying [added]; Holzman, Tom F [added]; Gubbins, Earl J [added]; Simmer, Robert L [added]. Anticancer Res. 2005 May-Jun;25(3c):2599.


Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs.

Han EK, Mcgonigal T, Wang J, Giranda VL, Luo Y.

Anticancer Res. 2004 Nov-Dec;24(6):3899-905.


Roles of cyclin D1 and related genes in growth inhibition, senescence and apoptosis.

Han EK, Ng SC, Arber N, Begemann M, Weinstein IB.

Apoptosis. 1999 Jun;4(3):213-9.


Protective effect of YHI and HHI-I against experimental acute pancreatitis in rabbits.

Zhao LG, Wu XX, Han EK, Chen YL, Chen C, Xu DQ.

World J Gastroenterol. 1998 Jun;4(3):256-259.


Blocking Chk1 expression induces apoptosis and abrogates the G2 checkpoint mechanism.

Luo Y, Rockow-Magnone SK, Kroeger PE, Frost L, Chen Z, Han EK, Ng SC, Simmer RL, Giranda VL.

Neoplasia. 2001 Sep-Oct;3(5):411-9.


Downregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells.

Liu X, Shi Y, Han EK, Chen Z, Rosenberg SH, Giranda VL, Luo Y, Ng SC.

Neoplasia. 2001 Jul-Aug;3(4):278-86.


A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors.

Tahir SK, Han EK, Credo B, Jae HS, Pietenpol JA, Scatena CD, Wu-Wong JR, Frost D, Sham H, Rosenberg SH, Ng SC.

Cancer Res. 2001 Jul 15;61(14):5480-5.


Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents.

Luo Y, Rockow-Magnone SK, Joseph MK, Bradner J, Butler CC, Tahir SK, Han EK, Ng SC, Severin JM, Gubbins EJ, Reilly RM, Rueter A, Simmer RL, Holzman TF, Giranda VL.

Anticancer Res. 2001 Jan-Feb;21(1A):23-8.


Identification and characterization of A-105972, an antineoplastic agent.

Wu-Wong JR, Alder JD, Alder L, Burns DJ, Han EK, Credo B, Tahir SK, Dayton BD, Ewing PJ, Chiou WJ.

Cancer Res. 2001 Feb 15;61(4):1486-92.


Modulation of drug resistance by alpha-tubulin in paclitaxel-resistant human lung cancer cell lines.

Han EK, Gehrke L, Tahir SK, Credo RB, Cherian SP, Sham H, Rosenberg SH, Ng S.

Eur J Cancer. 2000 Aug;36(12):1565-71. Erratum in: Eur J Cancer. 2007 Apr;43(6):1108. Kyu-Ho Han, E [corrected to Han, E K].


Modulation of paclitaxel resistance by annexin IV in human cancer cell lines.

Han EK, Tahir SK, Cherian SP, Collins N, Ng SC.

Br J Cancer. 2000 Jul;83(1):83-8.


The alpha isoform of protein kinase C mediates phorbol ester-induced growth inhibition and p21cip1 induction in HC11 mammary epithelial cells.

Slosberg ED, Klein MG, Yao Y, Han EK, Schieren I, Weinstein IB.

Oncogene. 1999 Nov 18;18(48):6658-66.


Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines.

Lim JT, Piazza GA, Han EK, Delohery TM, Li H, Finn TS, Buttyan R, Yamamoto H, Sperl GJ, Brendel K, Gross PH, Pamukcu R, Weinstein IB.

Biochem Pharmacol. 1999 Oct 1;58(7):1097-107.


Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy.

Weinstein IB, Begemann M, Zhou P, Han EK, Sgambato A, Doki Y, Arber N, Ciaparrone M, Yamamoto H.

Clin Cancer Res. 1997 Dec;3(12 Pt 2):2696-702.


Identification of in vivo phosphorylation sites for basic-directed kinases in murine mdr1b P-glycoprotein by combination of mass spectrometry and site-directed mutagenesis.

Glavy JS, Wolfson M, Nieves E, Han EK, Yang CP, Horwitz SB, Orr GA.

Methods Enzymol. 1998;292:342-58. No abstract available.


Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines.

Han EK, Arber N, Yamamoto H, Lim JT, Delohery T, Pamukcu R, Piazza GA, Xing WQ, Weinstein IB.

Breast Cancer Res Treat. 1998 Apr;48(3):195-203.


Overexpression of PKCepsilon in R6 fibroblasts causes increased production of active TGFbeta.

Cacace AM, Ueffing M, Han EK, Marmè D, Weinstein IB.

J Cell Physiol. 1998 Jun;175(3):314-22.


Cyclin D1 expression in human prostate carcinoma cell lines and primary tumors.

Han EK, Lim JT, Arber N, Rubin MA, Xing WQ, Weinstein IB.

Prostate. 1998 May;35(2):95-101.


A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes.

Arber N, Han EK, Sgambato A, Piazza GA, Delohery TM, Begemann M, Weghorst CM, Kim NH, Pamukcu R, Ahnen DJ, Reed JC, Weinstein IB, Holt PR.

Gastroenterology. 1997 Dec;113(6):1892-900.


Effects of cyclin D1 overexpression on G1 progression-related events.

Imoto M, Doki Y, Jiang W, Han EK, Weinstein IB.

Exp Cell Res. 1997 Oct 10;236(1):173-80.


Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin D1.

Doki Y, Imoto M, Han EK, Sgambato A, Weinstein IB.

Carcinogenesis. 1997 Jun;18(6):1139-48.


Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells.

Arber N, Doki Y, Han EK, Sgambato A, Zhou P, Kim NH, Delohery T, Klein MG, Holt PR, Weinstein IB.

Cancer Res. 1997 Apr 15;57(8):1569-74.


PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase.

Cacace AM, Ueffing M, Philipp A, Han EK, Kolch W, Weinstein IB.

Oncogene. 1996 Dec 19;13(12):2517-26.


Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis.

Han EK, Begemann M, Sgambato A, Soh JW, Doki Y, Xing WQ, Liu W, Weinstein IB.

Cell Growth Differ. 1996 Jun;7(6):699-710.


Characterization of the glucose-induced inactivation of maltose permease in Saccharomyces cerevisiae.

Medintz I, Jiang H, Han EK, Cui W, Michels CA.

J Bacteriol. 1996 Apr;178(8):2245-54.


Altered expression of cyclins and c-fos in R6 cells that overproduce PKC epsilon.

Han EK, Cacace AM, Sgambato A, Weinstein IB.

Carcinogenesis. 1995 Oct;16(10):2423-8.


Characterization of AGT1 encoding a general alpha-glucoside transporter from Saccharomyces.

Han EK, Cotty F, Sottas C, Jiang H, Michels CA.

Mol Microbiol. 1995 Sep;17(6):1093-107.


Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors.

Sgambato A, Han EK, Zhang YJ, Moon RC, Santella RM, Weinstein IB.

Carcinogenesis. 1995 Sep;16(9):2193-8.


Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth.

Han EK, Sgambato A, Jiang W, Zhang YJ, Santella RM, Doki Y, Cacace AM, Schieren I, Weinstein IB.

Oncogene. 1995 Mar 2;10(5):953-61.


Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites.

Orr GA, Han EK, Browne PC, Nieves E, O'Connor BM, Yang CP, Horwitz SB.

J Biol Chem. 1993 Nov 25;268(33):25054-62.


Point mutation at codon 12 of the c-Ha-ras gene in human gastric cancers.

Koh EH, Chung HC, Lee KB, Han EK, Oh SH, Min JS, Choi EM, Youn JK, Kim BS.

J Korean Med Sci. 1992 Jun;7(2):110-5.


Biochemical and genetic characterization of the multidrug resistance phenotype in murine macrophage-like J774.2 cells.

Kirschner LS, Greenberger LM, Hsu SI, Yang CP, Cohen D, Piekarz RL, Castillo G, Han EK, Yu LJ, Horwitz SB.

Biochem Pharmacol. 1992 Jan 9;43(1):77-87.


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