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Genomic and transcriptomic landscapes of Epstein-Barr virus in extranodal natural killer T-cell lymphoma.

Peng RJ, Han BW, Cai QQ, Zuo XY, Xia T, Chen JR, Feng LN, Lim JQ, Chen SW, Zeng MS, Guo YM, Li B, Xia XJ, Xia Y, Laurensia Y, Chia BKH, Huang HQ, Young KH, Lim ST, Ong CK, Zeng YX, Bei JX.

Leukemia. 2018 Dec 13. doi: 10.1038/s41375-018-0324-5. [Epub ahead of print]


Design, Synthesis and Evaluation of Novel 3/4-((Substituted benzamidophenoxy)methyl)-N-hydroxybenzamides / propenamides as Histone Deacetylase Inhibitors and Antitumor Agents.

Anh DT, Thuan NT, Hai PT, Huong LT, Yen NTK, Han BW, Park EJ, Choi YJ, Kang JS, Hue VTM, Han SB, Nam NH.

Anticancer Agents Med Chem. 2018 Nov 13. doi: 10.2174/1871520618666181114113347. [Epub ahead of print]


Association of MCP-1 promoter polymorphism with susceptibility to nasopharyngeal carcinoma.

Niu Y, Zhou G, Wang Y, Qin J, Ping J, Zhang Q, Han BW, Liu YX, Yang C, Zhai Y, Zhang H, He F, Mai HQ, Bei JX, Li Y, Zhou G.

J Cell Biochem. 2018 Oct 28. doi: 10.1002/jcb.27962. [Epub ahead of print]


Global identification and characterization of lncRNAs that control inflammation in malignant cholangiocytes.

Han BW, Ye H, Wei PP, He B, Han C, Chen ZH, Chen YQ, Wang WT.

BMC Genomics. 2018 Oct 11;19(1):735. doi: 10.1186/s12864-018-5133-8.


Effects of metabolic abnormalities, hyperandrogenemia and clomiphene on liver function parameters among Chinese women with polycystic ovary syndrome: results from a randomized controlled trial.

Cai WY, Gao JS, Luo X, Ma HL, Ge H, Liu N, Xia Q, Wang Y, Han BW, Wu XK.

J Endocrinol Invest. 2018 Oct 3. doi: 10.1007/s40618-018-0953-6. [Epub ahead of print]


Lysyl-Transfer RNA Synthetase Induces the Maturation of Dendritic Cells through MAPK and NF-κB Pathways, Strongly Contributing to Enhanced Th1 Cell Responses.

Lim HX, Jung HJ, Lee A, Park SH, Han BW, Cho D, Kim TS.

J Immunol. 2018 Nov 1;201(9):2832-2841. doi: 10.4049/jimmunol.1800386. Epub 2018 Oct 1.


Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity.

Park JS, Park MC, Lee KY, Goughnour PC, Jeong SJ, Kim HS, Kim HJ, Lee BJ, Kim S, Han BW.

Int J Biol Macromol. 2018 Dec;120(Pt A):835-845. doi: 10.1016/j.ijbiomac.2018.08.171. Epub 2018 Aug 30.


Molecular organization of the type II-A CRISPR adaptation module and its interaction with Cas9 via Csn2.

Ka D, Jang DM, Han BW, Bae E.

Nucleic Acids Res. 2018 Oct 12;46(18):9805-9815. doi: 10.1093/nar/gky702.


Structural basis for the substrate recognition of peptidoglycan pentapeptides by Enterococcus faecalis VanYB.

Kim HS, Hahn H, Kim J, Jang DM, Lee JY, Back JM, Im HN, Kim H, Han BW, Suh SW.

Int J Biol Macromol. 2018 Nov;119:335-344. doi: 10.1016/j.ijbiomac.2018.07.081. Epub 2018 Jul 27.


Optimal bounds for the generalized Euler-Mascheroni constant.

Huang TR, Han BW, Ma XY, Chu YM.

J Inequal Appl. 2018;2018(1):118. doi: 10.1186/s13660-018-1711-1. Epub 2018 May 18.


Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells.

Hahn YI, Kim SJ, Choi BY, Cho KC, Bandu R, Kim KP, Kim DH, Kim W, Park JS, Han BW, Lee J, Na HK, Cha YN, Surh YJ.

Sci Rep. 2018 Apr 23;8(1):6409. doi: 10.1038/s41598-018-23840-2.


Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death.

Schneider NFZ, Cerella C, Lee JY, Mazumder A, Kim KR, de Carvalho A, Munkert J, Pádua RM, Kreis W, Kim KW, Christov C, Dicato M, Kim HJ, Han BW, Braga FC, Simões CMO, Diederich M.

Front Pharmacol. 2018 Mar 1;9:70. doi: 10.3389/fphar.2018.00070. eCollection 2018.


The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition.

Schnekenburger M, Mathieu V, Lefranc F, Jang JY, Masi M, Kijjoa A, Evidente A, Kim HJ, Kiss R, Dicato M, Han BW, Diederich M.

Molecules. 2018 Feb 5;23(2). pii: E333. doi: 10.3390/molecules23020333.


Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ.

Jang JY, Bae H, Lee YJ, Choi YI, Kim HJ, Park SB, Suh SW, Kim SW, Han BW.

Sci Rep. 2018 Jan 8;8(1):31. doi: 10.1038/s41598-017-18274-1.


Cytostatic hydroxycoumarin OT52 induces ER/Golgi stress and STAT3 inhibition triggering non-canonical cell death and synergy with BH3 mimetics in lung cancer.

Lee JY, Talhi O, Jang D, Cerella C, Gaigneaux A, Kim KW, Lee JW, Dicato M, Bachari K, Han BW, Silva AMS, Orlikova B, Diederich M.

Cancer Lett. 2018 Mar 1;416:94-108. doi: 10.1016/j.canlet.2017.12.007. Epub 2017 Dec 13.


The dialkyl resorcinol stemphol disrupts calcium homeostasis to trigger programmed immunogenic necrosis in cancer.

Ji S, Lee JY, Schrör J, Mazumder A, Jang DM, Chateauvieux S, Schnekenburger M, Hong CR, Christov C, Kang HJ, Lee Y, Han BW, Kim KW, Shin HY, Dicato M, Cerella C, König GM, Orlikova B, Diederich M.

Cancer Lett. 2018 Mar 1;416:109-123. doi: 10.1016/j.canlet.2017.12.011. Epub 2017 Dec 13.


Cell density-dependent differential proliferation of neural stem cells on omnidirectional nanopore-arrayed surface.

Cha KJ, Kong SY, Lee JS, Kim HW, Shin JY, La M, Han BW, Kim DS, Kim HJ.

Sci Rep. 2017 Oct 12;7(1):13077. doi: 10.1038/s41598-017-13372-6.


Protein energy malnutrition alters mucosal IgA responses and reduces mucosal vaccine efficacy in mice.

Rho S, Kim H, Shim SH, Lee SY, Kim MJ, Yang BG, Jang MH, Han BW, Song MK, Czerkinsky C, Kim JO.

Immunol Lett. 2017 Oct;190:247-256. doi: 10.1016/j.imlet.2017.08.025. Epub 2017 Aug 30.


Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.

Schnekenburger M, Goffin E, Lee JY, Jang JY, Mazumder A, Ji S, Rogister B, Bouider N, Lefranc F, Miklos W, Mathieu V, de Tullio P, Kim KW, Dicato M, Berger W, Han BW, Kiss R, Pirotte B, Diederich M.

J Med Chem. 2017 Jun 8;60(11):4714-4733. doi: 10.1021/acs.jmedchem.7b00533. Epub 2017 May 25.


Structural basis for differential activities of enantiomeric PPARγ agonists: Binding of S35 to the alternate site.

Jang JY, Koh M, Bae H, An DR, Im HN, Kim HS, Yoon JY, Yoon HJ, Han BW, Park SB, Suh SW.

Biochim Biophys Acta Proteins Proteom. 2017 Jun;1865(6):674-681. doi: 10.1016/j.bbapap.2017.03.008. Epub 2017 Mar 22.


The N-terminal region of organic anion transporting polypeptide 1B3 (OATP1B3) plays an essential role in regulating its plasma membrane trafficking.

Chun SE, Thakkar N, Oh Y, Park JE, Han S, Ryoo G, Hahn H, Maeng SH, Lim YR, Han BW, Lee W.

Biochem Pharmacol. 2017 May 1;131:98-105. doi: 10.1016/j.bcp.2017.02.013. Epub 2017 Feb 23.


Corrigendum: Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection.

Ahn YH, Park S, Choi JJ, Park BK, Rhee KH, Kang E, Ahn S, Lee CH, Lee JS, Inn KS, Cho ML, Park SH, Park K, Park HJ, Lee JH, Park JW, Kwon NH, Shim H, Han BW, Kim P, Lee JY, Jeon Y, Huh JW, Jin M, Kim S.

Nat Microbiol. 2017 Jan 23;2:17015. doi: 10.1038/nmicrobiol.2017.15. No abstract available.


Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection.

Ahn YH, Park S, Choi JJ, Park BK, Rhee KH, Kang E, Ahn S, Lee CH, Lee JS, Inn KS, Cho ML, Park SH, Park K, Park HJ, Lee JH, Park JW, Kwon NH, Shim H, Han BW, Kim P, Lee JY, Jeon Y, Huh JW, Jin M, Kim S.

Nat Microbiol. 2016 Oct 17;2:16191. doi: 10.1038/nmicrobiol.2016.191. Erratum in: Nat Microbiol. 2017 Jan 23;2:17015.


A comprehensive review of microRNA-related polymorphisms in gastric cancer.

Han BW, Li ZH, Liu SF, Han HB, Dong SJ, Zou HJ, Sun RF, Jia J.

Genet Mol Res. 2016 Jul 14;15(2). doi: 10.4238/gmr.15028289. Review.


Design, synthesis and biological evaluation of novel hydroxamic acids bearing artemisinin skeleton.

Ha VT, Kien VT, Binh le H, Tien VD, My NT, Nam NH, Baltas M, Hahn H, Han BW, Thao do T, Vu TK.

Bioorg Chem. 2016 Jun;66:63-71. doi: 10.1016/j.bioorg.2016.03.008. Epub 2016 Mar 17.


Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells.

Florean C, Schnekenburger M, Lee JY, Kim KR, Mazumder A, Song S, Kim JM, Grandjenette C, Kim JG, Yoon AY, Dicato M, Kim KW, Christov C, Han BW, Proksch P, Diederich M.

Oncotarget. 2016 Apr 26;7(17):24027-49. doi: 10.18632/oncotarget.8210.


Structure and Stability of the Dimeric Triosephosphate Isomerase from the Thermophilic Archaeon Thermoplasma acidophilum.

Park SH, Kim HS, Park MS, Moon S, Song MK, Park HS, Hahn H, Kim SJ, Bae E, Kim HJ, Han BW.

PLoS One. 2015 Dec 28;10(12):e0145331. doi: 10.1371/journal.pone.0145331. eCollection 2015.


PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine.

Lee JH, Park KM, Han DJ, Bang NY, Kim DH, Na H, Lim S, Kim TB, Kim DG, Kim HJ, Chung Y, Sung SH, Surh YJ, Kim S, Han BW.

PLoS One. 2015 Nov 10;10(11):e0142624. doi: 10.1371/journal.pone.0142624. eCollection 2015.


Synergistic induction of apoptosis by salinomycin and gefitinib through lysosomal and mitochondrial dependent pathway overcomes gefitinib resistance in colorectal cancer.

Zou ZZ, Nie PP, Li YW, Hou BX, Rui-Li, Shi XP, Ma ZK, Han BW, Luo XY.

Oncotarget. 2017 Apr 4;8(14):22414-22432. doi: 10.18632/oncotarget.5628.


Genome-wide screen identified let-7c/miR-99a/miR-125b regulating tumor progression and stem-like properties in cholangiocarcinoma.

Lin KY, Ye H, Han BW, Wang WT, Wei PP, He B, Li XJ, Chen YQ.

Oncogene. 2016 Jun 30;35(26):3376-86. doi: 10.1038/onc.2015.396. Epub 2015 Oct 12.


Overexpression of forkhead box protein M1 (FOXM1) plays a critical role in colorectal cancer.

Zhang HG, Xu XW, Shi XP, Han BW, Li ZH, Ren WH, Chen PJ, Lou YF, Li B, Luo XY.

Clin Transl Oncol. 2016 May;18(5):527-32. doi: 10.1007/s12094-015-1400-1. Epub 2015 Sep 14.


Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms.

Wang W, Han BW, Tipping C, Ge DT, Zhang Z, Weng Z, Zamore PD.

Mol Cell. 2015 Sep 3;59(5):819-30. doi: 10.1016/j.molcel.2015.08.007.


The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of L,D-Carboxypeptidase.

Kim HS, Im HN, An DR, Yoon JY, Jang JY, Mobashery S, Hesek D, Lee M, Yoo J, Cui M, Choi S, Kim C, Lee NK, Kim SJ, Kim JY, Bang G, Han BW, Lee BI, Yoon HJ, Suh SW.

J Biol Chem. 2015 Oct 9;290(41):25103-17. doi: 10.1074/jbc.M115.658781. Epub 2015 Aug 25.


Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing.

Han BW, Layman H, Rode NA, Conway A, Schaffer DV, Boudreau NJ, Jackson WM, Healy KE.

Tissue Eng Part A. 2015 Sep;21(17-18):2366-78. doi: 10.1089/ten.TEA.2014.0281.


Novel 3-substituted-2-oxoindoline-based N-hydroxypropenamides as histone deacetylase inhibitors and antitumor agents.

Dung do TM, Dung PT, Oanh DT, Hai PT, Huong le TT, Loi VD, Hahn H, Han BW, Kim J, Han SB, Nam NH.

Med Chem. 2015;11(8):725-35.


H-phosphonate-mediated sulfonylation of heteroaromatic N-oxides: a mild and metal-free one-pot synthesis of 2-sulfonyl quinolines/pyridines.

Sun K, Chen XL, Li X, Qu LB, Bi WZ, Chen X, Ma HL, Zhang ST, Han BW, Zhao YF, Li CJ.

Chem Commun (Camb). 2015 Aug 4;51(60):12111-4. doi: 10.1039/c5cc04484g.


Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs.

Chou MT, Han BW, Hsiao CP, Zamore PD, Weng Z, Hung JH.

Nucleic Acids Res. 2015 Sep 30;43(17):e109. doi: 10.1093/nar/gkv537. Epub 2015 May 24.


Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production.

Han BW, Wang W, Li C, Weng Z, Zamore PD.

Science. 2015 May 15;348(6236):817-21. doi: 10.1126/science.aaa1264.


Crystal structure of the protein At3g01520, a eukaryotic universal stress protein-like protein from Arabidopsis thaliana in complex with AMP.

Kim DJ, Bitto E, Bingman CA, Kim HJ, Han BW, Phillips GN Jr.

Proteins. 2015 Jul;83(7):1368-73. doi: 10.1002/prot.24821. Epub 2015 May 14.


The BioMart community portal: an innovative alternative to large, centralized data repositories.

Smedley D, Haider S, Durinck S, Pandini L, Provero P, Allen J, Arnaiz O, Awedh MH, Baldock R, Barbiera G, Bardou P, Beck T, Blake A, Bonierbale M, Brookes AJ, Bucci G, Buetti I, Burge S, Cabau C, Carlson JW, Chelala C, Chrysostomou C, Cittaro D, Collin O, Cordova R, Cutts RJ, Dassi E, Di Genova A, Djari A, Esposito A, Estrella H, Eyras E, Fernandez-Banet J, Forbes S, Free RC, Fujisawa T, Gadaleta E, Garcia-Manteiga JM, Goodstein D, Gray K, Guerra-Assunção JA, Haggarty B, Han DJ, Han BW, Harris T, Harshbarger J, Hastings RK, Hayes RD, Hoede C, Hu S, Hu ZL, Hutchins L, Kan Z, Kawaji H, Keliet A, Kerhornou A, Kim S, Kinsella R, Klopp C, Kong L, Lawson D, Lazarevic D, Lee JH, Letellier T, Li CY, Lio P, Liu CJ, Luo J, Maass A, Mariette J, Maurel T, Merella S, Mohamed AM, Moreews F, Nabihoudine I, Ndegwa N, Noirot C, Perez-Llamas C, Primig M, Quattrone A, Quesneville H, Rambaldi D, Reecy J, Riba M, Rosanoff S, Saddiq AA, Salas E, Sallou O, Shepherd R, Simon R, Sperling L, Spooner W, Staines DM, Steinbach D, Stone K, Stupka E, Teague JW, Dayem Ullah AZ, Wang J, Ware D, Wong-Erasmus M, Youens-Clark K, Zadissa A, Zhang SJ, Kasprzyk A.

Nucleic Acids Res. 2015 Jul 1;43(W1):W589-98. doi: 10.1093/nar/gkv350. Epub 2015 Apr 20.


Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells.

Kong SY, Park MH, Lee M, Kim JO, Lee HR, Han BW, Svendsen CN, Sung SH, Kim HJ.

PLoS One. 2015 Feb 23;10(2):e0118188. doi: 10.1371/journal.pone.0118188. eCollection 2015.


The initial uridine of primary piRNAs does not create the tenth adenine that Is the hallmark of secondary piRNAs.

Wang W, Yoshikawa M, Han BW, Izumi N, Tomari Y, Weng Z, Zamore PD.

Mol Cell. 2014 Dec 4;56(5):708-16. doi: 10.1016/j.molcel.2014.10.016. Epub 2014 Nov 20.


Structural basis for the recognition of muramyltripeptide by Helicobacter pylori Csd4, a D,L-carboxypeptidase controlling the helical cell shape.

Kim HS, Kim J, Im HN, An DR, Lee M, Hesek D, Mobashery S, Kim JY, Cho K, Yoon HJ, Han BW, Lee BI, Suh SW.

Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):2800-12. doi: 10.1107/S1399004714018732. Epub 2014 Oct 16.


Crystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway.

Park MS, Bitto E, Kim KR, Bingman CA, Miller MD, Kim HJ, Han BW, Phillips GN Jr.

PLoS One. 2014 Oct 30;9(10):e111142. doi: 10.1371/journal.pone.0111142. eCollection 2014.


piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing.

Han BW, Wang W, Zamore PD, Weng Z.

Bioinformatics. 2015 Feb 15;31(4):593-5. doi: 10.1093/bioinformatics/btu647. Epub 2014 Oct 17.


5-aryl-1,3,4-thiadiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents: synthesis, bioevaluation and docking study.

Huong TT, Dung do TM, Oanh DT, Lan TT, Dung PT, Loi VD, Kim KR, Han BW, Yun J, Kang JS, Kim Y, Han SB, Nam NH.

Med Chem. 2015;11(3):296-304.


Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calcium.

Lee J, Jung J, Tak MH, Wee J, Lee B, Jang Y, Chun H, Yang DJ, Yang YD, Park SH, Han BW, Hyun S, Yu J, Cho H, Hartzell HC, Oh U.

Pflugers Arch. 2015 Aug;467(8):1677-87. doi: 10.1007/s00424-014-1603-2. Epub 2014 Sep 19.



Han BW, Zamore PD.

Curr Biol. 2014 Aug 18;24(16):R730-3. doi: 10.1016/j.cub.2014.07.037. No abstract available.


MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia.

Zeng CW, Chen ZH, Zhang XJ, Han BW, Lin KY, Li XJ, Wei PP, Zhang H, Li Y, Chen YQ.

Autophagy. 2014 Oct 1;10(10):1726-37. doi: 10.4161/auto.29592. Epub 2014 Jul 18.

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