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Structure of the full-length Clostridium difficile toxin B.

Chen P, Lam KH, Liu Z, Mindlin FA, Chen B, Gutierrez CB, Huang L, Zhang Y, Hamza T, Feng H, Matsui T, Bowen ME, Perry K, Jin R.

Nat Struct Mol Biol. 2019 Aug;26(8):712-719. doi: 10.1038/s41594-019-0268-0. Epub 2019 Jul 15.


Incidence, determinants and impact of acute kidney injury in patients with diabetes mellitus and multivessel disease undergoing coronary revascularization: Results from the FREEDOM trial.

Arbel Y, Fuster V, Baber U, Hamza TH, Siami FS, Farkouh ME.

Int J Cardiol. 2019 Jun 13. pii: S0167-5273(18)36664-6. doi: 10.1016/j.ijcard.2019.05.064. [Epub ahead of print]


Response to "Be alert to leukocyte antibodies when prescribing granulocyte transfusions".

Price TH, McCullough J, Strauss RG, Ness PM, Hamza TH, Harrison RW, Assmann SF.

Transfusion. 2019 Jun;59(6):2174-2175. doi: 10.1111/trf.15258. No abstract available.


SYNTAX Score in Patients With Diabetes Undergoing Coronary Revascularization in the FREEDOM Trial.

Esper RB, Farkouh ME, Ribeiro EE, Hueb W, Domanski M, Hamza TH, Siami FS, Godoy LC, Mathew V, French J, Fuster V.

J Am Coll Cardiol. 2018 Dec 11;72(23 Pt A):2826-2837. doi: 10.1016/j.jacc.2018.09.046.


Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota.

Tam J, Hamza T, Ma B, Chen K, Beilhartz GL, Ravel J, Feng H, Melnyk RA.

Nat Commun. 2018 Dec 7;9(1):5233. doi: 10.1038/s41467-018-07705-w.


Long-Term Survival Following Multivessel Revascularization in Patients With Diabetes: The FREEDOM Follow-On Study.

Farkouh ME, Domanski M, Dangas GD, Godoy LC, Mack MJ, Siami FS, Hamza TH, Shah B, Stefanini GG, Sidhu MS, Tanguay JF, Ramanathan K, Sharma SK, French J, Hueb W, Cohen DJ, Fuster V; FREEDOM Follow-On Study Investigators.

J Am Coll Cardiol. 2019 Feb 19;73(6):629-638. doi: 10.1016/j.jacc.2018.11.001. Epub 2018 Nov 11.


WBC alloimmunization: effects on the laboratory and clinical endpoints of therapeutic granulocyte transfusions.

Price TH, McCullough J, Strauss RG, Ness PM, Hamza TH, Harrison RW, Assmann SF.

Transfusion. 2018 May;58(5):1280-1288. doi: 10.1111/trf.14551. Epub 2018 Mar 1.


Mice with Inflammatory Bowel Disease are Susceptible to Clostridium difficile Infection With Severe Disease Outcomes.

Zhou F, Hamza T, Fleur AS, Zhang Y, Yu H, Chen K, Heath JE, Chen Y, Huang H, Feng H.

Inflamm Bowel Dis. 2018 Feb 15;24(3):573-582. doi: 10.1093/ibd/izx059.


Compliance With Guideline-Directed Medical Therapy in Contemporary Coronary Revascularization Trials.

Pinho-Gomes AC, Azevedo L, Ahn JM, Park SJ, Hamza TH, Farkouh ME, Serruys PW, Milojevic M, Kappetein AP, Stone GW, Lamy A, Fuster V, Taggart DP.

J Am Coll Cardiol. 2018 Feb 13;71(6):591-602. doi: 10.1016/j.jacc.2017.11.068.


Fracture Resistance of Monolithic Glass-Ceramics Versus Bilayered Zirconia-Based Restorations.

Hamza TA, Sherif RM.

J Prosthodont. 2019 Jan;28(1):e259-e264. doi: 10.1111/jopr.12684. Epub 2017 Oct 18.


The role of purified Clostridium difficile glucosylating toxins in disease pathogenesis utilizing a murine cecum injection model.

Zhang Y, Yang Z, Gao S, Hamza T, Yfantis HG, Lipsky M, Feng H.

Anaerobe. 2017 Dec;48:249-256. doi: 10.1016/j.anaerobe.2017.10.006. Epub 2017 Oct 12.


Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial.

Uhl L, Assmann SF, Hamza TH, Harrison RW, Gernsheimer T, Slichter SJ.

Blood. 2017 Sep 7;130(10):1247-1258. doi: 10.1182/blood-2017-01-757930. Epub 2017 Jul 5.


Clinical outcomes in a cohort of patients with heparin-induced thrombocytopenia.

Kuter DJ, Konkle BA, Hamza TH, Uhl L, Assmann SF, Kiss JE, Kaufman RM, Key NS, Sachais BS, Hess JR, Ness P, McCrae KR, Leissinger C, Strauss RG, McFarland JG, Neufeld E, Bussel JB, Ortel TL.

Am J Hematol. 2017 Aug;92(8):730-738. doi: 10.1002/ajh.24759. Epub 2017 Apr 26.


Vitamin D status and abdominal aortic calcification in postmenopausal women.

El Maghraoui A, Hamza T, Sadni S, El Maataoui A, Majjad A, Rezqi A, Ouzzif Z, Mounach A.

J Bone Miner Metab. 2018 Mar;36(2):229-237. doi: 10.1007/s00774-017-0832-9. Epub 2017 Mar 31.


Dual Antiplatelet Therapy Versus Aspirin Monotherapy in Diabetics With Multivessel Disease Undergoing CABG: FREEDOM Insights.

van Diepen S, Fuster V, Verma S, Hamza TH, Siami FS, Goodman SG, Farkouh ME.

J Am Coll Cardiol. 2017 Jan 17;69(2):119-127. doi: 10.1016/j.jacc.2016.10.043.


In vitro evaluation of marginal discrepancy of monolithic zirconia restorations fabricated with different CAD-CAM systems.

Hamza TA, Sherif RM.

J Prosthet Dent. 2017 Jun;117(6):762-766. doi: 10.1016/j.prosdent.2016.09.011. Epub 2016 Nov 9.


Investigation of solar noise impact on the performance of underwater wireless optical communication links.

Hamza T, Khalighi MA, Bourennane S, Léon P, Opderbecke J.

Opt Express. 2016 Oct 31;24(22):25832-25845. doi: 10.1364/OE.24.025832.


LightAssembler: fast and memory-efficient assembly algorithm for high-throughput sequencing reads.

El-Metwally S, Zakaria M, Hamza T.

Bioinformatics. 2016 Nov 1;32(21):3215-3223. Epub 2016 Jul 13.


Comparative efficacy of coronary artery bypass surgery vs. percutaneous coronary intervention in patients with diabetes and multivessel coronary artery disease with or without chronic kidney disease.

Baber U, Farkouh ME, Arbel Y, Muntner P, Dangas G, Mack MJ, Hamza TH, Mehran R, Fuster V.

Eur Heart J. 2016 Dec 7;37(46):3440-3447. doi: 10.1093/eurheartj/ehw378. Epub 2016 Aug 29.


Is there a relation between pre-sarcopenia, sarcopenia, cachexia and osteoporosis in patients with ankylosing spondylitis?

El Maghraoui A, Ebo'o FB, Sadni S, Majjad A, Hamza T, Mounach A.

BMC Musculoskelet Disord. 2016 Jul 11;17:268. doi: 10.1186/s12891-016-1155-z.


Pilin Vaccination Stimulates Weak Antibody Responses and Provides No Protection in a C57Bl/6 Murine Model of Acute Clostridium difficile Infection.

Maldarelli GA, Matz H, Gao S, Chen K, Hamza T, Yfantis HG, Feng H, Donnenberg MS.

J Vaccines Vaccin. 2016;7(3). pii: 321. Epub 2016 May 27.


A novel co-culture model of murine K12 osteosarcoma cells and S. aureus on common orthopedic implant materials: 'the race to the surface' studied in vitro.

McConda DB, Karnes JM, Hamza T, Lindsey BA.

Biofouling. 2016 Jul;32(6):627-34. doi: 10.1080/08927014.2016.1172572.


Nanoparticles targeting to osteoblasts for potential intracellular pathogen elimination.

Chen X, Jiang B, Hamza T, Li B.

J Control Release. 2015 Sep 10;213:e10-1. doi: 10.1016/j.jconrel.2015.05.013. Epub 2015 Aug 19. No abstract available.


Flexural strength of small connector designs of zirconia-based partial fixed dental prostheses.

Hamza TA, Attia MA, El-Hossary MM, Mosleh IE, Shokry TE, Wee AG.

J Prosthet Dent. 2016 Feb;115(2):224-9. doi: 10.1016/j.prosdent.2015.06.022. Epub 2015 Nov 4.


Defective mutations within the translocation domain of Clostridium difficile toxin B impair disease pathogenesis.

Hamza T, Zhang Z, Melnyk RA, Feng H.

Pathog Dis. 2016 Feb;74(1):ftv098. doi: 10.1093/femspd/ftv098. Epub 2015 Oct 26.


Efficacy of transfusion with granulocytes from G-CSF/dexamethasone-treated donors in neutropenic patients with infection.

Price TH, Boeckh M, Harrison RW, McCullough J, Ness PM, Strauss RG, Nichols WG, Hamza TH, Cushing MM, King KE, Young JA, Williams E, McFarland J, Holter Chakrabarty J, Sloan SR, Friedman D, Parekh S, Sachais BS, Kiss JE, Assmann SF.

Blood. 2015 Oct 29;126(18):2153-61. doi: 10.1182/blood-2015-05-645986. Epub 2015 Sep 2.


Masking autoprocessing of Clostridium difficile toxin A by the C-terminus combined repetitive oligo peptides.

Zhang Y, Hamza T, Gao S, Feng H.

Biochem Biophys Res Commun. 2015 Apr 3;459(2):259-263. doi: 10.1016/j.bbrc.2015.02.095. Epub 2015 Feb 26.


Mechanisms of protection against Clostridium difficile infection by the monoclonal antitoxin antibodies actoxumab and bezlotoxumab.

Yang Z, Ramsey J, Hamza T, Zhang Y, Li S, Yfantis HG, Lee D, Hernandez LD, Seghezzi W, Furneisen JM, Davis NM, Therien AG, Feng H.

Infect Immun. 2015 Feb;83(2):822-31. doi: 10.1128/IAI.02897-14. Epub 2014 Dec 8.


Glutamate receptor gene GRIN2A, coffee, and Parkinson disease.

Hamza TH, Hill-Burns EM, Scott WK, Vance JM, Factor SA, Zabetian CP, Payami H.

PLoS Genet. 2014 Nov 20;10(11):e1004774. doi: 10.1371/journal.pgen.1004774. eCollection 2014 Nov. No abstract available.


Cardiac tamponade masquerading as gastritis: a case report.

Ahmed A, Harsha TS, Hamza T, Allen A, Mohamed E.

J Med Case Rep. 2014 Jul 30;8:264. doi: 10.1186/1752-1947-8-264.


Differential responses of osteoblasts and macrophages upon Staphylococcus aureus infection.

Hamza T, Li B.

BMC Microbiol. 2014 Jul 25;14:207. doi: 10.1186/s12866-014-0207-5.


Effect of polyhedral silsesquioxane (POSS) on the flexural strength and color of interim materials.

Hamza TA, Johnston WM, Schricker SR.

J Prosthet Dent. 2014 Aug;112(2):228-34. doi: 10.1016/j.prosdent.2014.01.008. Epub 2014 Mar 28.


Identification of a novel Parkinson's disease locus via stratified genome-wide association study.

Hill-Burns EM, Wissemann WT, Hamza TH, Factor SA, Zabetian CP, Payami H.

BMC Genomics. 2014 Feb 10;15:118. doi: 10.1186/1471-2164-15-118.


Next-generation sequence assembly: four stages of data processing and computational challenges.

El-Metwally S, Hamza T, Zakaria M, Helmy M.

PLoS Comput Biol. 2013;9(12):e1003345. doi: 10.1371/journal.pcbi.1003345. Epub 2013 Dec 12. Review.


Intra-cellular Staphylococcus aureus alone causes infection in vivo.

Hamza T, Dietz M, Pham D, Clovis N, Danley S, Li B.

Eur Cell Mater. 2013 Jul 8;25:341-50; discussion 350.


Unique antimicrobial effects of platelet-rich plasma and its efficacy as a prophylaxis to prevent implant-associated spinal infection.

Li H, Hamza T, Tidwell JE, Clovis N, Li B.

Adv Healthc Mater. 2013 Sep;2(9):1277-84. doi: 10.1002/adhm.201200465. Epub 2013 Feb 27.


Accuracy of ceramic restorations made with two CAD/CAM systems.

Hamza TA, Ezzat HA, El-Hossary MM, Katamish HA, Shokry TE, Rosenstiel SF.

J Prosthet Dent. 2013 Feb;109(2):83-7. doi: 10.1016/S0022-3913(13)60020-7.


A genetic basis for the variable effect of smoking/nicotine on Parkinson's disease.

Hill-Burns EM, Singh N, Ganguly P, Hamza TH, Montimurro J, Kay DM, Yearout D, Sheehan P, Frodey K, McLear JA, Feany MB, Hanes SD, Wolfgang WJ, Zabetian CP, Factor SA, Payami H.

Pharmacogenomics J. 2013 Dec;13(6):530-7. doi: 10.1038/tpj.2012.38. Epub 2012 Oct 2.


Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.

Pankratz N, Beecham GW, DeStefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T; PD GWAS Consortium.

Ann Neurol. 2012 Mar;71(3):370-84. doi: 10.1002/ana.22687.


Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.

Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L.

PLoS Genet. 2012;8(3):e1002548. doi: 10.1371/journal.pgen.1002548. Epub 2012 Mar 15.


Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee.

Hamza TH, Chen H, Hill-Burns EM, Rhodes SL, Montimurro J, Kay DM, Tenesa A, Kusel VI, Sheehan P, Eaaswarkhanth M, Yearout D, Samii A, Roberts JW, Agarwal P, Bordelon Y, Park Y, Wang L, Gao J, Vance JM, Kendler KS, Bacanu SA, Scott WK, Ritz B, Nutt J, Factor SA, Zabetian CP, Payami H.

PLoS Genet. 2011 Aug;7(8):e1002237. doi: 10.1371/journal.pgen.1002237. Epub 2011 Aug 18.


An attempt to replicate interaction between coffee and CYP1A2 gene in connection to Parkinson's disease.

Hill-Burns EM, Hamza TH, Zabetian CP, Factor SA, Payami H.

Eur J Neurol. 2011 Sep;18(9):e107-8; author reply e109. doi: 10.1111/j.1468-1331.2011.03464.x. No abstract available.


A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2.

Kay DM, Stevens CF, Hamza TH, Montimurro JS, Zabetian CP, Factor SA, Samii A, Griffith A, Roberts JW, Molho ES, Higgins DS, Gancher S, Moses L, Zareparsi S, Poorkaj P, Bird T, Nutt J, Schellenberg GD, Payami H.

Neurology. 2010 Sep 28;75(13):1189-94. doi: 10.1212/WNL.0b013e3181f4d832.


Random effects meta-analysis of event outcome in the framework of the generalized linear mixed model with applications in sparse data.

Stijnen T, Hamza TH, Ozdemir P.

Stat Med. 2010 Dec 20;29(29):3046-67. doi: 10.1002/sim.4040.


Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.

Hamza TH, Zabetian CP, Tenesa A, Laederach A, Montimurro J, Yearout D, Kay DM, Doheny KF, Paschall J, Pugh E, Kusel VI, Collura R, Roberts J, Griffith A, Samii A, Scott WK, Nutt J, Factor SA, Payami H.

Nat Genet. 2010 Sep;42(9):781-5. doi: 10.1038/ng.642. Epub 2010 Aug 15.


Interleukin 12 a key immunoregulatory cytokine in infection applications.

Hamza T, Barnett JB, Li B.

Int J Mol Sci. 2010 Feb 26;11(3):789-806. doi: 10.3390/ijms11030789. Review.


The heritability of risk and age at onset of Parkinson's disease after accounting for known genetic risk factors.

Hamza TH, Payami H.

J Hum Genet. 2010 Apr;55(4):241-3. doi: 10.1038/jhg.2010.13. Epub 2010 Mar 5.


Effect of metal selection and porcelain firing on the marginal accuracy of titanium-based metal ceramic restorations.

Shokry TE, Attia M, Mosleh I, Elhosary M, Hamza T, Shen C.

J Prosthet Dent. 2010 Jan;103(1):45-52. doi: 10.1016/S0022-3913(09)60216-X. Epub 2009 Dec 22.


Multivariate random effects meta-analysis of diagnostic tests with multiple thresholds.

Hamza TH, Arends LR, van Houwelingen HC, Stijnen T.

BMC Med Res Methodol. 2009 Nov 10;9:73. doi: 10.1186/1471-2288-9-73.


Differences in characteristics and risk of cardiovascular disease in familial hypercholesterolemia patients with and without tendon xanthomas: a systematic review and meta-analysis.

Oosterveer DM, Versmissen J, Yazdanpanah M, Hamza TH, Sijbrands EJ.

Atherosclerosis. 2009 Dec;207(2):311-7. doi: 10.1016/j.atherosclerosis.2009.04.009. Epub 2009 Apr 17. Review.


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