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Items: 1 to 50 of 154

1.

In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots.

Toda M, Yukawa H, Yamada J, Ueno M, Kinoshita S, Baba Y, Hamuro J.

Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):4008-4020. doi: 10.1167/iovs.19-27788.

PMID:
31560364
2.

A physical biomarker of the quality of cultured corneal endothelial cells and of the long-term prognosis of corneal restoration in patients.

Yamamoto A, Tanaka H, Toda M, Sotozono C, Hamuro J, Kinoshita S, Ueno M, Tanaka M.

Nat Biomed Eng. 2019 Dec;3(12):953-960. doi: 10.1038/s41551-019-0429-9. Epub 2019 Jul 22.

PMID:
31332343
3.

Distinctly regulated functions and mobilization of CD11c-positive cells elicited by TLR3- and IPS-1 signaling in the cornea.

Ueta M, Hamuro J, Ohsako S, Kinoshita S.

Immunol Lett. 2019 Feb;206:49-53. doi: 10.1016/j.imlet.2018.12.004. Epub 2018 Dec 17.

4.

Association of Upregulated Angiogenic Cytokines With Choroidal Abnormalities in Chronic Central Serous Chorioretinopathy.

Terao N, Koizumi H, Kojima K, Yamagishi T, Nagata K, Kitazawa K, Yamamoto Y, Yoshii K, Hiraga A, Toda M, Kinoshita S, Sotozono C, Hamuro J.

Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5924-5931. doi: 10.1167/iovs.18-25517.

PMID:
30551200
5.

Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration.

Terao N, Koizumi H, Kojima K, Yamagishi T, Yamamoto Y, Yoshii K, Kitazawa K, Hiraga A, Toda M, Kinoshita S, Sotozono C, Hamuro J.

Sci Rep. 2018 Jul 12;8(1):10520. doi: 10.1038/s41598-018-28484-w.

6.

Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy.

Kinoshita S, Koizumi N, Ueno M, Okumura N, Imai K, Tanaka H, Yamamoto Y, Nakamura T, Inatomi T, Bush J, Toda M, Hagiya M, Yokota I, Teramukai S, Sotozono C, Hamuro J.

N Engl J Med. 2018 Mar 15;378(11):995-1003. doi: 10.1056/NEJMoa1712770.

7.

Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1-keratin 5-specific transgenic mice.

Ueta M, Hamuro J, Nishigaki H, Nakamura N, Shinomiya K, Mizushima K, Hitomi Y, Tamagawa-Mineoka R, Yokoi N, Naito Y, Tokunaga K, Katoh N, Sotozono C, Kinoshita S.

Allergy. 2018 Feb;73(2):395-404. doi: 10.1111/all.13308. Epub 2017 Oct 16.

PMID:
28914974
8.

Corneal Endothelial Cells Have an Absolute Requirement for Cysteine for Survival.

Okumura N, Inoue R, Kakutani K, Nakahara M, Kinoshita S, Hamuro J, Koizumi N.

Cornea. 2017 Aug;36(8):988-994. doi: 10.1097/ICO.0000000000001242.

PMID:
28542086
9.

Production of Homogeneous Cultured Human Corneal Endothelial Cells Indispensable for Innovative Cell Therapy.

Toda M, Ueno M, Hiraga A, Asada K, Montoya M, Sotozono C, Kinoshita S, Hamuro J.

Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2011-2020. doi: 10.1167/iovs.16-20703.

PMID:
28384722
10.

The Ingenious Interactions Between Macrophages and Functionally Plastic Retinal Pigment Epithelium Cells.

Yamawaki T, Ito E, Mukai A, Ueno M, Yamada J, Sotozono C, Kinoshita S, Hamuro J.

Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):5945-5953. doi: 10.1167/iovs.16-20604.

PMID:
27820950
11.

MicroRNA Profiles Qualify Phenotypic Features of Cultured Human Corneal Endothelial Cells.

Ueno M, Asada K, Toda M, Hiraga A, Montoya M, Sotozono C, Kinoshita S, Hamuro J.

Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5509-5517. doi: 10.1167/iovs.16-19804.

PMID:
27768788
12.

Metabolic Plasticity in Cell State Homeostasis and Differentiation of Cultured Human Corneal Endothelial Cells.

Hamuro J, Ueno M, Asada K, Toda M, Montoya M, Sotozono C, Kinoshita S.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4452-4463. doi: 10.1167/iovs.16-19807.

PMID:
27750287
13.

Cell Homogeneity Indispensable for Regenerative Medicine by Cultured Human Corneal Endothelial Cells.

Hamuro J, Toda M, Asada K, Hiraga A, Schlötzer-Schrehardt U, Montoya M, Sotozono C, Ueno M, Kinoshita S.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4749-61. doi: 10.1167/iovs.16-19770.

PMID:
27607421
14.

Allogeneic Sensitization and Tolerance Induction After Corneal Endothelial Cell Transplantation in Mice.

Yamada J, Ueno M, Toda M, Shinomiya K, Sotozono C, Kinoshita S, Hamuro J.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4572-80. doi: 10.1167/iovs.15-19020.

PMID:
27603721
15.

The Different Binding Properties of Cultured Human Corneal Endothelial Cell Subpopulations to Descemet's Membrane Components.

Toda M, Ueno M, Yamada J, Hiraga A, Tanaka H, Schlötzer-Schrehardt U, Sotozono C, Kinoshita S, Hamuro J.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4599-605. doi: 10.1167/iovs.16-20087.

PMID:
27598865
16.

Concomitant Evaluation of a Panel of Exosome Proteins and MiRs for Qualification of Cultured Human Corneal Endothelial Cells.

Ueno M, Asada K, Toda M, Nagata K, Sotozono C, Kosaka N, Ochiya T, Kinoshita S, Hamuro J.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4393-402. doi: 10.1167/iovs.16-19805.

PMID:
27564521
17.

Cultured Human Corneal Endothelial Cell Aneuploidy Dependence on the Presence of Heterogeneous Subpopulations With Distinct Differentiation Phenotypes.

Hamuro J, Ueno M, Toda M, Sotozono C, Montoya M, Kinoshita S.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4385-92. doi: 10.1167/iovs.16-19771.

PMID:
27564520
18.

Gene Signature-Based Development of ELISA Assays for Reproducible Qualification of Cultured Human Corneal Endothelial Cells.

Ueno M, Asada K, Toda M, Schlötzer-Schrehardt U, Nagata K, Montoya M, Sotozono C, Kinoshita S, Hamuro J.

Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4295-305. doi: 10.1167/iovs.16-19806.

PMID:
27552407
19.

Rho kinase inhibitor enables cell-based therapy for corneal endothelial dysfunction.

Okumura N, Sakamoto Y, Fujii K, Kitano J, Nakano S, Tsujimoto Y, Nakamura S, Ueno M, Hagiya M, Hamuro J, Matsuyama A, Suzuki S, Shiina T, Kinoshita S, Koizumi N.

Sci Rep. 2016 May 18;6:26113. doi: 10.1038/srep26113.

20.

IKZF1, a new susceptibility gene for cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement.

Ueta M, Sawai H, Sotozono C, Hitomi Y, Kaniwa N, Kim MK, Seo KY, Yoon KC, Joo CK, Kannabiran C, Wakamatsu TH, Sangwan V, Rathi V, Basu S, Ozeki T, Mushiroda T, Sugiyama E, Maekawa K, Nakamura R, Aihara M, Matsunaga K, Sekine A, Gomes JÁ, Hamuro J, Saito Y, Kubo M, Kinoshita S, Tokunaga K.

J Allergy Clin Immunol. 2015 Jun;135(6):1538-45.e17. doi: 10.1016/j.jaci.2014.12.1916. Epub 2015 Feb 8.

PMID:
25672763
21.

Clinical study of autologous cultivated oral mucosal epithelial transplantation for severe ocular surface disorders.

Sotozono C, Inatomi T, Nakamura T, Koizumi N, Hamuro J, Kinoshita S.

Nihon Rinsho. 2015 Ju;73 Suppl 5:447-51. Japanese. No abstract available.

PMID:
30458095
22.

Cell surface markers of functional phenotypic corneal endothelial cells.

Okumura N, Hirano H, Numata R, Nakahara M, Ueno M, Hamuro J, Kinoshita S, Koizumi N.

Invest Ophthalmol Vis Sci. 2014 Nov 11;55(11):7610-8. doi: 10.1167/iovs.14-14980.

PMID:
25389199
23.

LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis.

Nakamura T, Hamuro J, Takaishi M, Simmons S, Maruyama K, Zaffalon A, Bentley AJ, Kawasaki S, Nagata-Takaoka M, Fullwood NJ, Itami S, Sano S, Ishii M, Barrandon Y, Kinoshita S.

J Clin Invest. 2014 Jan;124(1):385-97. doi: 10.1172/JCI71488. Epub 2013 Dec 9.

24.

Establishment of a human corneal epithelial cell line lacking the functional TACSTD2 gene as an in vitro model for gelatinous drop-like dystrophy.

Kitazawa K, Kawasaki S, Shinomiya K, Aoi K, Matsuda A, Funaki T, Yamasaki K, Nakatsukasa M, Ebihara N, Murakami A, Hamuro J, Kinoshita S.

Invest Ophthalmol Vis Sci. 2013 Aug 23;54(8):5701-11. doi: 10.1167/iovs.12-11043.

PMID:
23868985
25.

Rho-associated kinase inhibitor eye drop treatment as a possible medical treatment for Fuchs corneal dystrophy.

Koizumi N, Okumura N, Ueno M, Nakagawa H, Hamuro J, Kinoshita S.

Cornea. 2013 Aug;32(8):1167-70. doi: 10.1097/ICO.0b013e318285475d.

PMID:
23715376
26.

The ROCK inhibitor eye drop accelerates corneal endothelium wound healing.

Okumura N, Koizumi N, Kay EP, Ueno M, Sakamoto Y, Nakamura S, Hamuro J, Kinoshita S.

Invest Ophthalmol Vis Sci. 2013 Apr 3;54(4):2493-502. doi: 10.1167/iovs.12-11320.

PMID:
23462749
27.

Inhibition of TGF-β signaling enables human corneal endothelial cell expansion in vitro for use in regenerative medicine.

Okumura N, Kay EP, Nakahara M, Hamuro J, Kinoshita S, Koizumi N.

PLoS One. 2013;8(2):e58000. doi: 10.1371/journal.pone.0058000. Epub 2013 Feb 25.

28.

Epithelial-mesenchymal transition-like phenotypic changes of retinal pigment epithelium induced by TGF-β are prevented by PPAR-γ agonists.

Hatanaka H, Koizumi N, Okumura N, Kay EP, Mizuhara E, Hamuro J, Kinoshita S.

Invest Ophthalmol Vis Sci. 2012 Oct 5;53(11):6955-63. doi: 10.1167/iovs.12-10488.

PMID:
22956604
29.

ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue.

Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Tsuchiya H, Hamuro J, Kinoshita S.

Am J Pathol. 2012 Jul;181(1):268-77. doi: 10.1016/j.ajpath.2012.03.033. Epub 2012 Jun 14.

PMID:
22704232
30.

Simultaneous analysis of multiple cytokines in the vitreous of patients with sarcoid uveitis.

Nagata K, Maruyama K, Uno K, Shinomiya K, Yoneda K, Hamuro J, Sugita S, Yoshimura T, Sonoda KH, Mochizuki M, Kinoshita S.

Invest Ophthalmol Vis Sci. 2012 Jun 20;53(7):3827-33. doi: 10.1167/iovs.11-9244.

PMID:
22589430
31.

The new therapeutic concept of using a rho kinase inhibitor for the treatment of corneal endothelial dysfunction.

Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Hamuro J, Kinoshita S.

Cornea. 2011 Oct;30 Suppl 1:S54-9. doi: 10.1097/ICO.0b013e3182281ee1.

PMID:
21912232
32.

Intracellular glutathione redox status in human dendritic cells regulates IL-27 production and T-cell polarization.

Kamide Y, Utsugi M, Dobashi K, Ono A, Ishizuka T, Hisada T, Koga Y, Uno K, Hamuro J, Mori M.

Allergy. 2011 Sep;66(9):1183-92. doi: 10.1111/j.1398-9995.2011.02611.x. Epub 2011 May 5.

PMID:
21545428
33.

The transcription factor Sp1 plays a crucial role in dok-7 gene expression.

Hamuro J, Hishida Y, Higuchi O, Yamanashi Y.

Biochem Biophys Res Commun. 2011 May 6;408(2):293-9. doi: 10.1016/j.bbrc.2011.04.020. Epub 2011 Apr 9.

PMID:
21504746
34.

Enhancement of corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops.

Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Hirata K, Torii R, Hamuro J, Kinoshita S.

Br J Ophthalmol. 2011 Jul;95(7):1006-9. doi: 10.1136/bjo.2010.194571. Epub 2011 Mar 11.

PMID:
21398412
35.

Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis.

Higuchi O, Hamuro J, Motomura M, Yamanashi Y.

Ann Neurol. 2011 Feb;69(2):418-22. doi: 10.1002/ana.22312.

PMID:
21387385
36.

Amino Acid profiles in human tear fluids analyzed by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry.

Nakatsukasa M, Sotozono C, Shimbo K, Ono N, Miyano H, Okano A, Hamuro J, Kinoshita S.

Am J Ophthalmol. 2011 May;151(5):799-808.e1. doi: 10.1016/j.ajo.2010.11.003. Epub 2011 Feb 18.

PMID:
21310375
37.

Establishment of a new animal model of focal subretinal fibrosis that resembles disciform lesion in advanced age-related macular degeneration.

Jo YJ, Sonoda KH, Oshima Y, Takeda A, Kohno R, Yamada J, Hamuro J, Yang Y, Notomi S, Hisatomi T, Ishibashi T.

Invest Ophthalmol Vis Sci. 2011 Aug 1;52(9):6089-95. doi: 10.1167/iovs.10-5189.

PMID:
21051730
38.

Spatio-temporal dual effects of IκBζ dictates the caution on visual disturbance resulting from IκBζ deficiency.

Ueta M, Hamuro J, Kinoshita S.

Immunol Lett. 2010 Oct 30;133(2):115. doi: 10.1016/j.imlet.2010.08.004. Epub 2010 Aug 14. No abstract available.

PMID:
20713088
39.

Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy.

Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Tsujikawa M, Tanioka H, Nagata-Takaoka M, Hamuro J, Kinoshita S.

Am J Pathol. 2010 Sep;177(3):1344-55. doi: 10.2353/ajpath.2010.100149. Epub 2010 Jul 22.

40.

Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis.

Matsuda A, Ebihara N, Yokoi N, Maruyama K, Hamuro J, Kinoshita S, Murakami A.

J Allergy Clin Immunol. 2010 Dec;126(6):1310-2.e1. doi: 10.1016/j.jaci.2010.06.001. Epub 2010 Jul 16. No abstract available.

PMID:
20638114
41.

Pre-operative intracellular glutathione levels of peripheral monocytes as a biomarker to predict survival of colorectal cancer patients.

Uno K, Okuno K, Kato T, Tada-Oikawa S, Kan N, Saotome H, Yagi K, Hamuro J.

Cancer Immunol Immunother. 2010 Oct;59(10):1457-65. doi: 10.1007/s00262-010-0868-3. Epub 2010 Jun 1.

PMID:
20514541
42.

Intracellular thiol redox status regulates lymphangiogenesis and dictates corneal limbal graft survival.

Fukumoto A, Maruyama K, Walsh T, Kajiya K, Hamuro J, D'Amore PA, Kinoshita S.

Invest Ophthalmol Vis Sci. 2010 May;51(5):2450-8. doi: 10.1167/iovs.09-4618. Epub 2009 Dec 30.

PMID:
20042658
43.

Basophils in the giant papillae of chronic allergic keratoconjunctivitis.

Matsuda A, Ebihara N, Yokoi N, Okayama Y, Watanabe Y, Kawasaki S, Tanioka H, Walls AF, Hamuro J, Kinoshita S, Murakami A.

Br J Ophthalmol. 2010 Apr;94(4):513-8. doi: 10.1136/bjo.2009.165316. Epub 2009 Oct 14.

PMID:
19828516
44.

Regeneration of peritoneum using amniotic membrane to prevent postoperative adhesions.

Kuriu Y, Yamagishi H, Otsuji E, Nakashima S, Miyagawa K, Yoshikawa T, Kin S, Nakase Y, Fukuda K, Okamoto K, Sakakura C, Hamuro J, Kurihara E, Hagiwara A.

Hepatogastroenterology. 2009 Jul-Aug;56(93):1064-8.

PMID:
19760942
45.

Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis.

Matsuda A, Ebihara N, Yokoi N, Kawasaki S, Tanioka H, Inatomi T, de Waal Malefyt R, Hamuro J, Kinoshita S, Murakami A.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):151-5. doi: 10.1167/iovs.09-4183. Epub 2009 Sep 9.

PMID:
19741251
46.

The role of interleukin-33 in chronic allergic conjunctivitis.

Matsuda A, Okayama Y, Terai N, Yokoi N, Ebihara N, Tanioka H, Kawasaki S, Inatomi T, Katoh N, Ueda E, Hamuro J, Murakami A, Kinoshita S.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4646-52. doi: 10.1167/iovs.08-3365. Epub 2009 May 20.

PMID:
19458329
47.

Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor.

Okumura N, Ueno M, Koizumi N, Sakamoto Y, Hirata K, Hamuro J, Kinoshita S.

Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3680-7. doi: 10.1167/iovs.08-2634. Epub 2009 Apr 22.

PMID:
19387080
48.

Hyperexpression of the high-affinity IgE receptor-beta chain in chronic allergic keratoconjunctivitis.

Matsuda A, Okayama Y, Ebihara N, Yokoi N, Hamuro J, Walls AF, Ra C, Hopkin JM, Kinoshita S.

Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2871-7. doi: 10.1167/iovs.08-3022. Epub 2009 Jan 10.

PMID:
19136704
49.

MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice.

Yamada J, Hamuro J, Fukushima A, Ohteki T, Terai K, Iwakura Y, Yagita H, Kinoshita S.

Invest Ophthalmol Vis Sci. 2009 May;50(5):2139-46. doi: 10.1167/iovs.08-2993. Epub 2009 Jan 10.

PMID:
19136699
50.

Glutathione redox regulates TGF-beta-induced fibrogenic effects through Smad3 activation.

Ono A, Utsugi M, Masubuchi K, Ishizuka T, Kawata T, Shimizu Y, Hisada T, Hamuro J, Mori M, Dobashi K.

FEBS Lett. 2009 Jan 22;583(2):357-62. doi: 10.1016/j.febslet.2008.12.021. Epub 2008 Dec 25.

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