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Items: 42


Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress.

Aridgides DS, Mellinger DL, Armstrong DA, Hazlett HF, Dessaint JA, Hampton TH, Atkins GT, Carroll JL, Ashare A.

Sci Rep. 2019 Jul 3;9(1):9624. doi: 10.1038/s41598-019-46045-7.


Profiling microRNA expression in Atlantic killifish (Fundulus heteroclitus) gill and responses to arsenic and hyperosmotic stress.

Goodale BC, Hampton TH, Ford EN, Jackson CE, Shaw JR, Stanton BA, King BL.

Aquat Toxicol. 2019 Jan;206:142-153. doi: 10.1016/j.aquatox.2018.11.009. Epub 2018 Nov 12.


Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish.

Hampton TH, Jackson C, Jung D, Chen CY, Glaholt SP, Stanton BA, Colbourne JK, Shaw JR.

Environ Sci Technol. 2018 Aug 7;52(15):8811-8821. doi: 10.1021/acs.est.8b01550. Epub 2018 Jul 20.


Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa.

Barnaby R, Koeppen K, Nymon A, Hampton TH, Berwin B, Ashare A, Stanton BA.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L432-L438. doi: 10.1152/ajplung.00461.2017. Epub 2017 Nov 16.


ScanGEO: parallel mining of high-throughput gene expression data.

Koeppen K, Stanton BA, Hampton TH.

Bioinformatics. 2017 Nov 1;33(21):3500-3501. doi: 10.1093/bioinformatics/btx452.


An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.

Hvorecny KL, Dolben E, Moreau-Marquis S, Hampton TH, Shabaneh TB, Flitter BA, Bahl CD, Bomberger JM, Levy BD, Stanton BA, Hogan DA, Madden DR.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L150-L156. doi: 10.1152/ajplung.00383.2017. Epub 2017 Oct 5.


Effectiveness of table top water pitcher filters to remove arsenic from drinking water.

Barnaby R, Liefeld A, Jackson BP, Hampton TH, Stanton BA.

Environ Res. 2017 Oct;158:610-615. doi: 10.1016/j.envres.2017.07.018. Epub 2017 Jul 15.


The landscape of extreme genomic variation in the highly adaptable Atlantic killifish.

Reid NM, Jackson CE, Gilbert D, Minx P, Montague MJ, Hampton TH, Helfrich LW, King BL, Nacci DE, Aluru N, Karchner SI, Colbourne JK, Hahn ME, Shaw JR, Oleksiak MF, Crawford DL, Warren WC, Whitehead A.

Genome Biol Evol. 2017 Feb 13. doi: 10.1093/gbe/evx023. [Epub ahead of print] No abstract available.


Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.

Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):136-141. doi: 10.1073/pnas.1610242114. Epub 2016 Dec 15.


Immune modulation associated with vascular endothelial growth factor (VEGF) blockade in patients with glioblastoma.

Thomas AA, Fisher JL, Hampton TH, Christensen BC, Tsongalis GJ, Rahme GJ, Whipple CA, Steel SE, Davis MC, Gaur AB, Lewis LD, Ernstoff MS, Fadul CE.

Cancer Immunol Immunother. 2017 Mar;66(3):379-389. doi: 10.1007/s00262-016-1941-3. Epub 2016 Dec 9.


Use of a Multiplex Transcript Method for Analysis of Pseudomonas aeruginosa Gene Expression Profiles in the Cystic Fibrosis Lung.

Gifford AH, Willger SD, Dolben EL, Moulton LA, Dorman DB, Bean H, Hill JE, Hampton TH, Ashare A, Hogan DA.

Infect Immun. 2016 Sep 19;84(10):2995-3006. doi: 10.1128/IAI.00437-16. Print 2016 Oct.


A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles.

Koeppen K, Hampton TH, Jarek M, Scharfe M, Gerber SA, Mielcarz DW, Demers EG, Dolben EL, Hammond JH, Hogan DA, Stanton BA.

PLoS Pathog. 2016 Jun 13;12(6):e1005672. doi: 10.1371/journal.ppat.1005672. eCollection 2016 Jun.


The mitogen-activated protein kinase pathway plays a critical role in regulating immunological properties of BRAF mutant cutaneous melanoma cells.

Whipple CA, Boni A, Fisher JL, Hampton TH, Tsongalis GJ, Mellinger DL, Yan S, Tafe LJ, Brinckerhoff CE, Turk MJ, Mullins DW, Fadul CE, Ernstoff MS.

Melanoma Res. 2016 Jun;26(3):223-35. doi: 10.1097/CMR.0000000000000244.


Analysis of Lung Microbiota in Bronchoalveolar Lavage, Protected Brush and Sputum Samples from Subjects with Mild-To-Moderate Cystic Fibrosis Lung Disease.

Hogan DA, Willger SD, Dolben EL, Hampton TH, Stanton BA, Morrison HG, Sogin ML, Czum J, Ashare A.

PLoS One. 2016 Mar 4;11(3):e0149998. doi: 10.1371/journal.pone.0149998. eCollection 2016.


Regulatory T cells are not a strong predictor of survival for patients with glioblastoma.

Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE.

Neuro Oncol. 2015 Jun;17(6):801-9. doi: 10.1093/neuonc/nou363. Epub 2015 Jan 24.


Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis.

Willger SD, Grim SL, Dolben EL, Shipunova A, Hampton TH, Morrison HG, Filkins LM, O'Toole GA, Moulton LA, Ashare A, Sogin ML, Hogan DA.

Microbiome. 2014 Nov 3;2:40. doi: 10.1186/2049-2618-2-40. eCollection 2014.


Natural selection canalizes expression variation of environmentally induced plasticity-enabling genes.

Shaw JR, Hampton TH, King BL, Whitehead A, Galvez F, Gross RH, Keith N, Notch E, Jung D, Glaholt SP, Chen CY, Colbourne JK, Stanton BA.

Mol Biol Evol. 2014 Nov;31(11):3002-15. doi: 10.1093/molbev/msu241. Epub 2014 Aug 25.


Letter to the editor.

Fadul CE, Fisher JL, Hampton TH, Ernstoff MS.

J Immunother Cancer. 2014 Jul 15;2:22. doi: 10.1186/2051-1426-2-22. eCollection 2014. No abstract available.


The microbiome in pediatric cystic fibrosis patients: the role of shared environment suggests a window of intervention.

Hampton TH, Green DM, Cutting GR, Morrison HG, Sogin ML, Gifford AH, Stanton BA, O'Toole GA.

Microbiome. 2014 Apr 28;2:14. doi: 10.1186/2049-2618-2-14. eCollection 2014.


The microbiota regulates susceptibility to Fas-mediated acute hepatic injury.

Celaj S, Gleeson MW, Deng J, O'Toole GA, Hampton TH, Toft MF, Morrison HG, Sogin ML, Putra J, Suriawinata AA, Gorham JD.

Lab Invest. 2014 Sep;94(9):938-49. doi: 10.1038/labinvest.2014.93. Epub 2014 Jul 28.


Unique microbial communities persist in individual cystic fibrosis patients throughout a clinical exacerbation.

Price KE, Hampton TH, Gifford AH, Dolben EL, Hogan DA, Morrison HG, Sogin ML, O'Toole GA.

Microbiome. 2013 Nov 1;1(1):27. doi: 10.1186/2049-2618-1-27.


Iron supplementation does not worsen respiratory health or alter the sputum microbiome in cystic fibrosis.

Gifford AH, Alexandru DM, Li Z, Dorman DB, Moulton LA, Price KE, Hampton TH, Sogin ML, Zuckerman JB, Parker HW, Stanton BA, O'Toole GA.

J Cyst Fibros. 2014 May;13(3):311-8. doi: 10.1016/j.jcf.2013.11.004. Epub 2013 Dec 13.


Anr and its activation by PlcH activity in Pseudomonas aeruginosa host colonization and virulence.

Jackson AA, Gross MJ, Daniels EF, Hampton TH, Hammond JH, Vallet-Gely I, Dove SL, Stanton BA, Hogan DA.

J Bacteriol. 2013 Jul;195(13):3093-104. doi: 10.1128/JB.02169-12. Epub 2013 May 10.


Gene expression profile of peripheral blood lymphocytes from renal cell carcinoma patients treated with IL-2, interferon-α and dendritic cell vaccine.

Wolf B, Schwarzer A, Côté AL, Hampton TH, Schwaab T, Huarte E, Tomlinson CR, Gui J, Fisher JL, Fadul CE, Hamilton JW, Ernstoff MS.

PLoS One. 2012;7(12):e50221. doi: 10.1371/journal.pone.0050221. Epub 2012 Dec 3.


Regulatory T-cells and associated pathways in metastatic renal cell carcinoma (mRCC) patients undergoing DC-vaccination and cytokine-therapy.

Schwarzer A, Wolf B, Fisher JL, Schwaab T, Olek S, Baron U, Tomlinson CR, Seigne JD, Crosby NA, Gui J, Hampton TH, Fadul CE, Heaney JA, Ernstoff MS.

PLoS One. 2012;7(10):e46600. doi: 10.1371/journal.pone.0046600. Epub 2012 Oct 31.


Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: interaction between intestinal and respiratory tracts and impact of nutritional exposures.

Madan JC, Koestler DC, Stanton BA, Davidson L, Moulton LA, Housman ML, Moore JH, Guill MF, Morrison HG, Sogin ML, Hampton TH, Karagas MR, Palumbo PE, Foster JA, Hibberd PL, O'Toole GA.

MBio. 2012 Aug 21;3(4). pii: e00251-12. doi: 10.1128/mBio.00251-12. Print 2012.


Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells?

Hampton TH, Ballok AE, Bomberger JM, Rutkowski MR, Barnaby R, Coutermarsh B, Conejo-Garcia JR, O'Toole GA, Stanton BA.

Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L509-18. doi: 10.1152/ajplung.00226.2011. Epub 2012 Jul 20.


Prevalence of streptococci and increased polymicrobial diversity associated with cystic fibrosis patient stability.

Filkins LM, Hampton TH, Gifford AH, Gross MJ, Hogan DA, Sogin ML, Morrison HG, Paster BJ, O'Toole GA.

J Bacteriol. 2012 Sep;194(17):4709-17. doi: 10.1128/JB.00566-12. Epub 2012 Jun 29.


2-Heptyl-4-quinolone, a precursor of the Pseudomonas quinolone signal molecule, modulates swarming motility in Pseudomonas aeruginosa.

Ha DG, Merritt JH, Hampton TH, Hodgkinson JT, Janecek M, Spring DR, Welch M, O'Toole GA.

J Bacteriol. 2011 Dec;193(23):6770-80. doi: 10.1128/JB.05929-11. Epub 2011 Sep 30.


Immune response in patients with newly diagnosed glioblastoma multiforme treated with intranodal autologous tumor lysate-dendritic cell vaccination after radiation chemotherapy.

Fadul CE, Fisher JL, Hampton TH, Lallana EC, Li Z, Gui J, Szczepiorkowski ZM, Tosteson TD, Rhodes CH, Wishart HA, Lewis LD, Ernstoff MS.

J Immunother. 2011 May;34(4):382-9. doi: 10.1097/CJI.0b013e318215e300.


Immune modulation effects of concomitant temozolomide and radiation therapy on peripheral blood mononuclear cells in patients with glioblastoma multiforme.

Fadul CE, Fisher JL, Gui J, Hampton TH, Côté AL, Ernstoff MS.

Neuro Oncol. 2011 Apr;13(4):393-400. doi: 10.1093/neuonc/noq204. Epub 2011 Feb 20.


Iron and CF-related anemia: expanding clinical and biochemical relationships.

Gifford AH, Miller SD, Jackson BP, Hampton TH, O'Toole GA, Stanton BA, Parker HW.

Pediatr Pulmonol. 2011 Feb;46(2):160-5. doi: 10.1002/ppul.21335. Epub 2010 Oct 20.


A novel approach to analyze gene expression data demonstrates that the DeltaF508 mutation in CFTR downregulates the antigen presentation pathway.

Hampton TH, Stanton BA.

Am J Physiol Lung Cell Mol Physiol. 2010 Apr;298(4):L473-82. doi: 10.1152/ajplung.00379.2009. Epub 2009 Dec 31. Review.


Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung.

Kozul CD, Hampton TH, Davey JC, Gosse JA, Nomikos AP, Eisenhauer PL, Weiss DJ, Thorpe JE, Ihnat MA, Hamilton JW.

Environ Health Perspect. 2009 Jul;117(7):1108-15. doi: 10.1289/ehp.0800199. Epub 2009 Mar 4.


Perturbation of defense pathways by low-dose arsenic exposure in zebrafish embryos.

Mattingly CJ, Hampton TH, Brothers KM, Griffin NE, Planchart A.

Environ Health Perspect. 2009 Jun;117(6):981-7. doi: 10.1289/ehp.0900555. Epub 2009 Feb 22.


GeneComps and ChemComps: a new CTD metric to identify genes and chemicals with shared toxicogenomic profiles.

Davis AP, Murphy CG, Saraceni-Richards CA, Rosenstein MC, Wiegers TC, Hampton TH, Mattingly CJ.

Bioinformation. 2009 Oct 15;4(4):173-4.


Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung.

Kozul CD, Nomikos AP, Hampton TH, Warnke LA, Gosse JA, Davey JC, Thorpe JE, Jackson BP, Ihnat MA, Hamilton JW.

Chem Biol Interact. 2008 May 28;173(2):129-40. doi: 10.1016/j.cbi.2008.02.008. Epub 2008 Mar 4.


Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins.

Shaw JR, Colbourne JK, Davey JC, Glaholt SP, Hampton TH, Chen CY, Folt CL, Hamilton JW.

BMC Genomics. 2007 Dec 21;8:477.


Chromium(VI)-induced DNA lesions and chromium distribution in rat kidney, liver, and lung.

Tsapakos MJ, Hampton TH, Wetterhahn KE.

Cancer Res. 1983 Dec;43(12 Pt 1):5662-7.


The carcinogen chromate causes DNA damage and inhibits drug-mediated induction of porphyrin accumulation and glucuronidation in chick embryo hepatocytes.

Tsapakos MJ, Hampton TH, Sinclair PR, Sinclair JF, Bement WJ, Wetterhahn KE.

Carcinogenesis. 1983 Aug;4(8):959-66.


Nickel carbonate induces DNA-protein crosslinks and DNA strand breaks in rat kidney.

Ciccarelli RB, Hampton TH, Jennette KW.

Cancer Lett. 1981 May;12(4):349-54.


The carcinogen chromate induces DNA cross-links in rat liver and kidney.

Tsapakos MJ, Hampton TH, Jennette KW.

J Biol Chem. 1981 Apr 25;256(8):3623-6.

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