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Items: 1 to 50 of 71

1.

Integrating after CEN Excision (ICE) Plasmids: Combining the ease of yeast recombination cloning with the stability of genomic integration.

Flagg MP, Kao A, Hampton RY.

Yeast. 2019 May 10. doi: 10.1002/yea.3400. [Epub ahead of print]

PMID:
31074531
2.

Assays for protein retrotranslocation in ERAD.

Neal S, Duttke SH, Hampton RY.

Methods Enzymol. 2019;619:1-26. doi: 10.1016/bs.mie.2019.01.002. Epub 2019 Feb 15.

PMID:
30910017
3.

"Mallostery"-ligand-dependent protein misfolding enables physiological regulation by ERAD.

Wangeline MA, Hampton RY.

J Biol Chem. 2018 Sep 21;293(38):14937-14950. doi: 10.1074/jbc.RA118.001808. Epub 2018 Jul 17.

4.

The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.

Neal S, Jaeger PA, Duttke SH, Benner C, Glass CK, Ideker T, Hampton RY.

Mol Cell. 2018 Mar 1;69(5):915. doi: 10.1016/j.molcel.2018.02.014. No abstract available.

5.

Systematic Gene-to-Phenotype Arrays: A High-Throughput Technique for Molecular Phenotyping.

Jaeger PA, Ornelas L, McElfresh C, Wong LR, Hampton RY, Ideker T.

Mol Cell. 2018 Jan 18;69(2):321-333.e3. doi: 10.1016/j.molcel.2017.12.016.

6.

The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.

Neal S, Jaeger PA, Duttke SH, Benner C, K Glass C, Ideker T, Hampton RY.

Mol Cell. 2018 Jan 18;69(2):306-320.e4. doi: 10.1016/j.molcel.2017.12.012. Erratum in: Mol Cell. 2018 Mar 1;69(5):915.

7.

Proteostatic Tactics in the Strategy of Sterol Regulation.

Wangeline MA, Vashistha N, Hampton RY.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:467-489. doi: 10.1146/annurev-cellbio-111315-125036. Review.

8.

New developments for protein quality control.

Hampton RY, Dargemont C.

Science. 2017 Aug 4;357(6350):450-451. doi: 10.1126/science.aao1896. No abstract available.

PMID:
28774913
9.

Direct and essential function for Hrd3 in ER-associated degradation.

Vashistha N, Neal SE, Singh A, Carroll SM, Hampton RY.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):5934-9. doi: 10.1073/pnas.1603079113. Epub 2016 May 11.

10.

The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins.

Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ.

Mol Cell. 2015 Jul 2;59(1):35-49. doi: 10.1016/j.molcel.2015.04.026. Epub 2015 Jun 4.

11.

Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.

Theesfeld CL, Hampton RY.

J Biol Chem. 2013 Mar 22;288(12):8519-30. doi: 10.1074/jbc.M112.404517. Epub 2013 Jan 10.

12.

Finding the will and the way of ERAD substrate retrotranslocation.

Hampton RY, Sommer T.

Curr Opin Cell Biol. 2012 Aug;24(4):460-6. doi: 10.1016/j.ceb.2012.05.010. Epub 2012 Jul 30. Review.

PMID:
22854296
13.

Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p.

Li S, Spooner RA, Hampton RY, Lord JM, Roberts LM.

PLoS One. 2012;7(7):e41119. doi: 10.1371/journal.pone.0041119. Epub 2012 Jul 19.

14.

The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.

Theesfeld CL, Pourmand D, Davis T, Garza RM, Hampton RY.

J Biol Chem. 2011 Jul 29;286(30):26298-307. doi: 10.1074/jbc.M111.244798. Epub 2011 May 31.

15.

San1-mediated quality control: substrate recognition "sans" chaperones.

Hampton RY.

Mol Cell. 2011 Jan 7;41(1):2-3. doi: 10.1016/j.molcel.2010.12.022.

16.

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1.

Heck JW, Cheung SK, Hampton RY.

Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1106-11. doi: 10.1073/pnas.0910591107. Epub 2009 Dec 28.

17.

Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.

Carroll SM, Hampton RY.

J Biol Chem. 2010 Feb 19;285(8):5146-56. doi: 10.1074/jbc.M109.067876. Epub 2009 Nov 24.

18.

Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.

Garza RM, Tran PN, Hampton RY.

J Biol Chem. 2009 Dec 18;284(51):35368-80. doi: 10.1074/jbc.M109.023994.

19.

Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase.

Sato BK, Schulz D, Do PH, Hampton RY.

Mol Cell. 2009 Apr 24;34(2):212-22. doi: 10.1016/j.molcel.2009.03.010.

20.

In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase.

Garza RM, Sato BK, Hampton RY.

J Biol Chem. 2009 May 29;284(22):14710-22. doi: 10.1074/jbc.M809607200. Epub 2009 Mar 26.

21.

Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway.

Hampton RY, Garza RM.

Chem Rev. 2009 Apr;109(4):1561-74. doi: 10.1021/cr800544v. Review. No abstract available.

PMID:
19243134
22.

A cholesterol toggle switch.

Hampton RY.

Cell Metab. 2008 Dec;8(6):451-3. doi: 10.1016/j.cmet.2008.11.006.

23.

Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae.

Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY.

Mol Biol Cell. 2008 Oct;19(10):4506-20. doi: 10.1091/mbc.E07-11-1188. Epub 2008 Jul 30.

24.

Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo.

Bazirgan OA, Hampton RY.

J Biol Chem. 2008 May 9;283(19):12797-810. doi: 10.1074/jbc.M801122200. Epub 2008 Mar 5.

25.

Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.

Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC.

J Biol Chem. 2007 Nov 16;282(46):33776-87. Epub 2007 Sep 24.

26.

Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis.

Sato BK, Hampton RY.

Yeast. 2006 Oct-Nov;23(14-15):1053-64.

27.

Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase.

Bazirgan OA, Garza RM, Hampton RY.

J Biol Chem. 2006 Dec 22;281(51):38989-9001. Epub 2006 Oct 11.

28.
29.

INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins.

Flury I, Garza R, Shearer A, Rosen J, Cronin S, Hampton RY.

EMBO J. 2005 Nov 16;24(22):3917-26. Epub 2005 Nov 3.

30.

The dynamic ER: experimental approaches and current questions.

Federovitch CM, Ron D, Hampton RY.

Curr Opin Cell Biol. 2005 Aug;17(4):409-14. Review.

PMID:
15975777
31.

Cell biology: sterol sensor comes up for air.

Garza RM, Hampton RY.

Nature. 2005 May 5;435(7038):37-8. No abstract available.

PMID:
15875007
32.

Cdc48-Ufd2-Rad23: the road less ubiquitinated?

Bazirgan OA, Hampton RY.

Nat Cell Biol. 2005 Mar;7(3):207-9. No abstract available.

PMID:
15738968
33.

Lipid-mediated, reversible misfolding of a sterol-sensing domain protein.

Shearer AG, Hampton RY.

EMBO J. 2005 Jan 12;24(1):149-59. Epub 2005 Jan 6.

34.

Membrane biogenesis and the unfolded protein response.

Ron D, Hampton RY.

J Cell Biol. 2004 Oct 11;167(1):23-5.

35.

Management of community-acquired pneumonia in persons with spinal cord injury.

Burns SP, Weaver FM, Parada JP, Evans CT, Chang H, Hampton RY, Kapur V.

Spinal Cord. 2004 Aug;42(8):450-8.

PMID:
15037861
36.
37.

Measuring protein degradation with green fluorescent protein.

Cronin SR, Hampton RY.

Methods Enzymol. 1999;302:58-73. No abstract available.

PMID:
12876763
38.

IRE1: a role in UPREgulation of ER degradation.

Hampton RY.

Dev Cell. 2003 Feb;4(2):144-6. Review.

39.

ER-associated degradation in protein quality control and cellular regulation.

Hampton RY.

Curr Opin Cell Biol. 2002 Aug;14(4):476-82. Review.

PMID:
12383799
40.

Proteolysis and sterol regulation.

Hampton RY.

Annu Rev Cell Dev Biol. 2002;18:345-78. Epub 2002 Apr 2. Review.

PMID:
12142284
41.

Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis.

Cronin SR, Rao R, Hampton RY.

J Cell Biol. 2002 Jun 10;157(6):1017-28. Epub 2002 Jun 10.

42.

Cdc48-Ufd1-Npl4: stuck in the middle with Ub.

Bays NW, Hampton RY.

Curr Biol. 2002 May 14;12(10):R366-71. Review.

43.

HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins.

Bays NW, Wilhovsky SK, Goradia A, Hodgkiss-Harlow K, Hampton RY.

Mol Biol Cell. 2001 Dec;12(12):4114-28.

44.
45.

An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast.

Gardner RG, Shan H, Matsuda SP, Hampton RY.

J Biol Chem. 2001 Mar 23;276(12):8681-94. Epub 2000 Dec 27.

46.

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY.

Nat Cell Biol. 2001 Jan;3(1):24-9.

PMID:
11146622
47.

Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

Gardner RG, Swarbrick GM, Bays NW, Cronin SR, Wilhovsky S, Seelig L, Kim C, Hampton RY.

J Cell Biol. 2000 Oct 2;151(1):69-82.

48.

ER stress response: getting the UPR hand on misfolded proteins.

Hampton RY.

Curr Biol. 2000 Jul 13;10(14):R518-21. Review.

49.

Cholesterol homeostasis: ESCAPe from the ER.

Hampton RY.

Curr Biol. 2000 Apr 20;10(8):R298-301. Review.

50.

Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p.

Cronin SR, Khoury A, Ferry DK, Hampton RY.

J Cell Biol. 2000 Mar 6;148(5):915-24.

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