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2003 2
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Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types.
Neves JV, Ramos MF, Moreira AC, Silva T, Gomes MS, Rodrigues PNS. Neves JV, et al. Sci Rep. 2017 Nov 1;7(1):14793. doi: 10.1038/s41598-017-14933-5. Sci Rep. 2017. PMID: 29093559 Free PMC article.
This raises the question of whether ferroportin is similarly regulated by the iron regulator Hamp1 and the antimicrobial Hamp2. In sea bass (Dicentrarchus labrax), iron overload prompted a downregulation of ferroportin, associated with an upregulation of hamp1, whereas an …
This raises the question of whether ferroportin is similarly regulated by the iron regulator Hamp1 and the antimicrobial Hamp2. In se …
Inductively coupled mass spectrometry analysis of biometals in conditional Hamp1 and Hamp1 and Hamp2 transgenic mouse models.
Lu S, Seravalli J, Harrison-Findik D. Lu S, et al. Transgenic Res. 2015 Aug;24(4):765-73. doi: 10.1007/s11248-015-9879-3. Epub 2015 Apr 23. Transgenic Res. 2015. PMID: 25904410 Free PMC article.
Humans express one hepcidin gene, HAMP but mice express two hepcidin genes, Hamp1 and Hamp2. Consecutive gene targeting events were performed to produce transgenic mice expressing conditional alleles of either Hamp1 or both Hamp1 and Hamp2 (Hamp1/2). The deletion of …
Humans express one hepcidin gene, HAMP but mice express two hepcidin genes, Hamp1 and Hamp2. Consecutive gene targeting events were p …
The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters.
Truksa J, Lee P, Beutler E. Truksa J, et al. Blood Cells Mol Dis. 2007 Nov-Dec;39(3):255-62. doi: 10.1016/j.bcmd.2007.06.014. Epub 2007 Aug 6. Blood Cells Mol Dis. 2007. PMID: 17689119 Free PMC article.
There are two murine hepcidin genes: hepcidin-1 (Hamp1) and hepcidin-2 (Hamp2). Hamp1 gene responds to both IL-6 and BMPs while Hamp2 responds to neither. We replaced the putative functional regulatory motifs of the Hamp1 promoter with the corresponding putative "no …
There are two murine hepcidin genes: hepcidin-1 (Hamp1) and hepcidin-2 (Hamp2). Hamp1 gene responds to both IL-6 and BMPs while Ha …
Modifications of the GH Axis Reveal Unique Sexually Dimorphic Liver Signatures for Lcn13, Asns, Hamp2, Hao2, and Pgc1a.
Brie B, Sarmento-Cabral A, Pascual F, Cordoba-Chacon J, Kineman RD, Becu-Villalobos D. Brie B, et al. J Endocr Soc. 2024 Jan 31;8(3):bvae015. doi: 10.1210/jendso/bvae015. eCollection 2024 Jan 16. J Endocr Soc. 2024. PMID: 38370444 Free PMC article.
We dissected the steps of the GH regulatory cascade modifying GH-dependent genes involved in metabolism, focusing on the male-predominant genes Lcn13, Asns, and Cyp7b1, and the female-predominant genes Hao2, Pgc1a, Hamp2, Cyp2a4, and Cyp2b9. We explored mRNA expression in …
We dissected the steps of the GH regulatory cascade modifying GH-dependent genes involved in metabolism, focusing on the male-predominant ge …
Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice.
Krijt J, Cmejla R, Sýkora V, Vokurka M, Vyoral D, Necas E. Krijt J, et al. J Hepatol. 2004 Jun;40(6):891-6. doi: 10.1016/j.jhep.2004.02.029. J Hepatol. 2004. PMID: 15158327
RESULTS: Ferroportin1, transferrin receptor 2 and HAMP mRNA levels displayed no significant strain differences. However, HAMP2 mRNA levels were higher in DBA/2N mice. In both strains, HAMP2 mRNA content was sex-dependent, with higher values in female animals. ...CON …
RESULTS: Ferroportin1, transferrin receptor 2 and HAMP mRNA levels displayed no significant strain differences. However, HAMP2 mRNA l …
B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice.
Hayakawa K, Zhou Y, Shinton SA. Hayakawa K, et al. Immun Ageing. 2024 Apr 3;21(1):22. doi: 10.1186/s12979-024-00415-6. Immun Ageing. 2024. PMID: 38570827 Free PMC article.
ATA B cells showed CD11b(+)CD22(++), CD24 down, and hepcidin Hamp2(++) with iron down. This mouse V8-12 similar to human V2-5, and V2-5 showed several cancers with macrophages/neutrophils generated hepcidin(+) iron(low) or some showed hepcidin(-) iron(+) with tumor, and mo …
ATA B cells showed CD11b(+)CD22(++), CD24 down, and hepcidin Hamp2(++) with iron down. This mouse V8-12 similar to human V2-5, and V2 …
Antimicrobial peptides within the Yellowtail Kingfish (Seriola lalandi).
Muncaster S, Kraakman K, Gibbons O, Mensink K, Forlenza M, Jacobson G, Bird S. Muncaster S, et al. Dev Comp Immunol. 2018 Mar;80:67-80. doi: 10.1016/j.dci.2017.04.014. Epub 2017 Apr 19. Dev Comp Immunol. 2018. PMID: 28433529
Phylogenetic analysis of known vertebrate hepcidin antimicrobial peptide (HAMP) sequences, shows sequences from the Neoteleostei clade of bony fish form two very separate groups, HAMP1 and HAMP2, with the S. lalandi hepcidin gene grouped with the HAMP1 sequences. HAMP2 …
Phylogenetic analysis of known vertebrate hepcidin antimicrobial peptide (HAMP) sequences, shows sequences from the Neoteleostei clade of bo …
The Era of Antimicrobial Peptides: Use of Hepcidins to Prevent or Treat Bacterial Infections and Iron Disorders.
Barroso C, Carvalho P, Nunes M, Gonçalves JFM, Rodrigues PNS, Neves JV. Barroso C, et al. Front Immunol. 2021 Sep 27;12:754437. doi: 10.3389/fimmu.2021.754437. eCollection 2021. Front Immunol. 2021. PMID: 34646277 Free PMC article.
In this study, we tested the administration of sea bass derived hepcidins in models of infection and iron overload. Administration with hamp2 substantially reduced fish mortalities and bacterial loads, presenting itself as a viable alternative to the use of antibiotics. .. …
In this study, we tested the administration of sea bass derived hepcidins in models of infection and iron overload. Administration with h …
Genomic characterization and gene expression analysis of four hepcidin genes in the redbanded seabream (Pagrus auriga).
Martin-Antonio B, Jiménez-Cantizano RM, Salas-Leiton E, Infante C, Manchado M. Martin-Antonio B, et al. Fish Shellfish Immunol. 2009 Mar;26(3):483-91. doi: 10.1016/j.fsi.2009.01.012. Fish Shellfish Immunol. 2009. PMID: 19340950
Phylogenetic analysis revealed that HAMPs could group in two main clusters with HAMP2, HAMP3 and HAMP4 belonging to the more complex and diversified HAMP2-like group of acanthopterygians. ...However, expression profiles differed in magnitude and time course response …
Phylogenetic analysis revealed that HAMPs could group in two main clusters with HAMP2, HAMP3 and HAMP4 belonging to the more complex …
HAMP domain signal relay mechanism in a sensory rhodopsin-transducer complex.
Wang J, Sasaki J, Tsai AL, Spudich JL. Wang J, et al. J Biol Chem. 2012 Jun 15;287(25):21316-25. doi: 10.1074/jbc.M112.344622. Epub 2012 Apr 16. J Biol Chem. 2012. PMID: 22511775 Free PMC article.
Light-activated SRII transmits a signal through two HAMP switch domains (HAMP1 and HAMP2) in HtrII that bridge the photoreceptive membrane domain of the complex and the cytoplasmic output kinase-modulating domain. ...The opposite conformational changes and corresponding op …
Light-activated SRII transmits a signal through two HAMP switch domains (HAMP1 and HAMP2) in HtrII that bridge the photoreceptive mem …
46 results