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Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation.

Ma M, Ren Q, Yang J, Zhang K, Xiong Z, Ishima T, Pu Y, Hwang SH, Toyoshima M, Iwayama Y, Hisano Y, Yoshikawa T, Hammock BD, Hashimoto K.

Proc Natl Acad Sci U S A. 2019 Mar 19. pii: 201819234. doi: 10.1073/pnas.1819234116. [Epub ahead of print]


One-step ultra-sensitive bioluminescent enzyme immunoassay based on nanobody/nano-luciferase fusion for detection of Aflatoxin B1 in cereal.

Ren W, Li Z, Xu Y, Wan D, Barnych B, Li Y, Tu Z, He Q, Fu J, Hammock BD.

J Agric Food Chem. 2019 Mar 18. doi: 10.1021/acs.jafc.9b00688. [Epub ahead of print]


Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats.

Hrdlička J, Neckář J, Papoušek F, Husková Z, Kikerlová S, Vaňourková Z, Vernerová Z, Akat F, Vašinová J, Hammock BD, Hwang SH, Imig JD, Falck JR, Červenka L, Kolář F.

Front Pharmacol. 2019 Mar 1;10:159. doi: 10.3389/fphar.2019.00159. eCollection 2019.


A novel and simple imidazo[1,2-a]pyridin fluorescent probe for the sensitive and selective imaging of cysteine in living cells and zebrafish.

Zhu M, Wang L, Wu X, Na R, Wang Y, Li QX, Hammock BD.

Anal Chim Acta. 2019 Jun 13;1058:155-165. doi: 10.1016/j.aca.2019.01.023. Epub 2019 Jan 25.


Development of a camelid variable domain of heavy chain antibody-based immunoassay for the detection of carbaryl in cereals.

Liu Z, Wang K, Wu S, Wang Z, Ding G, Hao X, Li QX, Li J, Gee SJ, Hammock BD, Xu T.

J Sci Food Agric. 2019 Mar 9. doi: 10.1002/jsfa.9672. [Epub ahead of print]


Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif).

Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD.

Anal Chim Acta. 2019 May 30;1057:106-113. doi: 10.1016/j.aca.2018.12.060. Epub 2019 Jan 9.


One-step immunoassay for the insecticide carbaryl using a chicken single-chain variable fragment (scFv) fused to alkaline phosphatase.

He J, Tao X, Wang K, Ding G, Li J, Li QX, Gee SJ, Hammock BD, Xu T.

Anal Biochem. 2019 Mar 1;572:9-15. doi: 10.1016/j.ab.2019.02.022. [Epub ahead of print]


Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK.

Luo Y, Wu MY, Deng BQ, Huang J, Hwang SH, Li MY, Zhou CY, Zhang QY, Yu HB, Zhao DK, Zhang G, Qin L, Peng A, Hammock BD, Liu JY.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5154-5159. doi: 10.1073/pnas.1815746116. Epub 2019 Feb 25.


Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis.

Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song CQ, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, Shih PB, Lee KSS, Minter LM, Kim D, Xiao H, Liu JY, Hammock BD, Zeldin DC, Zhang G.

Cancer Res. 2019 Feb 25. pii: canres.3221.2018. doi: 10.1158/0008-5472.CAN-18-3221. [Epub ahead of print]


Inhibition of Soluble Epoxide Hydrolase Ameliorates Hyperhomocysteinemia-Induced Hepatic Steatosis by Enhancing β-oxidation of Fatty Acid in Mice.

Yao L, Cao B, Cheng Q, Cai W, Ye C, Liang J, Liu W, Tan L, Yan M, Li B, He J, Hwang SH, Zhang X, Wang C, Ai D, Hammock BD, Zhu Y.

Am J Physiol Gastrointest Liver Physiol. 2019 Feb 21. doi: 10.1152/ajpgi.00148.2018. [Epub ahead of print]


The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.

de Oliveira GS, Adriani PP, Ribeiro JA, Morisseau C, Hammock BD, Dias MVB, Chambergo FS.

Int J Biol Macromol. 2019 Feb 13;129:653-658. doi: 10.1016/j.ijbiomac.2019.02.070. [Epub ahead of print]


Pharmacological Blockade of Soluble Epoxide Hydrolase Attenuates the Progression of Congestive Heart Failure Combined With Chronic Kidney Disease: Insights From Studies With Fawn-Hooded Hypertensive Rats.

Vacková Š, Kopkan L, Kikerlová S, Husková Z, Sadowski J, Kompanowska-Jezierska E, Hammock BD, Imig JD, Táborský M, Melenovský V, Červenka L.

Front Pharmacol. 2019 Jan 23;10:18. doi: 10.3389/fphar.2019.00018. eCollection 2019.


Development of a one-step immunoassay for triazophos using camel single-domain antibody-alkaline phosphatase fusion protein.

Wang K, Liu Z, Ding G, Li J, Vasylieva N, Li QX, Li D, Gee SJ, Hammock BD, Xu T.

Anal Bioanal Chem. 2019 Feb;411(6):1287-1295. doi: 10.1007/s00216-018-01563-7. Epub 2019 Feb 1.


Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor.

Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hwang SH, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1698-1703. doi: 10.1073/pnas.1803999116. Epub 2019 Jan 15.


Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity.

Hiesinger K, Wagner KM, Hammock BD, Proschak E, Hwang SH.

Prostaglandins Other Lipid Mediat. 2019 Feb;140:31-39. doi: 10.1016/j.prostaglandins.2018.12.003. Epub 2018 Dec 26. Review.


Quantitative Detection of Fipronil and Fipronil-Sulfone in Sera of Black-Tailed Prairie Dogs and Rats after Oral Exposure to Fipronil by Camel Single-Domain Antibody-Based Immunoassays.

Wang K, Vasylieva N, Wan D, Eads DA, Yang J, Tretten T, Barnych B, Li J, Li QX, Gee SJ, Hammock BD, Xu T.

Anal Chem. 2018 Dec 6. doi: 10.1021/acs.analchem.8b04653. [Epub ahead of print]


Competitive and noncompetitive immunoassays for the detection of benzothiostrobin using magnetic nanoparticles and fluorescein isothiocyanate-labeled peptides.

Chen H, Yang Q, Ding Y, Vasylieva N, Bever CS, Hua X, Wang M, Hammock BD.

Anal Bioanal Chem. 2019 Jan;411(2):527-535. doi: 10.1007/s00216-018-1478-8. Epub 2018 Nov 26.


Soluble epoxide hydrolase inhibitor, APAU, protects dopaminergic neurons against rotenone induced neurotoxicity: Implications for Parkinson's disease.

Lakkappa N, Krishnamurthy PT, M D P, Hammock BD, Hwang SH.

Neurotoxicology. 2019 Jan;70:135-145. doi: 10.1016/j.neuro.2018.11.010. Epub 2018 Nov 22.


Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time.

Hennebelle M, Metherel AH, Kitson AP, Otoki Y, Yang J, Lee KSS, Hammock BD, Bazinet RP, Taha AY.

J Lipid Res. 2019 Mar;60(3):671-682. doi: 10.1194/jlr.D084228. Epub 2018 Nov 21.


Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders.

Zarriello S, Tuazon JP, Corey S, Schimmel S, Rajani M, Gorsky A, Incontri D, Hammock BD, Borlongan CV.

Prog Neurobiol. 2019 Jan;172:23-39. doi: 10.1016/j.pneurobio.2018.11.001. Epub 2018 Nov 14. Review.


Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei.

de Oliveira GS, Adriani PP, Wu H, Morisseau C, Hammock BD, Chambergo FS.

Mol Biol Rep. 2019 Feb;46(1):371-379. doi: 10.1007/s11033-018-4481-4. Epub 2018 Nov 13.


Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors.

Kodani SD, Wan D, Wagner KM, Hwang SH, Morisseau C, Hammock BD.

ACS Omega. 2018 Oct 31;3(10):14076-14086. doi: 10.1021/acsomega.8b01625. Epub 2018 Oct 25.


Development of a Highly Sensitive Direct Competitive Fluorescence Enzyme Immunoassay Based on a Nanobody-Alkaline Phosphatase Fusion Protein for Detection of 3-Phenoxybenzoic Acid in Urine.

Huo J, Li Z, Wan D, Li D, Qi M, Barnych B, Vasylieva N, Zhang J, Hammock BD.

J Agric Food Chem. 2018 Oct 31;66(43):11284-11290. doi: 10.1021/acs.jafc.8b04521. Epub 2018 Oct 17.


Omega-3 PUFA attenuate mice myocardial infarction injury by emerging a protective eicosanoid pattern.

Fang X, Cai W, Cheng Q, Ai D, Wang X, Hammock BD, Zhu Y, Zhang X.

Prostaglandins Other Lipid Mediat. 2018 Nov;139:1-9. doi: 10.1016/j.prostaglandins.2018.09.002. Epub 2018 Sep 14. Review.


Development of a Nanobody-AviTag Fusion Protein and Its Application in a Streptavidin-Biotin-Amplified Enzyme-Linked Immunosorbent Assay for Ochratoxin A in Cereal.

Sun Z, Lv J, Liu X, Tang Z, Wang X, Xu Y, Hammock BD.

Anal Chem. 2018 Sep 4;90(17):10628-10634. doi: 10.1021/acs.analchem.8b03085. Epub 2018 Aug 22.


Strong and oriented conjugation of nanobodies onto magnetosomes for the development of a rapid immunomagnetic assay for the environmental detection of tetrabromobisphenol-A.

He J, Tian J, Xu J, Wang K, Li J, Gee SJ, Hammock BD, Li QX, Xu T.

Anal Bioanal Chem. 2018 Oct;410(25):6633-6642. doi: 10.1007/s00216-018-1270-9. Epub 2018 Aug 1.


Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption.

Napimoga MH, Rocha EP, Trindade-da-Silva CA, Demasi APD, Martinez EF, Macedo CG, Abdalla HB, Bettaieb A, Haj FG, Clemente-Napimoga JT, Inceoglu B, Hammock BD.

J Periodontal Res. 2018 Oct;53(5):743-749. doi: 10.1111/jre.12559. Epub 2018 May 31.


Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride-Induced Model of Liver Injury.

Harris TR, Kodani S, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD.

Mol Pharmacol. 2018 Aug;94(2):834-841. doi: 10.1124/mol.118.111831. Epub 2018 May 29.


Adamantyl thioureas as soluble epoxide hydrolase inhibitors.

Burmistrov V, Morisseau C, Pitushkin D, Karlov D, Fayzullin RR, Butov GM, Hammock BD.

Bioorg Med Chem Lett. 2018 Jul 15;28(13):2302-2313. doi: 10.1016/j.bmcl.2018.05.024. Epub 2018 May 23.


An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats.

Minaz N, Razdan R, Hammock BD, Goswami SK.

Prostaglandins Other Lipid Mediat. 2018 May;136:84-89. doi: 10.1016/j.prostaglandins.2018.05.004. Epub 2018 May 8.


Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.

Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5815-E5823. doi: 10.1073/pnas.1802179115. Epub 2018 May 7.


Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation.

Wang W, Yang J, Zhang J, Wang Y, Hwang SH, Qi W, Wan D, Kim D, Sun J, Sanidad KZ, Yang H, Park Y, Liu JY, Zhao X, Zheng X, Liu Z, Hammock BD, Zhang G.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):5283-5288. doi: 10.1073/pnas.1721711115. Epub 2018 May 1.


Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy.

Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD.

J Med Chem. 2018 May 10;61(9):4271. doi: 10.1021/acs.jmedchem.8b00582. Epub 2018 Apr 27. No abstract available.


Celecoxib use and circulating oxylipins in a colon polyp prevention trial.

Martinez JA, Yang J, Wertheim BC, Roe DJ, Schriewer A, Lance P, Alberts DS, Hammock BD, Thompson PA.

PLoS One. 2018 Apr 26;13(4):e0196398. doi: 10.1371/journal.pone.0196398. eCollection 2018.


Noncompetitive Homogeneous Detection of Small Molecules Using Synthetic Nanopeptamer-Based Luminescent Oxygen Channeling.

Lassabe G, Kramer K, Hammock BD, González-Sapienza G, González-Techera A.

Anal Chem. 2018 May 15;90(10):6187-6192. doi: 10.1021/acs.analchem.8b00657. Epub 2018 May 1.


Effects of triclosan in breast milk on the infant fecal microbiome.

Bever CS, Rand AA, Nording M, Taft D, Kalanetra KM, Mills DA, Breck MA, Smilowitz JT, German JB, Hammock BD.

Chemosphere. 2018 Jul;203:467-473. doi: 10.1016/j.chemosphere.2018.03.186. Epub 2018 Mar 28.


Biotinylated single-chain variable fragment-based enzyme-linked immunosorbent assay for glycocholic acid.

Cui X, Vasylieva N, Shen D, Barnych B, Yang J, He Q, Jiang Z, Zhao S, Hammock BD.

Analyst. 2018 Apr 30;143(9):2057-2065. doi: 10.1039/c7an02024d.


Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.

Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD.

J Med Chem. 2018 Apr 26;61(8):3541-3550. doi: 10.1021/acs.jmedchem.7b01804. Epub 2018 Apr 10.


Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia.

Tu R, Armstrong J, Lee KSS, Hammock BD, Sapirstein A, Koehler RC.

Sci Rep. 2018 Mar 27;8(1):5279. doi: 10.1038/s41598-018-23504-1.


Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension.

Červenka L, Husková Z, Kopkan L, Kikerlová S, Sedláková L, Vaňourková Z, Alánová P, Kolář F, Hammock BD, Hwang SH, Imig JD, Falck JR, Sadowski J, Kompanowska-Jezierska E, Neckář J.

J Hypertens. 2018 Jun;36(6):1326-1341. doi: 10.1097/HJH.0000000000001708.


Indomethacin Enhances Brown Fat Activity.

Hao L, Kearns J, Scott S, Wu D, Kodani SD, Morisseau C, Hammock BD, Sun X, Zhao L, Wang S.

J Pharmacol Exp Ther. 2018 Jun;365(3):467-475. doi: 10.1124/jpet.117.246256. Epub 2018 Mar 22.


Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability.

Pecic S, Zeki AA, Xu X, Jin GY, Zhang S, Kodani S, Halim M, Morisseau C, Hammock BD, Deng SX.

Prostaglandins Other Lipid Mediat. 2018 May;136:90-95. doi: 10.1016/j.prostaglandins.2018.02.004. Epub 2018 Mar 20.


Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease.

Čertíková Chábová V, Kujal P, Škaroupková P, Varňourková Z, Vacková Š, Husková Z, Kikerlová S, Sadowski J, Kompanowska-Jezierska E, Baranowska I, Hwang SH, Hammock BD, Imig JD, Tesař V, Červenka L.

Kidney Blood Press Res. 2018;43(2):329-349. doi: 10.1159/000487902. Epub 2018 Mar 6.


Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistula.

Kala P, Sedláková L, Škaroupková P, Kopkan L, Vaňourková Z, Táborský M, Nishiyama A, Hwang SH, Hammock BD, Sadowski J, Melenovský V, Imig JD, Červenka L.

Physiol Res. 2018 Jul 17;67(3):401-415. Epub 2018 Mar 12.


Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides.

Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg F, Gizzi P, Erakovic Haber V, Bencetic Mihaljevic V, Tavcar B, Portelius E, Pannee J, Blennow K, Zetterberg H, Garbis SD, Auvray P, Gerber H, Fraering J, Fraering PC, Meijer L.

J Alzheimers Dis. 2018;62(4):1663-1681. doi: 10.3233/JAD-170875.


Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function.

Yamanashi H, Boeglin WE, Morisseau C, Davis RW, Sulikowski GA, Hammock BD, Brash AR.

J Lipid Res. 2018 Apr;59(4):684-695. doi: 10.1194/jlr.M082701. Epub 2018 Feb 19.


Metabolic/inflammatory/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target.

Swardfager W, Hennebelle M, Yu D, Hammock BD, Levitt AJ, Hashimoto K, Taha AY.

Neurosci Biobehav Rev. 2018 Apr;87:56-66. doi: 10.1016/j.neubiorev.2018.01.010. Epub 2018 Feb 2. Review.


Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.

Kodani SD, Bhakta S, Hwang SH, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):762-768. doi: 10.1016/j.bmcl.2018.01.003. Epub 2018 Jan 4.


LC-MS/MS Analysis of the Epoxides and Diols Derived from the Endocannabinoid Arachidonoyl Ethanolamide.

Rand AA, Helmer PO, Inceoglu B, Hammock BD, Morisseau C.

Methods Mol Biol. 2018;1730:123-133. doi: 10.1007/978-1-4939-7592-1_10.


Inhibition of soluble epoxide hydrolase attenuates eosinophil recruitment and food allergen-induced gastrointestinal inflammation.

Bastan I, Ge XN, Dileepan M, Greenberg YG, Guedes AG, Hwang SH, Hammock BD, Washabau RJ, Rao SP, Sriramarao P.

J Leukoc Biol. 2018 Jul;104(1):109-122. doi: 10.1002/JLB.3MA1017-423R. Epub 2018 Jan 17.


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