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Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models.

Wagner KM, Atone J, Hammock BD.

Brain Res. 2019 Nov 29:146573. doi: 10.1016/j.brainres.2019.146573. [Epub ahead of print]


Inactivation of SERCA2 cysteine 674 increases blood pressure by induction of endoplasmic reticulum stress and soluble epoxide hydrolase.

Liu G, Wu F, Jiang X, Que Y, Qin Z, Hu P, Lee KSS, Yang J, Zeng C, Hammock BD, Tong X.

Br J Pharmacol. 2019 Nov 23. doi: 10.1111/bph.14937. [Epub ahead of print]


Ultrasensitive and rapid detection of ochratoxin A in agro-products by a nanobody-mediated FRET-based immunosensor.

Tang Z, Liu X, Su B, Chen Q, Cao H, Yun Y, Xu Y, Hammock BD.

J Hazard Mater. 2019 Nov 12:121678. doi: 10.1016/j.jhazmat.2019.121678. [Epub ahead of print]


Prostaglandins and other lipid mediators cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases.

Atone J, Wagner K, Hashimoto K, Hammock BD.

Prostaglandins Other Lipid Mediat. 2019 Nov 5;147:106385. doi: 10.1016/j.prostaglandins.2019.106385. [Epub ahead of print] Review.


Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids.

Otoki Y, Metherel AH, Pedersen T, Yang J, Hammock BD, Bazinet RP, Newman JW, Taha AY.

Lipids. 2019 Nov 6. doi: 10.1002/lipd.12197. [Epub ahead of print]


COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence.

Zhang CY, Duan JX, Yang HH, Sun CC, Zhong WJ, Tao JH, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX.

FEBS J. 2019 Oct 24. doi: 10.1111/febs.15105. [Epub ahead of print]


Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2.

Rand AA, Rajamani A, Kodani SD, Harris TR, Schlatt L, Barnych B, Passerini AG, Hammock BD.

J Lipid Res. 2019 Dec;60(12):1996-2005. doi: 10.1194/jlr.M094219. Epub 2019 Oct 22.


Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation.

Dileepan M, Rastle-Simpson S, Greenberg Y, Wijesinghe DS, Kumar NG, Yang J, Hwang SH, Hammock BD, Sriramarao P, Rao SP.

Front Pharmacol. 2019 Sep 27;10:1118. doi: 10.3389/fphar.2019.01118. eCollection 2019.


Investigation of the Small Size of Nanobodies for a Sensitive Fluorescence Polarization Immunoassay for Small Molecules: 3-Phenoxybenzoic Acid, an Exposure Biomarker of Pyrethroid Insecticides as a Model.

Wang Y, Li Z, Barnych B, Huo J, Wan D, Vasylieva N, Xu J, Li P, Liu B, Zhang C, Hammock BD.

J Agric Food Chem. 2019 Oct 16;67(41):11536-11541. doi: 10.1021/acs.jafc.9b04621. Epub 2019 Oct 7.


Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways.

Lee KSS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD.

ACS Cent Sci. 2019 Sep 25;5(9):1614-1624. doi: 10.1021/acscentsci.9b00770. Epub 2019 Sep 3.


Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets.

Yang J, Bruun DA, Wang C, Wan D, McReynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD.

Toxicol Appl Pharmacol. 2019 Nov 1;382:114749. doi: 10.1016/j.taap.2019.114749. Epub 2019 Sep 12.


Microfluidic cap-to-dispense (μCD): a universal microfluidic-robotic interface for automated pipette-free high-precision liquid handling.

Wang J, Deng K, Zhou C, Fang Z, Meyer C, Deshpande KU, Li Z, Mi X, Luo Q, Hammock BD, Tan C, Chen Y, Pan T.

Lab Chip. 2019 Oct 9;19(20):3405-3415. doi: 10.1039/c9lc00622b.


Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors.

Codony S, Valverde E, Leiva R, Brea J, Isabel Loza M, Morisseau C, Hammock BD, Vázquez S.

Bioorg Med Chem. 2019 Oct 15;27(20):115078. doi: 10.1016/j.bmc.2019.115078. Epub 2019 Aug 26.


A label-free optical whole-cell Escherichia coli biosensor for the detection of pyrethroid insecticide exposure.

Riangrungroj P, Bever CS, Hammock BD, Polizzi KM.

Sci Rep. 2019 Aug 28;9(1):12466. doi: 10.1038/s41598-019-48907-6.


Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.

Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knöll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati GE, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E.

J Med Chem. 2019 Sep 26;62(18):8443-8460. doi: 10.1021/acs.jmedchem.9b00445. Epub 2019 Sep 17.


Fluorescent "Turn off-on" Small-Molecule-Monitoring Nanoplatform Based on Dendrimer-like Peptides as Competitors.

Chen H, Ding Y, Yang Q, Barnych B, González-Sapienza G, Hammock BD, Wang M, Hua X.

ACS Appl Mater Interfaces. 2019 Sep 11;11(36):33380-33389. doi: 10.1021/acsami.9b13111. Epub 2019 Aug 30.


1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer's Signaling in Human Nerve Cells.

Liang Z, Zhang B, Xu M, Morisseau C, Hwang SH, Hammock BD, Li QX.

ACS Chem Neurosci. 2019 Sep 18;10(9):4018-4030. doi: 10.1021/acschemneuro.9b00271. Epub 2019 Aug 19.


Highly Specific Monoclonal Antibody and Sensitive Quantum Dot Beads-Based Fluorescence Immunochromatographic Test Strip for Tebuconazole Assay in Agricultural Products.

Wang Y, Xu J, Qiu Y, Li P, Liu B, Yang L, Barnych B, Hammock BD, Zhang C.

J Agric Food Chem. 2019 Aug 14;67(32):9096-9103. doi: 10.1021/acs.jafc.9b02832. Epub 2019 Aug 5.


Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model.

Shen Y, Peng W, Chen Q, Hammock BD, Liu J, Li D, Yang J, Ding J, Wang X.

Brain Behav Immun. 2019 Oct;81:535-544. doi: 10.1016/j.bbi.2019.07.014. Epub 2019 Jul 12.


Computer-Aided Selective Optimization of Side Activities of Talinolol.

Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner K, Hammock BD, Proschak E.

ACS Med Chem Lett. 2019 May 29;10(6):899-903. doi: 10.1021/acsmedchemlett.9b00075. eCollection 2019 Jun 13.


Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice.

Klocke J, Ulu A, Wu K, Rudolph B, Dragun D, Gollasch M, Schunck WH, Hammock BD, Riemekasten G, Enghard P.

Sci Rep. 2019 Jun 20;9(1):8993. doi: 10.1038/s41598-019-45299-5.


Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis.

McReynolds CB, Hwang SH, Yang J, Wan D, Wagner K, Morisseau C, Li D, Schmidt WK, Hammock BD.

Front Pharmacol. 2019 May 31;10:533. doi: 10.3389/fphar.2019.00533. eCollection 2019.


Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases.

Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP.

J Clin Invest. 2019 Jun 17;129(7):2964-2979. doi: 10.1172/JCI127282. eCollection 2019 Jun 17.


Dimethyl Sulfoxide Decreases Levels of Oxylipin Diols in Mouse Liver.

Deol P, Yang J, Morisseau C, Hammock BD, Sladek FM.

Front Pharmacol. 2019 May 29;10:580. doi: 10.3389/fphar.2019.00580. eCollection 2019.


Cyclic peptide: a safe and effective alternative to synthetic aflatoxin B1-competitive antigens.

Mukhtar H, Ma L, Pang Q, Zhou Y, Wang X, Xu T, Hammock BD, Wang J.

Anal Bioanal Chem. 2019 Jul;411(17):3881-3890. doi: 10.1007/s00216-019-01862-7. Epub 2019 May 31.


N-Substituted amino acid inhibitors of the phosphatase domain of the soluble epoxide hydrolase.

Matsumoto N, Kataoka M, Hirosaki H, Morisseau C, Hammock BD, Suzuki E, Hasumi K.

Biochem Biophys Res Commun. 2019 Jul 12;515(1):248-253. doi: 10.1016/j.bbrc.2019.05.088. Epub 2019 May 27.


In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea.

Wan D, Yang J, McReynolds CB, Barnych B, Wagner KM, Morisseau C, Hwang SH, Sun J, Blöcher R, Hammock BD.

Front Pharmacol. 2019 May 8;10:464. doi: 10.3389/fphar.2019.00464. eCollection 2019.


Impact of diabetes on male sexual function in streptozotocin-induced diabetic rats: Protective role of soluble epoxide hydrolase inhibitor.

Minaz N, Razdan R, Hammock BD, Mujwar S, Goswami SK.

Biomed Pharmacother. 2019 Jul;115:108897. doi: 10.1016/j.biopha.2019.108897. Epub 2019 May 15.


Nanobody-based fluorescence resonance energy transfer immunoassay for noncompetitive and simultaneous detection of ochratoxin a and ochratoxin B.

Tang Z, Liu X, Wang Y, Chen Q, Hammock BD, Xu Y.

Environ Pollut. 2019 Aug;251:238-245. doi: 10.1016/j.envpol.2019.04.135. Epub 2019 May 2.


Addition of milk fat globule membrane-enriched supplement to a high-fat meal attenuates insulin secretion and induction of soluble epoxide hydrolase gene expression in the postprandial state in overweight and obese subjects.

Beals E, Kamita SG, Sacchi R, Demmer E, Rivera N, Rogers-Soeder TS, Gertz ER, Van Loan MD, German JB, Hammock BD, Smilowitz JT, Zivkovic AM.

J Nutr Sci. 2019 Apr 26;8:e16. doi: 10.1017/jns.2019.11. eCollection 2019.


Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer's Disease-Like Complications of Diabetes.

Pardeshi R, Bolshette N, Gadhave K, Arfeen M, Ahmed S, Jamwal R, Hammock BD, Lahkar M, Goswami SK.

Front Pharmacol. 2019 Apr 24;10:288. doi: 10.3389/fphar.2019.00288. eCollection 2019.


Hapten Synthesis, Antibody Development, and a Highly Sensitive Indirect Competitive Chemiluminescent Enzyme Immunoassay for Detection of Dicamba.

Huo J, Barnych B, Li Z, Wan D, Li D, Vasylieva N, Knezevic SZ, Osipitan OA, Scott JE, Zhang J, Hammock BD.

J Agric Food Chem. 2019 May 22;67(20):5711-5719. doi: 10.1021/acs.jafc.8b07134. Epub 2019 May 7.


Improving the sensitivity of traditional Western blotting via Streptavidin containing Poly-horseradish peroxidase (PolyHRP).

Mishra M, Tiwari S, Gunaseelan A, Li D, Hammock BD, Gomes AV.

Electrophoresis. 2019 Jul;40(12-13):1731-1739. doi: 10.1002/elps.201900059. Epub 2019 May 9.


Phytochemical constituents from Scutellaria baicalensis in soluble epoxide hydrolase inhibition: Kinetics and interaction mechanism merged with simulations.

Liu ZB, Sun CP, Xu JX, Morisseau C, Hammock BD, Qiu F.

Int J Biol Macromol. 2019 Jul 15;133:1187-1193. doi: 10.1016/j.ijbiomac.2019.04.055. Epub 2019 Apr 10.


Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation.

Ma M, Ren Q, Yang J, Zhang K, Xiong Z, Ishima T, Pu Y, Hwang SH, Toyoshima M, Iwayama Y, Hisano Y, Yoshikawa T, Hammock BD, Hashimoto K.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7083-7088. doi: 10.1073/pnas.1819234116. Epub 2019 Mar 19.


One-Step Ultrasensitive Bioluminescent Enzyme Immunoassay Based on Nanobody/Nanoluciferase Fusion for Detection of Aflatoxin B1 in Cereal.

Ren W, Li Z, Xu Y, Wan D, Barnych B, Li Y, Tu Z, He Q, Fu J, Hammock BD.

J Agric Food Chem. 2019 May 8;67(18):5221-5229. doi: 10.1021/acs.jafc.9b00688. Epub 2019 Apr 24.


Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats.

Hrdlička J, Neckář J, Papoušek F, Husková Z, Kikerlová S, Vaňourková Z, Vernerová Z, Akat F, Vašinová J, Hammock BD, Hwang SH, Imig JD, Falck JR, Červenka L, Kolář F.

Front Pharmacol. 2019 Mar 1;10:159. doi: 10.3389/fphar.2019.00159. eCollection 2019.


A novel and simple imidazo[1,2-a]pyridin fluorescent probe for the sensitive and selective imaging of cysteine in living cells and zebrafish.

Zhu M, Wang L, Wu X, Na R, Wang Y, Li QX, Hammock BD.

Anal Chim Acta. 2019 Jun 13;1058:155-165. doi: 10.1016/j.aca.2019.01.023. Epub 2019 Jan 25.


Development of an immunoassay for the detection of carbaryl in cereals based on a camelid variable heavy-chain antibody domain.

Liu Z, Wang K, Wu S, Wang Z, Ding G, Hao X, Li QX, Li J, Gee SJ, Hammock BD, Xu T.

J Sci Food Agric. 2019 Jul;99(9):4383-4390. doi: 10.1002/jsfa.9672. Epub 2019 Apr 3.


Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif).

Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD.

Anal Chim Acta. 2019 May 30;1057:106-113. doi: 10.1016/j.aca.2018.12.060. Epub 2019 Jan 9.


One-step immunoassay for the insecticide carbaryl using a chicken single-chain variable fragment (scFv) fused to alkaline phosphatase.

He J, Tao X, Wang K, Ding G, Li J, Li QX, Gee SJ, Hammock BD, Xu T.

Anal Biochem. 2019 May 1;572:9-15. doi: 10.1016/j.ab.2019.02.022. Epub 2019 Mar 1.


Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK.

Luo Y, Wu MY, Deng BQ, Huang J, Hwang SH, Li MY, Zhou CY, Zhang QY, Yu HB, Zhao DK, Zhang G, Qin L, Peng A, Hammock BD, Liu JY.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5154-5159. doi: 10.1073/pnas.1815746116. Epub 2019 Feb 25.


Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis.

Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song CQ, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, Shih PB, Lee KSS, Minter LM, Kim D, Xiao H, Liu JY, Hammock BD, Zeldin DC, Zhang G.

Cancer Res. 2019 Apr 15;79(8):1822-1830. doi: 10.1158/0008-5472.CAN-18-3221. Epub 2019 Feb 25.


Inhibition of soluble epoxide hydrolase ameliorates hyperhomocysteinemia-induced hepatic steatosis by enhancing β-oxidation of fatty acid in mice.

Yao L, Cao B, Cheng Q, Cai W, Ye C, Liang J, Liu W, Tan L, Yan M, Li B, He J, Hwang SH, Zhang X, Wang C, Ai D, Hammock BD, Zhu Y.

Am J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G527-G538. doi: 10.1152/ajpgi.00148.2018. Epub 2019 Feb 21.


The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.

de Oliveira GS, Adriani PP, Ribeiro JA, Morisseau C, Hammock BD, Dias MVB, Chambergo FS.

Int J Biol Macromol. 2019 May 15;129:653-658. doi: 10.1016/j.ijbiomac.2019.02.070. Epub 2019 Feb 13.


Pharmacological Blockade of Soluble Epoxide Hydrolase Attenuates the Progression of Congestive Heart Failure Combined With Chronic Kidney Disease: Insights From Studies With Fawn-Hooded Hypertensive Rats.

Vacková Š, Kopkan L, Kikerlová S, Husková Z, Sadowski J, Kompanowska-Jezierska E, Hammock BD, Imig JD, Táborský M, Melenovský V, Červenka L.

Front Pharmacol. 2019 Jan 23;10:18. doi: 10.3389/fphar.2019.00018. eCollection 2019.


Development of a one-step immunoassay for triazophos using camel single-domain antibody-alkaline phosphatase fusion protein.

Wang K, Liu Z, Ding G, Li J, Vasylieva N, Li QX, Li D, Gee SJ, Hammock BD, Xu T.

Anal Bioanal Chem. 2019 Feb;411(6):1287-1295. doi: 10.1007/s00216-018-01563-7. Epub 2019 Feb 1.


Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor.

Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hwang SH, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1698-1703. doi: 10.1073/pnas.1803999116. Epub 2019 Jan 15.


Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity.

Hiesinger K, Wagner KM, Hammock BD, Proschak E, Hwang SH.

Prostaglandins Other Lipid Mediat. 2019 Feb;140:31-39. doi: 10.1016/j.prostaglandins.2018.12.003. Epub 2018 Dec 26. Review.


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