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Items: 1 to 50 of 231

1.

Proline-based allosteric inhibitors of Zika and Dengue virus NS2B/NS3 proteases.

Millies B, von Hammerstein F, Gellert A, Hammerschmidt S, Barthels F, Göppel U, Immerheiser M, Elgner F, Jung N, Basic M, Kersten C, Kiefer W, Bodem J, Hildt E, Windbergs M, Hellmich UA, Schirmeister T.

J Med Chem. 2019 Nov 26. doi: 10.1021/acs.jmedchem.9b01697. [Epub ahead of print]

PMID:
31769670
2.

Heterogeneous antimicrobial activity in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients.

Seinen J, Dieperink W, Mekonnen SA, Lisotto P, Harmsen HJM, Hiemstra B, Ott A, Schultz D, Lalk M, Oswald S, Hammerschmidt S, de Smet AMGA, van Dijl JM.

Virulence. 2019 Dec;10(1):879-891. doi: 10.1080/21505594.2019.1682797.

3.

In vivo proteomics identifies the competence regulon and AliB oligopeptide transporter as pathogenic factors in pneumococcal meningitis.

Schmidt F, Kakar N, Meyer TC, Depke M, Masouris I, Burchhardt G, Gómez-Mejia A, Dhople V, Håvarstein LS, Sun Z, Moritz RL, Völker U, Koedel U, Hammerschmidt S.

PLoS Pathog. 2019 Jul 29;15(7):e1007987. doi: 10.1371/journal.ppat.1007987. eCollection 2019 Jul.

4.

Streptococcus pneumoniae inhibits purinergic signaling and promotes purinergic receptor P2Y2 internalization in alveolar epithelial cells.

Olotu C, Lehmensiek F, Koch B, Kiefmann M, Riegel AK, Hammerschmidt S, Kiefmann R.

J Biol Chem. 2019 Aug 23;294(34):12795-12806. doi: 10.1074/jbc.RA118.007236. Epub 2019 Jul 9.

PMID:
31289122
5.

Cis autocatalytic cleavage of glycine-linked Zika virus NS2B-NS3 protease constructs.

von Hammerstein F, Lauth LM, Hammerschmidt S, Wagner A, Schirmeister T, Hellmich UA.

FEBS Lett. 2019 Aug;593(16):2204-2213. doi: 10.1002/1873-3468.13507. Epub 2019 Jul 9.

PMID:
31240714
6.

Extracellular Matrix Interactions with Gram-Positive Pathogens.

Hammerschmidt S, Rohde M, Preissner KT.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0041-2018. Review.

PMID:
31004421
7.

Von Willebrand Factor Mediates Pneumococcal Aggregation and Adhesion in Blood Flow.

Jagau H, Behrens IK, Lahme K, Lorz G, Köster RW, Schneppenheim R, Obser T, Brehm MA, König G, Kohler TP, Rohde M, Frank R, Tegge W, Fulde M, Hammerschmidt S, Steinert M, Bergmann S.

Front Microbiol. 2019 Mar 26;10:511. doi: 10.3389/fmicb.2019.00511. eCollection 2019.

8.

Electron Microscopy to Study the Fine Structure of the Pneumococcal Cell.

Hammerschmidt S, Rohde M.

Methods Mol Biol. 2019;1968:13-33. doi: 10.1007/978-1-4939-9199-0_2.

PMID:
30929202
9.

Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by the Streptococcus canis M protein SCM.

Nerlich A, Lapschies AM, Kohler TP, Cornax I, Eichhorn I, Goldmann O, Krienke P, Bergmann S, Nizet V, Hammerschmidt S, Rohde M, Fulde M.

Virulence. 2019 Dec;10(1):194-206. doi: 10.1080/21505594.2019.1589362.

10.

Contribution of Human Thrombospondin-1 to the Pathogenesis of Gram-Positive Bacteria.

Binsker U, Kohler TP, Hammerschmidt S.

J Innate Immun. 2019;11(4):303-315. doi: 10.1159/000496033. Epub 2019 Feb 27. Review.

11.

Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition.

Bülow S, Zeller L, Werner M, Toelge M, Holzinger J, Entzian C, Schubert T, Waldow F, Gisch N, Hammerschmidt S, Gessner A.

Front Immunol. 2018 Dec 5;9:2768. doi: 10.3389/fimmu.2018.02768. eCollection 2018.

12.

Fibronectin modulates formation of PF4/heparin complexes and is a potential factor for reducing risk of developing HIT.

Krauel K, Preuße P, Warkentin TE, Trabhardt C, Brandt S, Jensch I, Mandelkow M, Hammer E, Hammerschmidt S, Greinacher A.

Blood. 2019 Feb 28;133(9):978-989. doi: 10.1182/blood-2018-05-850370. Epub 2018 Dec 20.

PMID:
30573633
13.

Intranasal Vaccination With Lipoproteins Confers Protection Against Pneumococcal Colonisation.

Voß F, Kohler TP, Meyer T, Abdullah MR, van Opzeeland FJ, Saleh M, Michalik S, van Selm S, Schmidt F, de Jonge MI, Hammerschmidt S.

Front Immunol. 2018 Oct 18;9:2405. doi: 10.3389/fimmu.2018.02405. eCollection 2018.

14.

The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface.

Haleem KS, Ali YM, Yesilkaya H, Kohler T, Hammerschmidt S, Andrew PW, Schwaeble WJ, Lynch NJ.

Infect Immun. 2018 Dec 19;87(1). pii: e00742-18. doi: 10.1128/IAI.00742-18. Print 2019 Jan.

15.

CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo.

Hammerschmidt SI, Werth K, Rothe M, Galla M, Permanyer M, Patzer GE, Bubke A, Frenk DN, Selich A, Lange L, Schambach A, Bošnjak B, Förster R.

Front Immunol. 2018 Aug 28;9:1949. doi: 10.3389/fimmu.2018.01949. eCollection 2018.

16.

Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two-Component Regulatory System 08.

Gómez-Mejia A, Gámez G, Hirschmann S, Kluger V, Rath H, Böhm S, Voss F, Kakar N, Petruschka L, Völker U, Brückner R, Mäder U, Hammerschmidt S.

mSphere. 2018 May 16;3(3). pii: e00165-18. doi: 10.1128/mSphere.00165-18. eCollection 2018 May-Jun.

17.

Attachment of phosphorylcholine residues to pneumococcal teichoic acids and modification of substitution patterns by the phosphorylcholine esterase.

Waldow F, Kohler TP, Hess N, Schwudke D, Hammerschmidt S, Gisch N.

J Biol Chem. 2018 Jul 6;293(27):10620-10629. doi: 10.1074/jbc.RA118.003360. Epub 2018 May 15.

18.

Aerobic bacteria associated with chronic suppurative otitis media in Angola.

Uddén F, Filipe M, Reimer Å, Paul M, Matuschek E, Thegerström J, Hammerschmidt S, Pelkonen T, Riesbeck K.

Infect Dis Poverty. 2018 May 3;7(1):42. doi: 10.1186/s40249-018-0422-7.

19.

Interaction between the Staphylococcus aureus extracellular adherence protein Eap and its subdomains with platelets.

Palankar R, Binsker U, Haracska B, Wesche J, Greinacher A, Hammerschmidt S.

Int J Med Microbiol. 2018 Aug;308(6):683-691. doi: 10.1016/j.ijmm.2018.04.004. Epub 2018 Apr 18.

PMID:
29691140
20.

Mast Cells Are Activated by Streptococcus pneumoniae In Vitro but Dispensable for the Host Defense Against Pneumococcal Central Nervous System Infection In Vivo.

Fritscher J, Amberger D, Dyckhoff S, Bewersdorf JP, Masouris I, Voelk S, Hammerschmidt S, Schmetzer HM, Klein M, Pfister HW, Koedel U.

Front Immunol. 2018 Mar 19;9:550. doi: 10.3389/fimmu.2018.00550. eCollection 2018.

21.

Secreted Immunomodulatory Proteins of Staphylococcus aureus Activate Platelets and Induce Platelet Aggregation.

Binsker U, Palankar R, Wesche J, Kohler TP, Prucha J, Burchhardt G, Rohde M, Schmidt F, Bröker BM, Mamat U, Pané-Farré J, Graf A, Ebner P, Greinacher A, Hammerschmidt S.

Thromb Haemost. 2018 Apr;118(4):745-757. doi: 10.1055/s-0038-1637735. Epub 2018 Mar 19.

PMID:
29554697
22.

Proteomic response of Streptococcus pneumoniae to iron limitation.

Hoyer J, Bartel J, Gómez-Mejia A, Rohde M, Hirschfeld C, Heß N, Sura T, Maaß S, Hammerschmidt S, Becher D.

Int J Med Microbiol. 2018 Aug;308(6):713-721. doi: 10.1016/j.ijmm.2018.02.001. Epub 2018 Feb 13.

PMID:
29496408
23.

Metabolic inventory of Streptococcus pneumoniae growing in a chemical defined environment.

Leonard A, Gierok P, Methling K, Gómez-Mejia A, Hammerschmidt S, Lalk M.

Int J Med Microbiol. 2018 Aug;308(6):705-712. doi: 10.1016/j.ijmm.2018.01.001. Epub 2018 Jan 3.

PMID:
29398251
24.

Platelets kill bacteria by bridging innate and adaptive immunity via platelet factor 4 and FcγRIIA.

Palankar R, Kohler TP, Krauel K, Wesche J, Hammerschmidt S, Greinacher A.

J Thromb Haemost. 2018 Jun;16(6):1187-1197. doi: 10.1111/jth.13955. Epub 2018 Apr 23.

PMID:
29350833
25.

Port d'Entrée for Respiratory Infections - Does the Influenza A Virus Pave the Way for Bacteria?

Siemens N, Oehmcke-Hecht S, Mettenleiter TC, Kreikemeyer B, Valentin-Weigand P, Hammerschmidt S.

Front Microbiol. 2017 Dec 21;8:2602. doi: 10.3389/fmicb.2017.02602. eCollection 2017. Review.

26.

The variome of pneumococcal virulence factors and regulators.

Gámez G, Castro A, Gómez-Mejia A, Gallego M, Bedoya A, Camargo M, Hammerschmidt S.

BMC Genomics. 2018 Jan 3;19(1):10. doi: 10.1186/s12864-017-4376-0.

27.

Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae.

Heß N, Waldow F, Kohler TP, Rohde M, Kreikemeyer B, Gómez-Mejia A, Hain T, Schwudke D, Vollmer W, Hammerschmidt S, Gisch N.

Nat Commun. 2017 Dec 12;8(1):2093. doi: 10.1038/s41467-017-01720-z.

28.

Streptococcus pneumoniae two-component regulatory systems: The interplay of the pneumococcus with its environment.

Gómez-Mejia A, Gámez G, Hammerschmidt S.

Int J Med Microbiol. 2018 Aug;308(6):722-737. doi: 10.1016/j.ijmm.2017.11.012. Epub 2017 Nov 26. Review.

PMID:
29221986
29.

Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells.

Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Coldewey SM, Cseresnyés Z, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF.

J Infect Dis. 2018 Jan 17;217(3):358-370. doi: 10.1093/infdis/jix305.

PMID:
28968817
30.

CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens.

Kress E, Merres J, Albrecht LJ, Hammerschmidt S, Pufe T, Tauber SC, Brandenburg LO.

Cell Commun Signal. 2017 Sep 16;15(1):32. doi: 10.1186/s12964-017-0190-1.

31.

A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions.

Michalik S, Depke M, Murr A, Gesell Salazar M, Kusebauch U, Sun Z, Meyer TC, Surmann K, Pförtner H, Hildebrandt P, Weiss S, Palma Medina LM, Gutjahr M, Hammer E, Becher D, Pribyl T, Hammerschmidt S, Deutsch EW, Bader SL, Hecker M, Moritz RL, Mäder U, Völker U, Schmidt F.

Sci Rep. 2017 Sep 8;7(1):9718. doi: 10.1038/s41598-017-10059-w.

32.

Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats.

Kanwal S, Jensch I, Palm GJ, Brönstrup M, Rohde M, Kohler TP, Somplatzki D, Tegge W, Jenkinson HF, Hammerschmidt S.

Mol Microbiol. 2017 Sep;105(6):839-859. doi: 10.1111/mmi.13740. Epub 2017 Jul 7.

33.

IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia.

Schauer AE, Klassert TE, von Lachner C, Riebold D, Schneeweiß A, Stock M, Müller MM, Hammerschmidt S, Bufler P, Seifert U, Dietert K, Dinarello CA, Nold MF, Gruber AD, Nold-Petry CA, Slevogt H.

J Innate Immun. 2017;9(4):403-418. doi: 10.1159/000469661. Epub 2017 Jun 10.

34.

SCM, the M Protein of Streptococcus canis Binds Immunoglobulin G.

Bergmann S, Eichhorn I, Kohler TP, Hammerschmidt S, Goldmann O, Rohde M, Fulde M.

Front Cell Infect Microbiol. 2017 Mar 28;7:80. doi: 10.3389/fcimb.2017.00080. eCollection 2017.

35.

Role of purinergic signaling in experimental pneumococcal meningitis.

Zierhut M, Dyckhoff S, Masouris I, Klein M, Hammerschmidt S, Pfister HW, Ayata K, Idzko M, Koedel U.

Sci Rep. 2017 Mar 16;7:44625. doi: 10.1038/srep44625.

36.

Serotype 3 pneumococci sequester platelet-derived human thrombospondin-1 via the adhesin and immune evasion protein Hic.

Binsker U, Kohler TP, Krauel K, Kohler S, Habermeyer J, Schwertz H, Hammerschmidt S.

J Biol Chem. 2017 Apr 7;292(14):5770-5783. doi: 10.1074/jbc.M116.760504. Epub 2017 Feb 16.

37.

Modular Architecture and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L (CbpL) Contributing to Pneumococcal Pathogenesis.

Gutiérrez-Fernández J, Saleh M, Alcorlo M, Gómez-Mejía A, Pantoja-Uceda D, Treviño MA, Voß F, Abdullah MR, Galán-Bartual S, Seinen J, Sánchez-Murcia PA, Gago F, Bruix M, Hammerschmidt S, Hermoso JA.

Sci Rep. 2016 Dec 5;6:38094. doi: 10.1038/srep38094.

38.

Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.

Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, Wygrecka M.

Sci Rep. 2016 Nov 28;6:37758. doi: 10.1038/srep37758.

39.

Dendritic cell migration in health and disease.

Worbs T, Hammerschmidt SI, Förster R.

Nat Rev Immunol. 2017 Jan;17(1):30-48. doi: 10.1038/nri.2016.116. Epub 2016 Nov 28. Review.

PMID:
27890914
40.

Special Issue on 'Microbe-host interactions'.

Hammerschmidt S.

FEBS Lett. 2016 Nov;590(21):3703-3704. doi: 10.1002/1873-3468.12466. No abstract available.

41.

Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction.

Mühlenkamp MC, Hallström T, Autenrieth IB, Bohn E, Linke D, Rinker J, Riesbeck K, Singh B, Leo JC, Hammerschmidt S, Zipfel PF, Schütz MS.

J Innate Immun. 2017;9(1):33-51. doi: 10.1159/000449200. Epub 2016 Nov 1.

42.

PROGRESS - prospective observational study on hospitalized community acquired pneumonia.

Ahnert P, Creutz P, Scholz M, Schütte H, Engel C, Hossain H, Chakraborty T, Bauer M, Kiehntopf M, Völker U, Hammerschmidt S, Loeffler M, Suttorp N; PROGRESS study group.

BMC Pulm Med. 2016 Jul 28;16(1):108. doi: 10.1186/s12890-016-0255-8.

43.

Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion.

Kohler S, Voß F, Gómez Mejia A, Brown JS, Hammerschmidt S.

FEBS Lett. 2016 Nov;590(21):3820-3839. doi: 10.1002/1873-3468.12352. Epub 2016 Aug 24. Review.

44.

Thioredoxins and Methionine Sulfoxide Reductases in the Pathophysiology of Pneumococcal Meningitis.

Ribes S, Abdullah MR, Saleh M, Hanisch UK, Nau R, Hammerschmidt S.

J Infect Dis. 2016 Sep 15;214(6):953-61. doi: 10.1093/infdis/jiw268. Epub 2016 Jul 1.

PMID:
27368348
45.

Comparison of pulsed corona plasma and pulsed electric fields for the decontamination of water containing Legionella pneumophila as model organism.

Banaschik R, Burchhardt G, Zocher K, Hammerschmidt S, Kolb JF, Weltmann KD.

Bioelectrochemistry. 2016 Dec;112:83-90. doi: 10.1016/j.bioelechem.2016.05.006. Epub 2016 May 26.

PMID:
27293110
46.

Induction of Central Host Signaling Kinases during Pneumococcal Infection of Human THP-1 Cells.

Kohler TP, Scholz A, Kiachludis D, Hammerschmidt S.

Front Cell Infect Microbiol. 2016 Apr 26;6:48. doi: 10.3389/fcimb.2016.00048. eCollection 2016.

47.

Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics.

Schulz O, Hammerschmidt SI, Moschovakis GL, Förster R.

Annu Rev Immunol. 2016 May 20;34:203-42. doi: 10.1146/annurev-immunol-041015-055649. Epub 2016 Feb 22. Review.

PMID:
26907216
48.

Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif.

Hallström T, Singh B, Kraiczy P, Hammerschmidt S, Skerka C, Zipfel PF, Riesbeck K.

PLoS One. 2016 Jan 25;11(1):e0147709. doi: 10.1371/journal.pone.0147709. eCollection 2016.

49.

IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration.

Kulkarni U, Karsten CM, Kohler T, Hammerschmidt S, Bommert K, Tiburzy B, Meng L, Thieme L, Recke A, Ludwig RJ, Pollok K, Kalies K, Bogen B, Boettcher M, Kamradt T, Hauser AE, Langer C, Huber-Lang M, Finkelman FD, Köhl J, Wong DM, Manz RA.

J Allergy Clin Immunol. 2016 May;137(5):1487-1497.e6. doi: 10.1016/j.jaci.2015.10.018. Epub 2015 Dec 2.

PMID:
26653800
50.

Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.

Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M.

Infect Immun. 2015 Dec;83(12):4617-29. doi: 10.1128/IAI.00948-15. Epub 2015 Sep 14.

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